Localization of the primary metabolic block produced by 2-deoxyglucose
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2-DG is phosphorylated by hexokinase to 2-deoxyglucose-6-phosphate, which cannot be further metabolized, accumulates intracellularly, and competitively inhibits hexokinase to slow glucose uptake.
“2-DG is phosphorylated by hexokinase to produce 2-deoxyglucose-6-phosphate, which cannot be further metabolized by cells. It therefore accumulates intracellularly and competitively inhibits hexokinase to slow glucose uptake (Figure 3).”
From Targeting Metabolism for Cancer Therapy (2017) · cites this paper as Wick et al., 1957
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- Authors
- Wick, A. N., Drury, D. R., Nakada, H. I., Wolfe, J. B., Britton, B., & Grabowski, R.
- Affiliations
- Scripps Clinic (US)
- ORCID
- Wick, Arne N.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1957-02
- Volume
- 224
- Issue
- 2
- Pages
- 963-969
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1536070820
- Cited by
- 780
- References
- 13
- Citations by year
- 2026: 5 · 2025: 15 · 2024: 14 · 2023: 24 · 2022: 27 · 2021: 27 · 2020: 33 · 2019: 37 · 2018: 30 · 2017: 18 · 2016: 24 · 2015: 24 · 2014: 13 · 2013: 8 · 2012: 10
- FWCI
- 9.50
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Physical Sciences › Chemistry › Organic Chemistry › Carbohydrate Chemistry and Synthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- 2-deoxyglucose, metabolic block, glycolysis inhibition, glucose metabolism, enzyme localization, glycolytic enzymes
- MeSH terms
- Deoxyglucose, Glucose, Humans
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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