Receptor-Mediated Uptake of Lipoprotein-Cholesterol and Its Utilization for Steroid Synthesis in the Adrenal Cortex

The Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis

Goldstein, L. J., & Brown, S. M. (1977) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.46.070177.004341 · Cited by 2,455 · see citing works

The Metabolic Basis of Inherited Disease

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Binding and Degradation of Low Density Lipoproteins by Cultured Human Fibroblasts

Goldstein, J. L., & Brown, M. S. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42341-7 · Cited by 1,485 · see citing works

Receptor-Mediated Control of Cholesterol Metabolism

Brown, M. S., & Goldstein, J. L. (1976) · Science · doi:10.1126/science.174194 · Cited by 960 · see citing works

Role of the coated endocytic vesicle in the uptake of receptor-bound low density lipoprotein in human fibroblasts

Anderson, R. G. W., Brown, M. S., & Goldstein, J. L. (1977) · Cell · doi:10.1016/0092-8674(77)90022-8 · Cited by 698 · see citing works

Release of low density lipoprotein from its cell surface receptor by sulfated glycosaminoglycans

Goldstein, J. L., Basu, S. K., Brunschede, G. Y., & Brown, M. S. (1976) · Cell · doi:10.1016/0092-8674(76)90258-0 · Cited by 613 · see citing works

Familial hypercholesterolemia: Defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase activity

Brown, M. S., & Goldstein, J. L. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.3.788 · Cited by 598 · see citing works

Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Activity in Cultured Human Fibroblasts

Brown, M. S., Dana, S. E., & Goldstein, J. L. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42998-0 · Cited by 545 · see citing works

Disturbances in Lipid and Lipoprotein Metabolism

Bouchier, I. A. D. (1978) · Gut · doi:10.1136/gut.19.11.1088 · Cited by 495 · see citing works

Regulation of the activity of the low density lipoprotein receptor in human fibroblasts

Brown, M. S., & Goldstein, J. L. (1975) · Cell · doi:10.1016/0092-8674(75)90182-8 · Cited by 484 · see citing works

Lipoprotein structure and metabolism.

Jackson, R. L., Morrisett, J. D., & Gotto, A. M. (1976) · Physiological Reviews · doi:10.1152/physrev.1976.56.2.259 · Cited by 435 · see citing works

Role of lysosomal acid lipase in the metabolism of plasma low density lipoprotein. Observations in cultured fibroblasts from a patient with cholesteryl ester storage disease.

Goldstein, J. L., Dana, S. E., Faust, J., Beaudet, A. L., & Brown, M. (1975) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)40786-2 · Cited by 391 · see citing works

Inhibition of lipoprotein binding to cell surface receptors of fibroblasts following selective modification of arginyl residues in arginine-rich and B apoproteins.

Mahley, R. W., Innerarity, T. L., Pitas, R. E., Weisgraber, K. H., Brown, J. H., & Gross, E. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)66966-8 · Cited by 383 · see citing works

Cholesterol ester formation in cultured human fibroblasts. Stimulation by oxygenated sterols.

Brown, M., Dana, S., & Goldstein, J. (1975) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)41498-1 · Cited by 364 · see citing works

Regulation of Cholesterol Metabolism

Dietschy, J. M., & Wilson, J. D. (1970) · New England Journal of Medicine · doi:10.1056/nejm197005142822005 · Cited by 362 · see citing works

Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Activity in Human Fibroblasts by Lipoproteins

Brown, M. S., Dana, S. E., & Goldstein, J. L. (1973) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.70.7.2162 · Cited by 344 · see citing works

Localization of low density lipoprotein receptors on plasma membrane of normal human fibroblasts and their absence in cells from a familial hypercholesterolemia homozygote.

Anderson, R. G. W., Goldstein, J. L., & Brown, M. S. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.7.2434 · Cited by 324 · see citing works

Role of the low density lipoprotein receptor in regulating the content of free and esterified cholesterol in human fibroblasts.

Brown, M. S., Faust, J. R., & Goldstein, J. L. (1975) · Journal of Clinical Investigation · doi:10.1172/jci107989 · Cited by 321 · see citing works

Inhibition of proteolytic degradation of low density lipoprotein in human fibroblasts by chloroquine, concanavalin A, and Triton WR 1339.

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Esterification of Low Density Lipoprotein Cholesterol in Human Fibroblasts and Its Absence in Homozygous Familial Hypercholesterolemia

Goldstein, J. L., Dana, S. E., & Brown, M. S. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.11.4288 · Cited by 291 · see citing works

HORMONE-PRODUCING CULTURES OF ADRENAL AND PITUITARY TUMOR ORIGIN

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Clonal analysis of differentiated function in animal cell cultures. I. Possible correlated maintenance of differentiated function and the diploid karyotype.

