The Pharmacology of CD38/NADase: An Emerging Target in Cancer and Diseases of Aging

Chini, Eduardo N., Chini, Claudia C.S., Espindola Netto, Jair Machado, de Oliveira, Guilherme C., van Schooten, Wim·2018·Trends in Pharmacological Sciences

Cited by (226)

Items 101–200 of 226

  1. Anti-cancer activity of Biochanin A against multiple myeloma by targeting the CD38 and cancer stem-like cells
    Vinod Kumar Jaina, Abhisheik Eedara, Sasi Priya SVS, Surender Singh Jadav, Sabarinadh Chilaka, Ramakrishna Sistla, Sai Balaji Andugulapati · 2022 · Process Biochemistry
  2. Identifying the Role of Oxidative Stress‐Related Genes as Prognostic Biomarkers and Predicting the Response of Immunotherapy and Chemotherapy in Ovarian Cancer
    Qingyang Liu, Xiaocheng Yang, Yuhan Yin, Hao Zhang, Fanxing Yin, Panpan Guo, Xiaoxu Zhang, Chenxi Sun, Shining Li, Yanshuo Han et al. · 2022 · Oxidative Medicine and Cellular Longevity
  3. CD38 Deficiency Alleviates Diabetic Cardiomyopathy by Coordinately Inhibiting Pyroptosis and Apoptosis
    Ling-Fang Wang, Qian Li, Ke Wen, Qi‐Hang Zhao, Yating Zhang, Jia-Le Zhao, Qi Ding, Xiao‐Hui Guan, Yun‐Fei Xiao, Ke‐Yu Deng et al. · 2023 · International Journal of Molecular Sciences
  4. Designing in vitro Blood-Brain Barrier Models Reproducing Alterations in Brain Aging
    Elena D. Osipova, Yulia K. Komleva, Andrey V. Morgun, Olga L. Lopatina, Yu. A. Panina, Raissa Ya. Olovyannikova, E. F. Vais, Vladimir V. Salmin, Alla B. Salmina · 2018 · Frontiers in Aging Neuroscience
  5. Codonopsis pilosula Polysaccharides Alleviate Aβ1-40-Induced PC12 Cells Energy Dysmetabolism via CD38/NAD+ Signaling Pathway
    Yi R. Hu, San L. Xing, Chuan Chen, Ding Z. Shen, Jiu L. Chen · 2021 · Current Alzheimer Research
  6. CD38‐NADase is a new major contributor to Duchenne muscular dystrophic phenotype
    Antoine de Zélicourt, Abdallah Fayssoil, Mbarka Dakouane‐Giudicelli, Isley de Jesus, Ahmed Karoui, Faouzi Zarrouki, Florence Lefebvre, Arnaud Mansart, Jean‐Marie Launay, Jérôme Piquereau et al. · 2022 · EMBO Molecular Medicine
  7. Emerging roles of ADP-ribosyl-acceptor hydrolases (ARHs) in tumorigenesis and cell death pathways
    Xiangning Bu, Jiro Kato, Joel Moss · 2018 · Biochemical Pharmacology
  8. Perspectives for the Development of CD38-Specific Heavy Chain Antibodies as Therapeutics for Multiple Myeloma
    Peter Bannas, Friedrich Koch‐Nolte · 2018 · Frontiers in Immunology
  9. Targeting Epigenetic Mechanisms in Vascular Aging
    Zhongxiao Lin, Qian Ding, Xinzhi Li, Yuliang Feng, Hao He, Chuoji Huang, Yi Zhun Zhu · 2022 · Frontiers in Cardiovascular Medicine
  10. Distinct physical condition and social behavior phenotypes of CD157 and CD38 knockout mice during aging
    Maria Gerasimenko, Olga L. Lopatina, Anna A. Shabalova, Черепанов Станислав Михайлович, Alla B. Salmina, Shigeru Yokoyama, Hisanori Goto, Hiroshi Okamoto, Yasuhiko Yamamoto, Katsuhiko Ishihara et al. · 2020 · PLoS ONE
  11. ZDHHC9-mediated CD38 palmitoylation stabilizes CD38 expression and promotes pancreatic cancer growth
