Cited by 781Biochemical and Molecular ResearchCarbohydrate Chemistry and SynthesisMetabolism, Diabetes, and Cancer

Localization of the primary metabolic block produced by 2-deoxyglucose

Open access
Wick, Arne N., Drury, Douglas R., Nakada, Henry I., Wolfe, Jack B., Britton, Barbara, Grabowski, Ruth·1957·Journal of Biological Chemistry

Integrity signals

Registry

Crossref · 10.1016/s0021-9258(18)64988-9

Cites

13 of 13 references verified0 citation errors · 0 not checkable

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  • 2-DG is phosphorylated by hexokinase to 2-deoxyglucose-6-phosphate, which cannot be further metabolized, accumulates intracellularly, and competitively inhibits hexokinase to slow glucose uptake.

    “2-DG is phosphorylated by hexokinase to produce 2-deoxyglucose-6-phosphate, which cannot be further metabolized by cells. It therefore accumulates intracellularly and competitively inhibits hexokinase to slow glucose uptake (Figure 3).”

    From Targeting Metabolism for Cancer Therapy (2017) · cites this paper as Wick et al., 1957

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Authors
Wick, A. N., Drury, D. R., Nakada, H. I., Wolfe, J. B., Britton, B., & Grabowski, R.
Affiliations
Scripps Clinic (US)
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1957-02
Volume
224
Issue
2
Pages
963-969
ISSN
0021-9258 (ISSN-L)
OpenAlex
W1536070820
Cited by
780
References
13
Citations by year
2026: 5 · 2025: 15 · 2024: 14 · 2023: 24 · 2022: 27 · 2021: 27 · 2020: 33 · 2019: 37 · 2018: 30 · 2017: 18 · 2016: 24 · 2015: 24 · 2014: 13 · 2013: 8 · 2012: 10
FWCI
9.50
Type
journal article
Language
en
Open access
Locations
  • Journal of Biological Chemistry (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
  • Physical Sciences › Chemistry › Organic Chemistry › Carbohydrate Chemistry and Synthesis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords
2-deoxyglucose, metabolic block, glycolysis inhibition, glucose metabolism, enzyme localization, glycolytic enzymes
MeSH terms
Deoxyglucose, Glucose, Humans

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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