Metformin as an Anticancer Agent

Vancura, Ales, Bu, Pengli, Bhagwat, Madhura, Zeng, Joey, Vancurova, Ivana·2018·Trends in Pharmacological Sciences

Cited by (277)

Items 201–277 of 277

  1. Combination of Metformin and Laser against Head and Neck Cancer Cells In Vitro
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  2. Metformin synergistically increases the anticancer effects of lapatinib through induction of apoptosis and modulation of Akt/AMPK pathway in SK-BR3 breast cancer cell line.
    Davood Neamati, Azam Khedri, Mohammad Aberomand, Ali Asghar Hemati, Maryam Mohammadzadeh, Kourosh Akbari Baghbani, Ghorban Mohammadzadeh · 2021 · PubMed Central
  3. Evaluation of PEN2-ATP6AP1 axis as an antiparasitic target for metformin based on phylogeny analysis and molecular docking
    Congshan Liu, Shangrui Zhang, Jian Xue, Haobing Zhang, Jianhai Yin · 2023 · Molecular and Biochemical Parasitology
  4. Mitochondria and Tumor Metabolic Flexibility: Mechanisms and Therapeutic Perspectives
    Amandine M.F. Rovini, Kareem A. Heslop, Eduardo N. Maldonado · 2021 · Elsevier eBooks
  5. Synthesis and Anticancer Activity of Metformin‐Phenolic Acid Conjugates
    Biswajit Banerjee, Tripti Sharma, Sabyasachi Banerjee, Subhasis Banerjee, Arijit Mondal · 2025 · Chemistry & Biodiversity
  6. MALAT1 DEREPRESSES MIR-433-3P–MEDIATED RPTOR SUPPRESSION TO IMPAIR AUTOPHAGY AND DRIVE PYROPTOSIS IN ENDOTOXEMIA
    Kun Wu, Xiangyou Yu, Yi Wang, Xiang Li, Yuanyuan An, Zuyi Zhao, Long Ma · 2023 · Shock
  7. SMAD4 inhibits glycolysis in ovarian cancer through PI3K / AKT / HK2 signaling pathway by activating ARHGAP10
    Kui Wu, Wei Gong, Huanmei Sun, Wenjiao Li, Li Chen, Yingchun Duan, Jianlong Zhu, Hu Zhang, Huihui Ke · 2024 · Cancer Reports
  8. Effects of Biguanide-PROTACs in Pancreatic Cancer Cells
    Julie Vatté, Véronique Bourdeau, Gerardo Ferbeyre, Andreea R. Schmitzer · 2024 · Molecules
  9. Paclitaxel loaded into metformin oleate ionic liquid micelle: Preparation and synergistic antitumor
    Jiahong Huang, De Bai, Lin Hua Xie, Tianqi Liu, Jichuan Zhang, Zhenye Zhu, Chengyu Wu, Jiaheng Zhang · 2024 · Journal of Molecular Liquids
  10. Stilbenoid derivatives as potent inhibitors of HIF-1α-centric cancer metabolism under hypoxia
    Tae-Hee Han, Joohan Lee, Dipesh S. Harmalkar, Hyeseul Kang, Guanghai Jin, Min Kyung Park, Minkyoung Kim, Hyun-A Yang, Jin Su Kim, Su Jeong Kwon et al. · 2024 · Biomedicine & Pharmacotherapy
  11. Epidemiology of Bladder Cancer
    Ali A. Nasrallah, Stephen Bentley Williams · 2024 · Springer eBooks
  12. A Novel Strategy for Preventing and Treating Cancer: Alteration of Cancer-Associated Chromatin Configuration
    Gao-De Li · 2021 · OALib
  13. The metformin administration on pancreatic tissue damage in metastatic rat prostate cancer and STZ induced diabetes model
    Pınar Köroğlu, Onur Ertik, Ömür Karabulut Bulan, Refiye Yanardağ · 2025 · Journal of Molecular Histology
  14. Repurposing holistic effects of metformin from diabetes management to skin wound healing: a 3PM-guided innovation
    Shaoyu Zhou, Kun Zhang, Bingjie Cai, Jingan Li, Guangwen Yin · 2025 · The EPMA Journal
  15. Synthetic lethality in cancer: mechanism exploration and therapeutic applications
    Pusong Zhao, Peng Wang, Tianqi Xu, Ligang Chen, Qingge Jia, M H Li · 2026 · Cell Communication and Signaling