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Regulation of low density lipoprotein receptor activity in freshly isolated human lymphocytes.

Ho, Y. K., Brown, S., Bilheimer, D. W., & Goldstein, J. L. (1976) · Journal of Clinical Investigation · doi:10.1172/jci108603 · Cited by 258 · see citing works

Receptor-mediated uptake of low density lipoprotein and utilization of its cholesterol for steroid synthesis in cultured mouse adrenal cells.

Faust, J. R., Goldstein, J. L., & Brown, M. S. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40133-5 · Cited by 241 · see citing works

Characterization of the low density lipoprotein receptor in membranes prepared from human fibroblasts.

Basu, S., Goldstein, J. L., & Brown, M. S. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34768-3 · Cited by 210 · see citing works

Receptor-dependent hydrolysis of cholesteryl esters contained in plasma low density lipoprotein.

Brown, M. S., Dana, S. E., & Goldstein, J. L. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.8.2925 · Cited by 209 · see citing works

Lipoprotein-mediated regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesteryl ester metabolism in the adrenal gland of the rat.

Balasubramaniam, S., Goldstein, J. L., Faust, J. R., Brunschede, G. Y., & Brown, M. S. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40617-x · Cited by 205 · see citing works

Control of Bovine Adrenal Cortical Cell Proliferation by Fibroblast Growth Factor. Lack of Effect of Epidermal Growth Factor

Gospodarowicz, D., Ill, C. R., Hornsby, P. J., & Gill, G. N. (1977) · Endocrinology · doi:10.1210/endo-100-4-1080 · Cited by 201 · see citing works

Replacement of endogenous cholesteryl esters of low density lipoprotein with exogenous cholesteryl linoleate. Reconstitution of a biologically active lipoprotein particle.

Krieger, M., Brown, M. S., Faust, J. R., & Goldstein, J. L. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34687-2 · Cited by 193 · see citing works

Regulation of sterol synthesis in 15 tissues of rat. II. Role of rat and human high and low density plasma lipoproteins and of rat chylomicron remnants.

Andersen, J. M., & Dietschy, J. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40302-4 · Cited by 192 · see citing works

The Origin of Cholesterol in Liver, Small Intestine, Adrenal Gland, and Testis of the Rat: Dietary versus Endogenous Contributions

Morris, M. D., & Chaikoff, I. L. (1959) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98137-8 · Cited by 183 · see citing works

The LDL Pathway in Human Fibroblasts: A Receptor-Mediated Mechanism for the Regulation of Cholesterol Metabolism

Goldstein, J. L., & Brown, M. S. (1976) · Current topics in cellular regulation · doi:10.1016/b978-0-12-152811-9.50011-0 · Cited by 182 · see citing works

Low Density Lipoprotein Receptors in Bovine Adrenal Cortex. II. Low Density Lipoprotein Binding to Membranes Prepared from Fresh Tissue*

Kovanen, P. T., Basu, S. K., Goldstein, J. L., & Brown, M. S. (1979) · Endocrinology · doi:10.1210/endo-104-3-610 · Cited by 171 · see citing works

Low Density Lipoprotein Receptors in Bovine Adrenal Cortex. I. Receptor-Mediated Uptake of Low Density Lipoprotein and Utilization of Its Cholesterol for Steroid Synthesis in Cultured Adrenocortical Cells*

Kovanen, P. T., Faust, J. R., Brown, M. S., & Goldstein, J. L. (1979) · Endocrinology · doi:10.1210/endo-104-3-599 · Cited by 163 · see citing works

THE BIOLOGICAL CONVERSION OF CHOLESTEROL TO PREGNANEDIOL

Bloch, K. (1945) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)51101-7 · Cited by 153 · see citing works

Interaction of swine lipoproteins with the low density lipoprotein receptor in human fibroblasts

Bersot, T. P., Mahley, R. W., Brown, M. S., & Goldstein, J. L. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33600-1 · Cited by 150 · see citing works

Adrenal cholesterol uptake from plasma lipoproteins: regulation by corticotropin.

Gwynne, J. T., MAHAFFEE, D. D., Brewer, H. B., & Ney, R. L. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.12.4329 · Cited by 144 · see citing works

Regulation of cholesterol synthesis by low density lipoprotein in isolated human lymphocytes

Ho, Y. K., Faust, J. R., Bilheimer, D. W., Brown, M., & Goldstein, J. L. (1977) · The Journal of Experimental Medicine · doi:10.1084/jem.145.6.1531 · Cited by 143 · see citing works

Genetics of the low density lipoprotein receptor. Diminished receptor activity in lymphocytes from heterozygotes with familial hypercholesterolemia.

