The DOI matches its Crossref record.
cAMP: From Long-Range Second Messenger to Nanodomain Signalling
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Consistent with earlier studies showing that cAMP signaling regulates key physiological processes, including gonadotropin-releasing hormone secretion, insulin granule dynamics and cardiac function91–94”
From ABCC4 impairs the clearance of plasma LDL cholesterol through suppressing LDLR expression in the liver (2025) · cites this paper as [94]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
No references could be resolved yet.
Research works printed but not linked: 79
- Conti, 2007, Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling, Annu. Rev. Biochem., 76, 481, 10.1146/annurev.biochem.76.060305.150444 · DOI
- Maurice, 2014, Advances in targeting cyclic nucleotide phosphodiesterases, Nat. Rev. Drug Discov., 13, 290, 10.1038/nrd4228 · DOI
- Berthet, 1957, The relationship of epinephrine and glucagon to liver phosphorylase. IV. Effect of epinephrine and glucagon on the reactivation of phosphorylase in liver homogenates, J. Biol. Chem., 224, 463, 10.1016/S0021-9258(18)65045-8 · DOI
- Buxton, 1983, Compartments of cyclic AMP and protein kinase in mammalian cardiomyocytes, J. Biol. Chem., 258, 10233, 10.1016/S0021-9258(17)44447-4 · DOI
- Dworkin, 1977, Solubility and diffusion coefficient of adenosine 3′:5′-monophosphate, J. Biol. Chem., 252, 864, 10.1016/S0021-9258(19)75177-1 · DOI
- Kasai, 1994, Spatial dynamics of second messengers: IP3 and cAMP as long-range and associative messengers, Trends Neurosci., 17, 95, 10.1016/0166-2236(94)90112-0 · DOI
- Taylor, 2013, PKA: lessons learned after twenty years, Biochim. Biophys. Acta, 1834, 1271, 10.1016/j.bbapap.2013.03.007 · DOI
- Schmidt, 2013, Exchange protein directly activated by cAMP (epac): a multidomain cAMP mediator in the regulation of diverse biological functions, Pharmacol. Rev., 65, 670, 10.1124/pr.110.003707 · DOI
- Kaupp, 2002, Cyclic nucleotide-gated ion channels, Physiol. Rev., 82, 769, 10.1152/physrev.00008.2002 · DOI
- Schindler, 2016, The Popeye domain containing protein family–a novel class of cAMP effectors with important functions in multiple tissues, Prog. Biophys. Mol. Biol., 120, 28, 10.1016/j.pbiomolbio.2016.01.001 · DOI
- Rall, 1975, Introduction, Adv. Cyclic Nucleotide Res. Commun., 5, 1
- Hayes, 1979, Hormonally specific expression of cardiac protein kinase activity, Proc. Natl. Acad. Sci. U. S. A., 76, 1570, 10.1073/pnas.76.4.1570 · DOI
- Jiang, 2017, Interrogating cyclic AMP signaling using optical approaches, Cell Calcium, 64, 47, 10.1016/j.ceca.2017.02.010 · DOI
- Lissandron, 2005, Improvement of a FRET-based indicator for cAMP by linker design and stabilization of donor-acceptor interaction, J. Mol. Biol., 354, 546, 10.1016/j.jmb.2005.09.089 · DOI
- Calebiro, 2009, Persistent cAMP-signals triggered by internalized G-protein-coupled receptors, PLoS Biol., 7, 10.1371/journal.pbio.1000172 · DOI
- Di Benedetto, 2008, Protein kinase A type I and type II define distinct intracellular signaling compartments, Circ. Res., 103, 836, 10.1161/CIRCRESAHA.108.174813 · DOI
- Mika, 2012, PDEs create local domains of cAMP signaling, J. Mol. Cell. Cardiol., 52, 323, 10.1016/j.yjmcc.2011.08.016 · DOI
- McCormick, 2014, Compartmentalisation of second messenger signalling pathways, Curr. Opin. Genet. Dev., 27, 20, 10.1016/j.gde.2014.02.001 · DOI
- Brescia, 2016, Modulation of compartmentalised cyclic nucleotide signalling via local inhibition of phosphodiesterase activity, Int. J. Mol. Sci., 17, 10.3390/ijms17101672 · DOI
- Ilouz, 2017, Isoform-specific subcellular localization and function of protein kinase A identified by mosaic imaging of mouse brain, Elife, 6, 10.7554/eLife.17681 · DOI