  16. Features of blood parameters and adaptational status of Balb/c and C57Bl/6 mice lines in the absence of special influences
    Galina V. Zhukova, Elena Mikhaylovna Frantsiyants, Alla Ivanovna Shikhlyarova, Irina Viktorovna Kaplieva, Lidiya Konstantinovna Trepitaki, Polina Sergeevna Kachesova, Anastasia V. Galina, Н. Д. Ушакова, Elena Vladimirovna Shalashnaya, Ишонина Оксана Георгиевна · 2023 · South Russian Journal of Cancer
  17. BENEFITS OF METFORMIN USE BY BREAST AND COLORECTAL CANCER PATIENTS WITH TYPE 2 DIABBETES MILLITUS: A CASE-CONTROL STUDY IN JIJEL PROVINCE (ALGERIA)
    Arbia Abbes, Rihab Boudemia, Hocine Rechreche · 2023 · Journal of Applied Biological Sciences
  18. Targeting Cancer Metabolism Dependencies
    Kayla Harding · 2023 · CABI eBooks
  19. Metformin in Cervical Cancer: Metabolic Reprogramming
    Małgorzata Tyszka‐Czochara, Marcin Majka · 2019 · IntechOpen eBooks
  20. How to starve cancer cells when nutrients are abundant
    Hamidullah Khan, Stefan M. Schieke · 2020 · Molecular & Cellular Oncology
  21. THERAPEUTIC USE OF METFORMIN IN THYROID CANCER
    Fatimah Haitham Fathi, Ammar A. Y. Almulathanon, Jehan Abdulwahab Mohammad · 2022 · Military Medical Science Letters
  22. Metformin in the Era of New Antidiabetics
    Ez Alddin Rajjoub Al-Mahdi, Vivencio Barrios, José Luís Zamorano · 2021 · Future Cardiology
  23. Metformin Sensitizes Leukemic Cells to Cytotoxic Lymphocytes by Increasing Expression of Intercellular Adhesion Molecule-1 (ICAM-1)
    Nerea Allende-Vega, Joaquín Marco-Brualla, Paolo Falvo, Catherine Alexia, Michael Constantinides, Alexis Fayd’herbe de Maudave, Loïs Coënon, Delphine Gitenay, Giulia Mitola, Paul E. Massa et al. · 2021 · Research Square
  24. Respiratory Complex I Regulates Dendritic Cell Maturation in Explant Model of Human Tumor Immune Microenvironment
    Rita Turpin, Ruixian Liu, Pauliina Munne, Aino Peura, Jenna H. Rannikko, Gino Philips, Bram Boeckx, Natasha Salmelin, Elina Hurskainen, Ilida Suleymanova et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  25. Apoptotic and proliferative processes in the small intestine of rats with type 2 diabetes mellitus after metformin and propionic acid treatment
    Л.В. Натрус, Olha Lisakovska, Anton Smirnov, Yuliia Osadchuk, Yuliia Klys · 2024 · Frontiers in Pharmacology
  26. Association Between Metformin Use and Mortality Among Individuals With Non-Small Cell Lung Cancer Receiving Immune Checkpoint Inhibitors
    Xinyi Sun, James Heyward, Joseph Christopher Murray, G. Caleb Alexander, Hemalkumar B. Mehta · 2025 · Journal of Immunotherapy
  27. Metabolic Imprint of Poliovirus on Glioblastoma Cells and Its Role in Virus Replication and Cytopathic Activity
    Martin A. Zenov, Dmitry V. Yanvarev, Olga N. Ivanova, Ekaterina A. Denisova, Mikhail V. Golikov, Artemy P. Fedulov, Roman I. Frykin, Viktoria A. Sarkisova, Dmitry A. Goldstein, Peter M. Chumakov et al. · 2025 · International Journal of Molecular Sciences
  28. Sex differences in the skeletal muscle response to metformin treatment and the possible association with gut-muscle axis in rats
    Lin Song, Rui Wang, Jiaqi Cui, Shuyuan Hu, Jingyue Wang, Jiaming Xie, Pudan Miao, Bo Sun · 2025 · Frontiers in Endocrinology
