Nitroxyl (HNO): the Cinderella of the nitric oxide story

Irvine, Jennifer C., Ritchie, Rebecca H., Favaloro, Joanne L., Andrews, Karen L., Widdop, Robert E., Kemp-Harper, Barbara K.·2008·Trends in Pharmacological Sciences

DOI 10.1016/j.tips.2008.08.005

Cited by (279)

Items 201–279 of 279

Nitrite- and nitroxyl-induced relaxation in porcine coronary (micro-) arteries: Underlying mechanisms and role as endothelium-derived hyperpolarizing factor(s)
Ilse P.G. Botden, Wendy W. Batenburg, René DE VRIES, Janneke G. Langendonk, Eric J.G. Sijbrands, A.H. Jan Danser · 2012 · Pharmacological Research
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Augusto C. H. Da Silva, Juarez L. F. Da Silva, Douglas Wagner Franco · 2016 · Dalton Transactions
Amphiphilic Copolymers Capable of Concomitant Release of HNO and Small Molecule Organics
Derek C. Church, Saghar Nourian, Chang‐Uk Lee, Neal A. Yakelis, John P. Toscano, Andrew J. Boydston · 2016 · ACS Macro Letters
Nitric oxide as a target for the hypotensive and vasorelaxing effects induced by (Z)-ethyl 12-nitrooxy-octadec-9-enoate in rats
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Comparison of Reductive Ligation‐Based Detection Strategies for Nitroxyl (HNO) and S‐Nitrosothiols
Zhengrui Miao, S. Bruce King · 2016 · ChemistryOpen
Synthesis of Nitric Oxide Donors Derived from Piloty’s Acid and Study of Their Effects on Dopamine Secretion from PC12 Cells
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Qiujuan Ma, Junhong Xu, Guojiang Mao, Xiaoyu Guo, Beibei Liang, Yu Bai, Chunyan Wang · 2019 · Analytical Methods
An activatable near-infrared fluorescent probe for tracking nitroxyl in vitro and in vivo
Zhe Zhou, Xiaofeng Xia, Zheng Li, Tianshuo Zhou, Erfei Wang, Chao Ma, Cuifen Lu, Junqi Nie, Guichun Yang, Juan Wang et al. · 2022 · Dyes and Pigments
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Qing-Bo Lu, Xue-Xue Zhu, Guo Chen, Jia-Bao Su, Chen-Yang Zhao, An‐Jing Xu, Jin‐Song Bian, Hai‐Jian Sun · 2025 · Antioxidants and Redox Signaling
The effects of nitroxyl (HNO) on H2O2 metabolism and possible mechanisms of HNO signaling
Matthew Irick Jackson, Hannah F. Fields, Timothy S. Lujan, Megan M. Cantrell, Joseph Lin, Jon M. Fukuto · 2013 · Archives of Biochemistry and Biophysics
Mechanisms Associated to Nitroxyl (HNO)-Induced Relaxation in the Intestinal Smooth Muscle
Mirko Gastreich-Seelig, Marcel Jiménez, Ervice Pouokam · 2020 · Frontiers in Physiology
Bioinspired oxidation of oximes to nitric oxide with dioxygen by a nonheme iron(II) complex
Shrabanti Bhattacharya, Triloke Ranjan Lakshman, Subhankar Sutradhar, Chandan Kumar Tiwari, Tapan Kanti Paine · 2019 · JBIC Journal of Biological Inorganic Chemistry
Quinoline-2-thiol Derivatives as Fluorescent Sensors for Metals, pH and HNO
Naphtali A. O’Connor, Gustavo E. López, Anthony Cruz · 2014 · Current Chemistry Letters
Electronic Modification of a Reduced Mononuclear Nonheme Iron Nitrosyl Complex Leads to HNO Release
Jacob A. Wade, Aniruddha Dey, Alex M. Confer, Sudha Yadav, Maxime A. Siegler, Therese Albert, Pierre Moënne‐Loccoz, Yisong Guo, Van Sara Thoi, David Philip Goldberg · 2025 · Journal of the American Chemical Society
A novel NIR fluorescent probe to image HNO during ferroptosis
Changyi Li, Xiaokai Wang, Xiaofei Zhu, Jianfei Liu, Yong Ye · 2024 · Analytica Chimica Acta
Endogenous plant nitroxyl, a new component of nitric oxide biology
Jolanta Floryszak‐Wieczorek, Ewa Sobieszczuk‐Nowicka, Magdalena Arasimowicz‐Jelonek · 2023 · Trends in Biochemical Sciences
A highly efficient coumarin-based turn-on fluorescent probe for specific and sensitive detection of exogenous and endogenous Nitroxyl in vivo and in vitro
Xin Zhou, Tongtong Xu, Wenhao Du, Yueyin Liang, Shuai Gong, Zhiyuan Meng, Xu Xu, Shifa Wang, Zhonglong Wang · 2024 · Journal of Molecular Structure
