Nucleoside transporters: from scavengers to novel therapeutic targets

The equilibrative nucleoside transporter family, SLC29

Beal, P. R., Yao, S. Y. M., Baldwin, S. A., Young, J. D., King, A. E., & Cass, C. E. (2004) · Pfl�gers Archiv European Journal of Physiology · doi:10.1007/s00424-003-1103-2 · Cited by 710

Adenosine and Brain Function

Fredholm, B. B., Chen, J.-F., Cunha, R. A., Svenningsson, P., & Vaugeois, J.-M. (2005) · International Review of Neurobiology · doi:10.1016/s0074-7742(05)63007-3 · Cited by 692

Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine

Huang, Z.-L., Qu, W.-M., Eguchi, N., Chen, J.-F., Schwarzschild, M. A., Fredholm, B. B., Urade, Y., & Hayaishi, O. (2005) · Nature Neuroscience · doi:10.1038/nn1491 · Cited by 640

Adenosine as a neuromodulator and as a homeostatic regulator in the nervous system: different roles, different sources and different receptors

Cunha, R. A. (2001) · Neurochemistry International · doi:10.1016/s0197-0186(00)00034-6 · Cited by 631

Nucleoside analogues and nucleobases in cancer treatment

Galmarini, C. M., Mackey, J. R., & Dumontet, C. (2002) · The Lancet Oncology · doi:10.1016/s1470-2045(02)00788-x · Cited by 606

Brain site-specificity of extracellular adenosine concentration changes during sleep deprivation and spontaneous sleep: an in vivo microdialysis study

Porkka-Heiskanen, T., Strecker, R. E., & McCarley, R. W. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00220-7 · Cited by 463

The Absence of Human Equilibrative Nucleoside Transporter 1 Is Associated with Reduced Survival in Patients With Gemcitabine-Treated Pancreas Adenocarcinoma

Spratlin, J., Sangha, R., Glubrecht, D., Dabbagh, L., Young, J. D., Dumontet, C., Cass, C., Lai, R., & Mackey, J. R. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-0224 · Cited by 430

Cloning of a human nucleoside transporter implicated in the Cellular uptake of adenosine and chemotherapeutic drugs

Griffiths, M., Beaumont, N., Yao, S. Y. M., Sundaram, M., Boumah, C. E., Davies, A., Kwong, F. Y. P., Coe, I., Cass, C. E., Young, J. D., et al. (1997) · Nature Medicine · doi:10.1038/nm0197-89 · Cited by 422

The concentrative nucleoside transporter family, SLC28

Gray, J. H., Owen, R. P., & Giacomini, K. M. (2004) · Pfl�gers Archiv European Journal of Physiology · doi:10.1007/s00424-003-1107-y · Cited by 419

Adenosinergic modulation of basal forebrain and preoptic/anterior hypothalamic neuronal activity in the control of behavioral state

Strecker, R. E., Morairty, S., Thakkar, M. M., Porkka-Heiskanen, T., Basheer, R., Dauphin, L. J., Rainnie, D. G., Portas, C. M., Greene, R. W., & McCarley, R. W. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00258-8 · Cited by 357

Adenosine in the spinal cord and periphery: release and regulation of pain

Sawynok, J., & Liu, X. J. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00050-9 · Cited by 353

Functional Characterization of Novel Human and Mouse Equilibrative Nucleoside Transporters (hENT3 and mENT3) Located in Intracellular Membranes

Baldwin, S. A., Yao, S. Y. M., Hyde, R. J., Ng, A. M. L., Foppolo, S., Barnes, K., Ritzel, M. W. L., Cass, C. E., & Young, J. D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414337200 · Cited by 323

Nucleoside anticancer drugs: the role of nucleoside transporters in resistance to cancer chemotherapy

Damaraju, V. L., Damaraju, S., Young, J. D., Baldwin, S. A., Mackey, J., Sawyer, M. B., & Cass, C. E. (2003) · Oncogene · doi:10.1038/sj.onc.1206952 · Cited by 318

Kinetic and Pharmacological Properties of Cloned Human Equilibrative Nucleoside Transporters, ENT1 and ENT2, Stably Expressed in Nucleoside Transporter-deficient PK15 Cells

Ward, J. L., Sherali, A., Mo, Z.-P., & Tse, C.-M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.8375 · Cited by 311

Ethanol increases extracellular adenosine by inhibiting adenosine uptake via the nucleoside transporter.

