The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Polyglutamine neurodegeneration: protein misfolding revisited
Open accessAbstract
Polyglutamine diseases are a major cause of neurodegenerative disease worldwide. Recent studies highlight the importance of protein quality control mechanisms in regulating polyglutamine-induced toxicity. Drawing on these studies, we propose a model of disease pathogenesis that integrates current understanding of the role of protein folding in polyglutamine disease. We also incorporate new findings on other age-related neurodegenerative diseases in an effort to explain how protein aggregation and normal aging processes might be involved in polyglutamine disease pathogenesis.
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1 retracted
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Metadata
- Authors
- Williams, A. J., & Paulson, H. L.
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 31
- Issue
- 10
- Pages
- 521-528
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W2153807318
- Cited by
- 341
- References
- 14
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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