Bilheimer, D. W., Ho, Y. K., Brown, M. S., Anderson, R. G. W., & Goldstein, J. L. (1978) · Journal of Clinical Investigation · doi:10.1172/jci108980 · Cited by 142 · see citing works

Hormonal Control of Adrenocortical Cell Proliferation

Hornsby, P. J., & Gill, G. N. (1977) · Journal of Clinical Investigation · doi:10.1172/jci108782 · Cited by 128 · see citing works

Binding, internalization, and hydrolysis of low density lipoprotein in long-term lymphoid cell lines from a normal subject and a patient with homozygous familial hypercholesterolemia.

Ho, Y. K., Brown, M. S., Kayden, H. J., & Goldstein, J. L. (1976) · The Journal of Experimental Medicine · doi:10.1084/jem.144.2.444 · Cited by 112 · see citing works

Regulation of cholesterol synthesis in rat adrenal gland through coordinate control of 3-hydroxy-3-methylglutaryl coenzyme A synthase and reductase activities.

Balasubramaniam, S., Goldstein, J. L., & Brown, M. S. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.4.1421 · Cited by 96 · see citing works

Characterization of Adult Bovine Adrenocortical Cells Throughout Their Life Span in Tissue Culture*

Hornsby, P. J., & GILI, G. N. (1978) · Endocrinology · doi:10.1210/endo-102-3-926 · Cited by 81 · see citing works

Stimulation of Adrenal Cholesterol Uptake from Plasma by Adrenocorticotrophin

DEXTER, R. N., Fishman, L. M., & Ney, R. L. (1970) · Endocrinology · doi:10.1210/endo-87-5-836 · Cited by 78 · see citing works

ACTH and the Metabolism of Adrenal Cell Cultures

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Evidence for regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol synthesis in nonhepatic tissues of rat.

Balasubramaniam, S., Goldstein, J. L., Faust, J. R., & Brown, M. S. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.8.2564 · Cited by 76 · see citing works

Studies on fatty liver induction by 4-aminopyrazolopyrimidine

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Regulation of sterol synthesis in adrenal gland of the rat by both high and low density human plasma lipoproteins

Andersen, J. M., & Dietschy, J. M. (1976) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(76)80214-8 · Cited by 56 · see citing works

High levels of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol synthesis in the ovary of the pregnant rabbit.

Kovanen, P. T., Goldstein, J. L., & Brown, M. S. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34666-5 · Cited by 53 · see citing works

The effect of hypoxia on uptake and degradation of low density lipoproteins by cultured human arterial smooth muscle cells

Albers, J. J., & Bierman, E. L. (1976) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(76)90031-x · Cited by 53 · see citing works

Solubilization of apolipoprotein B and its specific binding by the cellular receptor for low density lipoprotein

Shireman, R. B., Kilgore, L. L., & Fisher, W. R. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.11.5150 · Cited by 51 · see citing works

Metabolism of adrenal cholesterol in man

Borkowski, A. J., Delcroix, C., & Levin, S. (1972) · Journal of Clinical Investigation · doi:10.1172/jci106968 · Cited by 43 · see citing works

The cyanogen bromide peptides of the apoprotein of low density lipoprotein (apoB): Its molecular weight from a chemical view

Bradley, W. A., Rohde, M. F., Gotto, A. M., & Jackson, R. L. (1978) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(78)91440-7 · Cited by 39 · see citing works

Familial hypercholesterolemia: model for genetic receptor disease.

Brown, M. S., & Goldstein, J. L. (1979) · PubMed · Cited by 35 · see citing works

Interactions of native and modified human low density lipoproteins with human skin fibroblasts

Steinberg, D. H., Nestel, P. J., Weinstein, D. B., Remaut-Desmeth, M., & Chang, C. M. (1978) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(78)90194-7 · Cited by 32 · see citing works

Studies of the cyanogen bromide fragments of the apoprotein of human serum low density lipoproteins

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Metabolism of adrenal cholesterol in man

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Equilibration of plasma and adrenal cholesterol in man.

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Mutations affecting the binding, internalization, and lysosomal hydrolysis of low density lipoprotein in cultured human fibroblasts, lymphocytes, and aortic smooth muscle cells

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A Receptor-Mediated Pathway for Cholesterol Homeostasis

Brown, M. S., & Goldstein, J. L. (1986) · Science · doi:10.1126/science.3513311 · Cited by 5,703 · see citing works

The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders

Miller, W. L., & Auchus, R. J. (2011) · Endocrine Reviews · doi:10.1210/er.2010-0013 · Cited by 2,458 · see citing works

Molecular biology of steroid hormone synthesis

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Regulation of Plasma Cholesterol by Lipoprotein Receptors

Brown, M. S., Kovanen, P. T., & Goldstein, J. L. (1981) · Science · doi:10.1126/science.6261329 · Cited by 947 · see citing works

A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism

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β-arrestin-mediated receptor trafficking and signal transduction

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The role of lipoproteins in steroidogenesis and cholesterol metabolism in steroidogenic glands

GWYNNE, J. T., & STRAUSS, J. F. (1982) · Endocrine Reviews · doi:10.1210/edrv-3-3-299 · Cited by 586 · see citing works

Characterization of Several Clonal Lines of Cultured Ley dig Tumor Cells: Gonadotropin Receptors and Steroidogenic Responses*

Ascoli, M. (1981) · Endocrinology · doi:10.1210/endo-108-1-88 · Cited by 582 · see citing works

Early steps in steroidogenesis: intracellular cholesterol trafficking

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Role of acyl-CoA: cholesterol acyltransferase in cellular cholesterol metabolism.

