Cited by 326Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on BehaviorNeurogenesis and neuroplasticity mechanisms

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Serotonin: a regulator of neuronal morphology and circuitry

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Daubert, Elizabeth A., Condron, Barry G.·2010·Trends in Neurosciences

DOI 10.1016/j.tins.2010.05.005PMC PMC2929308

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Abstract

Serotonin is an important neuromodulator associated with a wide range of physiological effects in the central nervous system. The exact mechanisms whereby serotonin influences brain development are not well understood, although studies in invertebrate and vertebrate model organisms are beginning to unravel a regulatory role for serotonin in neuronal morphology and circuit formation. Recent data suggest a developmental window during which altered serotonin levels permanently influence neuronal circuitry, however, the temporal constraints and molecular mechanisms responsible are still under investigation. Growing evidence suggests that alterations in early serotonin signaling contribute to a number of neurodevelopmental and neuropsychiatric disorders. Thus, understanding how altered serotonin signaling affects neuronal morphology and plasticity, and ultimately animal physiology and pathophysiology, will be of great significance.

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Authors: Daubert, E. A., & Condron, B. G.
Affiliations: University of Virginia (US)
Corresponding author: Condron, Barry G.
ORCID: Condron, Barry G.
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 2010-09
Volume: 33
Issue: 9
Pages: 424-434
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/j.tins.2010.05.005
PMC: PMC2929308
OpenAlex: W1988394934
Cited by: 326
References: 116
Citations by year: 2026: 23 · 2025: 19 · 2024: 15 · 2023: 17 · 2022: 17 · 2021: 20 · 2020: 16 · 2019: 23 · 2018: 36 · 2017: 20 · 2016: 24 · 2015: 23 · 2014: 16 · 2013: 20 · 2012: 19
FWCI: 1.65
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Drug Abuse (R01DA020942)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: serotonin, neuromodulation, neuronal morphology, neural circuit formation, brain development, developmental windows, neurodevelopmental disorders, neuropsychiatric disorders, synaptic plasticity, serotonin signaling
MeSH terms: Animals, Central Nervous System, Humans, Nerve Net, Nervous System Diseases, Neurons, Receptors, Serotonin, Serotonin

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Serotonin: a regulator of neuronal morphology and circuitry

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