Microglial Phagocytosis: A Disease-Associated Process Emerging from Alzheimer’s Disease Genetics

Alzheimer's disease: the amyloid cascade hypothesis

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A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease

Keren-Shaul, H., Spinrad, A., Weiner, A., Matcovitch-Natan, O., Dvir-Szternfeld, R., Ulland, T. K., David, E., Baruch, K., Lara-Astaiso, D., Toth, B., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.018 · Cited by 5,493

2016 Alzheimer's disease facts and figures

Alzheimer's Association (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.03.001 · Cited by 5,069

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

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Meta-Analysis of 74,046 Individuals Identifies 11 New Susceptibility Loci for Alzheimer’s Disease

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Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

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The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

Krasemann, S., Madore, C., Cialic, R., Baufeld, C., Calcagno, N., El Fatimy, R., Beckers, L., O’Loughlin, E., Xu, Y., Fanek, Z., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.08.008 · Cited by 2,979

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

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Variant of TREM2 Associated with the Risk of Alzheimer's Disease

Jonsson, T., Stefansson, H., Steinberg, S., Jonsdottir, I., Jonsson, P. V., Snaedal, J., Bjornsson, S., Huttenlocher, J., Levey, A. I., Lah, J. J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1211103 · Cited by 2,558

A Gene Network Regulating Lysosomal Biogenesis and Function

Sardiello, M., Palmieri, M., di Ronza, A., Medina, D. L., Valenza, M., Gennarino, V. A., Di Malta, C., Donaudy, F., Embrione, V., Polishchuk, R. S., et al. (2009) · Science · doi:10.1126/science.1174447 · Cited by 2,543

Pyroptosis Signature Gene CHMP4B Regulates Microglia Pyroptosis by Inhibiting GSDMD in Alzheimer’s Disease

Ding, Y., Li, S.-Y., Lv, W., Li, L., Zhang, H., Zhang, Z., Zhang, Y.-J., Zhang, Z., & Lu, X.-W. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04255-9 · Cited by 9

Tau aggregation and its relation to selected forms of neuronal cell death.

Tolkovsky, A. M., & Spillantini, M. G. (2021) · Apollo (University of Cambridge) · doi:10.17863/cam.80530 · Cited by 9

Causal ALS genes impact the MHC class II antigen presentation pathway

Chi, B., Öztürk, M. M., Paraggio, C. L., Leonard, C. E., Sanita, M. E., Dastpak, M., O’Connell, J. D., Coady, J. A., Zhang, J., Gygi, S. P., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2305756120 · Cited by 8

Insulin Mediates Lipopolysaccharide-Induced Inflammatory Responses and Oxidative Stress in BV2 Microglia

Huang, C.-C., Tsai, S., Liu, S., Yeh, M.-C., Hung, H., Lee, C.-W., Cheng, C., Hsu, P., & Kuo, Y.-M. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s481101 · Cited by 9

Expression of anti-amyloid CARs in microglia promotes efficient and selective phagocytosis of Aβ1‒42

Heiss, C. N., Riise, R. E., Hanse, E., Fruhwürth, S., Zetterberg, H., & Björefeldt, A. (2025) · Gene Therapy · doi:10.1038/s41434-025-00534-9 · Cited by 9

DKK3-LRP1 complex and a chemical inhibitor regulate Aβ clearance in models of Alzheimer’s disease

Yang, R., Wang, L., Li, Y., Zhu, J., Wang, J., Schlessinger, D., & Sima, J. (2025) · Science Advances · doi:10.1126/sciadv.adz2099 · Cited by 8

Human iPSC‐Derived Microglia Integrate Into Cerebral Organoids and Assume an In Vivo‐Like Phenotype

Wogram, E., Sümpelmann, F., Khalil, A. S., Flamier, A., Fu, D., Bell, G. W., & Jaenisch, R. (2025) · European Journal of Neuroscience · doi:10.1111/ejn.70281 · Cited by 8

Neuroproteomics Chip-Based Mass Spectrometry and Other Techniques for Alzheimer’s Disease Biomarkers – Update

Pomilio, A. B., Vitale, A. A., & Lazarowski, A. (2022) · Current Pharmaceutical Design · doi:10.2174/1381612828666220413094918 · Cited by 9