    Hui Guo, Zhiqing Lin, Di Zhang, Qilong Qin, Zewen Li, Yuqing Yin, Jiang‐Fan Chen, Wei Mei Guo · 2025 · Communications Biology
  12. Nicotinamide Adenine Dinucleotide Supplementation to Alleviate Heart Failure: A Mitochondrial Dysfunction Perspective
    Yu Fan, Huiying Zhao, Luo Lu, Wei Wu · 2025 · Nutrients
  13. NAD+: An old but promising therapeutic agent for skeletal muscle ageing
    Yingying Xu, Weihua Xiao · 2023 · Ageing Research Reviews
  14. Roles of NAD+ and Its Metabolites Regulated Calcium Channels in Cancer
    Peilin Yu, Xiaobo Cai, Yan Liang, Mingxiang Wang, Wei Yang · 2020 · Molecules
  15. Novel Approach to Skin Anti-Aging: Boosting Pharmacological Effects of Exogenous Nicotinamide Adenine Dinucleotide (NAD+) by Synergistic Inhibition of CD38 Expression
    Seongsu Kang, Ji-Won Park, Zhihong Cheng, Sanghyun Ye, Seung‐Hyun Jun, Nae Gyu Kang · 2024 · Cells
  16. Daratumumab and Nanobody-Based Heavy Chain Antibodies Inhibit the ADPR Cyclase but not the NAD+ Hydrolase Activity of CD38-Expressing Multiple Myeloma Cells
    Natalie Baum, Ralf Fliegert, Andreas Bauche, Julia Hambach, Stephan Menzel, Friedrich Haag, Peter Bannas, Friedrich Koch‐Nolte · 2020 · Cancers
  17. Modulation of aryl hydrocarbon receptor (AHR) and the NAD+-consuming enzyme CD38: Searches of therapeutic options for nonalcoholic fatty liver disease (NAFLD)
    Karl Walter Bock · 2020 · Biochemical Pharmacology
  18. Overcoming resistance to rituximab in relapsed non-Hodgkin lymphomas by antibody-polymer drug conjugates actively targeted by anti-CD38 daratumumab
    Ondřej Lidický, Pavel Klener, Daniela Machová, Petra Vočková, Eva Pokorná, Karel Helman, Cory K. Mavis, Olga Janoušková, Tomáš Etrych · 2020 · Journal of Controlled Release
  19. Nicotinic acid riboside maintains NAD+ homeostasis and ameliorates aging-associated NAD+ decline
    Won-Suk Song, Xiyu Shen, Kang Du, Cuauhtemoc B. Ramirez, Sang Hee Park, Yang Cao, Johnny Le, Hosung Bae, Joo‐Hwan Kim, Yujin Chun et al. · 2025 · Cell Metabolism
  20. Comprehensive Proteomics Analysis Identifies CD38-Mediated NAD+ Decline Orchestrating Renal Fibrosis in Pediatric Patients With Obstructive Nephropathy
    Yuandong Tao, Jifeng Wang, Xuexue Lyu, Na Li, Dong Lai, Yuanyuan Liu, Xingyue Zhang, Pin Li, Shouqing Cao, Xiaoguang Zhou et al. · 2023 · Molecular & Cellular Proteomics
  21. Rigosertib promotes anti-tumor immunity via autophagic degradation of PD-L1 in colorectal cancer cells
    Xinyi Zhou, Dongliang Fu, Hang Sheng Yang, Chenqin Le, Yier Lu, Jingsun Wei, Yang Tang, Jiawei Zhang, Ying Yuan, Kefeng Ding et al. · 2023 · Cancer Letters
  22. Conceptual Framework for SARS-CoV-2–Related Lymphopenia
    Ilnaz Rahimmanesh, Shirin Kouhpayeh, Yadollah Azizi, Hossein Khanahmad · 2022 · Advanced Biomedical Research
  23. Anti‐CD38 monoclonal antibody interference with blood compatibility testing: Differentiating isatuximab and daratumumab via functional epitope mapping
    Btissam Chami, Makoto Okuda, Morvarid Moayeri, France Pirenne, Yoko Hidaka, Ashok Nambiar, Zhili Song, Olivier Bedel, Bailin Zhang, Joern Hopke et al. · 2022 · Transfusion
