Cited by 268Nanoparticles: synthesis and applicationsAutophagy in Disease and TherapyHeavy Metal Exposure and Toxicity

The DOI matches its Crossref record; 42 of the 43 references it cites were found in a registry or an index.

Zinc oxide nanoparticle induced autophagic cell death and mitochondrial damage via reactive oxygen species generation

Yu, Kyeong-Nam, Yoon, Tae-Jong, Minai-Tehrani, Arash, Kim, Ji-Eun, Park, Soo Jin, Jeong, Min Sook, Ha, Shin-Woo, Lee, Jin-Kyu, Kim, Jun Sung, Cho, Myung-Haing·2013·Toxicology in Vitro

DOI 10.1016/j.tiv.2013.02.010

Open this paper in CoChat — free account

Abstract

Zinc oxide nanoparticles (ZnO-np) are used in an increasing number of industrial products such as paint, coating and cosmetics, and in other biological applications. There have been many suggestions of a ZnO-np toxicity paradigm but the underlying molecular mechanisms about the toxicity of ZnO-np remain unclear. This study was done to determine the potential toxicity of ZnO-np and to assess the toxicity mechanism in normal skin cells. Synthesized ZnO-np generated reactive oxygen species (ROS), as determined by electron spin resonance. After uptake into cells, ZnO-np induced ROS in a concentration- and time-dependent manner. To demonstrate ZnO-np toxicity mechanism related to ROS, we detected abnormal autophagic vacuoles accumulation and mitochondria dysfunction after ZnO-np treatment. Furthermore mitochondria membrane potential and adenosine-5'-triphosphate (ATP) production are decreased for culture with ZnO-np. We conclude that ZnO-np leads to cell death through autophagic vacuole accumulation and mitochondria damage in normal skin cells via ROS induction. Accordingly, ZnO-np may cause toxicity and the results highlight and need for careful regulation of ZnO-np production and use.

Integrity signals

Registry

Crossref · 10.1016/j.tiv.2013.02.010

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

Concentration-dependent toxicity of iron oxide nanoparticles mediated by increased oxidative stress
Naqvi, Naqvi, Samim, M., Abdin, M. Z., Ahmad, F. J., C.K., P., & Dinda, A. K. (2010) · International Journal of Nanomedicine · doi:10.2147/ijn.s13244 · Cited by 474
Retracted
The hallmarks of cancer
Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219
Toxic potential of materials at the nanolevel
Nel, A., Xia, T., Mädler, L., & Li, N. (2006) · Science · doi:10.1126/science.1114397 · Cited by 9,324
Autophagy fights disease through cellular self-digestion
Mizushima, N., Levine, B., Cuervo, A. M., & Klionsky, D. J. (2008) · Nature · doi:10.1038/nature06639 · Cited by 6,452
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism
Kahn, B. B., Alquier, T., Carling, D., & Hardie, D. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.12.003 · Cited by 2,799
Protein Oxidation and Aging
Stadtman, E. R. (1992) · Science · doi:10.1126/science.1355616 · Cited by 2,701
Comparison of the Mechanism of Toxicity of Zinc Oxide and Cerium Oxide Nanoparticles Based on Dissolution and Oxidative Stress Properties
Xia, T., Kovochich, M., Liong, M., Mädler, L., Gilbert, B., Shi, H., Yeh, J. I., Zink, J. I., & Nel, A. E. (2008) · ACS Nano · doi:10.1021/nn800511k · Cited by 2,470
Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader11Mention of a trade name, proprietary product, or specific equipment does not constitute a guarantee by the United States Department of Agriculture and does not imply its approval to the exclusion of other products that may be suitable.
Wang, H., & Joseph, J. A. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00107-0 · Cited by 2,355
Dissection of the Autophagosome Maturation Process by a Novel Reporter Protein, Tandem Fluorescent-Tagged LC3
Kimura, S., Noda, T., & Yoshimori, T. (2007) · Autophagy · doi:10.4161/auto.4451 · Cited by 2,278
Role of autophagy in cancer
Mathew, R., Karantza-Wadsworth, V., & White, E. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2254 · Cited by 1,798

