The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Convergence of genetic findings for nicotine dependence and smoking related diseases with chromosome 15q24-25
Open accessAbstract
Due to the adverse health consequences related to smoking, it is important to understand factors that contribute to nicotine dependence. The most replicated genetic finding for nicotine dependence points to variants on chromosome 15, which includes the alpha5-alpha3-beta4 nicotinic receptor gene cluster. A compelling functional variant is a polymorphism, rs16969968, which alters an amino acid in the alpha5 nicotinic receptor subunit. Several prominent studies report that the replicated nicotine dependence locus also influences the risk for lung cancer and chronic obstructive pulmonary disease. This represents an exciting convergence of genetic findings, and highlights the potential for research on smoking to inform public health.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“variants in the CHRNA5 gene, encoding for the alpha- 5- subunit- containing nicotine receptor, which has been found to increase vulnerability to tobacco dependence 97 .”
From Substance use disorders: a comprehensive update of classification, epidemiology, neurobiology, clinical aspects, treatment and prevention (2023) · cites this paper as [97]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Fagerstrom Test for Nicotine Dependence: a revision of the Fagerstrom Tolerance Questionnaire
HEATHERTON, T. F., KOZLOWSKI, L. T., FRECKER, R. C., & FAGERSTROM, K. (1991) · British Journal of Addiction · doi:10.1111/j.1360-0443.1991.tb01879.x · Cited by 10,738
Actual causes of death in the United States
McGinnis, J. M. (1993) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1993.03510180077038 · Cited by 5,480
Actual Causes of Death in the United States, 2000
Mokdad, A. H. (2004) · JAMA · doi:10.1001/jama.291.10.1238 · Cited by 5,211
Hindorff, L. A., Sethupathy, P., Junkins, H. A., Ramos, E. M., Mehta, J. P., Collins, F. S., & Manolio, T. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903103106 · Cited by 4,013
A variant associated with nicotine dependence, lung cancer and peripheral arterial disease
Thorgeirsson, T. E., Geller, F., Sulem, P., Rafnar, T., Wiste, A., Magnusson, K. P., Manolescu, A., Thorleifsson, G., Stefansson, H., Ingason, A., et al. (2008) · Nature · doi:10.1038/nature06846 · Cited by 1,523
Cigarette Smoking Among Adults--United States, 2003
(2005) · JAMA · doi:10.1001/jama.294.2.172 · Cited by 1,520
SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap
Johnson, A. D., Handsaker, R. E., Pulit, S. L., Nizzari, M. M., O’Donnell, C. J., & de Bakker, P. I. W. (2008) · Bioinformatics · doi:10.1093/bioinformatics/btn564 · Cited by 1,339
Amos, C. I., Wu, X., Broderick, P., Gorlov, I. P., Gu, J., Eisen, T., Dong, Q., Zhang, Q., Gu, X., Vijayakrishnan, J., et al. (2008) · Nature Genetics · doi:10.1038/ng.109 · Cited by 1,310
Hung, R. J., McKay, J. D., Gaborieau, V., Boffetta, P., Hashibe, M., Zaridze, D., Mukeria, A., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., et al. (2008) · Nature · doi:10.1038/nature06885 · Cited by 1,275
Lignac, G. O. E. (1951) · PubMed · Cited by 1,013
Saccone, S. F., Hinrichs, A. L., Saccone, N. L., Chase, G. A., Konvicka, K., Madden, P. A. F., Breslau, N., Johnson, E. O., Hatsukami, D., Pomerleau, O., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddl438 · Cited by 850
Self-citationBetts, P., Mokry, B., Risser, D. R., Weiss, N. S., Williams, M. A., Sjoberg, E., Clanton, M. S., Frankel, L. S., Foxhall, L. E., Hancock, L. E., et al. (2004) · Cited by 840
Pillai, S. G., Ge, D., Zhu, G., Kong, X., Shianna, K. V., Need, A. C., Feng, S., Hersh, C. P., Bakke, P. S., Gulsvik, A., et al. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000421 · Cited by 777
Variants in Nicotinic Receptors and Risk for Nicotine Dependence
Bierut, L. J., Stitzel, J. A., Wang, J. C., Hinrichs, A. L., Grucza, R. A., Xuei, X., Saccone, N. L., Saccone, S. F., Bertelsen, S., Fox, L., et al. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.07111711 · Cited by 648
Self-citationFamilial Transmission of Substance Dependence: Alcohol, Marijuana, Cocaine, and Habitual Smoking
Bierut, L. J., Dinwiddie, S. H., Begleiter, H., Crowe, R., HESSELBROCK, V. M., Nürnberger, J. I., Bernice Porjesz, A., Schuckit, M. A., & Reich, T. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.11.982 · Cited by 484
Self-citation'Racial' differences in genetic effects for complex diseases
Ioannidis, J., Ntzani, E., & Trikalinos, T. (2004) · Nature Genetics · doi:10.1038/ng1474 · Cited by 467
α-5/α-3 nicotinic receptor subunit alleles increase risk for heavy smoking
Berrettini, W., Yuan, X., Tozzi, F., Song, K., Francks, C., Chilcoat, H., Waterworth, D., Muglia, P., & Mooser, V (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002154 · Cited by 465
Weiss, R. B., Baker, T. B., Cannon, D. S., von Niederhausern, A., Dunn, D. M., Matsunami, N., Singh, N. A., Baird, L., Coon, H., McMahon, W. M., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000125 · Cited by 271
Saccone, N. L., Wang, J. C. C., Breslau, N., Johnson, E. O., Hatsukami, D. K., Saccone, S. F., Grucza, R. A., Sun, L., Duan, W., Budde, J., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-0786 · Cited by 269
Self-citationTobacco use among adults--United States, 2005.