  24. Fingerstick blood assay maps real‐world NAD + disparity across gender and age
    Pei Wang, Meiting Chen, Yaying Hou, Jun Luan, Ruili Liu, Liuqing Chen, Min Hu, Qiuliyang Yu · 2023 · Aging Cell
  25. Pyridine Nucleotide Metabolites and Calcium Release from Intracellular Stores
    Antony Galione, Kai‐Ting Chuang · 2019 · Advances in experimental medicine and biology
  26. Mitochondrial dysfunction drives cellular senescence: Molecular mechanisms of inter-organelle communication
    Ziyue Xie, Xinyu Zhang, Yu Li, Ruigong Zhu · 2025 · Experimental Gerontology
  27. 89Zr-DFO-Isatuximab for CD38-Targeted ImmunoPET Imaging of Multiple Myeloma and Lymphomas
    Natalia Herrero Álvarez, Alexa L. Michel, Tara D. Viray, Marius Erik Mayerhoefer, Jason Stuart Lewis · 2023 · ACS Omega
  28. Codonopsis pilosula Polysaccharides Alleviate Aβ1-40-Induced PC12 Cells Energy Dysmetabolism via CD38/NAD+ Signaling Pathway
    2021 · Current Alzheimer Research
  29. Aging-related inflammation driven by cellular senescence enhances NAD consumption via activation of CD38 + pro-inflammatory macrophages
    2019
  30. CD38 activation by monosodium urate crystals contributes to inflammatory responses in human and murine macrophages
    Shijie Wen, Hiroshi Arakawa, Ikumi Tamai · 2021 · Biochemical and Biophysical Research Communications
  31. Selective targeting of CD38 hydrolase and cyclase activity as an approach to immunostimulation
    Thomas Zachary Benton, Catherine M. Mills, Jonathan M. Turner, Megan J. Francis, Dalan J. Solomon, Pieter B. Burger, Yuri Karl Peterson, Nathan G. Dolloff, André S. Bachmann, Patrick M. Woster · 2021 · RSC Advances
  32. A Molecular Perspective and Role of NAD+ in Ovarian Aging
    Mehboob Ahmed, Umair Riaz, Haimiao Lv, Liguo Yang · 2024 · International Journal of Molecular Sciences
  33. Exploring nicotinamide adenine dinucleotide precursors across biosynthesis pathways: Unraveling their role in the ovary
    Caifang Ren, Zhang Shuang, Yanyan Chen, Kaiping Deng, Meiqian Kuang, Zihao Gong, Ke Zhang, Panqi Wang, Pan Huang, Zhengrong Zhou et al. · 2024 · The FASEB Journal
  34. Myeloid but not hepatocytic CD38 is a key driver for hepatic ischemia/reperfusion injury
    Qi‐Hang Zhao, Yating Zhang, Ke Wen, Qi Ding, Ziying Chen, Dilinuer Tula, Jia-Hui Li, Juan Zhou, Yun‐Fei Xiao, Xiao‐Hui Guan et al. · 2025 · Signal Transduction and Targeted Therapy
  35. Brain Proteome Profiling Reveals Common and Divergent Signatures in Parkinson’s Disease, Multiple System Atrophy, and Progressive Supranuclear Palsy
    Fiona Dick, Gard Aasmund Skulstad Johanson, Ole‐Bjørn Tysnes, Guido Werner Alves, Christian Dölle, Charalampos Tzoulis · 2024 · Molecular Neurobiology
  36. Heavy-chain antibody targeting of CD38 NAD+ hydrolase ectoenzyme to prevent fibrosis in multiple organs
    Bo Shi, Asif Amin, Pranjali Dalvi, Wenxia Wang, Nicholas W. Lukacs, Li Kai, Paul Cheresh, Thais Peclat, Claudia C.S. Chini, Eduardo N. Chini et al. · 2023 · Scientific Reports