Show all 43 references

Sorted by citations

Items 101–200 of 268

Nano-scaled materials may induce severe neurotoxicity upon chronic exposure to brain tissues: A critical appraisal and recent updates on predisposing factors, underlying mechanism, and future prospects
Hussain, Z., Thu, H. E., Elsayed, I., Abourehab, M. A. S., Khan, S., Sohail, M. F., Sarfraz, R. M., & Farooq, M. A. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.10.053 · Cited by 45
Effects of silver and gold nanoparticles of different sizes in human pulmonary fibroblasts
Ávalos, A., Haza, A. I., Mateo, D., & Morales, P. (2015) · Toxicology Mechanisms and Methods · doi:10.3109/15376516.2015.1025347 · Cited by 46
Singly protonated dehydronorcantharidin silver coordination polymer induces apoptosis of lung cancer cells via reactive oxygen species-mediated mitochondrial pathway
Li, S., Zhang, S., Jin, X., Tan, X.-J., Lou, J., Zhang, X., & Zhao, Y. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.08.052 · Cited by 46
Transgenerational Effects of NMs
Poma, A. M., Colafarina, S., Fontecchio, G., & Chichiriccò, G. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-94-017-8739-0_12 · Cited by 45
Beclin1 overexpression suppresses tumor cell proliferation and survival via an autophagy‑dependent pathway in human synovial sarcoma cells
Zhu, J., Cai, Y., Xu, K., Ren, X., Sun, J., Lu, S., Chen, J., & Xu, P. (2018) · Oncology Reports · doi:10.3892/or.2018.6599 · Cited by 45
Zinc Oxide Nanoparticles Exhibit Both Cyclooxygenase- and Lipoxygenase-Mediated Apoptosis in Human Bone Marrow-Derived Mesenchymal Stem Cells
Kim, D.-Y., Kim, J., Lee, J., Won, M., Yang, S., Kim, H., & Wie, M. (2019) · Toxicological Research · doi:10.5487/tr.2019.35.1.083 · Cited by 45
Self-citation
Green synthesis of zinc oxide nanoparticles using plant extracts of Fumaria officinalis and Peganum harmala and their antioxidant and antibacterial activities
Hayat, K., Din, I. U., Alam, K., Khan, F. U., Khan, M., & Mohamed, H. I. (2024) · Biomass Conversion and Biorefinery · doi:10.1007/s13399-024-05804-x · Cited by 48
Biosynthesis of zinc oxide nanoparticles via neem extract and their anticancer and antibacterial activities
EL-BELTAGI, H. S., Ragab, M., Osman, A., El-Masry, R. A., Alwutayd, K. M., Althagafi, H. J., Alqahtani, L. S., Alazragi, R. S., Alhajri, A. S., & El-Saber, M. M. (2024) · PeerJ · doi:10.7717/peerj.17588 · Cited by 44
Overendocytosis of superparamagnetic iron oxide particles increases apoptosis and triggers autophagic cell death in human osteosarcoma cell under a spinning magnetic field
Du, S., Li, J., Du, C., Huang, Z., Chen, G., & Yan, W. (2016) · Oncotarget · doi:10.18632/oncotarget.14114 · Cited by 44
Cutaneous applied nano-ZnO reduce the ability of hair follicle stem cells to differentiate
Ge, W., Zhao, Y. M., Lai, F.-N., Liu, J., Sun, Y.-C., Wang, J., Cheng, S., Zhang, X., Sun, L.-L., Li, L., et al. (2017) · Nanotoxicology · doi:10.1080/17435390.2017.1310947 · Cited by 44
Role of Nrf2 in inflammatory response in lung of mice exposed to zinc oxide nanoparticles
Sehsah, R., Wu, W., Ichihara, S., Hashimoto, N., Hasegawa, Y., Zong, C., Itoh, K., Yamamoto, M. P., Elsayed, A. A., El-Bestar, S., et al. (2019) · Particle and Fibre Toxicology · doi:10.1186/s12989-019-0328-y · Cited by 44
Effect of UV Irradiation (A and C) on Casuarina equisetifolia-Mediated Biosynthesis and Characterization of Antimicrobial and Anticancer Activity of Biocompatible Zinc Oxide Nanoparticles
Khan, A. K., Renouard, S., Drouet, S., Blondeau, J., Anjum, I., Hano, C., Abbasi, B. H., & Anjum, S. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13111977 · Cited by 44
