The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Recent Structural Insights into Cytochrome P450 Function
Open accessAbstract
Cytochrome P450 (P450) enzymes are important in the metabolism of drugs, steroids, fat-soluble vitamins, carcinogens, pesticides, and many other types of chemicals. Their catalytic activities are important issues in areas such as drug-drug interactions and endocrine function. During the past 30 years, structures of P450s have been very helpful in understanding function, particularly the mammalian P450 structures available in the past 15 years. We review recent activity in this area, focusing on the past two years (2014–2015). Structural work with microbial P450s includes studies related to the biosynthesis of natural products and the use of parasitic and fungal P450 structures as targets for drug discovery. Studies on mammalian P450s include the utilization of information about ‘drug-metabolizing’ P450s to improve drug development and also to understand the molecular bases of endocrine dysfunction.
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Citations
Cites
Mammalian Microsomal Cytochrome P450 Monooxygenase
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Structural basis for androgen specificity and oestrogen synthesis in human aromatase
Ghosh, D., Griswold, J., Erman, M., & Pangborn, W. (2009) · Nature · doi:10.1038/nature07614 · Cited by 618
Structure of a cytochrome P450-redox partner electron-transfer complex
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Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system
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The role of cytochrome b5 in the biosynthesis of androgens by human P450c17
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Self-citationStructures of human steroidogenic cytochrome P450 17A1 with substrates
Petrunak, E. M., DeVore, N. M., Porubsky, P. R., & Scott, E. E. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.610998 · Cited by 119
Pallan, P. S., Lei, L., Wang, C., Waterman, M. R., Guengerich, F. P., & Egli, M. (2015) · Molecular Endocrinology · doi:10.1210/me.2015-1127 · Cited by 19
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Cited by
Cytochrome P450 Enzymes and Drug Metabolism in Humans
Zhao, M., Ma, J., Li, M., Zhang, Y., Jiang, B., Zhao, X., Huai, C., Shen, L., Zhang, N., He, L., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312808 · Cited by 1,070
Role of cytochrome P450s in the generation and metabolism of reactive oxygen species
Veith, A., & Moorthy, B. (2018) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2017.10.003 · Cited by 363
The landscape of sex-differential transcriptome and its consequent selection in human adults
Gershoni, M., & Pietrokovski, S. (2017) · BMC Biology · doi:10.1186/s12915-017-0352-z · Cited by 266
Reconciling conformational heterogeneity and substrate recognition in cytochrome P450
Dandekar, B. R., Ahalawat, N., & Mondal, J. (2021) · Biophysical Journal · doi:10.1016/j.bpj.2021.02.040 · Cited by 14
Ren, Z., Xue, Y., Xu, N., Feng, D., Geng, C., Wu, Y., Liu, D., Zhao, L., Zhang, X., Ma, H., et al. (2025) · Microbial Cell Factories · doi:10.1186/s12934-025-02857-z · Cited by 2
Metadata
- Authors
- Guengerich, F. P., Waterman, M. R., & Egli, M.
- Venue
- Trends in Pharmacological Sciences
- Publisher
- Elsevier BV
- Published
- 2016-08
- Volume
- 37
- Issue
- 8
- Pages
- 625-640
- ISSN
- 0165-6147 (ISSN-L)
- OpenAlex
- W2416192302
- Cited by
- 383
- References
- 7
- FWCI
- 7.63
- Type
- journal article
- Language
- en
- Open access
- green
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