Aversion to Nicotine Is Regulated by the Balanced Activity of β4 and α5 Nicotinic Receptor Subunits in the Medial Habenula
Open accessAbstract
Nicotine dependence is linked to single nucleotide polymorphisms in the CHRNB4-CHRNA3-CHRNA5 gene cluster encoding the α3β4α5 nicotinic acetylcholine receptor (nAChR). Here we show that the β4 subunit is rate limiting for receptor activity, and that current increase by β4 is maximally competed by one of the most frequent variants associated with tobacco usage (D398N in α5). We identify a β4-specific residue (S435), mapping to the intracellular vestibule of the α3β4α5 receptor in close proximity to α5 D398N, that is essential for its ability to increase currents. Transgenic mice with targeted overexpression of Chrnb4 to endogenous sites display a strong aversion to nicotine that can be reversed by viral-mediated expression of the α5 D398N variant in the medial habenula (MHb). Thus, this study both provides insights into α3β4α5 receptor-mediated mechanisms contributing to nicotine consumption, and identifies the MHb as a critical element in the circuitry controlling nicotine-dependent phenotypes.
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Overexpression of β4* nAChRs in mice using BAC transgenic technology resulted in greatly diminished sensitivity to the reinforcing properties of orally consumed nicotine solutions and far less consumption than wild-type mice.
“Specifically, overexpression of β4 Ã nAChRs in mice using BAC transgenic technology resulted in greatly diminished sensitivity to the reinforcing properties of orally consumed nicotine solutions and far less consumption of the drug than wild-type mice (Frahm et al. 2011).”
From Mechanisms of Nicotine Addiction (2021) · cites this paper as Frahm et al. 2011
A transgenic mouse overexpressing β4 nAChR subunits shows altered nicotine consumption and conditioned place aversion.
“Indeed, a transgenic mouse model that overexpresses β4 nAChR subunits exhibits altered nicotine consumption and CPA (Frahm et al. 2011)”
From Nicotine Withdrawal (2015) · cites this paper as Frahm et al. 2011
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- Authors
- Frahm, S., Ślimak, M. A., Ferrarese, L., Santos-Torres, J., Antolin-Fontes, B., Auer, S., Filkin, S., Pons, S., Fontaine, J.-F., Tsetlin, V., Maskos, U., & Ibañez-Tallon, I.
- Affiliations
- Max Delbrück Center (DE)
- Russian Academy of Sciences (RU)
- Centre National de la Recherche Scientifique (FR)
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2011-05
- Volume
- 70
- Issue
- 3
- Pages
- 522-535
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1995989957
- Cited by
- 283
- References
- 62
- Citations by year
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- FWCI
- 13.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
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- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 808 d)
- doi.org/10.15223/policy-017 (stm-asf)
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- Neuron (publishedVersion)
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- HAL (submittedVersion)
- Funders
- Helmholtz Association (31-002, SFB 665)
- Deutsche Forschungsgemeinschaft (DFG RA 424/5-1)
- Russian Foundation for Basic Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- nicotine aversion, nicotinic acetylcholine receptors, CHRNB4, CHRNA5, medial habenula, nicotine dependence, nicotine use, receptor subunit stoichiometry, transgenic mice, viral gene expression, tobacco use
- MeSH terms
- Administration, Oral, Analysis of Variance, Animals, Animals, Newborn, Asparagine, Aspartic Acid, Autoradiography, Cell Line, Transformed, Conditioning, Operant, Electric Stimulation, Humans, Iodine Isotopes, Mice, Transgenic, Models, Molecular, Mutation, Nerve Tissue Proteins, Neurons, Nicotine, Oocytes, Pyridines, Receptors, Nicotinic, Stereotaxic Techniques, Xenopus, Patch-Clamp Techniques, Nicotinic Agonists, Bridged Bicyclo Compounds, Heterocyclic, Habenula, Polymorphism, Single Nucleotide, Green Fluorescent Proteins, Mice, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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