Zinc oxide nanoparticles induced cyto- and genotoxicity in kidney epithelial cells
Üzar, N., Abudayyak, M., Akçay, N., Algün, G., & Özhan, G. (2015) · Toxicology Mechanisms and Methods · doi:10.3109/15376516.2015.1045654 · Cited by 41
Involvement of Mitophagy in Aluminum Oxide Nanoparticle–Induced Impairment of Learning and Memory in Mice
Huang, T., Guo, W., Wang, Y., Chang, L., Shang, N., Chen, J., Fan, R., Zhang, L., Gao, X., Niu, Q. L., et al. (2020) · Neurotoxicity Research · doi:10.1007/s12640-020-00283-0 · Cited by 42
Histopathological evaluation of the toxic effects of zinc oxide (ZnO) nanoparticles on testicular tissue of NMRI adult mice
Mozaffari, Z., Parivar, K., Roodbari, N. H., & Irani, S. (2015) · Advanced Studies in Biology · doi:10.12988/asb.2015.5425 · Cited by 41
Danthron suppresses autophagy and sensitizes pancreatic cancer cells to doxorubicin
Chen, H., Zhao, C., He, R., Zhou, M., Liu, Y., Guo, X., Wang, M., Zhu, F., Qin, R., & Xu, L. (2018) · Toxicology in Vitro · doi:10.1016/j.tiv.2018.10.019 · Cited by 45
Development and validation of TOF-SIMS and CLSM imaging method for cytotoxicity study of ZnO nanoparticles in HaCaT cells
Lee, P.-L., Chen, B.-C., Gollavelli, G., Shen, S.-Y., Yin, Y., Lei, S.-L., Jhang, C.-L., Lee, W.-R., & Ling, Y. (2014) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2014.03.046 · Cited by 40
In vitro anthelmintic effect of biologically synthesized silver nanoparticles on liver amphistome, Gigantocotyle explanatum
Rehman, A., Ullah, R., Uddin, I., Zia, I., Rehman, L., & Abidi, S. M. A. (2019) · Experimental Parasitology · doi:10.1016/j.exppara.2019.02.005 · Cited by 40
Exploiting autophagy-regulative nanomaterials for activation of dendritic cells enables reinforced cancer immunotherapy
Guan, Y., Wang, N., Deng, Z., Chen, X., & Liu, Y. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121434 · Cited by 39
Probing Nanoparticle–Cell Interaction Using Micro-Raman Spectroscopy: Silver and Gold Nanoparticle-Induced Stress Effects on Optically Trapped Live Red Blood Cells
Barkur, S., Lukose, J., & Chidangil, S. (2020) · ACS Omega · doi:10.1021/acsomega.9b02988 · Cited by 39
Vanadium pentoxide nanoparticle mediated perturbations in cellular redox balance and the paradigm of autophagy to apoptosis
Suma, P. R. P., Padmanabhan, R. A., Telukutla, S. R., Ravindran, R., Velikkakath, A. K. G., Dekiwadia, C. D., Paul, W., Laloraya, M., Srinivasula, S. M., Bhosale, S. V., et al. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.10.008 · Cited by 39
Mechanistic Approaches to the Application of Nano-Zinc in the Poultry and Biomedical Industries: A Comprehensive Review of Future Perspectives and Challenges
Younas, Z., Mashwani, Z., Ahmad, I., Khan, M., Zaman, S., Sawati, L., & Sohail, S. (2023) · Molecules · doi:10.3390/molecules28031064 · Cited by 37
Zinc oxide nanoparticles exacerbate skin epithelial cell damage by upregulating pro-inflammatory cytokines and exosome secretion in M1 macrophages following UVB irradiation-induced skin injury
Wang, B.-J., Chen, Y., Chang, H.-H., Chen, R.-J., Wang, Y., & Lee, Y. (2024) · Particle and Fibre Toxicology · doi:10.1186/s12989-024-00571-z · Cited by 38
MicroRNA-1228* inhibit apoptosis in A549 cells exposed to fine particulate matter
Li, X., Ding, Z., Zhang, C., Zhang, X., Meng, Q., Wu, S., Wang, S., Yin, L., Pu, Y., & Chen, R. (2016) · Environmental Science and Pollution Research · doi:10.1007/s11356-016-6253-9 · Cited by 36
Zinc oxide nanoparticles induce murine photoreceptor cell death via mitochondria-related signaling pathway
Wang, L., Chen, C., Guo, L., Li, Q., Ding, H., Bi, H., & Guo, D. (2018) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2018.1446018 · Cited by 36