  37. Development of a machine learning-based predictive risk model combining fatty acid metabolism and ferroptosis for immunotherapy response and prognosis in prostate cancer
    Zepeng Wang, Zhihong Dai, Yuren Gao, Zhongxiang Zhao, Zhen Li, Liang Wang, Xiang Gao, Qiuqiu Qiu, Xiaofu Qiu, Zhiyu Liu · 2025 · Discover Oncology
  38. A novel prognostic model for prostate cancer based on androgen biosynthetic and catabolic pathways
    Aoyu Fan, Yunyan Zhang, Jiangting Cheng, Yunpeng Li, Wei Chen · 2022 · Frontiers in Oncology
  39. Evolutionary Views of Tuberculosis: Indoleamine 2,3‐Dioxygenase Catalyzed Nicotinamide Synthesis Reflects Shifts in Macrophage Metabolism
    Melinda Shelley Suchard, Clement Gascua Adu-Gyamfi, Bridgette M. Cumming, Dana M. Savulescu · 2020 · BioEssays
  40. Nicotinamide and Pyridoxine in Muscle Aging: Nutritional Regulation of Redox, Inflammation, and Regeneration
    Agnieszka Nowacka, Maciej Śniegocki, Martyna Śniegocka, Ewa Ziółkowska · 2025 · Antioxidants
  41. The known unknowns of mitochondrial carcinogenesis:de novoNUMTs and intercellular mitochondrial transfer
    Tigran A. Harutyunyan · 2023 · Mutagenesis
  42. The role of NAD+ metabolism in macrophages in age-related macular degeneration
    Ruoyi Lin, Jing Yu · 2022 · Mechanisms of Ageing and Development
  43. Role of CD38 in Adipose Tissue: Tuning Coenzyme Availability?
    Andrea Benzi, Alessia Grozio, Sonia Spinelli, Laura Sturla, Andreas H. Guse, Antonio DE FLORA, Elena Zocchi, Jöerg Heeren, Santina Bruzzone · 2021 · Nutrients
  44. Nicotinamide N-Methyltransferase (NNMT) and Liver Cancer: From Metabolic Networks to Therapeutic Targets
    Shi-Yan Lai, Xiaojuan Zhu, Wei-Dong Sun, Shuang-Zhou Bi, Chen-Ying Zhang, An Liu, Jiang-Hua Li · 2025 · Biomolecules
  45. Cell Type–Specific Roles of CD38 in the Interactions of Isoniazid with NAD+ in the Liver
    Junjie Zhu, Jie Li Lu, Hung‐Chun Tung, Ke Liu, Jianhua Li, Denis M. Grant, Wen Xie, Xiaochao Ma · 2020 · Drug Metabolism and Disposition
  46. Of Mice and Men: NAD+ Boosting with Niacin Provides Hope for Mitochondrial Myopathy Patients
    Eduardo N. Chini · 2020 · Cell Metabolism
  47. Apigenin inhibits NLRP3 inflammasome activation in monocytes and macrophages independently of CD38
    Knut Husø Lauritzen, Kuan Yang, Michael Frisk, Mieke C. Louwe, Maria Belland Olsen, Mathias Ziegler, William Edward Louch, Bente Lise Halvorsen, Pål Aukrust, Arne Yndestad et al. · 2025 · Frontiers in Immunology
  48. NAD-Linked Metabolism and Intervention in Short Telomere Syndromes and Murine Models of Telomere Dysfunction
    Amanda J. Stock, Yie Liu · 2021 · Frontiers in Aging
  49. Paracrine ADP Ribosyl Cyclase-Mediated Regulation of Biological Processes
    Cecilia Astigiano, Andrea Benzi, Maria Elena Laugieri, Francesco Piacente, Laura Sturla, Lucrezia Guida, Santina Bruzzone, Antonio DE FLORA · 2022 · Cells
  50. Mechanism of CD38 via NAD + in the Development of Non-alcoholic Fatty Liver Disease
    Min Dong, Shuo Wang, Zuowei Pei · 2023 · International Journal of Medical Sciences
