Regulation of transcription factor activity by interconnected post-translational modifications

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

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Transcriptional regulation by calcium, calcineurin, and NFAT

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Concepts in sumoylation: a decade on

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PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse

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Estrogen Receptor-α Directs Ordered, Cyclical, and Combinatorial Recruitment of Cofactors on a Natural Target Promoter

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Mammalian SIRT1 Represses Forkhead Transcription Factors

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Cross Talk Between O-GlcNAcylation and Phosphorylation: Roles in Signaling, Transcription, and Chronic Disease

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Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

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TRANSCRIPTIONAL CONTROL OF MUSCLE DEVELOPMENT BY MYOCYTE ENHANCER FACTOR-2 (MEF2) PROTEINS

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RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

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Cyclic, proteasome-mediated turnover of unliganded and liganded ERalpha on responsive promoters is an integral feature of estrogen signaling.

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Arsenic Trioxide Controls the Fate of the PML-RARα Oncoprotein by Directly Binding PML

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Ubiquitin-Binding Proteins: Decoders of Ubiquitin-Mediated Cellular Functions

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Arsenic degrades PML or PML–RARα through a SUMO-triggered RNF4/ubiquitin-mediated pathway

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A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

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The CREB Coactivator TORC2 Functions as a Calcium- and cAMP-Sensitive Coincidence Detector

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SUMO‐1 modification activates the transcriptional response of p53

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Small-Molecule Inhibitors of the MDM2-p53 Protein-Protein Interaction to Reactivate p53 Function: A Novel Approach for Cancer Therapy

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Integrated proteomic analysis of post-translational modifications by serial enrichment

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Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1

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Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation

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Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation

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Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation

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Concerted Dephosphorylation of the Transcription Factor NFAT1 Induces a Conformational Switch that Regulates Transcriptional Activity

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FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP

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Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation

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Insulin Stimulates Phosphorylation of the Forkhead Transcription Factor FKHR on Serine 253 through a Wortmannin-sensitive Pathway

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A Calcium-Regulated MEF2 Sumoylation Switch Controls Postsynaptic Differentiation

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Global Identification and Characterization of Both O-GlcNAcylation and Phosphorylation at the Murine Synapse

Trinidad, J. C., Barkan, D. T., Gulledge, B. F., Thalhammer, A., Šali, A., Schoepfer, R., & Burlingame, A. L. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.o112.018366 · Cited by 426 · see citing works

Systematic Functional Prioritization of Protein Posttranslational Modifications

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linking metabolism to epigenetics through O-GlcNAcylation

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Emerging Roles of Ubiquitin in Transcription Regulation

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ABL Tyrosine Kinases: Evolution of Function, Regulation, and Specificity

Colicelli, J. (2010) · Science Signaling · doi:10.1126/scisignal.3139re6 · Cited by 365 · see citing works

Regulation of transcription factor function by phosphorylation

Whitmarsh, A. J., & Davis, R. J. (2000) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000757 · Cited by 345 · see citing works

Multisite phosphorylation provides sophisticated regulation of transcription factors

Holmberg, C. I., Tran, S. E. F., Eriksson, J., & Sistonen, L. (2002) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(02)02207-7 · Cited by 323 · see citing works

Ubiquitin and Proteasomes in Transcription

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Phosphorylation of Serine 256 Suppresses Transactivation by FKHR (FOXO1) by Multiple Mechanisms

Zhang, X., Gan, L., Pan, H., Guo, S., He, X., Olson, S. T., Mesecar, A. D., Adam, S. A., & Unterman, T. G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m208063200 · Cited by 294 · see citing works

SUMO: A Multifaceted Modifier of Chromatin Structure and Function

Cubeñas-Potts, C., & Matunis, M. J. (2013) · Developmental Cell · doi:10.1016/j.devcel.2012.11.020 · Cited by 281 · see citing works

Regulation of MEF2 by Histone Deacetylase 4- and SIRT1 Deacetylase-Mediated Lysine Modifications

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Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1: characterization of phosphorylation- and 14-3-3-dependent and -independent mechanisms

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Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion

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A SIM-ultaneous role for SUMO and ubiquitin

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Cracking the O-GlcNAc code in metabolism

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Cellular functions of the DUBs

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Carm1 Regulates Pax7 Transcriptional Activity through MLL1/2 Recruitment during Asymmetric Satellite Stem Cell Divisions

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Acute promyelocytic leukemia, arsenic, and PML bodies

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Betulinic acid-induced programmed cell death in human melanoma cells involves mitogen-activated protein kinase activation.