MicroRNA sequencing and molecular mechanisms analysis of the effects of gold nanoparticles on human dermal fibroblasts
Huang, Y., Lü, X., Qu, Y., Yang, Y., & Wu, S. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.10.042 · Cited by 35
Impact of labile metal nanoparticles on cellular homeostasis. Current developments in imaging, synthesis and applications
Chevallet, M., Veronesi, G., Fuchs, A., Mintz, E., Michaud‐Soret, I., & Deniaud, A. (2016) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2016.12.012 · Cited by 36
Copper-based fungicide copper hydroxide accelerates the evolution of antibiotic resistance via gene mutations in Escherichia coli
Yu, S., Wang, Y., Shen, F., Fang, H., & Yu, Y. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.152885 · Cited by 36
Comparative study of the effects of PM1-induced oxidative stress on autophagy and surfactant protein B and C expressions in lung alveolar type II epithelial MLE-12 cells
Bai, R., Guan, L., Zhang, W., Xu, J., Rui, W., Zhang, F., & Ding, W. (2016) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2016.05.020 · Cited by 35
Cow dung extract mediated green synthesis of zinc oxide nanoparticles for agricultural applications
Javed, Z., Tripathi, G. D., Mishra, M., Gattupalli, M., & Dashora, K. (2022) · Scientific Reports · doi:10.1038/s41598-022-22099-y · Cited by 34
Evidence for Nanoparticle-Induced Lysosomal Dysfunction in Lung Adenocarcinoma (A549) Cells
Sipos, A., Kim, K., Sioutas, C., & Crandall, E. D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215253 · Cited by 34
Micro‐ and Nanostructured Biomaterials for Sutureless Tissue Repair
Frost, S. J., Mawad, D., Hook, J. M., & Lauto, A. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201500589 · Cited by 34
Morphometric and stereological assessment of the effects of zinc oxide nanoparticles on the mouse testicular tissue
Moridian, M., Khorsandi, L., & Talebi, A. R. (2015) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.4149/bll_2015_060 · Cited by 33
Copper Ion from Cu2O Crystal Induces AMPK-Mediated Autophagy via Superoxide in Endothelial Cells
Seo, Y., Cho, Y., Huh, Y., & Park, H. (2016) · Molecules and Cells · doi:10.14348/molcells.2016.2198 · Cited by 34
Enhanced steroidogenic and altered antioxidant response by ZnO nanoparticles in mouse testis Leydig cells
Bara, N., & Kaul, G. (2018) · Toxicology and Industrial Health · doi:10.1177/0748233718774220 · Cited by 31
Effects of zinc oxide nanoparticles and zinc sulfate on the testis of common carp, Cyprinus carpio
Deepa, S., Murugananthkumar, R., Gupta, Y. R., Manjunatha Gowda, K. S., & Senthilkumaran, B. (2019) · Nanotoxicology · doi:10.1080/17435390.2018.1541259 · Cited by 28
Perturbation of autophagy: An intrinsic toxicity mechanism of nanoparticles
Zhou, X., Jin, W., Sun, H., Li, C., & Jia, J. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.153629 · Cited by 31
Recent Advances in Nanotechnology for Autophagy Detection
Lin, Y., Wang, Y., & Wang, H. (2017) · Small · doi:10.1002/smll.201700996 · Cited by 30
Effects of substrate conductivity on cell morphogenesis and proliferation using tailored, atomic layer deposition-grown ZnO thin films
Choi, W. J., Jung, J., Lee, S.-J., Chung, Y. J., Yang, C., Lee, Y. K., Lee, Y.-S., Park, J. K., Ko, H. W., & Lee, J.-O. (2015) · Scientific Reports · doi:10.1038/srep09974 · Cited by 30
Self-citation
In vitro comparative cytotoxicity study of aminated polystyrene, zinc oxide and silver nanoparticles on a cervical cancer cell line
Sharma, A., Gorey, B., & Casey, A. (2018) · Drug and Chemical Toxicology · doi:10.1080/01480545.2018.1424181 · Cited by 30
