Metformin as an Anticancer Agent

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Items 101–200 of 277

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3. Metformin – a new approach
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7. Metformin as an Adjuvant to Photodynamic Therapy in Resistant Basal Cell Carcinoma Cells
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8. Nano Liposomal and Cubosomal Formulations with Platinum-Based Anticancer Agents: Therapeutic Advances and Challenges
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13. Patient-derived microphysiological model identifies the therapeutic potential of metformin for thoracic aortic aneurysm
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14. Co-encapsulation of metformin hydrochloride and reserpine into flexible liposomes: Characterization and comparison of in vitro release profile
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15. Phenformin inhibits proliferation, invasion, and angiogenesis of cholangiocarcinoma cells via AMPK-mTOR and HIF-1A pathways
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16. Antitumor Activity of Combination Therapy with Metformin and Trametinib in Non-Small Cell Lung Cancer Cells
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17. Metformin prevents BAFF activation of Erk1/2 from B-cell proliferation and survival by impeding mTOR-PTEN/Akt signaling pathway
    Xiaoling Chen, Jing Ma, Yajie Yao, Jiawei Zhu, Zhihan Zhou, Rui Zhao, Xiaoqing Dong, Wei Gao, Shuangquan Zhang, Shile Huang et al. · 2021 · International Immunopharmacology
18. Exploring the synergistic effects of metformin and doxorubicin loaded chitosan nanoparticles for A549 lung cancer therapy
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19. The development and benefits of metformin in various diseases
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20. Phase I / II trial of metformin as a chemo-radiosensitizer in a head and neck cancer patient population
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21. Metformin inhibits the growth of SCLC cells by inducing autophagy and apoptosis via the suppression of EGFR and AKT signalling
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22. Respiratory complex I regulates dendritic cell maturation in explant model of human tumor immune microenvironment
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23. Pretreatment with metformin protects mice from whole-body irradiation
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24. Anticancer properties of novel pyrazole‐containing biguanide derivatives with activating the adenosine monophosphate‐activated protein kinase signaling pathway
    Sichun Zhou, Leichuan Xu, Mengru Cao, Zhiren Wang, Di Xiao, Simeng Xu, Jun Deng, Xin Hu, Caimei He, Ting Tao et al. · 2019 · Archiv der Pharmazie
25. Clinical relevance of ARF/ARL family genes and oncogenic function of ARL4C in endometrial cancer
    Jiawen Zhang, Qinyi Zhang, Cong Sun, Yanjuan Huang, Jing Zhang, Qingying Wang · 2020 · Biomedicine & Pharmacotherapy
26. Metformin reverse minocycline to inhibit minocycline-resistant Acinetobacter baumannii by destroy the outer membrane and enhance membrane potential in vitro
    Tingting Guo, Xiaoli Sun, Jie Yang, Liying Yang, Mengying Li, Yuhang Wang, Hongmei Jiao, Guocai Li · 2022 · BMC Microbiology
27. Synergistic Enhancement of Paclitaxel-induced Inhibition of Cell Growth by Metformin in Melanoma Cells
    Gihyun Ko, Taehyung Kim, Eunjeong Ko, Deokbae Park, Youngki Lee · 2019 · Development & Reproduction
28. Proteomics-based target identification of natural products affecting cancer metabolism
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29. Effects of metformin on tumor hypoxia and radiotherapy efficacy: a [18F]HX4 PET imaging study in colorectal cancer xenografts
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30. Activation of Adenosine Monophosphate—Activated Protein Kinase Reduces the Onset of Diet‐Induced Hepatocellular Carcinoma in Mice
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31. Inhibition of multiple uptake transporters in cardiomyocytes/mitochondria alleviates doxorubicin-induced cardiotoxicity
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32. Obesity-specific improvement of lung cancer outcomes and immunotherapy efficacy with metformin
    Randall J. Smith, Robert A. Zollo, Sukumar Kalvapudi, Yeshwanth Vedire, Akhil Goud Pachimatla, Cara M. Petrucci, Garrison Shaller, Deschana Washington, R. Robert Vethanayagam, Stephanie N. Sass et al. · 2024 · JNCI Journal of the National Cancer Institute