- Dema, 2015, Pharmacological targeting of AKAP-directed compartmentalized cAMP signalling, Cell. Signal., 27, 2474, 10.1016/j.cellsig.2015.09.008 · DOI
- Torres-Quesada, 2017, The many faces of compartmentalized PKA signalosomes, Cell. Signal., 37, 1, 10.1016/j.cellsig.2017.05.012 · DOI
- Perera, 2015, Microdomain switch of cGMP-regulated phosphodiesterases leads to ANP-induced augmentation of beta-adrenoceptor-stimulated contractility in early cardiac hypertrophy, Circ. Res., 116, 1304, 10.1161/CIRCRESAHA.116.306082 · DOI
- Berisha, 2017, Cyclic nucleotide imaging and cardiovascular disease, Pharmacol. Ther., 175, 107, 10.1016/j.pharmthera.2017.02.038 · DOI
- Zaccolo, 2011, Spatial control of cAMP signalling in health and disease, Curr. Opin. Pharmacol., 11, 649, 10.1016/j.coph.2011.09.014 · DOI
- Zaccolo, 2002, Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes, Science, 295, 1711, 10.1126/science.1069982 · DOI
- Maiellaro, 2016, cAMP signals in Drosophila motor neurons are confined to single synaptic boutons, Cell Rep., 17, 1238, 10.1016/j.celrep.2016.09.090 · DOI
- Terrin, 2012, PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome, J. Cell Biol., 198, 607, 10.1083/jcb.201201059 · DOI
- DiPilato, 2004, Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signalling within discrete subcellular compartments, Proc. Natl. Acad. Sci., 101, 16513, 10.1073/pnas.0405973101 · DOI
- Sprenger, 2015, In vivo model with targeted cAMP biosensor reveals changes in receptor-microdomain communication in cardiac disease, Nat. Commun., 6, 6965, 10.1038/ncomms7965 · DOI
- Monterisi, 2012, CFTR regulation in human airway epithelial cells requires integrity of the actin cytoskeleton and compartmentalized cAMP and PKA activity, J. Cell Sci., 125, 1106, 10.1242/jcs.089086 · DOI
- Terrin, 2006, PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different cAMP: role of compartmentalized phosphodiesterases, J. Cell Biol., 175, 441, 10.1083/jcb.200605050 · DOI
- Zacharias, 2002, Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells, Science, 296, 913, 10.1126/science.1068539 · DOI
- Averaimo, 2016, A plasma membrane microdomain compartmentalizes ephrin-generated cAMP signals to prune developing retinal axon arbors, Nat. Commun., 7, 12896, 10.1038/ncomms12896 · DOI
- Agarwal, 2014, Role of membrane microdomains in compartmentation of cAMP signaling, PLoS One, 9, 10.1371/journal.pone.0095835 · DOI
- Sezgin, 2017, The mystery of membrane organization: composition, regulation and roles of lipid rafts, Nat. Rev. Mol. Cell Biol., 18, 361, 10.1038/nrm.2017.16 · DOI · Paper page
- Halls, 2017, Adenylyl cyclase signalling complexes - Pharmacological challenges and opportunities, Pharmacol. Ther., 172, 171, 10.1016/j.pharmthera.2017.01.001 · DOI
- Acin-Perez, 2011, A phosphodiesterase 2A isoform localized to mitochondria regulates respiration, J. Biol. Chem., 286, 30423, 10.1074/jbc.M111.266379 · DOI
- Steegborn, 2014, Structure, mechanism, and regulation of soluble adenylyl cyclases - similarities and differences to transmembrane adenylyl cyclases, Biochim. Biophys. Acta, 1842, 2535, 10.1016/j.bbadis.2014.08.012 · DOI
- Di Benedetto, 2013, Mitochondrial Ca(2)(+) uptake induces cyclic AMP generation in the matrix and modulates organelle ATP levels, Cell Metab., 17, 965, 10.1016/j.cmet.2013.05.003 · DOI
- Lefkimmiatis, 2013, The inner and outer compartments of mitochondria are sites of distinct cAMP/PKA signaling dynamics, J. Cell Biol., 202, 453, 10.1083/jcb.201303159 · DOI
- Monterisi, 2017, PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signalling, Elife, 6, 10.7554/eLife.21374 · DOI
- Surdo, 2017, FRET biosensor uncovers cAMP nano-domains at beta-adrenergic targets that dictate precise tuning of cardiac contractility, Nat. Commun., 8, 15031, 10.1038/ncomms15031 · DOI