Physicochemical insights of irradiation-enhanced hydroxyl radical generation from ZnO nanoparticles
Yang, Q., Lin, T., Burton, C., Park, S. H., & Ma, Y. (2015) · Toxicology Research · doi:10.1039/c5tx00384a · Cited by 29
Self-citation
Toxicological effects of graphene oxide on Saccharomyces cerevisiae
Zhu, S., Luo, F., Zhu, B., & Wang, G. (2017) · Toxicology Research · doi:10.1039/c7tx00103g · Cited by 29
Human lung adenocarcinoma cells with an EGFR mutation are sensitive to non-autophagic cell death induced by zinc oxide and aluminium-doped zinc oxide nanoparticles
Bai, K., Chuang, K.-J., Ma, C., Chang, T.-Y., & Chuang, H. (2017) · The Journal of Toxicological Sciences · doi:10.2131/jts.42.437 · Cited by 29
Defect-induced electronic states amplify the cellular toxicity of ZnO nanoparticles
Persaud, I., Raghavendra, A. J., Paruthi, A., Alsaleh, N. B., Minarchick, V. C., Roede, J. R., Podila, R., & Brown, J. M. (2019) · Nanotoxicology · doi:10.1080/17435390.2019.1668067 · Cited by 29
Impact of lithiated cobalt oxide and phosphate nanoparticles on rainbow trout gill epithelial cells
Melby, E. S., Cui, Y., Borgatta, J. R., Mensch, A. C., Hang, M. N., Chrisler, W., Dohnalkova, A. C., Gilder, J. M. V., Alvarez, C. M., Smith, J. N., et al. (2018) · Nanotoxicology · doi:10.1080/17435390.2018.1508785 · Cited by 28
Long-term sediment exposure to ZnO nanoparticles induces oxidative stress in Caenorhabditis elegans
Huang, C., Li, S.-W., & Liao, V. H. (2019) · Environmental Science Nano · doi:10.1039/c9en00039a · Cited by 28
Polyethyleneimine coated Fe 3 O 4 magnetic nanoparticles induce autophagy, NF-κB and TGF-β signaling pathway activation in HeLa cervical carcinoma cells via reactive oxygen species generation
Man, S., Li, M., Zhou, J., Wang, H., Zhang, J., & Ma, L. (2019) · Biomaterials Science · doi:10.1039/c9bm01563a · Cited by 28
Selenium nanoparticles coupling with Astragalus Polysaccharides exert their cytotoxicities in MCF-7 cells by inhibiting autophagy and promoting apoptosis
Duan, Z., Liang, M., Yang, C., Yan, C., Wang, L., Song, J., Han, L., Fan, Y., Li, W., Liang, T., et al. (2022) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2022.127006 · Cited by 28
Biocompatible UV-absorbing polymer nanoparticles prepared by electron irradiation for application in sunscreen
Lee, S. Y., Lim, H. S., Lee, N. E., & Cho, S. O. (2020) · RSC Advances · doi:10.1039/c9ra09752j · Cited by 27
How macrophages respond to two-dimensional materials: a critical overview focusing on toxicity
Lin, H., Song, Z., & Bianco, A. (2021) · Journal of Environmental Science and Health Part B · doi:10.1080/03601234.2021.1885262 · Cited by 26
NMR Metabolomics Reveals Metabolism-Mediated Protective Effects in Liver (HepG2) Cells Exposed to Subtoxic Levels of Silver Nanoparticles
Carrola, J., Pinto, R. J. B., Nasirpour, M., Freire, C. S. R., Gil, A. M., Santos, C., Oliveira, H., & Duarte, I. F. (2018) · Journal of Proteome Research · doi:10.1021/acs.jproteome.7b00905 · Cited by 27
A link between nanoparticles and Parkinson’s disease. Which nanoparticles are most harmful?
Mohammadipour, A., Haghir, H., & Ebrahimzadeh‐Bideskan, A. (2020) · Reviews on Environmental Health · doi:10.1515/reveh-2020-0043 · Cited by 28
Gold nanoparticle adsorption alters the cell stiffness and cell wall bio-chemical landscape of Candida albicans fungal cells
Penman, R., Kariuki, R., Shaw, Z. L., Dekiwadia, C. D., Christofferson, A. J., Bryant, G., Vongsvivut, J. P., Bryant, S. J., & Elbourne, A. J. (2023) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2023.10.017 · Cited by 26