Nagy, L. E., Diamond, I., Casso, D. J., Franklin, C., & Gordon, A. S. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39923-5 · Cited by 261

Anti-hyperalgesic and morphine-sparing actions of propentofylline following peripheral nerve injury in rats: mechanistic implications of spinal glia and proinflammatory cytokines

Raghavendra, V., Tanga, F., Rutkowski, M. D., & DeLeo, J. A. (2003) · Pain · doi:10.1016/s0304-3959(03)00138-6 · Cited by 259

The type 1 equilibrative nucleoside transporter regulates ethanol intoxication and preference

Choi, D.-S., Cascini, M.-G., Mailliard, W., Young, H., Paredes, P., McMahon, T., Diamond, I., Bonci, A., & Messing, R. O. (2004) · Nature Neuroscience · doi:10.1038/nn1288 · Cited by 255

Adenosine and sleep

Porkka-Heiskanen, T., Alanko, L., Kalinchuk, A., & Stenberg, D. (2002) · Sleep Medicine Reviews · doi:10.1053/smrv.2001.0201 · Cited by 236

Molecular cloning and functional expression of cDNAs encoding a human Na+-nucleoside cotransporter (hCNT1)

Ritzel, M. W. L., Yao, S. Y., Huang, M., Elliott, J. F., Cass, C. E., & Young, J. D. (1997) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1997.272.2.c707 · Cited by 234

Purine and pyrimidine transport in pathogenic protozoa: From biology to therapy

de Koning, H. P., Bridges, D. J., & Burchmore, R. J. S. (2005) · FEMS Microbiology Reviews · doi:10.1016/j.femsre.2005.03.004 · Cited by 196

Interaction of Organic Cations with a Newly Identified Plasma Membrane Monoamine Transporter

Engel, K., & Wang, J. (2005) · Molecular Pharmacology · doi:10.1124/mol.105.016832 · Cited by 190

Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine

Rlteel, M. W. L., Yaof, S. Y. M., Ng, A. M. L., Mackeyt, J. R., Cass, C. E., & Young, J. D. (1998) · Molecular Membrane Biology · doi:10.3109/09687689709044322 · Cited by 187

Differential Expression of Human Nucleoside Transporters in Normal and Tumor Tissue

Pennycooke, M., Chaudary, N., Shuralyova, I., Zhang, Y., & Coe, I. R. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.4205 · Cited by 186

Functional and Molecular Characterization of Nucleobase Transport by Recombinant Human and Rat Equilibrative Nucleoside Transporters 1 and 2

Yao, S. Y. M., Ng, A. M. L., Vickers, M. F., Sundaram, M., Cass, C. E., Baldwin, S. A., & Young, J. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200966200 · Cited by 173

Topology of a Human Equilibrative, Nitrobenzylthioinosine (NBMPR)-sensitive Nucleoside Transporter (hENT1) Implicated in the Cellular Uptake of Adenosine and Anti-cancer Drugs

Sundaram, M., Yao, S. Y. M., Ingram, J. C., Berry, Z. A., Abidi, F., Cass, C. E., Baldwin, S. A., & Young, J. D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107169200 · Cited by 143

Adenosine receptor agonists: from basic medicinal chemistry to clinical development

Luo, Y., Burbiel, J. C., Maaß, A., & Müller, C. E. (2003) · Expert Opinion on Emerging Drugs · doi:10.1517/14728214.8.2.537 · Cited by 139

Cell entry and export of nucleoside analogues

Pastor‐Anglada, M., Cano‐Soldado, P., Molina‐Arcas, M., Lostao, M. P., Larráyoz, I. M., Martínez‐Picado, J., & Casado, F. J. (2004) · Virus Research · doi:10.1016/j.virusres.2004.11.005 · Cited by 136

Nucleoside transport inhibition: a therapeutic approach to cardioprotection via adenosine?

