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Non-genomic Effects of Glucocorticoids: An Updated View
Open accessAbstract
Glucocorticoid (GC) anti-inflammatory effects generally require a prolonged onset of action and involve genomic processes. Because of the rapidity of some of the GC effects, however, the concept that non-genomic actions may contribute to GC mechanisms of action has arisen. While the mechanisms have not been completely elucidated, the non-genomic effects may play a role in the management of inflammatory diseases. For instance, we recently reported that GCs 'rapidly' enhanced the effects of bronchodilators, agents used in the treatment of allergic asthma. In this review article, we discuss (i) the non-genomic effects of GCs on pathways relevant to the pathogenesis of inflammatory diseases and (ii) the putative role of the membrane GC receptor. Since GC side effects are often considered to be generated through its genomic actions, understanding GC non-genomic effects will help design GCs with a better therapeutic index.
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“suggesting that also the effects on synaptic transmission in the CeA are mediated via non-genomic GR signaling.”
From Alcohol dependence and withdrawal increase sensitivity of central amygdalar GABAergic synapses to the glucocorticoid receptor antagonist mifepristone in male rats (2022) · cites this paper as Panettieri et al., 2019
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“most non-genomic glucocorticoid effects are sensitive to mifepristone antagonism (Panettieri et al., 2019)”
From Alcohol dependence and withdrawal increase sensitivity of central amygdalar GABAergic synapses to the glucocorticoid receptor antagonist mifepristone in male rats (2022) · cites this paper as Panettieri et al., 2019
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“…been reported to act on nearly all parts of the body and function in various physiological processes by activating glucocorticoid receptors (GRs), exerting anti-inflammatory and immunosuppressive effects and regulating neuronal functions of the limbic system (including the hippocampus) [243, 244].”
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“Much attention has been focussed on the very potent effects of GCs that rely on transcription and then translation to have their effects (141).”
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“Some effects occur very rapidly and are therefore believed to be transcription-independent [17].”
BackgroundLiu, P., Gao, C., Chen, H., Vong, C. T., Wu, X., Tang, X., Wang, S., & Wang, Y. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.11.003 · Cited by 168
Metadata
- Authors
- Panettieri, R. A., Schaafsma, D., Amrani, Y., Koziol-White, C., Ostrom, R., & Tliba, O.
- Affiliations
- Rutgers, The State University of New Jersey (US)
- NIHR Leicester Respiratory Biomedical Research Unit (GB)
- Chapman University (US)
- Long Island University (US)
- Corresponding author
- Tliba, Omar
- Venue
- Trends in Pharmacological Sciences
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 40
- Issue
- 1
- Pages
- 38-49
- ISSN
- 0165-6147 (ISSN-L)
- PMC
- PMC7106476
- OpenAlex
- W2902671349
- Cited by
- 297
- References
- 68
- Citations by year
- 2026: 33 · 2025: 42 · 2024: 38 · 2023: 54 · 2022: 47 · 2021: 43 · 2020: 24 · 2019: 16
- FWCI
- 2.90
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Trends in Pharmacological Sciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Chapman University Digital Commons (Chapman University) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institutes of Health (7R01HL111541-07, 2P01HL114471-06, GM107094)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- glucocorticoids, non-genomic effects, anti-inflammatory mechanism, rapid onset of action, bronchodilators, allergic asthma, inflammatory diseases, glucocorticoid adverse effects, therapeutic index
- MeSH terms
- Animals, Anti-Inflammatory Agents, Glucocorticoids, Humans, Inflammation, Receptors, Glucocorticoid, Genomics
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