Mariolis, P., Rock, V., Asman, K. J., Merritt, R., Malarcher, A., Husten, C., & Pechacek, T. (2006) · MMWR. Morbidity and mortality weekly report · doi:10.1097/01.cot.0000290043.11887.85 · Cited by 262
Genome-Wide and Candidate Gene Association Study of Cigarette Smoking Behaviors
Caporaso, N. E., Gu, F., Chatterjee, N., Jin, S. C., Yu, K., Yeager, M., Chen, C., Jacobs, K. B., Wheeler, W., Landi, M. T., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004653 · Cited by 252
Genomic Priorities and Public Health
Merikangas, K. R., & RISCH, N. J. (2003) · Science · doi:10.1126/science.1091468 · Cited by 251
Cigarette smoking among adults--United States, 2007.
(2008) · PubMed · Cited by 230
Spitz, M. R., Amos, C. I., Dong, Q., Lin, J. M., & Wu, X. (2008) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djn363 · Cited by 229
Saccone, N. L., Saccone, S. F., Hinrichs, A. L., Stitzel, J. A., Duan, W., Pergadia, M. L., Agrawal, A., Breslau, N., Grucza, R. A., Hatsukami, D., et al. (2009) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30828 · Cited by 215
Self-citationMarchand, L. L., Derby, K. S., Murphy, S. E., Hecht, S. S., Hatsukami, D. K., Carmella, S. G., Tiirikainen, M., & Wang, H. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-2271 · Cited by 203
Wang, J. C. C., Cruchaga, C., Saccone, N. L., Bertelsen, S. E., Liu, P., Budde, J., Duan, W., Fox, L. W., Grucza, R. A., Kern, J., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp231 · Cited by 194
Self-citationNicotinic Receptor Gene Variants Influence Susceptibility to Heavy Smoking
Stevens, V. L., Bierut, L. J., Talbot, J. T., Wang, J. C., Sun, J., Hinrichs, A. L., Thun, M. J., Goate, A., & Calle, E. E. (2008) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-08-0585 · Cited by 190
Self-citationA Risk Allele for Nicotine Dependence in CHRNA5 Is a Protective Allele for Cocaine Dependence
Grucza, R. A., Wang, J. C., Stitzel, J. A., Hinrichs, A. L., Saccone, S. F., Saccone, N. L., Bucholz, K. K., Cloninger, C. R., Neuman, R. J., Budde, J. P., et al. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.04.018 · Cited by 152
Self-citationFreathy, R. M., Ring, S. M., Shields, B. M., Galobardes, B., Knight, B. A., Weedon, M. N., Smith, G. D., Frayling, T. M., & Hattersley, A. T. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp216 · Cited by 148
The genetics of nicotine dependence
Li, M. D. (2006) · Current Psychiatry Reports · doi:10.1007/s11920-006-0016-0 · Cited by 143
Conti, D. V., Lee, W., Li, D., Liu, J., Van Den Berg, D., Thomas, P. D., Bergen, A. W., Swan, G. E., Tyndale, R. F., Benowitz, N. L., et al. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn181 · Cited by 136
Tobacco use among adults--United States, 2005.