  51. Nicotinamide riboside and dietary restriction effects on gut microbiota and liver inflammatory and morphologic markers in cafeteria diet–induced obesity in rats
    Larisse Longo, Josimar Macedo de Castro, Melina Belén Keingeski, Pabulo Henrique Rampelotto, Dirson João Stein, Gabriel Tayguara Silveira Guerreiro, Valessa Emanoele Gabriel de Souza, Carlos Thadeu Schmidt Cerski, Carolina Uribe Cruz, Iraci Lucena da Silva Torres et al. · 2023 · Nutrition
  52. Design of new CD38 inhibitors based on CoMFA modelling and molecular docking analysis of 4‑amino-8-quinoline carboxamides and 2,4-diamino-8-quinazoline carboxamides
    Bakhtyar Sepehri, Raouf Ghavami · 2018 · SAR and QSAR in environmental research
  53. NAD+-Consuming Enzymes in Stem Cell Homeostasis
    Xiuna Ji, Mingyue Zheng, Tao Yu, Jie Kang, Ting‐Jun Fan, Bin Xu · 2023 · Oxidative Medicine and Cellular Longevity
  54. Unveiling the role of NAD glycohydrolase CD38 in aging and age-related diseases: insights from bibliometric analysis and comprehensive review
    Xianghui Zhao, Peiying Lv, Zixing Cai, Jun Dong, Wenxiang Chen, Liang Sun, Ruiyue Yang · 2025 · Frontiers in Immunology
  55. NAD+ glycohydrolases-CD38 as a therapeutic target in aging: physiological roles, molecular mechanisms, and future opportunities in anti-aging research
    Jing-Yu Sun, Zhifei Wang, Wenhui Xu, Jun Zhao · 2025 · Biochemical Pharmacology
  56. Regulating the regulators via targeting CD38 in the tumor microenvironment
    Navnita Dutta, Nabanita Halder, Eduardo N. Chini, Sungjune Kim, Alak Manna · 2026 · Frontiers in Immunology
  57. Functional identification of soluble uric acid as an endogenous inhibitor of CD38
    Shijie Wen, Hiroshi Arakawa, Shigeru Yokoyama, Yoshiyuki Shirasaka, Haruhiro Higashida, Ikumi Tamai · 2024 · eLife
  58. The Purinergic Landscape of Non-Small Cell Lung Cancer
    Serena Janho dit Hreich, Jonathan Benzaquen, Paul M Hofman, Valérie Vouret‐Craviari · 2022 · Cancers
  59. Role of Liver CD38 in the Regulation of Metabolic Pathways during Cold-Induced Thermogenesis in Mice
    Andrea Benzi, Sonia Spinelli, Laura Sturla, Markus Heine, Alexander W. Fischer, Friedrich Koch‐Nolte, Hans‐Willi Mittrücker, Andreas H. Guse, Antonio DE FLORA, Jöerg Heeren et al. · 2022 · Cells
  60. Stimulation of natural killer cells with small molecule inhibitors of CD38 for the treatment of neuroblastoma
    Catherine M. Mills, Thomas Zachary Benton, Ivett C. Piña, Megan J. Francis, Leticia Reyes, Nathan G. Dolloff, Yuri Karl Peterson, Patrick M. Woster · 2023 · Chemical Science
  61. Characterization, Preclinical Efficacy and Toxicity Evaluations of Flavonoids Glycosides based Standardized Fenugreek Seed Extract (FEFLG)
    Prasad Arvind Thakurdesai, Pallavi Deshpande, Mukul P Pore · 2023 · Pharmacognosy Journal
  62. Comparison of monoclonal antibodies targeting CD38, SLAMF7 and PD-1/PD-L1 in combination with Bortezomib/Immunomodulators plus dexamethasone/prednisone for the treatment of multiple myeloma: an indirect-comparison Meta-analysis of randomised controlled trials
