The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
β-arrestin-mediated receptor trafficking and signal transduction
Open accessAbstract
β-arrestins function as endocytic adaptors and mediate trafficking of a variety of cell-surface receptors, including seven-transmembrane receptors (7TMRs). In the case of 7TMRs, β-arrestins carry out these tasks while simultaneously inhibiting upstream G protein-dependent signaling and promoting alternate downstream signaling pathways. The mechanisms by which β-arrestins interact with a continuously expanding ensemble of protein partners and perform their multiple functions including trafficking and signaling are currently being uncovered. Molecular changes at the level of protein conformation as well as posttranslational modifications of β-arrestins likely form the basis for their dynamic interactions during receptor trafficking and signaling. It is becoming increasingly evident that β-arrestins, originally discovered as 7TMR adaptor proteins, indeed have much broader and more versatile roles in maintaining cellular homeostasis. Here we review the traditional and novel functions of β-arrestins and discuss the molecular attributes that might facilitate it multiple interactions in regulating cell signaling and receptor trafficking.
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“The serine-threonine clusters generally occur 9–19 residues downstream of the palmitoylation site found in the Rhodopsin family of 7TMRs and mutation of these clusters to alanines diminishes receptor phosphorylation and stability of βarrestin recruitment for the neurotensin-1, oxytocin, AT1a and V2 receptors, but not…”
BackgroundEndosomes: A legitimate platform for the signaling train
Murphy, J. E., Padilla, B. E., Hasdemir, B., Cottrell, G. S., & Bunnett, N. W. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906541106 · Cited by 373
Dishevelled 2 Recruits ß-Arrestin 2 to Mediate Wnt5A-Stimulated Endocytosis of Frizzled 4
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Lotta, L. A., Mokrosiński, J., Mendes de Oliveira, E., Li, C., Sharp, S. J., Luan, J., Brouwers, B., Ayinampudi, V., Bowker, N., Kerrison, N., et al. (2019) · Cell · doi:10.1016/j.cell.2019.03.044 · Cited by 284
Deshotels, M. R., Xia, H., Sriramula, S., Lazartigues, E., & Filipeanu, C. M. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.03743 · Cited by 264
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Metadata
- Authors
- Shenoy, S. K., & Lefkowitz, R. J.
- Venue
- Trends in Pharmacological Sciences
- Publisher
- Elsevier BV
- Published
- 2011-09
- Volume
- 32
- Issue
- 9
- Pages
- 521-533
- ISSN
- 0165-6147 (ISSN-L)
- OpenAlex
- W2165488941
- Cited by
- 712
- References
- 6
- FWCI
- 3.91
- Type
- journal article
- Language
- en
- Open access
- green
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