Actions of Angeli's salt, a nitroxyl (HNO) donor, on ion transport across mucosa—submucosa preparations from rat distal colon
Ervice Pouokam, Anna Bell, Martin Diener · 2013 · European Journal of Pharmacology
Angeli's Salt, a nitroxyl anion donor, reverses endothelin-1 mediated vascular dysfunction in murine aorta
Brandi Michele Wynne, Hicham Labazi, Zidonia Nunes Carneiro, Rita C. Tostes, Robert Clinton Webb · 2017 · European Journal of Pharmacology
S‐Nitrosothiol Chemistry at the Single‐Molecule Level
Lai‐Sheung Choi, Hagan Bayley · 2012 · Angewandte Chemie
An activatable fluorescent-photoacoustic dual-modal probe for highly sensitive imaging of nitroxyl in vivo
Fang-yuan Qi, Lei Qiao, Lan Peng, Yu Yang, Chonghua Zhang, Xianjun Liu · 2024 · The Analyst
New Insights on {FeNO}n (n=7, 8) Systems as Enzyme Models and HNO Donors
Todd C. Harrop · 2014 · Advances in inorganic chemistry
C‐Nitrosothioformamide: A Donor Template for Dual Release of HNO and H2S
Shane S. Kelly, Xiang Ni, Vivian Yuen, Miles N. Radford, Ming Xian · 2022 · ChemBioChem
Pro-luciferin probes containing (2-diphenylphosphino)benzoate and 2-thiolo-2-methylpropionate moieties: Synthesis, characterization, and reactivity toward nitroxyl
Marcin Szala, Julia Modrzejewska, Aleksandra Grzelakowska, Jolanta Kolińska, Radosław Michalski, Angelika Artelska, Adam Sikora, Radosław Podsiadły · 2022 · Dyes and Pigments
Phosphine-Based HNO Detection
Zhengrui Miao, S. Bruce King · 2016 · Elsevier eBooks
Nitric Oxide and Reactive Nitrogen Species
Magdalena Arasimowicz‐Jelonek, Jolanta Floryszak‐Wieczorek, Dariusz Abramowski, Karolina Izbiańska · 2014 · Springer eBooks
A diazen-1-ium-1,2-diolate analog of 7-azabenzobicyclo[2.2.1]heptane: Synthesis, nitric oxide and nitroxyl release, in vitro hemodynamic, and anti-hypertensive studies
Atul Bhardwaj, Zhangjian Huang, Jatinder Paul Kaur, Yang Feng-hua, John M. Seubert, Edward E. Knaus · 2013 · Bioorganic & Medicinal Chemistry Letters
Nitric oxide (NO) synthase but not NO, HNO or H2O2 mediates endothelium‐dependent relaxation of resistance arteries from patients with cardiovascular disease
Maximilian Matthies, Kristoffer Rosenstand, Inger Nissen, Stan Muitjens, Lars Peter Riber, Jo G. R. De Mey, Maria Bloksgaard · 2021 · British Journal of Pharmacology
Vasoprotective Actions of Nitroxyl (HNO): A Story of Sibling Rivalry
Barbara K. Kemp‐Harper · 2021 · Journal of Cardiovascular Pharmacology
Effective methods for preparation and characterization of HNO‐adducts of heme proteins
Kazimierz Czarnecki, James R. Kincaid · 2012 · Journal of Raman Spectroscopy
Reusable HNO Sensors Derived from Cu Cyclam: A DFT Study on the Mechanistic Origin of High Reactivity and Favorable Conformation Changes and Potential Improvements
Jia‐Min Chu, Dariya Baizhigitova, Vy Nguyen, Yong Zhang · 2024 · Inorganic Chemistry
Multi-coloured fluorescent sensing toolbox for selective detection of nitroxyl in vitro and ex vivo
Vicky Staikopoulos, Xiaoli Zhang, Bailey Pullen, Philipp Reineck, Achini K. Vidanapathirana, S. M. Lee, J Liu, Christina A. Bursill, Mark Rowland Hutchinson, Andrew David Abell · 2022 · Sensors & Diagnostics
The Therapeutic Potential of Angeli’s Salt in Mitigating Acute Trypanosoma cruzi Infection in Mice
Vera Lúcia Hideko Tatakihara, Aparecida Donizette Malvezi, Rito Santo Pereira, Bruno Fernando Cruz Lucchetti, Lucas Felipe dos Santos, Rúbens Cecchini, Lucy Megumi Yamauchi, Sueli Fumie Yamada‐Ogatta, Katrina M. Miranda, Waldiceu Aparecido Verri Jr et al. · 2023 · Pathogens
Mechanistic insights into the in vitro metal-promoted oxidation of (di)azine hydroxamic acids: evidence of HNO release and N , O -di(di)azinoyl hydroxylamine intermediate