    Ye Wu, Xia Wu, Xiaoyan Liu, Xue Yan Zheng, Jili Deng, Yuping Gong · 2021 · BMC Cancer
  63. Enzymatic and microenvironmental regulation in adenosine metabolism-mediated immunosuppression
    Chuang Li, Lifeng Chen, Zhihao Li, Ling Liang, Benyong Lou · 2026 · Frontiers in Immunology
  64. CD38 Inhibitor 78c Attenuates Pro-Inflammatory Cytokine Expression and Osteoclastogenesis in Macrophages
    William Lory, Nityananda Chowdhury, Bridgette Wellslager, Subramanya N. M. Pandruvada, Yan Qin Huang, Özlem Yilmaz, Hong H. Yu · 2024 · Cells
  65. CD38 deficiency promotes skeletal muscle and brown adipose tissue energy expenditure through activating NAD+-Sirt1-PGC1α signaling pathway
    Qi Ding, Ke Wen, Qian Li, Qi‐Hang Zhao, Jia-Le Zhao, Yun‐Fei Xiao, Xiao‐Hui Guan, Meixiu Jiang, Feng Zhang, Ling-Fang Wang · 2023 · Canadian Journal of Physiology and Pharmacology
  66. Targeting of CD38 and other NAD-dependent Enzymes in Leukemia Patients
    Zainab Hillel, Zainab N. Al-Abady · 2023 · Journal of Biomedicine and Biochemistry
  67. Snake venom NAD glycohydrolases: primary structures, genomic location, and gene structure
    Ivan Koludarov, Steven Douglas Aird · 2019 · PeerJ
  68. The omics based study for the role of superoxide dismutase 2 (SOD2) in keratinocytes: RNA sequencing, antibody-chip array and bioinformatics approaches
    Hai-Long Li, Jae-Rin Lee, Myong‐Joon Hahn, Jun‐Mo Yang, Fanguo Meng, Jiawei Wu, Yong‐Doo Park · 2019 · Journal of Biomolecular Structure and Dynamics
  69. Cardiomyocyte specific CD38 deletion protects heart from acute myocardial infarction by activating Sirt3 signaling pathway
    Ke Wen, Yating Zhang, Qi‐Hang Zhao, Qian Li, Jia-Le Zhao, Qi Ding, Yun‐Fei Xiao, Xiao‐Hui Guan, Meixiu Jiang, Yisong Qian et al. · 2025 · Scientific Reports
  70. CD38-NAD(+) Axis: New Insights into Glaucoma Therapy
    Wenyige Zhang, Haina Zheng, Yulian Pang, Yujia Wang, Xu Zhang · 2025 · Molecular Neurobiology
  71. Small Molecule CD38 Inhibitors: Synthesis of 8-Amino-N1-inosine 5′-monophosphate, Analogues and Early Structure-Activity Relationship
    Joanna M. Watt, Richard Milton Graeff, Barry V. L. Potter · 2021 · Molecules
  72. Protein Acetylation and NAD+ Homeostasis in Aging Muscle
    Li Li Ji · 2025 · Advances in experimental medicine and biology
  73. A comprehensive analysis reveals the relationship between artificial sweeteners and prostate cancer
    Kuiyuan Zhang, Bangwei Che, Pudong Gao, Wei Li · 2025 · Frontiers in Nutrition
  74. MITA/STING-driven CD38 induction in Siglec-Flow macrophages promotes regulatory T cell survival and non-small cell lung cancer progression
    Zhi-Dong Zhang, Yu-Lin Lin, Han-Yue Zhang, Cong Zuo, Zhong-Lin ZHU, Xing-Yuan Wang, Hao-Yu DUAN, Junjie Zhang, Dandan Lin, Bo Zhong · 2026 · Developmental Cell
  75. Evolving understandings for the roles of CD38 protein in autoimmunity and autoimmune disease
    Xiaochun Ye, Jieying Zhang, Mengping Song, Ping Wang, Irma Arés, Bernardo López-Torres, Marta Martínez, María‐Rosa Martínez‐Larrañaga, Jorge-Enrique Maximiliano, Arturo Anadón et al. · 2026 · Clinical & Experimental Immunology