An in vitro study on the cytotoxicity of bismuth oxychloride nanosheets in human HaCaT keratinocytes
Gao, X., Zhang, X., Wang, Y., Wang, Y., Peng, S., & Fan, C. (2015) · Food and Chemical Toxicology · doi:10.1016/j.fct.2015.02.018 · Cited by 26
Comparison of UVA-induced ROS and sunscreen nanoparticle-generated ROS in human immune cells
Shen, C., Turney, T. W., Piva, T., Feltis, B. N., & Wright, P. F. A. (2014) · Photochemical and Photobiological Sciences · doi:10.1039/c3pp50428j · Cited by 25
Autophagy as the effector and player in DNA damage response of cells to genotoxicants
Zhang, S.-M., Shang, Z., & Zhou, P. (2015) · Toxicology Research · doi:10.1039/c5tx00043b · Cited by 23
Zinc Oxide Nanowires Exposure Induces a Distinct Inflammatory Response via CCL11-Mediated Eosinophil Recruitment
Alghsham, R. S., Satpathy, S. R., Bodduluri, S. R., Hegde, B., Jala, V. R., Twal, W. O., Burlison, J. A., Sunkara, M. K., & Haribabu, B. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02604 · Cited by 25
Peptide-functionalized zinc oxide nanoparticles for the selective targeting of breast cancer expressing placenta-specific protein 1
Cagliani, R., Fayed, B. E., Jagal, J., Shakartalla, S. B., Soliman, S. S. M., & Haider, M. A. (2023) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2023.113357 · Cited by 25
Lawsonia inermis plant-based cobalt oxide nanoparticles: Synthesis, characterization and their biological studies
Kolahalam, L. A., Prasad, K. R. S., Krishna, P. M., & Supraja, N. (2024) · Results in Chemistry · doi:10.1016/j.rechem.2024.101367 · Cited by 25
Green-synthesized metal and metal oxide nanoparticles as emerging antifungal agents: current advances, mechanisms, and future perspectives
Vijayalakshmi, K., Swaramanjari, T., Shanmugavel, M., & Gnanamani, A. (2025) · Discover Biotechnology · doi:10.1007/s44340-025-00024-z · Cited by 27
Size is an essential parameter in governing the UVB-protective efficacy of silver nanoparticles in human keratinocytes
Palanki, R., Arora, S., Tyagi, N., Rusu, L., Singh, A. P., Palanki, S., Carter, J. E., & Singh, S. (2015) · BMC Cancer · doi:10.1186/s12885-015-1644-8 · Cited by 24
Husk-like Zinc Oxide Nanoparticles Induce Apoptosis through ROS Generation in Epidermoid Carcinoma Cells: Effect of Incubation Period on Sol-Gel Synthesis and Anti-Cancerous Properties
Alhoqail, W. A., Alothaim, A. S., Suhail, M., Iqbal, D., Kamal, M., Asmari, M. M., & Jamal, A. (2023) · Biomedicines · doi:10.3390/biomedicines11020320 · Cited by 25
Comparative Evaluation of the Cytotoxic Effects of Metal Oxide and Metalloid Oxide Nanoparticles: An Experimental Study
Sutunkova, M. P., Klinova, S. V., Ryabova, Y. V., Tazhigulova, A. V., Minigalieva, I. A., Shabardina, L. V., Solovyeva, S. N., Bushueva, T. V., & Privalova, L. I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24098383 · Cited by 23
Cigarette Smoking Condensate Disrupts Endoplasmic Reticulum–Golgi Network Homeostasis Through GOLPH3 Expression in Normal Lung Epithelial Cells
Yu, K., Kim, H.-J., Kim, S., Dawaadamdin, O., Lee, A.-Y., Hong, S.-H., Chang, S.-H., Choi, S., Shim, S., Lee, K., et al. (2016) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntw079 · Cited by 22
Self-citation
The Effects of 50 nm Unmodified Nano-ZnO on Lipid Metabolism and Semen Quality in Male Mice
Kong, T., Zhang, S., Zhang, C., Zhang, J., Yang, F., Wang, G., Yang, Z., Bai, D., Shi, Y.-Y., Liu, T., et al. (2019) · Biological Trace Element Research · doi:10.1007/s12011-019-01792-6 · Cited by 21
Mesoporous silica nanoparticle is comparatively safer than zinc oxide nanoparticle which can cause profound steroidogenic effects on pregnant mice and male offspring exposed in utero