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Charting the Fate of the “Good Cholesterol”: Identification and Characterization of the High-Density Lipoprotein Receptor SR-BI

Krieger, M. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.523 · Cited by 517 · see citing works

Defective Lipoprotein Receptors and Atherosclerosis

Epstein, F. H., Goldstein, J. L., Kita, T., & Brown, M. S. (1983) · New England Journal of Medicine · doi:10.1056/nejm198308043090507 · Cited by 468 · see citing works

The Regulation of the Mammalian Corpus Luteum

ROTHCHILD, I. (1981) · Elsevier eBooks · doi:10.1016/b978-0-12-571137-1.50009-8 · Cited by 422 · see citing works

Lipoprotein binding to canine hepatic membranes. Metabolically distinct apo-E and apo-B,E receptors.

Hui, D. Y., Innerarity, T. L., & Mahley, R. W. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)69254-9 · Cited by 383 · see citing works

Progress in understanding the LDL receptor and HMG-CoA reductase, two membrane proteins that regulate the plasma cholesterol

Goldstein, J. L., & Brown, M. S. (1984) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34418-7 · Cited by 383 · see citing works

Purification of the low density lipoprotein receptor, an acidic glycoprotein of 164,000 molecular weight.

Schneider, W. J., Beisiegel†, U., Goldstein, J. L., & Brown, M. S. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34975-5 · Cited by 376 · see citing works

Two independent lipoprotein receptors on hepatic membranes of dog, swine, and man. Apo-B,E and apo-E receptors.

Mahley, R. W., Hui, D. Y., Innerarity, T. L., & Weisgraber, K. H. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110365 · Cited by 375 · see citing works

Neurosteroids: Biosynthesis of Pregnenolone and Progesterone in Primary Cultures of Rat Glial Cells*

Jung‐Testas, I., Hu, Z. Y., BAULIEUf, E. E., & ROBEL, A. P. (1989) · Endocrinology · doi:10.1210/endo-125-4-2083 · Cited by 366 · see citing works

Steroidogenesis in the Fetal Testis and Its Susceptibility to Disruption by Exogenous Compounds

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Regulation of intramitochondrial cholesterol transfer to side-chain cleavage cytochrome P-450 in rat adrenal gland.

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Deletion in Cysteine-Rich Region of LDL Receptor Impedes Transport to Cell Surface in WHHL Rabbit

Yamamoto, T., Bishop, R. W., Brown, M. S., Goldstein, J. L., & Russell, D. W. (1986) · Science · doi:10.1126/science.3010466 · Cited by 334 · see citing works

1 Adrenal and gonadal androgen secretion in normal females

Longcope, C. (1986) · Clinics in Endocrinology and Metabolism · doi:10.1016/s0300-595x(86)80021-4 · Cited by 332 · see citing works

Neurosteroids: oligodendrocyte mitochondria convert cholesterol to pregnenolone.

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Control of adrenal androgen secretion.

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Structure and Localization of the Human Gene Encoding SR-BI/CLA-1

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THE LDL RECEPTOR LOCUS AND THE GENETICS OF FAMILIAL HYPERCHOLESTEROLEMIA

Goldstein, J. L., & Brown, M. S. (1979) · Annual Review of Genetics · doi:10.1146/annurev.ge.13.120179.001355 · Cited by 233 · see citing works

Cholesterol biosynthesis and metabolism

Russell, D. W. (1992) · Cardiovascular Drugs and Therapy · doi:10.1007/bf00054556 · Cited by 201 · see citing works

The LDL Receptor Defect in Familial Hypercholesterolemia: Implications for Pathogenesis and Therapy

Goldstein, J. L., & Brown, M. S. (1982) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)31424-9 · Cited by 193 · see citing works

Scavenger receptor class BI and selective cholesteryl ester uptake: partners in the regulation of steroidogenesis

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Apolipoprotein A-I is required for cholesteryl ester accumulation in steroidogenic cells and for normal adrenal steroid production.

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Disruption of cholesterol homeostasis by plant sterols

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cDNA cloning of the bovine low density lipoprotein receptor: feedback regulation of a receptor mRNA.