  29. Cytokines at the Crossroads of Mitochondrial Dysfunction and Inflammation in Colorectal Cancer: Implications for Postoperative Complications
    Klara Vokacova, Natalie Danesova, Ladislav Sojka, Veronika Polakova Vymetalkova · 2026 · Molecular Diagnosis & Therapy
  30. Electrochemical detection of the antidiabetic agent metformin using nickel-cobalt layered double hydroxide (Ni–Co LDH)
    Shiny Abinaya Thennava Selvan, Jinsa Elizebeth Paul, Noel Nesakumar, John Bosco Balaguru Rayappan, Sergei A. Kulinich, Arockia Jayalatha Kulandaisamy · 2026 · Journal of Applied Electrochemistry
  31. Immune checkpoints and immunoregulation in metabolic diseases and cancers: pathological mechanisms and therapeutic potential
    Minmin Xiang, Shuang Liu, Desheng Xiao, Yongguang Tao · 2026 · Signal Transduction and Targeted Therapy
  32. A prognostic model for oral squamous cell carcinoma patients with type 2 diabetes mellitus
    Xin Hu, Haofeng Xiong, Shiying Huang, Liujun Zeng, Tong Su · 2023 · Archives of Oral Biology
  33. A metformina como uma droga coadjuvante no tratamento de diversos tipos de cânceres: uma revisão integrativa da literatura
    Rodrigo Daniel Zanoni, Camila Raffa Reinalde, Vitor Barbosa Vieira, Ana Patrícia da Silva Arruda Cavalcante, João Pedro De Alcântara, Natália Batista Meireles, Geoeselita Borges Teixeira, Marília Barreto Rodrigues, Carlos Eduardo de Oliveira Pereira · 2024 · Brazilian Journal of Health Review
  34. Diabetes Mellitus and the Risk of Carcinogenesis: An Interdisciplinary Approach
    Halina Tkaczenko, Piotr Kamiński, Natalia Kurhaluk · 2024 · Interdisciplinary cancer research
  35. A potential protective effect of metformin in adenoid cystic carcinoma
    Peter J. Lancione, Bhavna Kumar, Songzhu Zhao, Edmund A. Mroz, Guy Nathaniel Brock, James William Rocco, Ricardo Luis Carrau, Amit Agrawal, Nolan B. Seim, Stephen Y. Kang et al. · 2020 · Oral Oncology
  36. Antitumor Effect of Metformin in Combination with Binimetinib on Melanoma Cells
    Eunsung Lee, Yongjae Kwon, Jiwon Kim, Deokbae Park, Youngki Lee · 2021 · Development & Reproduction
  37. Metformin: A Small Molecule with Multi-Targets and Diverse Therapeutic Applications
    Adel Farid Badria, Ahmed R. Ali, Ahmed Elbermawi, Yhiya M. Amen, Adel Farid Badria · 2022 · IntechOpen eBooks
  38. Biguanides exert antitumoral actions in pituitary tumor cells through AMPK-dependent and -independent mechanisms
    Aura Dulcinea Herrera-Martínez, Mari Carmen Vazquez-Borrego, Antonio C. Fuentes-Fayos, Fernando L-Lopez, Alejandro Ibáñez‐Costa, Paloma Moreno-Moreno, María Rosa Alhambra-Expósito, Ana Barrera-Martín, Cristóbal Blanco-Acevedo, Elena Dios et al. · 2019 · Endocrine Abstracts
  39. Metformin Sensitizes Leukemic Cells to Cytotoxic Lymphocytes by Increasing Expression of Intercellular Adhesion Molecule-1 (ICAM-1)
    Nerea Allende-Vega, Joaquín Marco-Brualla, Paolo Falvo, Catherine Alexia, Michael Constantinides, Alexis Fayd’herbe de Maudave, Loïs Coënon, Delphine Gitenay, Giulia Mitola, Paul E. Massa et al. · 2021 · Research Square
  40. Effect of High-Dose Metformin on the Metabolic Parameters and Functional State of the Liver of Agouti Mice with Melanocortin Obesity
    Kira Viktorovna Derkach, Irina V. Romanova, Inna I. Zorina, A. A. Bakhtyukov, А. А. Перминова, Alexander O Ivantsov, Alexander Olegovich Shpakov · 2020 · Advances in Gerontology