  76. Therapeutic Potential of ACMSD Inhibitors in NAD+ Deficient Diseases
    Min Chen, Hua Zhang, Pengfei Ji · 2025 · Drugs and Drug Candidates
  77. The Role of NAD+ in Anti-Aging Therapies
    Xu-Qian Liu, Tao-Sheng Huang · 2019 · American Journal of Biomedical Science & Research
  78. Profiling Glutathionylome in CD38-Mediated Epithelial–Mesenchymal Transition
    Yingying Ma, Songbiao Zhu, Meiqi Yi, Wenhao Zhang, Yuanyuan Xue, Xiaohui Liu, Haiteng Deng · 2022 · Journal of Proteome Research
  79. CD38 deficiency prevents diabetic nephropathy by inhibiting lipid accumulation and oxidative stress through activation of the SIRT3 pathway
    Ling-Fang Wang, Qian Li, Jia Le Zhao, Ke Wen, Yating Zhang, Qi‐Hang Zhao, Qi Ding, Jiahui Li, Xiao‐Hui Guan, Yun‐Fei Xiao et al. · 2024 · Biochemistry and Cell Biology
  80. Emerging antibody therapies for pancreatic adenocarcinoma: a review of recent phase 2 trials
    Jasmeet Kaur, Paramveer Singh, Thomas Enzler, Vaibhav Sahai · 2021 · Expert Opinion on Emerging Drugs
  81. Qualia NAD+® Increases NAD+ Levels In Human Participants: A Double-Blind, Placebo-Controlled Study
    Sarah A. Blomquist, Gregory Kelly, Sara Adães, Christopher R. D’Adamo, Abhimanyu Ardagh, Shawn Ramer, William Scuba · 2025 · medRxiv
  82. Rapid Discovery of CD38 Inhibitor via DNA-Encoded Natural Product Library Screening
    Xinyu Shi, Ze Liang, Wentao Meng, Guang Yang, Lei Yan · 2026 · Molecules
  83. Discovery of Potent and Orally Bioavailable Novel Cluster of Differentiation 38 (CD38) Small Molecule Inhibitors
    Reza Shiroodi, Timothy J. Montavon, Brandon M. Nelson, John T. Randolph, Daniel E. O’Flynn, Leo Iu, Charles W. Hutchins, Tomas Baikstis, Javier Izquierdo, Don Smyth et al. · 2026 · Journal of Medicinal Chemistry
  84. Dysfunction of the CD38-Miro1 Axis Disrupts Astrocyte-neuron Mitochondrial Transfer in Alzheimer’s Disease: Mechanisms and Therapeutic Restoration
    Ahmed M Abdelaziz, Mustafa M Shokr, Mohamed K. Fathy, Mohamed N Fawzy · 2026 · Journal of Molecular Neuroscience
  85. Bioenergetic impairment-induced Tau acetylation: Converging pathways in Alzheimer’s disease
    Basavaraju K C, Poornima Priyadarshini C. G. · 2026 · International review of neurobiology
  86. Cd38 A Biomarker and Therapeutic Target in Non-Hematopoietic Tumors
    Susana G Barrientos-Robledo, Jorge Cebada, Juan Carlos Rodríguez‐Alba, Shantal Lizbeth Baltierra‐Uribe, María Alicia Díaz y Orea, Héctor Romero‐Ramírez · 2022 · Biomarkers in Medicine
  87. CAR-T cell therapy for multiple myeloma: An update on the current state and future potential
    Prateek A. Pophali, Jacalyn M. Rosenblatt, David Avigan · 2025 · Best Practice & Research Clinical Haematology
  88. Oxidative stress-induced proinflammatory secretion from retinal pigment epithelium disrupts NAD+ metabolism via CD38 on macrophages leading to immune microenvironment dysregulation
    Ruoyi Lin, Feng Liang, Chengyu Hu, Lei Jiang, Zhongqi Wan, Zihang Xu, Yunhong Luo, Jingyang Ma, Yan Wu, Wenting Cai et al. · 2025 · Free Radical Biology and Medicine
