The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
Nerve dependence in tissue, organ, and appendage regeneration
Open accessAbstract
Many regeneration contexts require the presence of regenerating nerves as a transient component of the progenitor cell niche. Here we review nerve involvement in regeneration of various structures in vertebrates and invertebrates. Nerves are also implicated as persistent determinants in the niche of certain stem cells in mammals, as well as in Drosophila. We consider our present understanding of the cellular and molecular mechanisms underlying nerve dependence, including evidence of critical interactions with glia and non-neural cell types. The example of the salamander aneurogenic limb illustrates that developmental interactions between the limb bud and its innervation can be determinative for adult regeneration. These phenomena provide a different perspective on nerve cells to that based on chemical and electrical excitability.
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In the citing paper
“Without this initial nerve signal, the wound stump heals, but no limb grows back in newts.”
From Wound repair and regeneration: Mechanisms, signaling, and translation (2014) · cites this paper as [131]
In the citing paper
“The release of nAG from nerves appears to kick-start expression of nAG in the wound epithelium (131).”
From Wound repair and regeneration: Mechanisms, signaling, and translation (2014) · cites this paper as [131]
Citations
Cites
Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche
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The bone marrow stem cell niche grows up: mesenchymal stem cells and macrophages move in
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Comparative Aspects of Animal Regeneration
Brockes, J. P., & Kumar, A. (2008) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.24.110707.175336 · Cited by 491
Self-citationMolecular Basis for the Nerve Dependence of Limb Regeneration in an Adult Vertebrate
Kumar, A., Godwin, J. W., Gates, P. B., Garza-Garcı́a, A., & Brockes, J. P. (2007) · Science · doi:10.1126/science.1147710 · Cited by 487
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Clark, L. D., Clark, R. K., & Heber‐Katz, E. (1998) · Clinical Immunology and Immunopathology · doi:10.1006/clin.1998.4519 · Cited by 342
A stepwise model system for limb regeneration
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Cited by
Sorted by citations
Wound repair and regeneration: Mechanisms, signaling, and translation
Eming, S. A., Martin, P., & Tomic-Canic, M. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009337 · Cited by 3,562
Cellular and molecular mechanisms of repair in acute and chronic wound healing
Martin, P. B., & Nunan, R. D. (2015) · British Journal of Dermatology · doi:10.1111/bjd.13954 · Cited by 1,183
Cancer neuroscience: State of the field, emerging directions
Winkler, F., Venkatesh, H. S., Amit, M., Batchelor, T. T., Demir, İ. E., Deneen, B., Gutmann, D. H., Hervey‐Jumper, S. L., Kuner, T., Mabbott, D., et al. (2023) · Cell · doi:10.1016/j.cell.2023.02.002 · Cited by 602
Advances in Regenerative Medicine and Tissue Engineering: Innovation and Transformation of Medicine
Dzobo, K., Thomford, N. E., Senthebane, D. A., Shipanga, H., Rowe, A., Dandara, C., Pillay, M., & Motaung, K. S. (2018) · Stem Cells International · doi:10.1155/2018/2495848 · Cited by 477
CGRP sensory neurons promote tissue healing via neutrophils and macrophages
Lu, Y., Nayer, B., Singh, S. K., Alshoubaki, Y. K., Yuan, E., Park, A. J., Maruyama, K., Akira, S., & Martino, M. M. (2024) · Nature · doi:10.1038/s41586-024-07237-y · Cited by 437
Metadata
- Authors
- Kumar, A., & Brockes, J. P.
- Affiliations
- Institute of Structural and Molecular Biology (GB)
- Corresponding author
- Brockes, Jeremy P.
- ORCID
- Brockes, Jeremy P.
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2012-11
- Volume
- 35
- Issue
- 11
- Pages
- 691-699
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W2048672935
- Cited by
- 290
- References
- 72
- Citations by year
- 2026: 11 · 2025: 26 · 2024: 19 · 2023: 21 · 2022: 14 · 2021: 23 · 2020: 22 · 2019: 21 · 2018: 18 · 2017: 25 · 2016: 33 · 2015: 26 · 2014: 24 · 2013: 7
- FWCI
- 1.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Trends in Neurosciences (publishedVersion, cc-by)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Planarian Biology and Electrostimulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- tissue regeneration, organ regeneration, appendage regeneration, stem cell niche, glial interactions, salamander regeneration, vertebrate regeneration
- MeSH terms
- Animals, Axons, Denervation, Drosophila melanogaster, Ear, External, Extremities, Fishes, Hydra, Invertebrates, Mice, Inbred Strains, Organ Specificity, Peripheral Nerves, Planarians, Regeneration, Schwann Cells, Species Specificity, Tail, Caudata, Urodela, Vertebrates, Xenopus laevis, Axotomy, Mice
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