Chemotherapy promotes astrocytic response to Aβ deposition, but not Aβ levels, in a mouse model of amyloid and APOE

Ng, C. A. S., Biran, L. P., Galvano, E., Mandelblatt, J. S., Vicini, S., & Rebeck, G. W. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105915 · Cited by 9

Application of Caenorhabditis elegans in the evaluation of food nutrition: A review

Li, Q., Xiao, M., Li, N., Cai, W., Zhao, C., Liu, B., & Zeng, F. (2023) · eFood · doi:10.1002/efd2.68 · Cited by 8

Regulation of the phagocytic activity of astrocytes by neuroimmune mediators endogenous to the central nervous system

Yang, S. S., Simtchouk, S., Gibon, J., & Klegeris, A. (2023) · PLoS ONE · doi:10.1371/journal.pone.0289169 · Cited by 7

The human microglia responsome: a resource for microglia states in health and disease

Snijders, G. J. L., Lopes, K. D. P., Sneeboer, M. A. M., Muller, B. Z., Gigase, F. A. J., D’Urso, D., Vialle, R. A., Missall, R. D., Kübler, R., Raj, T., et al. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.106095 · Cited by 9

Decrease in naturally occurring antibodies against epitopes of Alzheimer’s disease (AD) risk gene products is associated with cognitive decline in AD

Gu, D., Wang, L., Zhang, N., Wang, H., & Yu, X. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02750-9 · Cited by 9

Cellular specificity is key to deciphering epigenetic changes underlying Alzheimer's disease

Signal, B., Suárez, T. G. P., Taberlay, P. C., & Woodhouse, A. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106284 · Cited by 8

Impairment of the Glial Phagolysosomal System Drives Prion-Like Propagation in a Drosophila Model of Huntington's Disease

Davis, G. H., Zaya, A., & Pearce, M. M. P. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.1256-23.2024 · Cited by 7

Microglia contribute to the production of the amyloidogenic ABri peptide in familial British dementia

Arber, C., Casey, J. M., Crawford, S., Rambarack, N., Yaman, Ü., Wiethoff, S., Augustin, E., Piers, T. M., Price, M., Rostagno, A. A., et al. (2024) · Acta Neuropathologica · doi:10.1007/s00401-024-02820-z · Cited by 8

Identification and Quantitation of Novel ABI3 Isoforms Relative to Alzheimer’s Disease Genetics and Neuropathology

Turner, A. K., Shaw, B. C., Simpson, J. F., & Estus, S. (2022) · Genes · doi:10.3390/genes13091607 · Cited by 7

Coupling of Alzheimer’s Disease Genetic Risk Factors with Viral Susceptibility and Inflammation

Cao, C., Fu, G., Xu, R., & Li, N. (2023) · Aging and Disease · doi:10.14336/ad.2023.1017 · Cited by 8

Leveraging iPSC technology to assess neuro-immune interactions in neurological and psychiatric disorders

Michalski, C., & Wen, Z. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1291115 · Cited by 7

Cytokine-induced reprogramming of human macrophages toward Alzheimer’s disease-relevant molecular and cellular phenotypes in vitro

Podlesny‐Drabiniok, A., Romero‐Molina, C., Patel, T., See, W. Y., Liu, Y., Marcora, E. M., & Goate, A. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115909 · Cited by 7

Mesenchymal stem cells and secretome as modulators of neuroinflammation in neurological disorders

Yao, D., Nie, L., Liu, X., Wu, X., Tang, Y., Pan, C., Chen, S., Chen, D., Wu, D., Nie, H., et al. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08052-x · Cited by 6

APOE genotype and brain amyloid are associated with changes in the plasma proteome in elderly subjects without dementia

Philippi, S. M., Kailash, B. P., Raj, T., & Castellano, J. M. (2024) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.52250 · Cited by 7

Current methods for the microglia isolation: Overview and comparative analysis of approaches

Akhmetzyanova, E. R., Rizvanov, A. A., & Mukhamedshina, Y. O. (2023) · Cell and Tissue Research · doi:10.1007/s00441-023-03853-8 · Cited by 7

Breaking Barriers in Alzheimer’s Disease: the Role of Advanced Drug Delivery Systems

