The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.
Is resistance useless? Multidrug resistance and collateral sensitivity
Open accessAbstract
When cancer cells develop resistance to chemotherapeutics, it is frequently conferred by the ATP-dependent efflux pump P-glycoprotein (MDR1, P-gp, ABCB1). P-gp can efflux a wide range of cancer drugs; thus its expression confers cross-resistance, termed multidrug resistance (MDR), to a wide range of drugs. Strategies to overcome this resistance have been actively sought for over 30 years, yet no clinical solutions exist. A less understood aspect of MDR is the hypersensitivity of resistant cancer cells to other drugs, a phenomenon generally known as collateral sensitivity (CS). This review highlights the extent of this effect for the first time, discusses hypotheses such as ROS generation to account for the underlying generality of this phenomenon, and proposes the exploitation of CS as a strategy to improve response to chemotherapy.
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Cites
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Metadata
- Authors
- Hall, M. D., Handley, M. D., & Gottesman, M. M.
- Venue
- Trends in Pharmacological Sciences
- Publisher
- Elsevier BV
- Published
- 2009-10
- Volume
- 30
- Issue
- 10
- Pages
- 546-556
- ISSN
- 0165-6147 (ISSN-L)
- OpenAlex
- W1977594275
- Cited by
- 259
- References
- 77
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- green
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- Hall, M. D., Handley, M. D., & Gottesman, M. M. (2009). Is resistance useless? Multidrug resistance and collateral sensitivity. Trends in Pharmacological Sciences. https://doi.org/10.1016/j.tips.2009.07.003
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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