Russell, D. W., Yamamoto, T., Schneider, W. J., Slaughter, C. A., Brown, M. S., & Goldstein, J. L. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.24.7501 · Cited by 164 · see citing works

Clinical and Molecular Genetics of Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency

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Acute stimulation of steroidogenesis in corpus luteum and adrenal cortex by peptide hormones. Rapid induction of a similar protein in both tissues.

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Biosynthesis of the epidermal growth factor receptor in A431 cells.

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Lipoprotein Utilization and Cholesterol Synthesis by the Human Fetal Adrenal Gland*

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Development of the HPA axis: Where and when do sex differences manifest?

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The metabolism in vitro of human low-density lipoprotein by the human hepatoma cell line Hep G2

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Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine

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Cholesterol Metabolism by Ovarian Tissue

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Rat adrenal uptake and metabolism of high density lipoprotein cholesteryl ester

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Effects of high-dose simvastatin on adrenal and gonadal steroidogenesis in men with hypercholesterolemia

Dobs, A. S., Schrott, H. G., Davidson, M. H., Bays, H. E., Stein, E. A., Kush, D., Wu, M., Mitchel, Y., & Illingworth, R. (2000) · Metabolism · doi:10.1053/meta.2000.7716a · Cited by 116 · see citing works

Regulation of low density lipoprotein receptors by adrenocorticotropin in the adrenal gland of mice and rats in vivo.

Kovanen, P. T., Goldstein, J. L., Chappell, D. A., & Brown, M. S. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70671-1 · Cited by 115 · see citing works

Mitochondrial specificity of the early steps in steroidogenesis

Miller, W. L. (1995) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(95)00212-x · Cited by 111 · see citing works

Cholesterol uptake in adrenal and gonadal tissues: the SR-BI and “selective” pathway connection

Azhar, S. (2003) · Frontiers in bioscience · doi:10.2741/1165 · Cited by 109 · see citing works

Plasma Dehydroepiandrosterone Sulfate in Nursing Home Men

Rudman, D. R., Shetty, K. R., & Mattson, D. E. (1990) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1990.tb03540.x · Cited by 100 · see citing works

High-affinity uptake and degradation of ApoE-free high-density lipoprotein and low-density lipoprotein in cultured porcine hepatocytes

Bachorik, P. S., Franklin, F. A., Virgil, D. G., & Kwiterovich, P. O. (1982) · Biochemistry · doi:10.1021/bi00265a044 · Cited by 101 · see citing works

Cholesterol synthesis in vivo and in vitro in the WHHL rabbit, an animal with defective low density lipoprotein receptors

Dietschy, J. M., Kita, T., Suckling, K. E., Goldstein, J. L., & Brown, M. S. (1983) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37988-8 · Cited by 95 · see citing works

Receptor-mediated catabolism of homologous low density lipoproteins in cultured pig hepatocytes.

Pangburn, S., Newton, R. S., Chang, C. M., Weinstein, D. B., & Steinberg, D. H. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)69612-2 · Cited by 95 · see citing works

Impact of ACTH Signaling on Transcriptional Regulation of Steroidogenic Genes

Ruggiero, C., & Lalli, E. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00024 · Cited by 95 · see citing works

Heparin-releasable lipase activity of rat adrenals, ovaries and testes

Jansen, H., & GREEF, W. J. D. (1981) · Biochemical Journal · doi:10.1042/bj1960739 · Cited by 88 · see citing works

Adrenal Function in Heterozygous and Homozygous Hypobetalipoproteinemia*

Illingworth, D. R., Kenny, T., & ORWOLL, E. S. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-54-1-27 · Cited by 85 · see citing works

Plasma triglycerides determine low density lipoprotein composition, physical properties, and cell-specific binding in cultured cells.

McKeone, B. J., Patsch, J. R., & Pownall, H. J. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116411 · Cited by 84 · see citing works

The Effect of Mevinolin on Steroidogenesis in Patients with Defects in the Low Density Lipoprotein Receptor Pathway

Laue, L., Hoeg, J. M., Barnes, K. M., Loriaux, D. L., & Chrousos, G. P. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-64-3-531 · Cited by 81 · see citing works

EVOLUTION OF THE LDL RECEPTOR CONCEPT–FROM CULTURED CELLS TO INTACT ANIMALS *

Brown, M. S., Kovanen, P. T., & Goldstein, J. L. (1980) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1980.tb21290.x · Cited by 78 · see citing works

Cholesterol Synthesis in Human Fetal Tissues*

Carr, B. R., & Simpson, E. R. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-55-3-447 · Cited by 78 · see citing works

Inhibition of hormone-stimulated steroidogenesis in cultured Leydig tumor cells by a cholesterol-linked phosphorothioate oligodeoxynucleotide antisense to diazepam-binding inhibitor.