  89. Novel Roles for the Ectoenzyme CD38 in the Maintenance of Transcriptional and Metabolic Homeostasis in Astrocytes
    S. Basak, Alana M Colafrancesco, Raymundo D. Hernandez, Xiaoran Wei, Laura J. McMeekin, D. Dang, Megan Simmons, Jack L. Browning, K. Noel, Fuguo Zhou et al. · 2025 · Glia
  90. CD38 promotes LPS-induced innate-like activation and proliferation of CD8+ T lymphocytes in aged mice
    Wendolaine Santiago‐Cruz, Enrique Espinosa, Jocelyn C. Pérez-Lara, Héctor Romero‐Ramírez, Priyadharshini Devarajan, Fabio García‐García, Juan Carlos Rodríguez‐Alba · 2025 · Frontiers in Aging
  91. Integrative meta-GWAS and lipidomics reveal genetic regulators of nutritional fatty acids and lipid metabolites in chicken liver lipid accumulation
    Bingxing An, Na Luo, Peihao Liu, Limin Wei, Lingzhao Fang, Jie Wen, Guiping Zhao · 2026 · Journal of Agriculture and Food Research
  92. Precision targeting of CD38 in immune thrombocytopenia: Mechanistic foundations and therapeutic implications
    Xin Zhou, Yubao Liu, Peipei Zhang, Ningning Shan · 2026 · European Journal of Pharmacology
  93. Targeting Age-Associated Immune Senescence via Nanoparticle-Based Metabolic Reprogramming
    Preethi Gopalakrishnan Nair, B. S. Unnikrishnan, Vishnu Vijay Vijayan, Susan E. Howlett, Pieter R. Cullis, Shashi Ashok Gujar · 2026 · ACS Nano
  94. Apigenin Protects Against Cisplatin-Induced Cardiotoxicity: Potential Involvement of CD38-Sirt3 Signaling in Rats
    Natticha Sumneang, Jannarong Intakhad, Worakan Boonhoh, Arnon Pudgerd, Orawan Wongmekiat, Anongporn Kobroob · 2026 · Molecules
  95. Effect of acipimox on skeletal muscle biochemistry, structure and function in older people with probable sarcopenia: an experimental medicine study
    Claire McDonald, Craig Alderson, Matthew G. Birkbeck, Silvia Del Din, Gráinne S. Gorman, Kieren G. Hollingsworth, Cameron Kirk, Clare Massarella, Lynn Rochester, Helen A. L. Tuppen et al. · 2025 · GeroScience
  96. Elucidation of the cell signaling pathways mediating innate immunity and host-pathogen interactions
    Neel R. Nabar · 2019 · Figshare
  97. PRMT5 regulates the NAD-SIRT1-p53 signal axis by affecting the methylation of CD38 at R58 to promote malignant tumor cell proliferation
    Yanhong Zhou, Lin Liang, Chunxue Yue, Wentao Li, Mengxiang Gao, Feng Zeng, Junyu He, Zhengxi He, Xi Jin, Qianjin Liao et al. · 2022 · Research Square
  98. Peer Review #2 of "Snake venom NAD glycohydrolases: primary structures, genomic location, and gene structure (v0.1)"
    2019 · PeerJ
  99. Peer Review #2 of "Snake venom NAD glycohydrolases: primary structures, genomic location, and gene structure (v0.2)"
    2019 · PeerJ
  100. Comparison of Monoclonal Antibodies targeting CD38, SLAMF7 and PD-1/PD-L1 in combination with Bortezomib/Immunomodulators plus Dexamethasone/Prednisone for the treatment of Multiple Myeloma: An Indirect-Comparison Meta-Analysis of Randomized Controlled Trials
    Ye Wu, Xia Wu, Xiaoyan Liu, Xue Li Zheng, Jili Deng, Yuping Gong · 2020 · Research Square