  41. Metformin alleviates neuronal and renal related stress signals in diabetic C57BL/6 mice.
    Taskeen Fathima Docrat · 2019 · ResearchSpace (University of KwaZulu-Natal)
  42. Metformin in the prevention of colorectal cancer with diabetes mellitus
    И. В. Друк, Elena A. Lyalyukova, E. A. Fadeeva · 2022 · Экспериментальная и клиническая гастроэнтерология
  43. Metformin attenuates the progression of esophageal squamous cell carcinoma by downregulating miR-141-3p to enhance SCEL
    Shan Liu, Tianyou Chen, Fengying Jie · 2023 · Archives of Medical Science
  44. Novel Strategies for Metformin as an Anti-aging Drug in Skin Aging
    Gonul Kanigur-Sultuybek, Tuğba Soydaş · 2023 · Springer eBooks
  45. Advances in the mechanism of action of metformin in pituitary tumors
    Long-Yao Zhang, Yuhua Yin, Xuejian Wang · 2023 · World Journal of Meta-Analysis
  46. Correlation of the Components of the Metabolic Syndrome and Prostate Cancer
    晓涵 李 · 2023 · Advances in Clinical Medicine
  47. More on the Magic of Metformin
    Efstratios Koutroumpakis, Claire Huang-Lucas, Heinrich Taegtmeyer · 2023 · Cardiology
  48. Metformin mediates AMPK/KIF1B signalling pathway to inhibit metastasis in bladder cancer cells
    Tianbin Wen, Fei Huang, Mingyong Zha, Qi Wang, Yong Tang · 2023 · Research Square
  49. Protective effects of metformin against doxorubicin-induced hepatoxicity in rats
    Shabnam lal-Shahsavar, Naime Majidi Zolbanin, Abbas Jafari, Morteza Ghasemnejad‐Berenji · 2023 · Research Square
  50. Biguanide-PROTACs: Modulating Mitochondrial Proteins in Pancreatic Cancer Cells
    Julie Vatté, Véronique Bourdeau, Gerardo Ferbeyre, Andreea R. Schmitzer · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  51. Synergistic Effects of Sulfonylureas with Chemotherapeutics: In Vitro Screening Reveals Enhanced Cytotoxicity of Doxorubicin in Combination with Sulfonylureas
    Mateusz D. Tomczyk, Karolina Matczak, Marta Denel‐Bobrowska, Grzegorz Dzido, Anna Kubicka, Paulina Mędrala, Beata Powieczko, Waldemar Rzetelny, Agnieszka B. Olejniczak, Horacio Pérez‐Sánchez · 2024 · SSRN Electronic Journal
  52. An Assessment Article on the Cure of Sarcopenia and its Association with type 2 Diabetes in the Elderly
    Micah Isaac Anand W · 2023 · International Journal of Science and Research (IJSR)
  53. Examining the Effect of Metformin on Cell Death Mechanisms in Relation to Hippo Signaling in MDA-MB-231 Breast Cancer Cells
    Özge Rencüzoğulları, Zeynep Gülşah Sonalp · 2024 · Cumhuriyet Science Journal
  54. Fatty Acid Synthase (FASN) Inhibitors Suppress Metformin-Induced Fat Accumulation and Apoptosis in H4IIE Hepatocellular Carcinoma Cells
    Deokbae Park, Hye‐Jin Boo · 2024 · Development & Reproduction
  55. Interesting Metformin-based Derivatives with Versatile Pharmacology
    Rakesh Sahu, Kamal Shah · 2025 · Current Organic Chemistry
  56. Clenbuterol and metformin ameliorate cachexia parameters, but only clenbuterol reduces tumor growth via lipid peroxidation in Walker 256 tumor-bearing rats
    L.D.V. Henschel, M.E.R. de Lima, Francisco Eduardo Sampaio Fagundes, Thomas Horlem, Matheus Felipe Zazula, Katya Naliwaiko, Luiz Cláudio Fernandes · 2025 · Brazilian Journal of Medical and Biological Research
  57. Metabolic stress–mediated cell death and autophagy in human lung cancer cells
    Himani Joshi, Ying Huang, M. Saeed Sheikh · 2025 · Journal of Pharmacology and Experimental Therapeutics
  58. Additional file 1 of Activation of AMPK inhibits cervical cancer growth by hyperacetylation of H3K9 through PCAF