Edinilton Muniz Carvalho, Lionel Rechignat, Eduardo Henrique Silva Sousa, Luiz Gonzaga de França Lopes, Rémi Chauvin, Vania Bernardes‐Génisson · 2020 · New Journal of Chemistry
Using In Silico Tools To Map the Structural Landscape of Nitroxyl (HNO Donor) Compounds
Bhupinder Sandhu, Scott Savage, Hyunsoo Park, Andrew J. Ilott, Jacob W. Albrecht, Shawn X. Yin, Amy A. Narducci Sarjeant · 2022 · Crystal Growth & Design
Synthesis and characterization of a Cu( ii ) coordination-containing TAM radical as a nitroxyl probe
Wenbo Liu, Ouyang Tao, Li Chen, Yun Ling, Ming Zeng, Hong‐Guang Jin, Dengzhao Jiang · 2022 · RSC Advances
The Supersulfide-Producing Activity of Rat Cystathionine γ-Lyase Is Irreversibly Inactivated by L-CysNO but Not by L-GSNO
Shoma Araki, Tsuyoshi Takata, Sunghyeon Yoon, Shingo Kasamatsu, Hideshi Ihara, Hidehiko Nakagawa, Takaaki Akaike, Yukihiro Tsuchiya, Yasuo Watanabe · 2025 · Antioxidants
Poly(Piloty's acid): a slow releasing macromolecular HNO donor
Sarah N. Swilley, Evan M. Zajkowski, John B. Matson · 2023 · Polymer Chemistry
Developing Photoactive Coumarin-Caged N-Hydroxysulfonamides for Generation of Nitroxyl (HNO)
M. Shahinur Rahman, Vinay Bharadwaj, Anau K. H. S. Lautaha, Paul Sampson, Nicola E. Brasch, Alexander J. Seed · 2024 · Molecules
Potential Applications of Nitric Oxide Donors in Type 2 Diabetes
Zahra Bahadoran, Parvin Mirmiran, Mehrnoosh Bahmani, Asghar Ghasemi · 2022 · BENTHAM SCIENCE PUBLISHERS eBooks
Intracellular Crosstalk of the Gasotransmitter Trio (NO, CO, H2S) in Cardiovascular Health and Disease: From Molecular Signaling to Precision Gas Medicine
Tzong‐Shyuan Lee · 2026 · International Journal of Molecular Sciences
Arylazoamidoximes and Related Compounds as NO‐modulators
Alexander Schröder, Jürke Kotthaus, Dennis Schade, Bernd Clement, Klaus Rehse · 2009 · Archiv der Pharmazie
Synthesis and characterization of BODIPY-DPA-Cu(II)-conjugate HNO fluorescent probes: Effect of linker length on imaging properties
Wenbo Liu, Yufeng Zou, Yu Zhou, Jiangwei Zheng, Margaret Liu, Dengzhao Jiang · 2025 · Journal of Chemical Research
Mechanistic Origin of Favorable Substituent Effects in Excellent Cu Cyclam Based HNO Sensors
Yelu Shi, Gianna Stella, Jia‐Min Chu, Yong Zhang · 2022 · Angewandte Chemie
Ambient catalyst free nitrogen fixation with water dimer radical cation
Xiaoping Zhang, Liping Huang, Jingling Li, Wenwen Yang, Konstantin Chingin, Roman M. Balabin, Jingjing Wang, Xinglei Zhang, Weifeng Zhu, Rui Jun Su et al. · 2023 · ChemRxiv
The Chemistry of NO ‐ and HNO ‐Producing Diazeniumdiolates
Anthony S. Evans, John P. Toscano · 2010 · Patai's chemistry of functional groups
The Effects of Berberine and Nitroxl (HNO) on the Glucose Uptake in L929 Fibroblast Cells
Jude Chenge · 2012 · ScholarWorks - GVSU (Grand Valley State University)
Nitroxyl, the novel redox sibling of NO, suppresses cerebrovascular NADPH oxidase
Barbara K. Kemp‐Harper, Ravina Maru Ravi, Michelle L. Bullen, Rebecca Helen Ritchie, Christopher Graeme Sobey, Alyson A. Miller · 2009 · BMC Pharmacology
The Role of Phospholamban Cysteines in the Activation of the Cardiac Sarcoplasmic Reticulum Calcium Pump by Nitroxyl
Chevon N. Thorpe, Lesly De Arras, John P. Toscano, Gizem Keceli, Christopher M. Pavlos, Nazareno Paolocci, Jeffrey P. Froehlich, James E. Mahaney · 2009 · Biophysical Journal
The novel NO redox sibling, nitroxyl (HNO), prevents cardiomyocyte hypertrophy and superoxide generation via cGMP
Rebecca Helen Ritchie, Jennifer C. Irvine, Swati Gossain, Jane E Love, John David Horowitz, Barbara K. Kemp‐Harper · 2009 · BMC Pharmacology
Nitroksyl (HNO/NO-) - enigmatyczna cząsteczka o unikatowych właściwościach i potencjale farmakologicznym
J Goscimska, Aleksandra Augustyniak, Alina Błaszczyk · 2012
Mechanisms underlying the endothelium-dependent modulation of vascular tone
Polina L Iarova · 2011 · The University of Bath Online Publications Store (The University of Bath)
