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Inhibitory Interneurons Regulate Temporal Precision and Correlations in Cortical Circuits
Open accessAbstract
GABAergic interneurons, which are highly diverse, have long been thought to contribute to the timing of neural activity as well as to the generation and shaping of brain rhythms. GABAergic activity is crucial not only for entrainment of oscillatory activity across a neural population, but also for precise regulation of the timing of action potentials and the suppression of slow-timescale correlations. The diversity of inhibition provides the potential for flexible regulation of patterned activity, but also poses a challenge to identifying the elements of excitatory-inhibitory interactions underlying network engagement. This review highlights the key roles of inhibitory interneurons in spike correlations and brain rhythms, describes several scales on which GABAergic inhibition regulates timing in neural networks, and identifies potential consequences of inhibitory dysfunction.
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“Inhibitory interneurons regulate network oscillations, which synchronize neuronal activity to rhythms that are crucial to learning and memory [112–116].”
From Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer’s disease (2019) · cites this paper as [116]
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Metadata
- Authors
- Cardin, J. A.
- Affiliations
- Yale University (US)
- Corresponding author
- Cardin, Jessica A.
- ORCID
- Cardin, Jessica A.
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 41
- Issue
- 10
- Pages
- 689-700
- ISSN
- 0166-2236 (ISSN-L)
- PMC
- PMC6173199
- OpenAlex
- W2894521163
- Cited by
- 254
- References
- 134
- Citations by year
- 2026: 25 · 2025: 45 · 2024: 43 · 2023: 21 · 2022: 26 · 2021: 36 · 2020: 30 · 2019: 23 · 2018: 5
- FWCI
- 3.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Trends in Neurosciences (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (R01 MH102365, R01 EY022951, R01 MH113852)
- Ludwig Family Foundation
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- GABAergic interneurons, inhibitory interneurons, spike timing, spike correlation, neural oscillations, excitatory-inhibitory interactions, cortical circuits, neural entrainment, inhibitory dysfunction
- MeSH terms
- Action Potentials, Animals, Humans, Interneurons, Models, Neurological, Nerve Net, Neural Inhibition, Synapses
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