Boujrad, N., Hudson, J. R., & Papadopoulos, V. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.12.5728 · Cited by 77 · see citing works

The ldl receptor and the regulation of cellular cholesterol metabolism

Goldstein, J. L., & Brown, M. S. (1985) · Journal of Cell Science · doi:10.1242/jcs.1985.supplement_3.13 · Cited by 77 · see citing works

Lipoprotein Lipase: Its physiological and clinical significance

Hamosh, M., & Hamosh, P. (1983) · Molecular Aspects of Medicine · doi:10.1016/0098-2997(83)90006-7 · Cited by 74 · see citing works

Inverse Relation Between Low-Density Lipoprotein-Cholesterol and Dehydroisoandrosterone Sulfate in Human Fetal Plasma

Parker, C. R., Simpson, E. R., Bilheimer, D. W., Leveno, K. J., Carr, B. R., & MacDonald, P. C. (1980) · Science · doi:10.1126/science.6445079 · Cited by 75 · see citing works

Steroidogenesis—Adrenal Cell Signal Transduction

Gallo‐Payet, N., & Battista, M. (2014) · Comprehensive physiology · doi:10.1002/cphy.c130050 · Cited by 84 · see citing works

Steroid synthesis in rat brain cell cultures

Jung‐Testas, I., Hu, Z. Y., Baulieu, É.-É., & Röbel, P. (1989) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(89)90136-2 · Cited by 73 · see citing works

High density lipoprotein utilization by dispersed rat luteal cells

Schuler, L. A., Langenberg, K. K., Gwynne, J. T., & Strauss, J. F. (1981) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(81)90135-1 · Cited by 72 · see citing works

Immunologic cross-reactivity of the low density lipoprotein receptor from bovine adrenal cortex, human fibroblasts, canine liver and adrenal gland, and rat liver.

Beisiegel†, U., Kita, T., Anderson, R. G. W., Schneider, W. J., Brown, M. S., & Goldstein, J. L. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)69566-9 · Cited by 68 · see citing works

Hedgehog Signaling and Steroidogenesis

Finco, I., LaPensee, C. R., Krill, K. T., & Hammer, G. D. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-061214-111754 · Cited by 67 · see citing works

Attachment of steroidogenic lipid droplets to intermediate filaments in adrenal cells

Almahbobi, G., Williams, L. J., & Hall, P. F. (1992) · Journal of Cell Science · doi:10.1242/jcs.101.2.383 · Cited by 67 · see citing works

A Receptor‐Mediated Pathway for Cholesterol Homeostasis (Nobel Lecture)

Brown, M. S., & Goldstein, J. L. (1986) · Angewandte Chemie International Edition in English · doi:10.1002/anie.198605833 · Cited by 65 · see citing works

Effect of prostaglandin E1 and ACTH on proliferation and steroidogenic activity of bovine adreno-cortical cells in primary culture

Alain Duperray, B., & CHAMBAZ, E. M. (1980) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(80)90098-9 · Cited by 62 · see citing works

Dynamics of the fetal adrenal, cholesterol, and apolipoprotein B responses to antenatal betamethasone therapy

Parker, C. R., Atkinson, M., Owen, J., & Andrews, W. W. (1996) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(96)70428-3 · Cited by 58 · see citing works

Metabolism of High Density Lipoprotein by Human Fetal Adrenal Tissue*

Carr, B. R., Parker, C. R., MacDonald, P. C., & Simpson, E. R. (1980) · Endocrinology · doi:10.1210/endo-107-6-1849 · Cited by 58 · see citing works

Phosphorylation of serine 833 in cytoplasmic domain of low density lipoprotein receptor by a high molecular weight enzyme resembling casein kinase II.

Kishimoto, A., Brown, M. S., Slaughter, C. A., & Goldstein, J. L. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)75792-5 · Cited by 57 · see citing works

Difference in saturable binding of low density lipoprotein to liver membranes from normocholesterolemic subjects and patients with heterozygous familial hypercholesterolemia.

Harders-Spengel, K., Wood, C., Thompson, G. R., Myant, N. B., & Soutar, A. K. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.20.6355 · Cited by 56 · see citing works

Morphogenesis of a Zone-Specific Adrenocortical Cytotoxicity in Guinea Pigs Administered PD 132301-2, an Inhibitor of Acyl-CoA: Cholesterol Acyltransferase

Dominick, M. A., Bobrowski, W. A., MacDonald, J. R., & Gough, A. W. (1993) · Toxicologic Pathology · doi:10.1177/019262339302100107 · Cited by 54 · see citing works

Effects of pravastatin and cholestyramine on gonadal and adrenal steroid production in familial hypercholesterolaemia.