Bara, N., Muthusamy, E., Subaharan, K., & Kaul, G. (2018) · Toxicology and Industrial Health · doi:10.1177/0748233718757641 · Cited by 21
Potential cytotoxicity of silver nanoparticles: Stimulation of autophagy and mitochondrial dysfunction in cardiac cells
Khan, A. A., Alanazi, A. M., Alsaif, N. A., Alanazi, M. A., Sayed, A. Y. A., & Bhat, M. A. (2021) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2021.03.021 · Cited by 23
Antibacterial and antifungal activity of zinc oxide nanoparticles produced by Phaeodactylum tricornutum culture supernatants and their potential application to extend the shelf life of sweet cherry (Prunus avium L.)
Ouzakar, S., Senhaji, N. S., Saidi, M. Z., Hadri, M. E., Baaboua, A. E., Harsal, A. E., & Abrini, J. (2023) · Biocatalysis and Agricultural Biotechnology · doi:10.1016/j.bcab.2023.102666 · Cited by 20
Zinc oxide nanoparticles induce toxicity in diffuse large B-cell lymphoma cell line U2932 via activating PINK1/Parkin-mediated mitophagy.
Li, Z., Yin, X., Lyu, C., Wang, T., Wang, W., Zhang, J., Wang, J., Wang, Z., Han, C., Zhang, R., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114988 · Cited by 20
Edelfosine Lipid Nanoparticles Overcome Multidrug Resistance in K-562 Leukemia Cells by a Caspase-Independent Mechanism
Aznar, M. A., Lasa-Saracíbar, B., & Blanco‐Prieto, M. J. (2014) · Molecular Pharmaceutics · doi:10.1021/mp5000696 · Cited by 20
Light scattering based analyses of the effects of bovine serum proteins on interactions of magnetite spherical particles with cells
Guo, L., Wang, T., Chen, Z., He, N., Chen, Y., & Yuan, T. (2017) · Chinese Chemical Letters · doi:10.1016/j.cclet.2017.11.017 · Cited by 19
Controlled synthesis of zinc oxide nanoparticles through flame spray pyrolysis and evaluation of their anticancer effects against gastric cancer cell
Du, W., Feng, K., Li, C., Li, S., Abidin, Z. U., Yin, H., & Chen, S. (2023) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2023.105192 · Cited by 19
Green synthesis and Biomedical Applications of Zinc Oxide Nanoparticles. Review
Youssef, F. S., Ismail, S. H., Fouad, O. A., & Mohamed, G. G. (2023) · Egyptian Journal of Veterinary Science · doi:10.21608/ejvs.2023.225862.1576 · Cited by 20
Mitochondrial impairment and oxidative stress mediated apoptosis induced by α-Fe2O3nanoparticles in Saccharomyces cerevisiae
Zhu, S., Luo, F., Zhu, B., & Wang, G. (2017) · Toxicology Research · doi:10.1039/c7tx00123a · Cited by 19
Zinc oxide nanoparticles and l-carnitine effects on neuro-schistosomiasis mansoni induced in mice
Bauomy, A. A. (2020) · Environmental Science and Pollution Research · doi:10.1007/s11356-020-08356-5 · Cited by 20
Long-Term Effects of Unmodified 50 nm ZnO in Mice
Kong, T., Zhang, S., Zhang, C., Zhang, J., Yang, F., Wang, G., Yang, Z., Bai, D., Zhang, M., Wang, J., et al. (2018) · Biological Trace Element Research · doi:10.1007/s12011-018-1477-9 · Cited by 19
Antibacterial and biofilm inhibition of Helicobacter pylori using green synthesized MWCNTs/ZnO/Chitosan nanocomposites
Fallahizadeh, S., Yousefi, M., Ghasemi, A., Sadat, S. A., Mohtashemi, M., Rezagholizade-shirvan, A., & Naghmachi, M. (2025) · Environmental Technology & Innovation · doi:10.1016/j.eti.2025.104068 · Cited by 18
Unravelling the ZnO-NPs mechanistic pathway: Cellular changes and altered morphology in the gastrointestinal tract of the earthworm Eisenia andrei
Filipiak, Z. M., Woźnicka, O., & Bednarska, A. J. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.110532 · Cited by 17
Hyaluronic acid functionalized ZnO nanoparticles co-deliver AS and GOD for synergistic cancer starvation and oxidative damage