    Botao Pan, Liu, Can, Su, Jiyan, Xia, Chenglai · 2024 · Figshare
  59. Additional file 3 of Activation of AMPK inhibits cervical cancer growth by hyperacetylation of H3K9 through PCAF
    Botao Pan, Liu, Can, Su, Jiyan, Xia, Chenglai · 2024 · Figshare
  60. Additional file 1 of Genetic effect of metformin use on risk of cancers: evidence from Mendelian randomization analysis
    Chen, Yao, Bingjun Bai, Shuchang Ye, Gao, Xing, Xinnan Zheng, Kangkang Ying, Pan, Hongming, Xie, Binbin · 2023 · Figshare
  61. Additional file 2 of Activation of AMPK inhibits cervical cancer growth by hyperacetylation of H3K9 through PCAF
    Botao Pan, Liu, Can, Su, Jiyan, Xia, Chenglai · 2024 · Figshare
  62. Additional file 5 of Activation of AMPK inhibits cervical cancer growth by hyperacetylation of H3K9 through PCAF
    Botao Pan, Liu, Can, Su, Jiyan, Xia, Chenglai · 2024 · Figshare
  63. Additional file 6 of Activation of AMPK inhibits cervical cancer growth by hyperacetylation of H3K9 through PCAF
    Botao Pan, Liu, Can, Su, Jiyan, Xia, Chenglai · 2024 · Figshare
  64. Additional file 4 of Activation of AMPK inhibits cervical cancer growth by hyperacetylation of H3K9 through PCAF
    Botao Pan, Liu, Can, Su, Jiyan, Xia, Chenglai · 2024 · Figshare
  65. Metformin mitigates metabolic dysfunction-associated steatohepatitis in rats by altering steatosis-related micro-RNAs and Aquaporin-9
    Mohammad El-Nablaway, Mohamed Adel, Eslam Kamal Fahmy, Hossameldin Abouhish, Amal Fahmy Dawood, Mamdouh Basheir Eldesoqui · 2026 · Journal of Molecular Histology
  66. Du diabète au cancer : développement d'une nouvelle famille de molécules hybrides dérivées de la metformine : synthèse et caractérisation par RPE de sondes vectorisées pour l'étude du dysfonctionnement mitochondrial
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  67. EVT-701 : targeting electron transport chain complex I as therapeutic approach in cancer
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  68. Predicting stress-induced vulnerability to depression in diabetes
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  71. Targeting hexokinase 2 for cancer therapy: advances, limitations, and emerging opportunities in inhibitors and degraders
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  72. Mitochondria‐Homing Nanomedicine Triggers Metabolic Collapse for Synergistic Treatment of Metformin‐Resistant Breast Cancer
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  73. Preclinical and limited clinical evidence for metformin in ulcerative colitis: a systematic review and meta-analysis
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  74. Ellagic Acid and Metformin: In Vitro Synergy and Enhanced Cisplatin Efficacy In Vivo in Resistant Breast Cancer
    Balqis Jdaitawi, Moudi Mubarak Alasmari, Heba K. Alshaeri, Doaa Omar Anbarserry, Alexandra Makai, Hadeel Shaher Al Junaidi, Wamidh H. Talib, Márta Hock · 2026 · Nutrients
  75. Design of L-borneol-containing biguanide derivatives and their half-sandwich Ru(II)-p-cymene complexes: DNA/HSA binding properties, antioxidant activity and antiproliferative effects in glioblastoma cells
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  76. Transition Metal–Metformin Complexes Modulate the Physicochemical Properties of Biguanides and Exhibit Stable Binding at the AMPK ADaM Site
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  77. Drug Repurposing in Cancer Therapy: A Review of Therapeutic Potential Across Diverse Drug Classes
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