Shekho, D., Mishra, R., Kamal, R., Bhatia, R., & Awasthi, A. (2024) · AAPS PharmSciTech · doi:10.1208/s12249-024-02923-6 · Cited by 6

BHLHE40/41 regulate macrophage/microglia responses associated with Alzheimer’s disease and other disorders of lipid-rich tissuesPreprint

Podleśny-Drabiniok, A., Novikova, G., Liu, Y.-Y., Dunst, J., Temizer, R., Giannarelli, C., Marro, S. G., Kreslavsky, T., Marcora, E., & Goate, A. (2023) · bioRxiv · doi:10.1101/2023.02.13.528372 · Cited by 5

Identification and validation of pyroptosis-related genes in Alzheimer’s disease based on multi-transcriptome and machine learning

Wang, Y., Li, Y., Zhou, L., Yuan, Y., Liu, C., Zeng, Z., Chen, Y., He, Q., & Wu, Z. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1568337 · Cited by 5

Dysregulated Resolution of Inflammation After Respiratory Viral Infections: Molecular Pathways Linking Neuroinflammation to Post-Viral Neuropathic Pain—A Narrative Review

Popa, A. E., Popa, E., Dramba, T., Coman, A. E., Poroch, M., Ungureanu, M. I., Bacușcă, A. I., Slănină, A. M., Bacoanu, G., & Poroch, V. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262311383 · Cited by 7

Microglia-derived APOE2 improves remyelination even in the presence of endogenous APOE4

Nolt, G. L., Golden, L. R., Thorpe, S. P., Funnell, J. L., Stephens, I. O., Hernandez, G., MacLean, S. M., Lucido, C. C., Brock, C. R., Pallerla, A. V., et al. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03639-5 · Cited by 5

Complement receptor 3 (CR3)-dependent microglial synapse elimination drives Parkinson’s disease pathogenesis in systemic inflammation

Cai, L., Zhang, Y., Li, J., Hu, L., Meng, Q., Shao, J., Deng, H., Liu, Y., Liu, J., Liang, Y., et al. (2026) · Cell Death and Disease · doi:10.1038/s41419-026-08557-9 · Cited by 5

Programmable CAR immunotherapies for neurodegenerative proteinopathies

Pesce, G., Estivill-Alonso, M., & Ventura, S. (2026) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2026.02.009 · Cited by 5

3-Dimensional morphological characterization of neuroretinal microglia in Alzheimer’s disease via machine learning

Nassrallah, W. B., Li, H. R., Irani, L., Wijesinghe, P., Hogg, P. W., Hui, L., Oh, J., Mackenzie, I. R., Hirsch‐Reinshagen, V., Hsiung, G. R., et al. (2024) · Acta Neuropathologica Communications · doi:10.1186/s40478-024-01898-6 · Cited by 9

Unraveling the Role of Perivascular Macrophages in Alzheimer's Disease: Insights from the Crosstalk between Immunometabolism and Ferroptosis

Miao, X., Yue, W., Wang, J., Chen, J., Qiu, L., Paerhati, H., Zhou, Q., Li, P., Wu, A., & Zhang, M. (2025) · Current Neuropharmacology · doi:10.2174/011570159x417328250908080404 · Cited by 6

Perivascular SPP1 Mediates Microglial Engulfment of Synapses in Alzheimer’s Disease ModelsPreprint

Schepper, S. D., Ge, J. Z., Crowley, G., Ferreira, L. S. S., Garceau, D. T., Toomey, C. E., Sokolova, D., Childs, T., Lashley, T., Burden, J. J., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.04.04.486547 · Cited by 5

Functional border-associated macrophages limit Alzheimer’s Disease progressionPreprint

Adler, D. I., Pinheiro-Rosa, N., Millet, A., Gajic, Z. Z., Cheng, E., Gamallo‐Lana, B., Morizawa, Y. M., Klann, E., Gan, W., Mar, A. C., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.31.703045 · Cited by 8

Model of selective neurodegeneration driven by a Ccp1 mutation leads to atypical microglia with an increased response to pathological stimuli