(2006) · PubMed · Cited by 136
Light and intermittent smokers: Background and perspective
Shiffman, S. S. (2009) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntn020 · Cited by 133
Baker, T. B., Weiss, R. B., Bolt, D. M., von Niederhausern, A. C., Fiore, M. C., Dunn, D. M., Piper, M. E., Matsunami, N., Smith, S. S., Coon, H. H., et al. (2009) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntp064 · Cited by 120
Nicotine dependence and genetic variation in the nicotinic receptors
Bierut, L. J. (2009) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2009.06.003 · Cited by 103
Self-citationTranscription Deregulation at the 15q25 Locus in Association with Lung Adenocarcinoma Risk
Falvella, F. S., Galvan, A., Frullanti, E., Spinola, M., Calabrò, E., Carbone, A., Incarbone, M., Santambrogio, L., Pastorino, U., & Dragani, T. A. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-2107 · Cited by 82
Schwartz, A. G., Coté, M. L., Wenzlaff, A. S., Land, S. J., & Amos, C. I. (2009) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e3181b244ef · Cited by 75
Chen, D., Tian, T., Wang, H., Liu, H., Hu, Z., Wang, Y., Liu, Y., Ma, H., Fan, W., Miao, R., et al. (2008) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e328316d8d8 · Cited by 61
Potential for Genetics to Promote Public Health
Carlsten, C., & Burke, W. (2006) · JAMA · doi:10.1001/jama.296.20.2480 · Cited by 54
Breitling, L. P., Dahmen, N., Mittelstraß, K., Illig, T., Rujescu, D., Raum, E., Winterer, G., & Brenner, H. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.10.004 · Cited by 43
Setting Priorities for Genomic Research
Berrettini, W. H., Bierut, L. J., Crowley, T. J., Cubells, J. F., Frascella, J., Gelernter, J. E., Hewitt, J. K., Kreek, M. J., Lachman, H., Leppert, M., et al. (2004) · Science · doi:10.1126/science.304.5676.1445c · Cited by 18
Self-citationGenetic Research and Smoking Behavior
Bierut, L. J., Cubells, J. F., Iacono, W. G., Li, M. D., Madden, P. A. F., Nelson, E. C., Pollock, J. D., Rutter, J. L., Swan, G. E., & Vanyukov, M. M. (2007) · JAMA · doi:10.1001/jama.297.8.809 · Cited by 16
Self-citationReply to the Letter to the Editor from Wang
Falvella, F. S., Galvan, A., Frullanti, E., & Dragani, T. A. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1441 · Cited by 4
Cited by
Sorted by citations
_, _. (2008) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2008.0021 · Cited by 737
The behavioral economics of substance use disorders: reinforcement pathologies and their repair
Bickel, W. K., Johnson, M. W., Koffarnus, M. N., MacKillop, J., & Murphy, J. G. (2014) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032813-153724 · Cited by 655
The co‐occurring use and misuse of cannabis and tobacco: a review
Arpana Agrawal, A., Budney, A. J., & Lynskey, M. T. (2012) · Addiction · doi:10.1111/j.1360-0443.2012.03837.x · Cited by 534
Volkow, N. D., & Blanco, C. (2023) · World psychiatry · doi:10.1002/wps.21073 · Cited by 503
Frahm, S., Ślimak, M. A., Ferrarese, L., Santos-Torres, J., Antolin-Fontes, B., Auer, S., Filkin, S., Pons, S., Fontaine, J.-F., Tsetlin, V., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.04.013 · Cited by 283
Metadata
- Authors
- Bierut, L. J.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Bierut, Laura Jean
- ORCID
- Bierut, Laura Jean
- Venue
- Trends in Pharmacological Sciences
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 31
- Issue
- 1
- Pages
- 46-51
- ISSN
- 0165-6147 (ISSN-L)
- PMC
- PMC2993565
- OpenAlex
- W1981386943
- Cited by
- 120
- References
- 44
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 6 · 2022: 7 · 2021: 2 · 2020: 5 · 2019: 6 · 2018: 2 · 2017: 13 · 2016: 10 · 2015: 8 · 2014: 10 · 2013: 12 · 2012: 15
- FWCI
- 1.24
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Pharmacological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (K02DA021237)
- National Cancer Institute (P01CA089392)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- nicotine dependence, nicotinic acetylcholine receptors, CHRNA5, CHRNA3, CHRNB4, rs16969968, lung cancer risk, chronic obstructive pulmonary disease, smoking-related diseases, genetic susceptibility
- MeSH terms
- Animals, Chromosomes, Human, Pair 15, Humans, Lung Neoplasms, Nerve Tissue Proteins, Receptors, Nicotinic, Tobacco Use Disorder, Amino Acid Substitution, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Pulmonary Disease, Chronic Obstructive
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