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Regulation of CK2 by phosphorylation and O-GlcNAcylation revealed by semisynthesis

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Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activityPreprint

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The Fast-Growing Business of SUMO Chains

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Control of MEF2 Transcriptional Activity by Coordinated Phosphorylation and Sumoylation

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Myocyte Enhancer Factor 2 Acetylation by p300 Enhances Its DNA Binding Activity, Transcriptional Activity, and Myogenic Differentiation

Ma, K., Chan, J. K. L., Zhu, G., & Wu, Z. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.9.3575-3582.2005 · Cited by 165 · see citing works

Direct Binding of CoREST1 to SUMO-2/3 Contributes to Gene-Specific Repression by the LSD1/CoREST1/HDAC Complex

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An Acetylation/Deacetylation-SUMOylation Switch through a Phylogenetically Conserved ψKXEP Motif in the Tumor Suppressor HIC1 Regulates Transcriptional Repression Activity

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Regulation of gene expression by transcription factor acetylation

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Regulation of human epidermal stem cell proliferation and senescence requires polycomb- dependent and -independent functions of Cbx4

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Tunable Signal Processing Through Modular Control of Transcription Factor Translocation

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Pin1 Regulates the Dynamics of c-Myc DNA Binding To Facilitate Target Gene Regulation and Oncogenesis

Farrell, A. S., Pelz, C., Wang, X., Daniel, C. J., Wang, Z., Su, Y., Janghorban, M., Zhang, X., Morgan, C. W., Impey, S., et al. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01455-12 · Cited by 140 · see citing works

PTMcode: a database of known and predicted functional associations between post-translational modifications in proteins

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A Recurrent Phospho-Sumoyl Switch in Transcriptional Repression and Beyond

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Differential Effects of an O-GlcNAcase Inhibitor on Tau Phosphorylation

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A tumor suppressor role for PP2A-B56α through negative regulation of c-Myc and other key oncoproteins

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p300 Acetyltransferase activity differentially regulates the localization and activity of the FOXO homologues in skeletal muscle

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Ikaros SUMOylation: Switching Out of Repression

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Pin1 inhibitors: Pitfalls, progress and cellular pharmacology

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Structural basis for CARM1 inhibition by indole and pyrazole inhibitors

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Crosstalk between C/EBPβ phosphorylation, arginine methylation, and SWI/SNF/Mediator implies an indexing transcription factor code

Kowenz‐Leutz, E., Pleß, O., Dittmar, G. A. G., Knoblich, M., & Leutz, A. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.3 · Cited by 103 · see citing works

Bcl11b represses a mature T‐cell gene expression program in immature CD4+CD8+ thymocytes

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Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells

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Control of Activating Transcription Factor 4 (ATF4) Persistence by Multisite Phosphorylation Impacts Cell Cycle Progression and Neurogenesis*

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Phosphatases in SMAD regulation

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Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development

Yan, Q., Gong, L., Deng, M., Zhang, L., Sun, S., Liu, J., Ma, H., Yuan, D., Chen, P.-C., Hu, X., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1007866107 · Cited by 83 · see citing works

Myocyte Enhancer Factor-2 Transcription Factors in Neuronal Differentiation and Survival

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Regulation of Estrogen Receptor α N-Terminus Conformation and Function by Peptidyl Prolyl Isomerase Pin1

Rajbhandari, P., Finn, G., Solodin, N. M., Singarapu, K. K., Sahu, S. C., Markley, J. L., Kadunc, K., Miner, S. J., Kariagina, A., Haslam, S. Z., et al. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.06073-11 · Cited by 77 · see citing works

SUMOylation enhances DNA methyltransferase 1 activity

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Betulinic Acid Decreases Specificity Protein 1 (Sp1) Level via Increasing the Sumoylation of Sp1 to Inhibit Lung Cancer Growth

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Coordinated Regulation of Transcription Factor Bcl11b Activity in Thymocytes by the Mitogen-activated Protein Kinase (MAPK) Pathways and Protein Sumoylation

Zhang, L., Vogel, W., Liu, X., Topark‐Ngarm, A., Arbogast, B. L., Maier, C. S., Filtz, T. M., & Leid, M. E. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.344176 · Cited by 70 · see citing works

SUMOhydro: A Novel Method for the Prediction of Sumoylation Sites Based on Hydrophobic Properties

Chen, Y., Chen, Z., Gong, Y.-A., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039195 · Cited by 69 · see citing works

Pin1 modulates ERα levels in breast cancer through inhibition of phosphorylation-dependent ubiquitination and degradation

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Lysine methylation of promoter-bound transcription factors and relevance to cancer

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A Src family kinase–Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiationPreprint

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O-GlcNAcylation-Inducing Treatments Inhibit Estrogen Receptor α Expression and Confer Resistance to 4-OH-Tamoxifen in Human Breast Cancer-Derived MCF-7 Cells

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The folding energy landscape and phosphorylation: modeling the conformational switch of the NFAT regulatory domain

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Rnf165/Ark2C Enhances BMP-Smad Signaling to Mediate Motor Axon Extension

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Defining an Embedded Code for Protein Ubiquitination

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Dual regulation of Myc by Abl

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Selective Inhibition of CBP/p300 HAT

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