Pérez-Boyero, D., de la Mata, A., Castillo-Sanchez, J., Reverte, I., Yanguas‐Casás, N., Ávila-Zarza, C. A., Valero, J., Alonso, J. R., Arévalo, M., Ragozzino, D., et al. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.106248 · Cited by 4

Inhibition of neuroinflammation and neuronal damage by the selective non-steroidal ERβ agonist AC-186

Katola, F. O., Adana, M. Y., & Olajide, O. A. (2024) · Inflammation Research · doi:10.1007/s00011-024-01952-y · Cited by 4

Nimodipine reduces microglial activation in vitro as evidenced by morphological phenotype, phagocytic activity and high‐throughput RNA sequencing

Pesti, I., Varga, V., Qorri, E., Frank, R., Kata, D., Vinga, K., Szarvas, P. A., Menyhárt, Á., Gulya, K., Bari, F., et al. (2025) · British Journal of Pharmacology · doi:10.1111/bph.70060 · Cited by 5

Associations between endothelial dysfunction, cognitive reserve, and cognitive function in dementia-free older adults: A population-based study

Song, Y.-Z., Li, Y., Dong, Q., Zhang, Y. L., Wang, J., Han, X., Mao, M., Dong, Y., Tang, S. H., Hou, T., et al. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251385261 · Cited by 4

Genome-Wide Epistasis Study of Cerebrospinal Fluid Hyperphosphorylated Tau in ADNI Cohort

Chen, D., Li, J., Liu, H., Liu, X., Zhang, C., Luo, H., Wei, Y., Xi, Y., Liang, H., & Zhang, Q. (2023) · Genes · doi:10.3390/genes14071322 · Cited by 4

Microglia Detect Externalized Phosphatidylserine on Synapses for Elimination via TREM2 in Alzheimer’s Disease ModelsPreprint

Rueda‐Carrasco, J., Sokolova, D., Lee, S., Childs, T., Jurčáková, N., Schepper, S. D., Ge, J. Z., Lachica, J., Toomey, C. E., Freeman, O. J., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.04.04.486424 · Cited by 4

Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypesPreprint

Kim, D. W., Tu, K. J., Wei, A., Lau, A., Gonzalez-Gil, A., Cao, T., Braunstein, K. E., Ling, J. P., Troncoso, J. C., Wong, P. C., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1598611/v1 · Cited by 4

Ameboid Microglia as a Scavenger Role in Phagocytosis of Photoreceptor Outer Segment in an Experimental Retinal Detachment Model

Cao, M., Zhang, Y., Li, Y., Zhang, X., & Ma, M. (2025) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.66.3.4 · Cited by 3

FGFR1 agonists alleviate pathology and cognitive impairment in an Alzheimer's disease mouse model

Hung, W.-C., Sun, W., Su, T., Lee, Y.-J., & Cheng, I. H.-J. (2025) · Experimental Neurology · doi:10.1016/j.expneurol.2025.115357 · Cited by 6

Microglial estrogen receptor 1 signal designates sexual dimorphism of AQP4 antibody-induced neuroinflammation and demyelination

Zhou, Z., Deng, Z., Huang, Y., Chen, J., Yang, J. H., & Cao, Y. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116636 · Cited by 4

MerTK-triggered TGFβ1 autocrine signal regulates microglial response to neurodegeneration

Huang, Y., Deng, Z., Zhou, Z., Fu, K., Liu, F., Zhang, H., Chen, J., Yang, J. H., & Cao, Y. (2026) · Nature Communications · doi:10.1038/s41467-026-69189-3 · Cited by 4

Microglia beyond boundaries: Paradigm shifts in origin, distribution, state diversity, and therapeutic regeneration

Lan, Z., Liu, H., Huang, C., Li, J. R., Dai, Z., Yuan, Y. Z., He, C., Qin, S., & Su, Z. (2026) · Neurochemistry International · doi:10.1016/j.neuint.2026.106170 · Cited by 4

Perivascular signals drive microglial appetite

O’Brien, C. A., & Bennett, F. C. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01256-0 · Cited by 3

Microglial amyloid beta clearance is driven by PIEZO1 channelsPreprint

Konttinen, H., Sitnikova, V., Ishchenko, Y., Shakirzyanova, A., Giudice, L., Ugidos, I. F., Gómez‐Budia, M., Korvenlaita, N., Ohtonen, S., Belaya, I., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.18.484831 · Cited by 3

