The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
The distinct roles of cyclooxygenase-1 and -2 in neuroinflammation: implications for translational research
Open accessAbstract
Cyclooxygenases (COX-1 and COX-2) are key enzymes in the conversion of arachidonic acid to prostaglandins and other lipid mediators. Because it can be induced by inflammatory stimuli, COX-2 has been classically considered as the most appropriate target for anti-inflammatory drugs. However, recent data indicate that COX-2 can mediate neuroprotection and that COX-1 is a major player in the neuroinflammatory process. We discuss the specific contributions of COX-1 and COX-2 in various neurodegenerative diseases and in models of neuroinflammation. We suggest that, owing to its predominant localization in microglia, COX-1 might be the major player in neuroinflammation, whereas COX-2, which is localized in neurons, might have a major role in models in which the neurons are directly challenged. Overall, the benefit of using COX-2 inhibitors should be carefully evaluated and COX-1 preferential inhibitors should be further investigated as a potential therapeutic approach in neurodegenerative diseases with an inflammatory component.
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Cites
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“However, in the CNS COX-2 is also constitutively expressed, mainly in hippocampal and cortical glutamatergic neurons where it has a pivotal role in synaptic activity, long-term synaptic plasticity [18,19] and in the neurovascular coupling during functional hyperemia [18].”
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Cited by
Mechanisms underlying inflammation in neurodegeneration
Glass, C. K., Saijo, K., Winner, B., Marchetto, M. C., & Gage, F. H. (2010) · Cell · doi:10.1016/j.cell.2010.02.016 · Cited by 3,580
The Bidirectional Relationship of Depression and Inflammation: Double Trouble
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Depression as a Microglial Disease
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“However, studies on the use of non-steroid anti-inflammatory drugs (NSAIDs; Jiang and Chang, 1999) or COX-1 inhibitor (Choi et al., 2009), being COX-1 mainly activated in microglial cells, reported an increase of depressive episodes in psychiatrically healthy individuals.”
BackgroundAdibhatla, R. M., & Hatcher, J. F. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2668 · Cited by 480
Metadata
- Authors
- Choi, S.-H., Aid, S., & Bosetti, F.
- Venue
- Trends in Pharmacological Sciences
- Publisher
- Elsevier BV
- Published
- 2009-04
- Volume
- 30
- Issue
- 4
- Pages
- 174-181
- ISSN
- 0165-6147 (ISSN-L)
- OpenAlex
- W2031299209
- Cited by
- 402
- References
- 10
- FWCI
- 3.01
- Type
- journal article
- Language
- en
- Open access
- green
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