- Koschinski, 2015, A novel approach combining real-time imaging and the patch-clamp technique to calibrate FRET-based reporters for cAMP in their cellular microenvironment, Methods Mol. Biol., 1294, 25, 10.1007/978-1-4939-2537-7_3 · DOI
- Diviani, 2016, Emerging roles of A-kinase anchoring proteins in cardiovascular pathophysiology, Biochim. Biophys. Acta, 1863, 1926, 10.1016/j.bbamcr.2015.11.024 · DOI
- Gold, 2013, Local cAMP signaling in disease at a glance, J. Cell Sci., 126, 4537, 10.1242/jcs.133751 · DOI
- Yang, 1995, Regulation of cAMP-dependent protein kinase: enzyme activation without dissociation, Biochemistry, 34, 6267, 10.1021/bi00019a002 · DOI
- Smith, 2013, Intrinsic disorder within an AKAP–protein kinase A complex guides local substrate phosphorylation, Elife, 2, 10.7554/eLife.01319 · DOI
- Smith, 2017, Local protein kinase A action proceeds through intact holoenzymes, Science, 356, 1288, 10.1126/science.aaj1669 · DOI
- Walker-Gray, 2017, Mechanisms for restraining cAMP-dependent protein kinase revealed by subunit quantitation and cross-linking approaches, Proc. Natl. Acad. Sci. U. S. A., 114, 10414, 10.1073/pnas.1701782114 · DOI
- Mo, 2017, Genetically encoded biosensors for visualizing live-cell biochemical activity at super-resolution, Nat. Methods, 14, 427, 10.1038/nmeth.4221 · DOI
- Wang, 2014, Isoform-selective disruption of AKAP-localized PKA using hydrocarbon stapled peptides, ACS Chem. Biol., 9, 635, 10.1021/cb400900r · DOI
- Conti, 2014, Cyclic AMP compartments and signaling specificity: role of cyclic nucleotide phosphodiesterases, J. Gen. Physiol., 143, 29, 10.1085/jgp.201311083 · DOI
- Agarwal, 2016, Mechanisms restricting diffusion of intracellular cAMP, Sci. Rep., 6, 19577, 10.1038/srep19577 · DOI
- Bacskai, 1993, Spatially resolved dynamics of cAMP and protein kinase A subunits in Aplysia sensory neurons, Science, 260, 222, 10.1126/science.7682336 · DOI
- Richards, 2016, Intracellular tortuosity underlies slow cAMP diffusion in adult ventricular myocytes, Cardiovasc. Res., 110, 395, 10.1093/cvr/cvw080 · DOI
- Koschinski, 2017, Activation of PKA in cell requires higher concentration of cAMP than in vitro: implications for compartmentalization of cAMP signalling, Sci. Rep., 7, 14090, 10.1038/s41598-017-13021-y · DOI
- Adams, 1991, Fluorescence ratio imaging of cyclic AMP in single cells, Nature, 349, 694, 10.1038/349694a0 · DOI
- Saucerman, 2014, Mechanisms of cyclic AMP compartmentation revealed by computational models, J. Gen. Physiol., 143, 39, 10.1085/jgp.201311044 · DOI
- Saucerman, 2003, Modeling beta-adrenergic control of cardiac myocyte contractility in silico, J. Biol. Chem., 278, 47997, 10.1074/jbc.M308362200 · DOI
- Feinstein, 2012, Assessment of cellular mechanisms contributing to cAMP compartmentalization in pulmonary microvascular endothelial cells, Am. J. Physiol. Cell Physiol., 302, C839, 10.1152/ajpcell.00361.2011 · DOI
- Lohse, 2017, Experimental and mathematical analysis of cAMP nanodomains, PLoS One, 12, 10.1371/journal.pone.0174856 · DOI
- Yang, 2016, A computational modeling and simulation approach to investigate mechanisms of subcellular cAMP compartmentation, PLoS Comput. Biol., 12, 10.1371/journal.pcbi.1005005 · DOI
- Beavo, 1974, Activation of protein kinase by physiological concentrations of cyclic AMP, Proc. Natl. Acad. Sci. U. S. A., 71, 3580, 10.1073/pnas.71.9.3580 · DOI
- Borner, 2011, FRET measurements of intracellular cAMP concentrations and cAMP analog permeability in intact cells, Nat. Protoc., 6, 427, 10.1038/nprot.2010.198 · DOI
- Schnell, 2000, Enzyme kinetics at high enzyme concentration, Bull. Math. Biol., 62, 483, 10.1006/bulm.1999.0163 · DOI
- Hernandez-Ramirez, 2017, Cyclic 3′,5′-adenosine monophosphate (cAMP) signaling in the anterior pituitary gland in health and disease, Mol. Cell. Endocrinol.