Neuro‐immune interactions in health and disease: Insights from FENS‐Hertie 2022 Winter School

Binder, L. B., da Rosa, P. B., de Sousa, B. M., Chagas, L. D. S., Dubljević, O., Martineau, F. S., Mottarlini, F., Castany, S., Morton, L., Krstanović, F., et al. (2024) · European Journal of Neuroscience · doi:10.1111/ejn.16262 · Cited by 2

Inhibitor of bromodomain and extraterminal domain proteins decreases transcription of Cd33 in the brain of mice subjected to systemic inflammation; a promising strategy for neuroprotection

Czapski, G. A., Matuszewska, M., Cieślik, M., & Strosznajder, J. B. (2024) · Folia Neuropathologica · doi:10.5114/fn.2024.138140 · Cited by 2

Neoprzewaquinone A alters the migration, phagocytosis and energy metabolism of IL-15-induced HMC3 cells

Wang, H., Yang, J., Sun, Z., Nie, Y., & He, Y. (2024) · Molecular Immunology · doi:10.1016/j.molimm.2024.07.012 · Cited by 2

Immunity in Parkinson's disease – The role of innate responses

Iyengar, A. S., Dunkley, P. R., & Dickson, P. W. (2025) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2025.578716 · Cited by 4

Microglia become hypofunctional and release metalloproteases and tau seeds after phagocytosing live neurons with P301S tau aggregatesPreprint

Brelstaff, J., Mason, M., Katsinelos, T., McEwan, W. A., Ghetti, B. F., Tolkovsky, A. M., & Spillantini, M. G. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.26.433088 · Cited by 2

The autophagy proteome in the brain

Ito‐Silva, V. I., Smith, B. J., & Martins‐de‐Souza, D. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16204 · Cited by 2

Development of Engineered Microparticles for Investigating Enzymatic Degradation of Proteins and Peptides within Phagosomes

Fukuda, M., Lin, G. R., Liu, Y., Hammel, G., Kizer, A., Ayazi, M., Joshi, S., Liu, Y., Ren, Y., & Guan, J. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c22223 · Cited by 1

A new lens on Alzheimer's disease: Insights into the Edinger-Westphal nucleus and its circuits

Zhou, Y., Su, T., Yuan, M., Li, W., Zhou, Y., Kou, J., Chang, J.-S., Liu, D., Chen, L., Zhan, K., et al. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251372587 · Cited by 1

Identification of common human TMEM173 genotypes associated with Alzheimer's disease

Usher, M. R., Aybar-Torres, A., & Jin, L. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251396973 · Cited by 1

Beta‐Arrestin2‐Biased Activation by Pilocarpine Suppresses Microglial Inflammatory Response

Xie, Y. J., Wang, K., Wang, S., Yao, Y., Wang, D., Hongzhuan, C. H. E. N., Zhao, L., & Xu, J. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70334 · Cited by 1

Roles of Glia in Synapse Nano-organization

Choi, Y., & Chung, W. (2026) · Advances in neurobiology · doi:10.1007/978-3-032-12594-1_11 · Cited by 1

Phagocytosis and neuroinflammation: orchestrating central nervous system homeostasis, repair, and the resolution of inflammation

Gaudet, A. D., & Fonken, L. K. (2026) · Trends in Neurosciences · doi:10.1016/j.tins.2026.01.002 · Cited by 3

Impaired microglial TYROBP/DAP12 signaling exacerbates cortical cholinergic and noradrenergic axonal degeneration in Aβ amyloidosis

Hirota, Y., Yamamoto, J., Takatori, S., Sakakibara, Y., Takei, K., 佐治多美子, Sekiya, M., Tomita, T., & Iijima, K. (2026) · Molecular Neurodegeneration Advances · doi:10.1186/s44477-026-00032-1 · Cited by 1

Acupuncture regulating microglial activation in Alzheimer's disease: Research progress in its neuroinflammation mechanism

Wei, Y., Ming-li, S. U., Ren, D.-L., Zhang, X., Zhu, T., & Yan, X. (2024) · 世界针灸杂志：英文版 · doi:10.1016/j.wjam.2024.04.004 · Cited by 1

