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Convergence of genetic findings for nicotine dependence and smoking related diseases with chromosome 15q24-25
Open accessAbstract
Due to the adverse health consequences related to smoking, it is important to understand factors that contribute to nicotine dependence. The most replicated genetic finding for nicotine dependence points to variants on chromosome 15, which includes the alpha5-alpha3-beta4 nicotinic receptor gene cluster. A compelling functional variant is a polymorphism, rs16969968, which alters an amino acid in the alpha5 nicotinic receptor subunit. Several prominent studies report that the replicated nicotine dependence locus also influences the risk for lung cancer and chronic obstructive pulmonary disease. This represents an exciting convergence of genetic findings, and highlights the potential for research on smoking to inform public health.
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“variants in the CHRNA5 gene, encoding for the alpha- 5- subunit- containing nicotine receptor, which has been found to increase vulnerability to tobacco dependence 97 .”
From Substance use disorders: a comprehensive update of classification, epidemiology, neurobiology, clinical aspects, treatment and prevention (2023) · cites this paper as [97]
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Metadata
- Authors
- Bierut, L. J.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Bierut, Laura Jean
- ORCID
- Bierut, Laura Jean
- Venue
- Trends in Pharmacological Sciences
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 31
- Issue
- 1
- Pages
- 46-51
- ISSN
- 0165-6147 (ISSN-L)
- PMC
- PMC2993565
- OpenAlex
- W1981386943
- Cited by
- 120
- References
- 44
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 6 · 2022: 7 · 2021: 2 · 2020: 5 · 2019: 6 · 2018: 2 · 2017: 13 · 2016: 10 · 2015: 8 · 2014: 10 · 2013: 12 · 2012: 15
- FWCI
- 1.24
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Pharmacological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (K02DA021237)
- National Cancer Institute (P01CA089392)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- nicotine dependence, nicotinic acetylcholine receptors, CHRNA5, CHRNA3, CHRNB4, rs16969968, lung cancer risk, chronic obstructive pulmonary disease, smoking-related diseases, genetic susceptibility
- MeSH terms
- Animals, Chromosomes, Human, Pair 15, Humans, Lung Neoplasms, Nerve Tissue Proteins, Receptors, Nicotinic, Tobacco Use Disorder, Amino Acid Substitution, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Pulmonary Disease, Chronic Obstructive
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