- Zoccarato, 2015, Cardiac hypertrophy is inhibited by a local pool of cAMP regulated by phosphodiesterase 2, Circ. Res., 117, 707, 10.1161/CIRCRESAHA.114.305892 · DOI
- Fields, 2016, Sustained exposure to catecholamines affects cAMP/PKA compartmentalised signalling in adult rat ventricular myocytes, Cell. Signal., 28, 725, 10.1016/j.cellsig.2015.10.003 · DOI
- Nikolaev, 2010, Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation, Science, 327, 1653, 10.1126/science.1185988 · DOI
- Poppinga, 2015, A-kinase-anchoring proteins coordinate inflammatory responses to cigarette smoke in airway smooth muscle, Am. J. Physiol. Lung Cell. Mol. Physiol., 308, L766, 10.1152/ajplung.00301.2014 · DOI
- Brown, 2013, Phosphodiesterase-8A binds to and regulates Raf-1 kinase, Proc. Natl. Acad. Sci. U. S. A., 110, E1533, 10.1073/pnas.1303004110 · DOI
- Serrels, 2010, A complex between FAK, RACK1, and PDE4D5 controls spreading initiation and cancer cell polarity, Curr. Biol., 20, 1086, 10.1016/j.cub.2010.04.042 · DOI
- Sin, 2011, Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)-HSP20 complex attenuates the beta-agonist induced hypertrophic response in cardiac myocytes, J. Mol. Cell. Cardiol., 50, 872, 10.1016/j.yjmcc.2011.02.006 · DOI
- Ni, 2017, Live-cell imaging of cell signaling using genetically encoded fluorescent reporters, FEBS J.
- Oldenburger, 2012, Anti-inflammatory role of the cAMP effectors Epac and PKA: implications in chronic obstructive pulmonary disease, PLoS One, 7, 10.1371/journal.pone.0031574 · DOI
- Oldenburger, 2014, Epac1 and Epac2 are differentially involved in inflammatory and remodeling processes induced by cigarette smoke, FASEB J., 28, 4617, 10.1096/fj.13-248930 · DOI
- Zuo, 2017, Cigarette smoke changes cAMP microdomains in lung slices, Am. J. Respir. Crit. Care Med., 195
- Oldenburger, 2014, A-kinase anchoring proteins contribute to loss of E-cadherin and bronchial epithelial barrier by cigarette smoke, Am. J. Physiol. Cell Physiol., 306, C585, 10.1152/ajpcell.00183.2013 · DOI
Cited by
Sorted by citations
Physiological roles of mammalian transmembrane adenylyl cyclase isoforms
Ostrom, K. F., LaVigne, J. E., Brust, T. F., Seifert, R., Dessauer, C. W., Watts, V. J., & Ostrom, R. S. (2022) · Physiological Reviews · doi:10.1152/physrev.00013.2021 · Cited by 131
Phosphodiesterase 3A and Arterial Hypertension
Ercu, M., Markó, L., Schächterle, C., Tsvetkov, D., Cui, Y., Maghsodi, S., Bartolomaeus, T. U. P., Maass, P. G., Zühlke, K., Gregersen, N., et al. (2020) · Circulation · doi:10.1161/circulationaha.119.043061 · Cited by 51
Chen, J., Huang, H., Chen, C., Xia, G., Huang, H., Xiong, Y., Luo, P., Chen, Y., Li, J., Wen, L., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-08818-x · Cited by 1
Metadata
- Authors
- Musheshe, N., Schmidt, M., & Zaccolo, M.
- Venue
- Trends in Pharmacological Sciences
- Publisher
- Elsevier BV
- Published
- 2018-02
- Volume
- 39
- Issue
- 2
- Pages
- 209-222
- ISSN
- 0165-6147
- Cited by
- 132
- References
- 0
- Language
- en
- Funders
- British Heart Foundation (PG/10/75/28537, RG/12/3/29423)
- BHF Centre of Research Excellence (RE/08/004)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review