Functional Glial Activation Mediates Phenotypic Effects of APOEɛ4 and Sex in Alzheimer’s Disease

Lane, R. M., Li, D. X., & Darreh‐Shori, T. (2024) · Neuroglia · doi:10.3390/neuroglia5030022 · Cited by 2

Amyloid-beta and tau pathologies are both necessary to induce novel stage-specific microglia subtypes during Alzheimer’s disease progressionPreprint

Kim, D. W., Tu, K. J., Wei, A., Lau, A., Gonzalez-Gil, A., Cao, T., Braunstein, K. E., Ling, J. P., Troncoso, J. C., Wong, P. C., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.10.16.464454 · Cited by 1

Novel small molecules inhibit proteotoxicity and inflammation: Mechanistic and therapeutic implications for Alzheimer’s Disease, healthspan and lifespan- Aging as a consequence of glycolysisPreprint

Litke, R. R., Vicari, J. M., Huang, B. T., Shapiro, L. R., Roh, K.-H., Silver, A. E., Talreja, P., Palacios, N., Yoon, Y., Kellner, C. P., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.12.544352 · Cited by 1

Microglia undergo transcriptional, translational and functional adaptations to dark and light phases in laboratory micePreprint

Mattei, D., Ivanov, A., Hammer, J., Ugursu, B., Schalbetter, S. M., Richetto, J., Weber‐Stadlbauer, U., Mueller, F. S., Scarborough, J., Wolf, S. A., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.17.567571 · Cited by 1

Glial activation mediates phenotypic effects of APOEε4 and sex in Alzheimer’s diseasePreprint

Lane, R. M., Li, D., & Darreh‐Shori, T. (2024) · medRxiv · doi:10.1101/2024.03.08.24303882 · Cited by 1

Inflammatory Signatures of Microglia in the Mouse Model of Corticosterone-Induced DepressionPreprint

Zhao, Y., Huang, Y., Cao, Y., & Yang, J. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.21.608928 · Cited by 1

Nimodipine reduces microglial activation in vitro as evidenced by morphological phenotype, phagocytic activity and next generation RNA sequencingPreprint

Pesti, I., Varga, V., Qorri, E., Frank, R., Kata, D., Vinga, K., Szarvas, P. A., Menyhárt, Á., Gulya, K., Bari, F., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.11.623031 · Cited by 1

APOE4 alters the lipid droplet proteome and modulates droplet dynamicsPreprint

Friday, C. M., Stephens, I. O., Smith, C. T., Lee, S., Satish, D., Devanney, N. A., Cohen, S., Morganti, J. M., Gordon, S. M., & Johnson, L. A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.16.628710 · Cited by 1

Youth-associated protein TIMP2 alters microglial state and function in the context of agingPreprint

Hemmer, B. M., Ferreira, A. C., Philippi, S. M., Petridis, S. F., Phan, A., & Castellano, J. M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.20.655226 · Cited by 1

A validated method for banking mixed glial cultures that yield responsive microgliaPreprint

Sturno, A. M., Hassell, J. E., Baker, K. M., Potter, G. J., & Bruce, K. D. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.13.693524 · Cited by 1

Targeting Microglial Transcriptional Reprogramming as a Therapy Strategy for Alzheimer's Disease

Kim, B., Wang, S. S., Kim, J. R., & Kim, J. (2026) · BioEssays · doi:10.1002/bies.70186

New App knock-in mice that accumulate wild-type human Aβ as rapidly as App NL-G-F mice exhibit intensive cored plaque pathology and neuroinflammationPreprint

Sato, K., Watamura, N., Fujioka, R., Mihira, N., Sekiguchi, M., Nagata, K., Ohshima, T., Saito, T., Saido, T. C., & Sasaguri, H. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.04.30.442122

Three ALS genes regulate expression of the MHC class II antigen presentation pathwayPreprint

Chi, B., Öztürk, M. M., Paraggio, C. L., Leonard, C. E., Sanita, M. E., Dastpak, M., O’Connell, J. D., Coady, J. A., Zhang, J., Gygi, S. P., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.11.489680

