Rationale, pharmacology and clinical efficacy of partial agonists of α4β2 nACh receptors for smoking cessation

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2. Constitutional mechanisms of vulnerability and resilience to nicotine dependence
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3. Smoking cessation and neuropsychiatric adverse events: are family physicians caught between a rock and a hard place?
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4. Varenicline and mecamylamine attenuate locomotor sensitization and cross-sensitization induced by nicotine and morphine in mice
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5. Tobacco addiction: A biochemical model of nicotine dependence
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6. Recent Advances in Nicotinic Receptor Signaling in Alcohol Abuse and Alcoholism
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7. Preclinical pharmacology, efficacy, and safety of varenicline in smoking cessation and clinical utility in high risk patients
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8. Nicotine dependence (trait) and acute nicotinic stimulation (state) modulate attention but not inhibitory control: converging fMRI evidence from Go–Nogo and Flanker tasks
   Elise Lesage, Matthew T. Sutherland, Thomas J. Ross, Betty Jo Salmeron, Elliot A. Stein · 2020 · Neuropsychopharmacology
9. Novel Acetylcholine and Carbamoylcholine Analogues: Development of a Functionally Selective α4β2Nicotinic Acetylcholine Receptor Agonist
   Camilla P. Hansen, Anders A. Jensen, Jeppe K. Christensen, Thomas Balle, Tommy Liljefors, Bente Frølund · 2008 · Journal of Medicinal Chemistry
10. A Pharmacological Comparison of Two Isomeric Nicotinic Receptor Agonists: The Marine Toxin Isoanatabine and the Tobacco Alkaloid Anatabine
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11. Individual differences in amygdala reactivity following nicotinic receptor stimulation in abstinent smokers
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12. Acetylcholine
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13. Varenicline and nicotine enhance GABAergic synaptic transmission in rat CA1 hippocampal and medial septum/diagonal band neurons
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14. Effective Use of Animal Models for Therapeutic Development in Psychiatric and Substance Use Disorders
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15. Distinctive single-channel properties of α4β2-nicotinic acetylcholine receptor isoforms
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16. Varenicline decreases nicotine but not alcohol self-administration in genetically selected Marchigian Sardinian alcohol-preferring (msP) rats
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17. A comparison of brain and behavioral effects of varenicline and nicotine in rats
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18. Varenicline in smoking cessation
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19. Examination of the effects of varenicline, bupropion, lorcaserin, or naltrexone on responding for conditioned reinforcement in nicotine-exposed rats
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20. Successful Smoking Cessation and Improvement of Negative Symptoms With Varenicline in a Stable Schizophrenia Patient
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21. NAChR α4β2 Subtype and their Relation with Nicotine Addiction, Cognition, Depression and Hyperactivity Disorder
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22. Design, Synthesis and Discovery of Picomolar Selective α4β2 Nicotinic Acetylcholine Receptor Ligands
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23. Agonist and antagonist effects of cytisine in vivo
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24. Selective and regulated trapping of nicotinic receptor weak base ligands and relevance to smoking cessation
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25. Pharmacokinetic-Pharmacodynamic Modeling of the Effect of Varenicline on Nicotine Craving in Adult Smokers
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27. Involvement of neuronal β 2 subunit-containing nicotinic acetylcholine receptors in nicotine reward and withdrawal: Implications for pharmacotherapies
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28. Nicotinic Acetylcholine α4β2 Receptor Regulates the Motivational Effect of Intracranial Self Stimulation Behavior in the Runway Method
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29. Translational Research on Nicotine Dependence
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30. Structure–Activity Studies of 7-Heteroaryl-3-azabicyclo[3.3.1]non-6-enes: A Novel Class of Highly Potent Nicotinic Receptor Ligands
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31. T-Type Calcium Channel Antagonism Decreases Motivation for Nicotine and Blocks Nicotine- and Cue-Induced Reinstatement for a Response Previously Reinforced with Nicotine
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32. Predictors of Tobacco Abstinence in Outpatient Smokers with Schizophrenia or Bipolar Disorder Treated with Varenicline and Cognitive Behavioral Smoking Cessation Therapy
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33. Methadone’s effect on nAChRs—a link between methadone use and smoking?
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34. Synthesis and activity of substituted carbamates as potentiators of the α4β2 nicotinic acetylcholine receptor
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36. Changes in Temperature Have Opposing Effects on Current Amplitude in α7 and α4β2 Nicotinic Acetylcholine Receptors
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37. Brain Responses to Cigarette-Related and Emotional Images in Smokers During Smoking Cessation: No Effect of Varenicline or Bupropion on the Late Positive Potential
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40. Pharmacological treatments for tobacco dependence
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41. Levo-tetrahydropalmatine inhibits α4β2 nicotinic receptor response to nicotine in cultured SH-EP1 cells
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42. Implications of the non‐neuronal cholinergic system for therapeutic interventions of inflammatory skin diseases
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43. Preclinical evidence for combining the 5‐ HT2C receptor agonist lorcaserin and varenicline as a treatment for nicotine dependence
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44. Stoichiometry-Selective Antagonism of α4β2 Nicotinic Acetylcholine Receptors by Fluoroquinolone Antibiotics
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45. Varenicline Targets the Reinforcing-Enhancing Effect of Nicotine on Its Associated Salient Cue During Nicotine Self-administration in the Rat
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46. Inhibition of glycine transporter 1 attenuates nicotine- but not food-induced cue-potentiated reinstatement for a response previously paired with sucrose
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47. Highly Selective and Potent α4β2 nAChR Antagonist Inhibits Nicotine Self-Administration and Reinstatement in Rats
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48. The SARS-CoV-2 Virus and the Cholinergic System: Spike Protein Interaction with Human Nicotinic Acetylcholine Receptors and the Nicotinic Agonist Varenicline
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49. Evaluation of structurally diverse neuronal nicotinic receptor ligands for selectivity at the α6∗ subtype
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50. Plasma concentrations of cytisine, a commercially available plant-based alkaloid, in healthy adult smokers taking recommended doses for smoking cessation
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51. 5-HT2A and 5-HT2C receptors as potential targets for the treatment of nicotine use and dependence
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52. Nicotine Patch Alters Patterns of Cigarette Smoking-Induced Dopamine Release: Patterns Relate to Biomarkers Associated With Treatment Response
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53. Pharmacological characterization of (S)-(2)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine HCl (SIB-1508Y, Altinicline), a novel nicotinic acetylcholine receptor agonist
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58. The influence of acute varenicline administration on smoking and eating behavior in humans
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59. The smoking cessation drug varenicline improves deficient P20–N40 inhibition in DBA/2 mice
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60. High-throughput cell-based assays for identifying antagonists of multiple smoking-associated human nicotinic acetylcholine receptor subtypes
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61. des -Formylflustrabromine (dFBr): A Structure–Activity Study on Its Ability To Potentiate the Action of Acetylcholine at α4β2 Nicotinic Acetylcholine Receptors
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62. Synthesis of 2-(Substituted Phenyl)-3,5,5-trimethylmorpholine Analogues and Their Effects on Monoamine Uptake, Nicotinic Acetylcholine Receptor Function, and Behavioral Effects of Nicotine
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