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Cited by 172Sleep and Wakefulness ResearchMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

Synaptic plasticity in sleep: learning, homeostasis and disease

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Wang, Gordon, Grone, Brian, Colas, Damien, Appelbaum, Lior, Mourrain, Philippe·2011·Trends in Neurosciences
DOI 10.1016/j.tins.2011.07.005PMC PMC3385863
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Abstract

Sleep is a fundamental and evolutionarily conserved aspect of animal life. Recent studies have shed light on the role of sleep in synaptic plasticity. Demonstrations of memory replay and synapse homeostasis suggest that one essential role of sleep is in the consolidation and optimization of synaptic circuits to retain salient memory traces despite the noise of daily experience. Here, we review this recent evidence and suggest that sleep creates a heightened state of plasticity, which may be essential for this optimization. Furthermore, we discuss how sleep deficits seen in diseases such as Alzheimer's disease and autism spectrum disorders might not just reflect underlying circuit malfunction, but could also play a direct role in the progression of those disorders.

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  • Memory consolidation during sleep likely involves both synaptic and system consolidation processes.

    “It is likely that memory consolidation during sleep involves both synaptic and system consolidation processes (1305)”

    From About Sleep's Role in Memory (2013) · cites this paper as [1305]

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References 147 · Cited by 172

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Authors
Wang, G., Grone, B., Colas, D., Appelbaum, L., & Mourrain, P.
Affiliations
  • Stanford Medicine (US)
  • Stanford University (US)
  • Bar-Ilan University (IL)
  • Inserm (FR)
ORCID
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
2011-09
Volume
34
Issue
9
Pages
452-463
ISSN
0166-2236 (ISSN-L)
DOI
10.1016/j.tins.2011.07.005
PMC
PMC3385863
OpenAlex
W2031883843
Cited by
172
References
147
Citations by year
2026: 8 · 2025: 11 · 2024: 10 · 2023: 7 · 2022: 7 · 2021: 9 · 2020: 10 · 2019: 16 · 2018: 4 · 2017: 14 · 2016: 12 · 2015: 11 · 2014: 21 · 2013: 20 · 2012: 11
FWCI
1.44
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Trends in Neurosciences (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Diabetes and Digestive and Kidney Diseases (R56DK090065, DK090065, R01DK090065)
  • National Institute of Neurological Disorders and Stroke (R01NS062798, NS062798)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
sleep, synaptic plasticity, memory consolidation, memory replay, synaptic circuits, insufficient sleep, Alzheimer's disease, autism spectrum disorder, sleep disorders
MeSH terms
Alzheimer Disease, Animals, Child, Child Development Disorders, Pervasive, Circadian Rhythm, Cognition Disorders, Homeostasis, Humans, Learning, Memory, Nerve Net, Neuronal Plasticity, Sleep

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