Multiomic Phagosome Profiling as a New Tool to Study Human Microglia BiologyPreprint

Wogram, E., Sümpelmann, F., Dong, W., Rawat, E. S., Fernández-Maestre, I., Fu, D., Braswell, B., Khalil, A. S., Buescher, J. M., Borner, G. H. H., et al. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4585843

Sobrecarga de cobre y enfermedad de Alzheimer, búsqueda de posibles blancos terapéuticos

Zubillaga, M. (2023) · El Servicio de Difusión de la Creación Intelectual (National University of La Plata) · doi:10.35537/10915/165188

Long-read transcriptomic identification of synaptic adaptation to amyloid pathology in the App NL-G-F knock-in mouse model of the earliest phase of Alzheimer’s diseasePreprint

Yaman, Ü., Banks, G. T., Gustavsson, E. K., Mumford, P., Magusali, N., Taso, O. S., Macpherson, H. L., Carmona, S., Murray, M., Bains, R. S., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.10.607237

Neurovirology and Brain Health—A Microglial Perspective

Biswas, A. K., & Sarma, J. D. (2024) · Healthy ageing and longevity · doi:10.1007/978-3-031-68513-2_7

Cytokine-induced reprogramming of human macrophages toward Alzheimer’s disease-relevant molecular and cellular phenotypes in vitroPreprint

Podleśny-Drabiniok, A., Romero-Molina, C., Patel, T., Wen, Y.-S., Liu, Y.-Y., Marcora, E., & Goate, A. (2024) · bioRxiv · doi:10.1101/2024.10.24.619910 · Cited by 7

Mesenchymal Cell-Derived Extracellular Vesicles Ameliorate Age-Related Deficits in Working Memory as well as Brain MRI and CSF in vivo Biomarkers of Neurodegeneration in Rhesus MonkeysPreprint

Mackie, E. C., Cheng, C.-H., Alibrio, M. N., Rutledge, C., Xin, H., Chopp, M., McCann, R., Rosene, D. L., Yang, Q., Zeldich, E., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.14.623673

Additional file 5 of Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes

Kim, D. W., Tu, K. J., Wei, A., Lau, A., Gonzalez-Gil, A., Cao, T., Braunstein, K. E., Ling, J. P., Troncoso, J. C., Wong, P. C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26555684

Additional file 17 of Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes

Kim, D. W., Tu, K. J., Wei, A., Lau, A., Gonzalez-Gil, A., Cao, T., Braunstein, K. E., Ling, J. P., Troncoso, J. C., Wong, P. C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26555720

Additional file 9 of Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes

Kim, D. W., Tu, K. J., Wei, A., Lau, A., Gonzalez-Gil, A., Cao, T., Braunstein, K. E., Ling, J. P., Troncoso, J. C., Wong, P. C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26555696

Additional file 8 of Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes

Kim, D. W., Tu, K. J., Wei, A., Lau, A., Gonzalez-Gil, A., Cao, T., Braunstein, K. E., Ling, J. P., Troncoso, J. C., Wong, P. C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26555693

Additional file 1 of Microglial amyloid beta clearance is driven by PIEZO1 channels

Jäntti, H., Sitnikova, V., Ishchenko, Y., Shakirzyanova, A., Giudice, L., Ugidos, I. F., Gómez‐Budia, M., Korvenlaita, N., Ohtonen, S., Belaya, I., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20080821

Additional file 15 of Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes

Kim, D. W., Tu, K. J., Wei, A., Lau, A., Gonzalez-Gil, A., Cao, T., Braunstein, K. E., Ling, J. P., Troncoso, J. C., Wong, P. C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26555714

Additional file 16 of Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes

Kim, D. W., Tu, K. J., Wei, A., Lau, A., Gonzalez-Gil, A., Cao, T., Braunstein, K. E., Ling, J. P., Troncoso, J. C., Wong, P. C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26555717

Additional file 6 of Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes

Kim, D. W., Tu, K. J., Wei, A., Lau, A., Gonzalez-Gil, A., Cao, T., Braunstein, K. E., Ling, J. P., Troncoso, J. C., Wong, P. C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26555687