Belle, H. V. (1993) · Cardiovascular Research · doi:10.1093/cvr/27.1.68 · Cited by 126

Distinct regional distribution of human equilibrative nucleoside transporter proteins 1 and 2 (hENT1 and hENT2) in the central nervous system

Jennings, L. L., Hao, C., Cabrita, M. A., Vickers, M. F., Baldwin, S. A., Young, J. D., & Cass, C. E. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(00)00207-0 · Cited by 124

Distribution of Equilibrative, Nitrobenzylthioinosine‐Sensitive Nucleoside Transporters (ENT1) in Brain

Anderson, C. M., Xiong, W., Geiger, J. D., Young, J. D., Cass, C. E., Baldwin, S. A., & Parkinson, F. E. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0730867.x · Cited by 116

Chimeric Constructs between Human and Rat Equilibrative Nucleoside Transporters (hENT1 and rENT1) Reveal hENT1 Structural Domains Interacting with Coronary Vasoactive Drugs

Sundaram, M., Yao, S. Y. M., Ng, A. M. L., Griffiths, M. N. D., Cass, C. E., Baldwin, S. A., & Young, J. D. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.34.21519 · Cited by 114

Recent advances in the neurobiology of alcoholism: the role of adenosine

Mailliard, W. S., & Diamond, I. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2003.10.002 · Cited by 103

Electrophysiological characterization of a recombinant human Na+‐coupled nucleoside transporter (hCNT1) produced in Xenopus oocytes

Smith, K. M., Ng, A. M. L., Yao, S. Y. M., Labedz, K. A., Knaus, E. E., Wiebe, L. I., Cass, C. E., Baldwin, S. A., Chen, X., Karpinski, E., et al. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.068189 · Cited by 92

The Broadly Selective Human Na+/Nucleoside Cotransporter(hCNT3) Exhibits Novel Cation-coupled Nucleoside TransportCharacteristics

Smith, K. M., Slugoski, M. D., Loewen, S. K., Ng, A. M. L., Yao, S. Y. M., Chen, X., Karpinski, E., Cass, C. E., Baldwin, S. A., & Young, J. D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m409454200 · Cited by 85

Nucleoside transporters in the disposition and targeting of nucleoside analogs in the kidney

Mangravite, L. M., Badagnani, I., & Giacomini, K. M. (2003) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.08.076 · Cited by 84

Inhibition of Nucleoside Transport by Protein Kinase Inhibitors

Huang, M., Wang, Y., Cogut, S. B., Mitchell, B. S., & Graves, L. M. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.044214 · Cited by 78

Distribution of antinociceptive adenosine a1 receptors in the spinal cord dorsal horn, and relationship to primary afferents and neuronal subpopulations

Schulte, G., Robertson, B., Fredholm, B. B., DeLander, G. E., Shortland, P. J., & Molander, C. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00480-9 · Cited by 74

Distribution of mRNA encoding a nitrobenzylthioinosine-insensitive nucleoside transporter (ENT2) in rat brain

Anderson, C. M., Baldwin, S. A., Young, J. D., Cass, C. E., & Parkinson, F. E. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00164-3 · Cited by 73

Adaptations in Adenosine Signaling in Drug Dependence: Therapeutic Implications

Hack, S. P., & Christie, M. J. (2004) · Critical Reviews in Neurobiology · doi:10.1615/critrevneurobiol.v15.i34.30 · Cited by 66

The Role of Membrane Transporters in Cellular Resistance to Anticancer Nucleoside Drugs

Clarke, M. L., Mackey, J. R., Baldwin, S. A., Young, J. D., & Cass, C. E. (2002) · Cancer treatment and research · doi:10.1007/978-1-4615-1173-1_2 · Cited by 65