33. Could metformin be therapeutically useful in Huntington’s disease?
    Bor Luen Tang · 2019 · Reviews in the Neurosciences
34. Identification of osalmid metabolic profile and active metabolites with anti-tumor activity in human hepatocellular carcinoma cells
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35. Metformin Triggers Apoptosis and Induction of the G0/G1 Switch 2 Gene in Macrophages
    Xuming Hu, Huan Luo, Chunfeng Dou, Xujing Chen, Yi Huang, Liping Wang, Songlei Xue, Zhen Sun, Shihao Chen, Qi Xu et al. · 2021 · Genes
36. Targeting pancreatic stellate cells in chronic pancreatitis: Focus on therapeutic drugs and natural compounds
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37. Ternary Cobalt (II)-Metformin-Glycine/Histidine/Proline Complexes: Multispectroscopic DNA, HSA, and BSA Interaction and Cytotoxicity Studies
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38. Revisiting Circulating Extracellular Matrix Fragments as Disease Markers in Myelofibrosis and Related Neoplasms
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39. Age Is Just a Number: Progress and Obstacles in the Discovery of New Candidate Drugs for Sarcopenia
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40. Postdiagnostic metformin use and survival of patients with colorectal cancer: A Nationwide cohort study
    Wen‐Kuan Huang, Shu‐Hao Chang, Hung‐Chih Hsu, Wen‐Chi Chou, Tsai‐Sheng Yang, Jen‐Shi Chen, John Wen‐Cheng Chang, Yung‐Chang Lin, Chang‐Fu Kuo, Lai‐Chu See · 2020 · International Journal of Cancer
41. Metformin and bladder cancer: Drug repurposing as a potential tool for novel therapy: A review
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42. Role of the AMPK/ACC Signaling Pathway in TRPP2‐Mediated Head and Neck Cancer Cell Proliferation
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43. Activation of AMPK inhibits cervical cancer growth by hyperacetylation of H3K9 through PCAF
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44. A siramesine-loaded metal organic framework nanoplatform for overcoming multidrug resistance with efficient cancer cell targeting
    Jiahui Liu, Menghuan Tang, Yanghao Zhou, Yijuan Long, Yuan Zeng Cheng, Huzhi Zheng · 2020 · RSC Advances
45. Alteration of Cholesterol Metabolism by Metformin Is Associated With Improved Outcome in Type II Diabetic Patients With Diffuse Large B-Cell Lymphoma
    Xiang‐Nan Jiang, Yan Zhang, Weige Wang, Dong Sheng, Xiaoyan Zhou, Xiaoqiu Li · 2021 · Frontiers in Oncology
46. The Dual Role of Metformin: Repurposing an Antidiabetic Drug for Cancer Therapy
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47. HBXIP blocks myosin-IIA assembly by phosphorylating and interacting with NMHC-IIA in breast cancer metastasis
    Lu Zhang, Xiaolei Zhou, Bowen Liu, Xu-he Shi, Xian-meng Li, Feifei Xu, Xueli Fu, Xue Wang, Kai Ye, Tianzhi Jin et al. · 2022 · Acta Pharmaceutica Sinica B
48. Oxidative stress in pituitary neuroendocrine tumors: Affecting the tumor microenvironment and becoming a new target for pituitary neuroendocrine tumor therapy
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49. Effects of novel pyrrolomycin MP1 in MYCN amplified chemoresistant neuroblastoma cell lines alone and combined with temsirolimus
    Timothy R. McGuire, Donald W. Coulter, Dachang Bai, Jason A. Sughroue, Jerry Li, Zunhua Yang, Zhen Qiao, Yan Liu, Daryl J. Murry, Yashpal Singh Chhonker et al. · 2019 · BMC Cancer
50. New Insight into Metformin Mechanism of Action and Clinical Application
    Yun Yan, Karen L. Kover, Wayne V. Moore · 2020 · IntechOpen eBooks
51. Metformin Suppresses the Proliferation and Promotes the Apoptosis of Colon Cancer Cells Through Inhibiting the Expression of Long Noncoding RNA-UCA1
    Jianbo Guo, Yan Li, He Duan, Yuan Lu · 2020 · OncoTargets and Therapy · Retracted
52. Combination of metformin and cold atmospheric plasma induces glioma cell death to associate with c-Fos
    Fan Yang, Yuanshuai Zhou, Huidan Yu, Jiao Yang, Cheng Gang Zhu, Nafees Ahmad, Xingjun Meng, Rongchuan Zhao, Jie Zhuang, Minxuan Sun · 2020 · Neoplasma
53. Synergistic anticancer effects of metformin and Achillea vermicularis Trin-loaded nanofibers on human pancreatic cancer cell line: An in vitro study
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54. Association between visceral obesity, metformin use, and recurrence risk in early-stage colorectal cancer
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55. Proteomic Characterization of a 3D HER2+ Breast Cancer Model Reveals the Role of Mitochondrial Complex I in Acquired Resistance to Trastuzumab
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56. Identification of Antidiabetic Compounds from the Aqueous Extract of Sclerocarya birrea Leaves
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57. A Model-System to Address the Impact of Phenotypic Heterogeneity and Plasticity on the Development of Cancer Therapies
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58. Metformin Inducing the Change of Functional and Exhausted Phenotypic Tumor-Infiltrated Lymphocytes and the Correlation with JNK Signal Pathway in Triple-Negative Breast Cancer
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59. Sol-gel synthesis, physicochemical characteristics and in vitro pH-responsive metformin drug release of uniformly polydopamine coated mesoporous silica nanospheres
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60. Metformin inhibits pathological retinal neovascularization but promotes retinal fibrosis in experimental neovascular age-related macular degeneration
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61. A Retrospective Study on the Role of Metformin in Colorectal Cancer Liver Metastases
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62. Efficacy of metformin and electrical pulses in breast cancer MDA-MB-231 cells
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63. Metformin Restores the Drug Sensitivity of MCF-7 Cells Resistant Derivates via the Cooperative Modulation of Growth and Apoptotic-Related Pathways
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64. Metformin inhibits the activation of melanocortin receptors 2 and 3 in vitro: A possible mechanism for its anti-androgenic and weight balancing effects in vivo?
