Hippocampal long-term depression: master or minion in declarative memory processes?
Abstract
The neural mechanisms for the formation of declarative memory (memory for facts and events) are believed to be integrated from processes mediated by hippocampal long-term potentiation (LTP) and long-term depression (LTD). Traditionally, LTP has been designated as the main mediator of spatial memory storage in the hippocampus, whereas LTD has been assigned an auxiliary role in signal-to-noise regulation or in forgetting. It has recently become apparent, however, that LTD contributes directly to hippocampal information storage. In fact, LTD could dominate in the processing of precise spatial characteristics. Accumulating evidence supports the idea that LTP and LTD enable distinct and separate forms of information storage, which together facilitate the generation of a spatial cognitive map.
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Encoding induces synaptic long-term potentiation (LTP) or long-term depression (LTD) as major forms of learning-induced synaptic plasticity.
“Encoding induces synaptic long-term potentiation (LTP) or long-term depression (LTD) as major forms of learning-induced synaptic plasticity (222,527,616,629,1209).”
From About Sleep's Role in Memory (2013) · cites this paper as [629]
Learning during wakefulness relies both on LTP and LTD-like mechanisms.
“In light of clear evidence that learning during wakefulness relies both on LTP and LTDlike mechanisms (e.g., Refs.222, 629)”
From About Sleep's Role in Memory (2013) · cites this paper as [629]
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References 90 · Cited by 336
- Authors
- Kemp, A., & Manahan-Vaughan, D.
- Affiliations
- Ruhr University Bochum (DE)
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2007-03
- Volume
- 30
- Issue
- 3
- Pages
- 111-118
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W2065704317
- Cited by
- 336
- References
- 90
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 8 · 2023: 7 · 2022: 12 · 2021: 22 · 2020: 20 · 2019: 15 · 2018: 18 · 2017: 37 · 2016: 16 · 2015: 16 · 2014: 21 · 2013: 25 · 2012: 25
- FWCI
- 1.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- long-term potentiation, declarative memory, spatial memory, memory storage, cognitive maps, forgetting, hippocampus
- MeSH terms
- Animals, Hippocampus, Humans, Learning, Memory, Space Perception, Long-Term Potentiation, Long-Term Synaptic Depression
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