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Cited by 290Nerve injury and regenerationPlanarian Biology and ElectrostimulationNeurogenesis and neuroplasticity mechanisms

The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.

Nerve dependence in tissue, organ, and appendage regeneration

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Kumar, Anoop, Brockes, Jeremy P.·2012·Trends in Neurosciences
DOI 10.1016/j.tins.2012.08.003
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Abstract

Many regeneration contexts require the presence of regenerating nerves as a transient component of the progenitor cell niche. Here we review nerve involvement in regeneration of various structures in vertebrates and invertebrates. Nerves are also implicated as persistent determinants in the niche of certain stem cells in mammals, as well as in Drosophila. We consider our present understanding of the cellular and molecular mechanisms underlying nerve dependence, including evidence of critical interactions with glia and non-neural cell types. The example of the salamander aneurogenic limb illustrates that developmental interactions between the limb bud and its innervation can be determinative for adult regeneration. These phenomena provide a different perspective on nerve cells to that based on chemical and electrical excitability.

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Crossref · 10.1016/j.tins.2012.08.003

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Research works printed but not linked: 4

  1. Todd, 1823, On the process of reproduction of the members of the aquatic salamander, Q. J. Sci. Lit. Arts, 16, 84
  2. Huet, 1975, Role of the nervous system during the regeneration of an arm in a starfish: Asterina gibbosa Penn. (Echinodermata, Asteriidae), J. Embryol. Exp. Morphol., 33, 535
  3. Boilly-Marer, 1971, Role du systéme nerveux parapodial dans l’induction de parapodes supernumeraries par greffes hétérologues chez Nereis pelagica, C. R. Acad. Sci., 272, 261
  4. Guyenot, 1948, L’exploration du territoire de la patte antérieure du Triton, Rev. Suisse Zool., 55, 1

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Metadata

Authors
Kumar, A., & Brockes, J. P.
Affiliations
Institute of Structural and Molecular Biology (GB)
Corresponding author
Brockes, Jeremy P.
ORCID
Brockes, Jeremy P.
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
2012-11
Volume
35
Issue
11
Pages
691-699
ISSN
0166-2236 (ISSN-L)
DOI
10.1016/j.tins.2012.08.003
OpenAlex
W2048672935
Cited by
290
References
72
Citations by year
2026: 11 · 2025: 26 · 2024: 19 · 2023: 21 · 2022: 14 · 2021: 23 · 2020: 22 · 2019: 21 · 2018: 18 · 2017: 25 · 2016: 33 · 2015: 26 · 2014: 24 · 2013: 7
FWCI
1.93
Type
journal article
Language
en
Open access
Licence
Locations
  • Trends in Neurosciences (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
Medical Research Council
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Planarian Biology and Electrostimulation
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
tissue regeneration, organ regeneration, appendage regeneration, stem cell niche, glial interactions, salamander regeneration, vertebrate regeneration
MeSH terms
Animals, Axons, Denervation, Drosophila melanogaster, Ear, External, Extremities, Fishes, Hydra, Invertebrates, Mice, Inbred Strains, Organ Specificity, Peripheral Nerves, Planarians, Regeneration, Schwann Cells, Species Specificity, Tail, Caudata, Urodela, Vertebrates, Xenopus laevis, Axotomy, Mice

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