Additional file 7 of Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes

Kim, D. W., Tu, K. J., Wei, A., Lau, A., Gonzalez-Gil, A., Cao, T., Braunstein, K. E., Ling, J. P., Troncoso, J. C., Wong, P. C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26555690

Additional file 11 of Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes

Kim, D. W., Tu, K. J., Wei, A., Lau, A., Gonzalez-Gil, A., Cao, T., Braunstein, K. E., Ling, J. P., Troncoso, J. C., Wong, P. C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26555702

Additional file 4 of Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes

Kim, D. W., Tu, K. J., Wei, A., Lau, A., Gonzalez-Gil, A., Cao, T., Braunstein, K. E., Ling, J. P., Troncoso, J. C., Wong, P. C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26555681

Additional file 1 of Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes

Kim, D. W., Tu, K. J., Wei, A., Lau, A., Gonzalez-Gil, A., Cao, T., Braunstein, K. E., Ling, J. P., Troncoso, J. C., Wong, P. C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26555672

Additional file 13 of Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes

Kim, D. W., Tu, K. J., Wei, A., Lau, A., Gonzalez-Gil, A., Cao, T., Braunstein, K. E., Ling, J. P., Troncoso, J. C., Wong, P. C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26555708

Additional file 2 of Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes

Kim, D. W., Tu, K. J., Wei, A., Lau, A., Gonzalez-Gil, A., Cao, T., Braunstein, K. E., Ling, J. P., Troncoso, J. C., Wong, P. C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26555675

Additional file 3 of Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes

Kim, D. W., Tu, K. J., Wei, A., Lau, A., Gonzalez-Gil, A., Cao, T., Braunstein, K. E., Ling, J. P., Troncoso, J. C., Wong, P. C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26555678

Additional file 10 of Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes

Kim, D. W., Tu, K. J., Wei, A., Lau, A., Gonzalez-Gil, A., Cao, T., Braunstein, K. E., Ling, J. P., Troncoso, J. C., Wong, P. C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26555699

Additional file 1 of Decrease in naturally occurring antibodies against epitopes of Alzheimer’s disease (AD) risk gene products is associated with cognitive decline in AD

Gu, D., Wang, L., Zhang, N., Wang, H., & Yu, X. (2024) · Figshare · doi:10.6084/m9.figshare.26575418

Additional file 18 of Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes

Kim, D. W., Tu, K. J., Wei, A., Lau, A., Gonzalez-Gil, A., Cao, T., Braunstein, K. E., Ling, J. P., Troncoso, J. C., Wong, P. C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26555723

Additional file 12 of Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes

Kim, D. W., Tu, K. J., Wei, A., Lau, A., Gonzalez-Gil, A., Cao, T., Braunstein, K. E., Ling, J. P., Troncoso, J. C., Wong, P. C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26555705

Microglial efferocytosis: Diving into the Alzheimer’s disease gene pool

Romero-Molina, C., Garretti, F., Andrews, S. J., Marcora, E., & Goate, A. M. (2022) · Neuron · doi:10.1016/j.neuron.2022.10.015 · Cited by 111

Integration of Alzheimer’s disease genetics and myeloid genomics reveals novel disease risk mechanisms

Novikova, G., Marcora, E. M., Kapoor, M., Julia, T. C. W., Renton, A. E., Efthymiou, A. G., Abud, E. M., Bendl, J. M., Cheng, H. M., Fullard, J. F., et al. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.043897 · Cited by 27

Integration of Alzheimer’s disease genetics and myeloid genomics identifies disease risk regulatory elements and genes

Novikova, G., Kapoor, M., TCW, J., Abud, E. M., Efthymiou, A. G., Chen, S. X., Cheng, H., Fullard, J. F., Bendl, J., Liu, Y., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21823-y · Cited by 214

Genetic studies of Alzheimer's disease risk implicate clearance of lipid rich debris in myeloid cells

Novikova, G., Julia, T. C. W., Marcora, E. M., Kapoor, M., Renton, A. E., Efthymiou, A. G., Abud, E. M., Bendl, J. M., Cheng, H. M., Fullard, J. F., et al. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.040601

Genetic regulation of microglial function in Alzheimer’s disease: Mechanisms and therapeutic implications

Wijesinha, D. (2026) · Sri Lanka Journal of Neurology · doi:10.4038/sljon.v12i2.211