Jay, R., Sturley, R., Stirling, C., McGARRIGLE, H. H. G., Katz, M., Reckless, J. P. D., & Betteridge, D. J. (1991) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1991.tb03924.x · Cited by 53 · see citing works

Adrenal cortical function in homozygous familial hypercholesterolemia

Illingworth, D. R., Lees, A. M., & Lees, R. S. (1983) · Metabolism · doi:10.1016/0026-0495(83)90075-6 · Cited by 53 · see citing works

Generation of Regulatory Oxysterols: 26-Hydroxylation of Cholesterol by Ovarian Mitochondria*

Rennert, H., Fischer, R. T., Álvarez, J. G., Trzăskos, J. M., & Strauss, J. F. (1990) · Endocrinology · doi:10.1210/endo-127-2-738 · Cited by 52 · see citing works

Sustained therapy with 3-hydroxy-3-methylglutaryl-coenzyme-A reductase inhibitors does not impair steroidogenesis by adrenals and gonads

Travia, D., Tosi, F., Negri, C., Faccini, G., Moghetti, P., & Muggeo, M. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.3.7883839 · Cited by 52 · see citing works

Regulation of Ovarian Cholesterol Metabolism: Control of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase and Acyl Coenzyme A:Cholesterol Acyltransferase*

Schuler, L. A., Toaff, M. E., & Strauss, J. F. (1981) · Endocrinology · doi:10.1210/endo-108-4-1476 · Cited by 51 · see citing works

The Adrenal Cortex and its Disorders

Miller, W. L. (2009) · Wiley eBooks · doi:10.1002/9781444316728.ch13 · Cited by 51 · see citing works

Testicular Function in Type II Hyperlipoproteinemic Patients Treated with Lovastatin (Mevinolin) or Neomycin

Farnsworth, W., Hoeg, J. M., Maher, M. B., Brittain, E., Sherins, R. J., & Brewer, H. B. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-65-3-546 · Cited by 50 · see citing works

Endocrine Changes during Pregnancy in a Patient with Homozygous Familial Hypobetalipoproteinemia

Parker, C., Illingworth, D. R., Bissonnette, J. M., & Carr, B. R. (1986) · New England Journal of Medicine · doi:10.1056/nejm198602273140906 · Cited by 50 · see citing works

Association of the G Proteinαq/α11-Subunit with Cytoskeleton in Adrenal Glomerulosa Cells: Role in Receptor-Effector Coupling1

Côté, M., PAYET, M. D., Dufour, M.-N., Guillon, G., & Gallo‐Payet, N. (1997) · Endocrinology · doi:10.1210/endo.138.8.5319 · Cited by 50 · see citing works

The clinical and biochemical spectrum of congenital adrenal hyperplasia secondary to 21-hydroxylase deficiency.

Huynh, T., McGown, I. N., Cowley, D. M., Nyunt, O., Leong, G. M., Harris, M. A., & Cotterill, A. M. (2009) · PubMed Central · Cited by 47 · see citing works

Hormone changes during the menstrual cycle in abetalipoproteinemia: reduced luteal phase progesterone in a patient with homozygous hypobetalipoproteinemia.

Illingworth, D. R., Corbin, D., Kemp, E., & Keenan, E. J. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.21.6685 · Cited by 47 · see citing works

Characteristics of the binding of human and bovine high-density lipoproteins by bloodstream forms of the African trypanosome, Trypanosoma brucei brucei

Gillett, M. P. T., & Owen, J. S. (1992) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(92)90002-d · Cited by 47 · see citing works

Studies of the immunohistochemical and biochemical localization of the cytochrome P-450scc-linked monooxygenase system in the adult rat brain

Iwahashi, K., Ozaki Hiroki, S., Tsubaki, M., Ohnishi, J.-I., Takeuchi, Y., & Ichikawa, Y. (1990) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(90)90114-c · Cited by 45 · see citing works

Functional Roles of Plasma High Density Lipoprotein

Scanu, A. M., Byrne, R. E., & Mihovilovic, M. (1982) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238209108711 · Cited by 44 · see citing works

Atherosclerosis: An intracellular deficiency in essential fatty acids

Cornwell, D. G., & Panganamala, R. V. (1981) · Progress in Lipid Research · doi:10.1016/0163-7827(81)90069-2 · Cited by 43 · see citing works

Hypercholesterolemia due to Elevated Low Density Lipoprotein-Cholesterol in Newborns with Anencephaly and Adrenal Atrophy*

Parker, C. R., Carr, B. R., Winkel, C. A., Casey, M. L., Simpson, E. R., & MacDonald, P. C. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-57-1-37 · Cited by 43 · see citing works

Uptake of low density lipoproteins by rat tissues. Special emphasis on the luteinized ovary.

