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Cited by 2,124Lipid Membrane Structure and BehaviorCaveolin-1 and cellular processesCholesterol and Lipid Metabolism

The mystery of membrane organization: composition, regulation and roles of lipid rafts

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Sezgin, Erdinc, Levental, Ilya, Mayor, Satyajit, Eggeling, Christian·2017·Nature Reviews Molecular Cell Biology
DOI 10.1038/nrm.2017.16PMC PMC5500228
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Abstract

Cellular plasma membranes are laterally heterogeneous, featuring a variety of distinct subcompartments that differ in their biophysical properties and composition. A large number of studies have focused on understanding the basis for this heterogeneity and its physiological relevance. The membrane raft hypothesis formalized a physicochemical principle for a subtype of such lateral membrane heterogeneity, in which the preferential associations between cholesterol and saturated lipids drive the formation of relatively packed (or ordered) membrane domains that selectively recruit certain lipids and proteins. Recent studies have yielded new insights into this mechanism and its relevance in vivo, owing primarily to the development of improved biochemical and biophysical technologies.

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  • Plasma membrane lipids are not homogeneously distributed but segregated; lipid rafts are platforms enriched in cholesterol and sphingolipids where signalling proteins can accumulate.

    “Our understanding of the plasma membrane has evolved with the recognition that the lipids are not homogeneously distributed but are segregated; one early concept was ‘lipid rafts’ as platforms enriched in cholesterol and sphingolipids, in which specific proteins involved in signalling can accumulate [122,123].”

    From Phosphatidylinositol(4,5)bisphosphate: diverse functions at the plasma membrane (2020) · cites this paper as [122]

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Cited by

Sorted by citations

Authors
Sezgin, E., Levental, I., Mayor, S., & Eggeling, C.
Affiliations
  • The University of Texas Health Science Center at Houston (US)
  • Tata Institute of Fundamental Research (IN)
  • University of Oxford (GB)
Corresponding author
  • Mayor, Satyajit
  • Eggeling, Christian
ORCID
Venue
Nature Reviews Molecular Cell Biology
Publisher
Springer Science and Business Media LLC
Published
2017-03-30
Volume
18
Issue
6
Pages
361-374
ISSN
  • 1471-0072 (ISSN-L)
  • 1471-0080
DOI
10.1038/nrm.2017.16
PMC
PMC5500228
OpenAlex
W2599649240
Cited by
2,124
References
3
Citations by year
2026: 225 · 2025: 243 · 2024: 243 · 2023: 231 · 2022: 237 · 2021: 268 · 2020: 254 · 2019: 208 · 2018: 159 · 2017: 53 · 2015: 2 · 2012: 1
FWCI
17.25
Type
journal article
Language
en
Open access
Licence
Locations
  • Nature Reviews Molecular Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Wellcome Trust (. 104924/14/ Z/14, 104924)
  • Medical Research Council (MC_PC_16082, MC_UU_00008/9, MR/K01577X/1)
  • National Institute of General Medical Sciences (R01GM114282)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Keywords
lipid rafts, membrane organization, cholesterol, saturated lipids, membrane domains, plasma membrane, protein-lipid interactions, membrane packing
MeSH terms
Animals, Cell Membrane, Humans, Membrane Lipids, Membrane Microdomains

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