The Pharmacology of CD38/NADase: An Emerging Target in Cancer and Diseases of Aging
Open accessAbstract
Recent reports indicate that intracellular NAD levels decline in tissues during chronological aging, and that therapies aimed at increasing cellular NAD levels could have beneficial effects in many age-related diseases. The protein CD38 (cluster of differentiation 38) is a multifunctional enzyme that degrades NAD and modulates cellular NAD homeostasis. At the physiological level, CD38 has been implicated in the regulation of metabolism and in the pathogenesis of multiple conditions including aging, obesity, diabetes, heart disease, asthma, and inflammation. Interestingly, many of these functions are mediated by CD38 enzymatic activity. In addition, CD38 has also been identified as a cell-surface marker in hematologic cancers such as multiple myeloma, and a cytotoxic anti-CD38 antibody has been approved by the FDA for use in this disease. Although this is a remarkable development, killing CD38-positive tumor cells with cytotoxic anti-CD38 antibodies is only one of the potential pharmacological uses of targeting CD38. The present review discusses the biology of the CD38 enzyme and the current state of development of pharmacological tools aimed at CD38, and explores how these agents may represent a novel approach for treating human conditions including cancer, metabolic disease, and diseases of aging.
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Evidence is accumulating that inhibiting CD38 and other NAD+-consuming enzymes, such as PARPs, could be a promising way to boost NAD+ and extend human healthspan.
“Overall, mounting evidence suggests that targeting CD38 and related NAD+-consuming enzymes, such as PARPs, has great potential as an NAD+-boosting target to extend human healthspan, and several pharmacological approaches are in development to inhibit CD38 and its NADase activity232 (TABLE 1).”
From NAD+ metabolism and its roles in cellular processes during ageing (2021) · cites this paper as [232]
Several pharmacological approaches to inhibit CD38 and its NADase activity are being developed.
“Overall, mounting evidence suggests that targeting CD38 and related NAD+-consuming enzymes, such as PARPs, has great potential as an NAD+-boosting target to extend human healthspan, and several pharmacological approaches are in development to inhibit CD38 and its NADase activity232 (TABLE 1).”
From NAD+ metabolism and its roles in cellular processes during ageing (2021) · cites this paper as [232]
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Yoshino, J. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.02.002 · Cited by 26 · see citing works
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CD38 downregulation modulates NAD+ and NADP(H) levels in thermogenic adipose tissues
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- Authors
- Chini, E. N., Chini, C. C. S., Espindola Netto, J. M., de Oliveira, G. C., & van Schooten, W.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Chini, Eduardo N.
- Venue
- Trends in Pharmacological Sciences
- Publisher
- Elsevier BV
- Published
- 2018-04
- Volume
- 39
- Issue
- 4
- Pages
- 424-436
- ISSN
- 0165-6147 (ISSN-L)
- PMC
- PMC5885288
- OpenAlex
- W2788868093
- Cited by
- 227
- References
- 85
- Citations by year
- 2026: 22 · 2025: 27 · 2024: 19 · 2023: 28 · 2022: 37 · 2021: 28 · 2020: 32 · 2019: 27 · 2018: 7
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Trends in Pharmacological Sciences (acceptedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Ted Nash Long Life Foundation
- National Institute of Aging (AG-26094)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Keywords
- CD38, NADase, NAD+ homeostasis, aging, age-related diseases, cancer, multiple myeloma, anti-CD38 monoclonal antibody, NAD+ precursors, metabolic disorders, obesity, diabetes mellitus, inflammation, hematologic cancer
- MeSH terms
- Aging, Animals, Antibodies, Humans, NAD, NAD+ Nucleosidase, Neoplasms, ADP-ribosyl Cyclase 1, Small Molecule Libraries, Molecular Targeted Therapy
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