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66. Repurposing Metformin in Precision Oncology: Mechanistic Insights, Biomarker-Guided Strategies, and Translational Imperatives
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67. Multidimensional mechanisms of metformin in cancer treatment
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68. Enhanced anticancer effect of lysozyme-functionalized metformin-loaded shellac nanoparticles on a 3D cell model: role of the nanoparticle and payload concentrations
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69. Functional co-delivery nanoliposomes based on improving hypoxia for increasing photoimmunotherapy efficacy of cold tumors
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70. Recent advances in single-cell metabolomics using mass spectrometry: emerging challenges and future perspectives
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71. Metformin inhibits nerve growth factor-induced sympathetic neuron differentiation through p35/CDK5 inhibition
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72. Effect of metformin use on the risk and prognosis of ovarian cancer: an updated systematic review and meta-analysis
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73. Citrate Transporter Inhibitors: Possible New Anticancer Agents
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74. Commentary: Lactate-Induced Glucose Output Is Unchanged by Metformin at a Therapeutic Concentration—A Mass Spectrometry Imaging Study of the Perfused Rat Liver
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75. Novel mechanism whereby metformin improves glucose homeostasis: TXNIP–GLUT1 axis modulation enhances intestinal glucotonic effects
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76. A new link between apoptosis induced by the metformin derivative HL156A and autophagy in oral squamous cell carcinoma
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77. Super-Resolution Quantification of T2DM-Induced Mitochondrial Morphology Changes and Their Implications in Pharmacodynamics of Metformin and Sorafenib
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78. Axitinib attenuates the progression of liver fibrosis by restoring mitochondrial function
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79. A Comprehensive Study of P-g-C3N4/MOF-199 Composite for Electrochemical Sensing of Metformin in Pharmaceutical Samples
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80. Repurposing of atorvastatin and metformin denotes their individual and combined antiproliferative effects in non‐small cell lung cancer
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81. Versatile carrier-free binary nanodrug based on metformin/epigallocatechin gallate nanoparticles: exploring its properties and potential in cancer treatment
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82. Combining Sulfonylureas with Anticancer Drugs: Evidence of Synergistic Efficacy with Doxorubicin In Vitro and In Vivo
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83. The Effect of Metformin on Bladder Cancer Incidence and Outcomes: A Systematic Review and Meta-Analysis
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84. Effects of Cisplatin Combined with Metformin on Proliferation and Apoptosis of Nasopharyngeal Carcinoma Cells
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85. Dual-Ligand-Modified Nanoscale Liposomes Loaded with Curcumin and Metformin Inhibit Drug Resistance and Metastasis of Hepatocellular Carcinoma
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90. Synthesis and characterization of some Metal ions complexes with mixed ligand of azo dye and Metformin and evaluation of its effectiveness on the growth of some pathogenic bacteria clinically isolated and study of its Toxicity on normal and cancerous Hepatocytes
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91. Oxoaporphine-Metformin Rhodium(III) Mixed Complex Achieving Dual Antidiabetes and Anticancer Effects by Interfering with Glucose Metabolism Reprogramming.
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92. Metformin and its derivatives in breast cancer: from glycaemic control to tumor-intrinsic pathways
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93. Evaluating [18F]FDG and [18F]FLT Radiotracers as Biomarkers of Response for Combined Therapy Outcome in Triple-Negative and Estrogen-Receptor-Positive Breast Cancer Models
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94. Genetic effect of metformin use on risk of cancers: evidence from Mendelian randomization analysis
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95. Combating Drug Resistance in Lung Cancer: Exploring the Synergistic Potential of Metformin and Cisplatin in a Novel Combination Therapy; A Systematic Review
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96. Identification of patient characteristics associated with survival benefit from metformin treatment in patients with stage I non–small cell lung cancer
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97. LGR5/mTORC2 axis regulates cellular metabolic plasticity to maintain tumorigenesis in hepatocellular carcinoma
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98. Synthesis, characterization, DFT calculations, molecular docking, ADMET analysis and biological activity of Schiff base metal complexes against colon cancer cells
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99. Metformin alleviates doxorubicin-induced hepatic damage by modulating oxidative stress: a molecular, biochemical, and histopathological approach in a rat model
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100. Metformin and its Nanoformulations in Cancer Prevention and Therapy
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