The effects of diabetes on vascular function and potential treatment with a flavonol
Chen Huei Leo · 2012 · RMIT Research Repository (RMIT University Library)
Effekt des HNO-Donators NCA auf die Thromboxan A 2 Rezeptor vermittelte Gefäßkontraktion und Plättchenaggregation
Rainer H. Böger · 2013
Efeito relaxante do doador de nitroxil (sal de Angeli) em veia cava de ratos
Fabíola Cristina Zuchi · 2015
MECHANISTIC STUDIES ON THE REACTIONS OF VITAMIN B12 COMPLEXES WITH THE NITROXYL (HNO) DONORS ANGELI'S SALT AND PILOTY'S ACID
Harishchandra Subedi · 2014 · OhioLink ETD Center (Ohio Library and Information Network)
Investigation of the vasorelaxant properties of Nitroxyl during altered glycaemic conditions
Kimberley Sams · 2024 · PEARL (University of Plymouth)
Untersuchungen zu Struktur-Aktivitäts-Beziehungen am mARC-Enzymsystem
Eva Bauch · 2015 · Multimedialen Archiv und Publikationsserver der Christian-Albrechts-Universität zu Kiel (Christian-Albrechts-Universität zu Kiel)
STUDIES TOWARD THE SYNTHESIS OF PHOTOLABILE HNO DONORS - AN EXPLORATION OF SELECTIVITY FOR HNO GENERATION
Zachary A. Fejedelem · 2015 · OhioLink ETD Center (Ohio Library and Information Network)
HNO as an Oxygen Substitute in Enzymes
Xiaozhen Han, Murugaeson Ravi Kumar, Patrick J. Farmer · 2016 · Elsevier eBooks
The Reactions of HNO With Nonheme Proteins
Jon M. Fukuto, Robert J. Millikin · 2016 · Elsevier eBooks
Fluorescent Probes for Gaseous Biological Signaling Agents
K. Wang, D. Wang, Xingyue Ji, Yue‐Qing Zheng, Binghe Wang · 2016 · Elsevier eBooks
Duplicated DNA Damage-Inducible Genes DDI2/DDI3 in Budding Yeast Saccharomyces cerevisiae Encodes a Functional Cyanamide Hydratase
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Phosphine Based Fluorescent Probes for Nitroxyl Detection and Their Reactivity Toward S-Nitrosothiols
Zhengrui Miao · 2016 · WakeSpace Scholarship (Wake Forest University)
Estudo teórico-experimental de nitroxil e nitroxil complexos em tetraaminas de rutênio(II)
Augusto C. H. Da Silva · 2017
Noncovalent interactions in 1:1 complexes of nitrogen trifluoride and nitroxyl
Akram Hosseinian, Esmail Vessally, Mirzaagha Babazadeh, Ladan Edjlali, Moosa Es’haghi · 2017 · Journal of Theoretical and Computational Chemistry
NO Synthase but not NO, HNO or H2O2 Mediates Endothelium-Dependent Relaxation of Resistance Arteries from Patients with Resistant Cardiovascular Disease
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Ambient catalyst-free nitrogen fixation with water dimer
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Nitric oxide resistance in type 2 diabetes: Potential implications of HNO donors
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Oxidative HNO Formation Mechanisms from NH 2 OH via Two Different Heme Proteins and Effects from Hemes, Nearby Residues, and Protein Environments
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New Insights on {FeNO} (n= 7, 8) Systems as Enzyme Models and HNO Donors
Todd C. Harrop · 2025 · Advances in inorganic chemistry
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Edinilton Muniz Carvalho · 2020
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Rama Alhasan · 2024
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BindingDB Entry 50039402: Ethanesulfohydroxamic acid ester prodrugs of nonsteroidal anti-inflammatory drugs (NSAIDs): synthesis, nitric oxide and nitroxyl release, cyclooxygenase inhibition, anti-inflammatory, and ulcerogenicity index studies.
BindingDB · 2013 · UC San Diego
BindingDB Entry 50043315: Direct and nitroxyl (HNO)-mediated reactions of acyloxy nitroso compounds with the thiol-containing proteins glyceraldehyde 3-phosphate dehydrogenase and alkyl hydroperoxide reductase subunit C.
BindingDB · 2014 · UC San Diego