REAVEN, E. P., Chen, Y. I., Spicher, M., Hwang, S. F., Mondon, C. E., & Azhar, S. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112526 · Cited by 43 · see citing works

TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) causes reduction in the low density lipoprotein (LDL) receptor activities in the hepatic plasma membrane of the guinea pig and rat

Bombick, D. W., Matsumura, F., & Madhukar, B. V. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(84)91337-8 · Cited by 42 · see citing works

The differentiation of Leydig cells, steroidogenesis, and the spermatogenetic wave in the testis of Necturus maculosus

Pudney, J. A., Canick, J. A., Mak, P., & Callard, G. V. (1983) · General and Comparative Endocrinology · doi:10.1016/0016-6480(83)90241-1 · Cited by 42 · see citing works

Late onset congenital adrenal hyperplasia: a gynecologist’s perspective

Brodie, B. L., & Wentz, A. C. (1987) · Fertility and Sterility · doi:10.1016/s0015-0282(16)59339-x · Cited by 42 · see citing works

Regulation of human fetal testicular secretion of testosterone: Low-density lipoprotein-cholesterol and cholesterol synthesized de novo as steroid precursor

Carr, B. R., Parker, C. R., Ōhashi, M., MacDonald, P. C., & Simpson, E. R. (1983) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(83)90743-3 · Cited by 41 · see citing works

Metabolism of High Density Lipoproteins Reconstituted with [3H]Cholesteryl Ester and [14C]Cholesterol in the Rat, with Special Reference to the Ovary*

Nestler, J. E., Bamberger, M. J., Rothblat, G. H., & Strauss, J. F. (1985) · Endocrinology · doi:10.1210/endo-117-2-502 · Cited by 41 · see citing works

Control of Sterol Metabolism in Cultured Rat Granulosa Cells*

Rosenblum, M. F., HUTTLER, C. R., & Strauss, J. F. (1981) · Endocrinology · doi:10.1210/endo-109-5-1518 · Cited by 41 · see citing works

Studies on Lipoprotein and Adrenal Steroidogenesis: I. Roles of Low Density Lipoprotein- and High Density Lipoprotein- Cholesterol in Steroid Production in Cultured Human Adrenocortical Cells.

HIGASHIJIMA, M., Nawata, H., KATO, K.-I., & Ibayashi, H. (1987) · Endocrinologia Japonica · doi:10.1507/endocrj1954.34.635 · Cited by 40 · see citing works

Regulation of insect prothoracic glands: Existence of a haemolymph stimulatory factor in Manduca sexta

Watson, R. D., Ciancio, M. J., Gunnar, W., Gilbert, L. I., & Bollenbacher, W. E. (1985) · Journal of Insect Physiology · doi:10.1016/0022-1910(85)90097-6 · Cited by 40 · see citing works

The Control of Steroidogenesis by Human Fetal Adrenal Cells in Tissue Culture. I. Responses to Adrenocorticotropin*

Fujieda, K., Faiman, C., Reyes, F. I., & Winter, J. S. D. (1981) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-53-1-34 · Cited by 40 · see citing works

De Novo Synthesis of Cholesterol by the Human Fetal Adrenal Gland*

Carr, B. R., & Simpson, E. R. (1981) · Endocrinology · doi:10.1210/endo-108-6-2154 · Cited by 40 · see citing works

Receptor-mediated uptake of low density lipoprotein and utilization of its cholesterol for steroid synthesis in cultured mouse adrenal cells.

Faust, J. R., Goldstein, J. L., & Brown, M. S. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40133-5 · Cited by 241 · see citing works

Low Density Lipoprotein Receptors in Bovine Adrenal Cortex. I. Receptor-Mediated Uptake of Low Density Lipoprotein and Utilization of Its Cholesterol for Steroid Synthesis in Cultured Adrenocortical Cells*

Kovanen, P. T., Faust, J. R., Brown, M. S., & Goldstein, J. L. (1979) · Endocrinology · doi:10.1210/endo-104-3-599 · Cited by 163 · see citing works

Regulation of lipid droplets and cholesterol metabolism in adrenal cortical cells

Dalen, K. T., & Li, Y. (2023) · Vitamins and hormones · doi:10.1016/bs.vh.2023.06.007 · Cited by 4 · see citing works

Studies on Lipoprotein and Adrenal Steroidogenesis: I. Roles of Low Density Lipoprotein- and High Density Lipoprotein- Cholesterol in Steroid Production in Cultured Human Adrenocortical Cells.

HIGASHIJIMA, M., Nawata, H., KATO, K.-I., & Ibayashi, H. (1987) · Endocrinologia Japonica · doi:10.1507/endocrj1954.34.635 · Cited by 40 · see citing works

Role of exogenous cholesterol in regulation of adrenal steroidogenesis in the rat.

Verschoor-Klootwyk, A. H., Verschoor, L., Azhar, S., & Reaven, G. M. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34432-6 · Cited by 59 · see citing works