Adenosine A1 Receptors Reduce Release from Excitatory But Not Inhibitory Synaptic Inputs onto Lateral Horn Neurons

Deuchars, S. A., Brooke, R. E., & Deuchars, J. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-16-06308.2001 · Cited by 63

Control of glutamatergic neurotransmission in the rat spinal dorsal horn by the nucleoside transporter ENT1

Ackley, M. A., Governo, R. J. M., Cass, C. E., Young, J. D., Baldwin, S. A., & King, A. E. (2003) · The Journal of Physiology · doi:10.1111/j.1469-7793.2003.00507.x · Cited by 63

Enzymes of adenosine metabolism in the brain: diurnal rhythm and the effect of sleep deprivation

Mackiewicz, M., Nikonova, E. V., Zimmerman, J. E., Galante, R. J., Zhang, L., Cater, J. R., Geiger, J. D., & Pack, A. I. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01687.x · Cited by 62

Functional genomics of membrane transporters in human populationsPreprint

Urban, T. J., Sebro, R., Hurowitz, E. H., Leabman, M. K., Badagnani, I., Lagpacan, L. L., RISCH, N. J., & Giacomini, K. M. (2005) · Genome Research · doi:10.1101/gr.4356206 · Cited by 54

Distribution of CNT2 and ENT1 transcripts in rat brain: selective decrease of CNT2 mRNA in the cerebral cortex of sleep‐deprived rats

Guillén‐Gómez, E., Calbet, M., Casado, J. F., de Lecea, L., Soriano, E., Pastor‐Anglada, M., & Burgaya, F. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02545.x · Cited by 51

Intrathecal Morphine Reduces Allodynia after Peripheral Nerve Injury in Rats via Activation of a Spinal A1 Adenosine Receptor

Zhang, Y., Conklin, D. R., Li, X., & Eisenach, J. C. (2005) · Anesthesiology · doi:10.1097/00000542-200502000-00027 · Cited by 44

An ancient prevertebrate Na+-nucleoside cotransporter (hfCNT) from the Pacific hagfish (Eptatretus stouti)

Yao, S. Y. M., Ng, A. M. L., Loewen, S. K., Cass, C. E., Baldwin, S. A., & Young, J. D. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00587.2001 · Cited by 31

Pharmacological analysis of the activity of the adenosine uptake inhibitor, dipyridamole, on the sinoatrial and atrioventricular nodes of the guinea‐pig

Meester, B. J., Shankley, N. P., Welsh, N. J., et al. (1998) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701892 · Cited by 27

Nitrobenzylthioinosine (NBMPR) binding and nucleoside transporter ENT1 mRNA expression after prolonged wakefulness and recovery sleep in the cortex and basal forebrain of rat

Alanko, L., Stenberg, D., & Porkka‐Heiskanen, T. (2003) · Journal of Sleep Research · doi:10.1046/j.0962-1105.2003.00372.x · Cited by 26

Regulation by equilibrative nucleoside transporter of adenosine outward currents in adult rat spinal dorsal horn neurons

Liu, T., Fujita, T., Kawasaki, Y., & Kumamoto, E. (2004) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2004.05.002 · Cited by 24

Physiology of Astroglia

Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678

International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors—An Update

Fredholm, B. B., IJzerman, A. P., Jacobson, K. A., Linden, J., & Müller, C. E. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.003285 · Cited by 1,301

Nucleotide- and nucleoside-converting ectoenzymes: Important modulators of purinergic signalling cascade

Yegutkin, G. G. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.01.024 · Cited by 1,154

The human concentrative and equilibrative nucleoside transporter families, SLC28 and SLC29

Young, J. D., Yao, S. Y. M., Baldwin, J. M., Cass, C. E., & Baldwin, S. A. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.05.007 · Cited by 356

Physiology of Astroglia

Verkhratsky, A., Parpura, V., Vardjan, N., & Zorec, R. (2019) · Advances in Experimental Medicine and Biology · doi:10.1007/978-981-13-9913-8_3 · Cited by 312