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Serotonin: a regulator of neuronal morphology and circuitry
Open accessAbstract
Serotonin is an important neuromodulator associated with a wide range of physiological effects in the central nervous system. The exact mechanisms whereby serotonin influences brain development are not well understood, although studies in invertebrate and vertebrate model organisms are beginning to unravel a regulatory role for serotonin in neuronal morphology and circuit formation. Recent data suggest a developmental window during which altered serotonin levels permanently influence neuronal circuitry, however, the temporal constraints and molecular mechanisms responsible are still under investigation. Growing evidence suggests that alterations in early serotonin signaling contribute to a number of neurodevelopmental and neuropsychiatric disorders. Thus, understanding how altered serotonin signaling affects neuronal morphology and plasticity, and ultimately animal physiology and pathophysiology, will be of great significance.
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“A molecular relationship between 5-HT and different types of neuroplasticity is well established (Daubert and Condron, 2010;Gaspar et al., 2003).”
From Serotonin and neuroplasticity – Links between molecular, functional and structural pathophysiology in depression (2017) · cites this paper as Daubert and Condron, 2010
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Metadata
- Authors
- Daubert, E. A., & Condron, B. G.
- Affiliations
- University of Virginia (US)
- Corresponding author
- Condron, Barry G.
- ORCID
- Condron, Barry G.
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 33
- Issue
- 9
- Pages
- 424-434
- ISSN
- 0166-2236 (ISSN-L)
- PMC
- PMC2929308
- OpenAlex
- W1988394934
- Cited by
- 326
- References
- 116
- Citations by year
- 2026: 23 · 2025: 19 · 2024: 15 · 2023: 17 · 2022: 17 · 2021: 20 · 2020: 16 · 2019: 23 · 2018: 36 · 2017: 20 · 2016: 24 · 2015: 23 · 2014: 16 · 2013: 20 · 2012: 19
- FWCI
- 1.65
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Drug Abuse (R01DA020942)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- serotonin, neuromodulation, neuronal morphology, neural circuit formation, brain development, developmental windows, neurodevelopmental disorders, neuropsychiatric disorders, synaptic plasticity, serotonin signaling
- MeSH terms
- Animals, Central Nervous System, Humans, Nerve Net, Nervous System Diseases, Neurons, Receptors, Serotonin, Serotonin
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