Ren, Z., Han, X., Wang, L., & Wang, Y. (2022) · Scientific Reports · doi:10.1038/s41598-022-08627-w · Cited by 17
Zinc Oxide Particles Induce Activation of the Lysosome–Autophagy System
Popp, L., & Segatori, L. (2019) · ACS Omega · doi:10.1021/acsomega.8b01497 · Cited by 17
Autophagy regulation by inorganic, organic, and organic/inorganic hybrid nanoparticles: Organelle damage, regulation factors, and potential pathways
Qiao, D., Zhang, T., & Tang, M. X. (2023) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23429 · Cited by 16
ZnO Nanorods Create a Hypoxic State with Induction of HIF-1 and EPAS1, Autophagy, and Mitophagy in Cancer and Non-Cancer Cells
Aventaggiato, M., Preziosi, A., Bidsorkhi, H. C., Schifano, E., Vespa, S., Mardente, S., Zicari, A., Uccelletti, D., Mancini, P., Lotti, L. V., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24086971 · Cited by 15
Antitumor Effect and Toxicity of an Albumin-Paclitaxel Nanocarrier System Constructed via Controllable Alkali-Induced Conformational Changes
Gong, G., Jiao, Y., Pan, Q., Tang, H., An, Y., Yuan, A., Wang, K., Huang, C., Dai, W., Lu, Y., et al. (2019) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.9b00312 · Cited by 15
Effect of ZnO nanoparticles in the oxygen uptake during aerobic wastewater treatment
Cervantes-Aviles, P. A., Brito, E. M. S., Duran, R., Bernal-Martínez, A., & Cuevas‐Rodríguez, G. (2016) · Journal of Nanoparticle Research · doi:10.1007/s11051-016-3481-3 · Cited by 14
Modular air–liquid interface aerosol exposure system (MALIES) to study toxicity of nanoparticle aerosols in 3D-cultured A549 cells in vitro
Küstner, M., Eckstein, D., Brauer, D., Mai, P., Hampl, J., Weise, F., Schuhmann, B., Hause, G., Glahn, F., Foth, H., et al. (2024) · Archives of Toxicology · doi:10.1007/s00204-023-03673-3 · Cited by 13
Bone marrow mesenchymal stem cells protect against n-hexane-induced neuropathy through beclin 1-independent inhibition of autophagy
Hao, J., Li, S., Shi, X., Qian, Z., Sun, Y., Wang, D., Zhou, X., Qu, H., Hu, S., Zuo, E., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-22857-x · Cited by 13
Sex-Dependent Bioaccumulation of Nano Zinc Oxide and Its Adverse Effects on Sexual Behavior and Reproduction in Japanese Medaka
Paul, V., Krishnakumar, S., Gowd, G. S., Nair, S. V., Koyakutty, M., & Paul‐Prasanth, B. (2021) · ACS Applied Bio Materials · doi:10.1021/acsabm.1c00575 · Cited by 12
Convergence of Nanotechnology and Cancer Prevention: Are We There Yet?
Menter, D. G., Patterson, S. L., Logsdon, C. D., Kopetz, S., Sood, A. K., & Hawk, E. T. (2014) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-14-0079 · Cited by 12
Toxicological Effects of Metal Nanoparticles Employed in Biomedicine: Biocompatibility, Clinical Trials, and Future Perspective
Krishna, R., Nagar, V., Kaur, A., Rai, A. R., Awasthi, K. K., Awasthi, G., & Sankhla, M. S. (2024) · Macromolecular Symposia · doi:10.1002/masy.202300057 · Cited by 11
Biocompatibility assessment of Fe3O4 nanoparticles using Saccharomyces cerevisiae as a model organism
Luo, F., Zhu, S., Hu, Y., Yang, K., He, M.-S., Zhu, B., Wang, G., & Ling, F. (2019) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2019.108645 · Cited by 11
More serious autophagy can be induced by ZnO nanoparticles than single‐walled carbon nanotubes in rat tracheal epithelial cells
Zhang, H., Chen, F., Li, Y., Shan, X., Yin, L., Hao, X., & Zhong, Y. (2020) · Environmental Toxicology · doi:10.1002/tox.23029 · Cited by 11
MTH1 is involved in the toxic and carcinogenic long-term effects induced by zinc oxide and cobalt nanoparticles
Barguilla, I., Barszczewska-Pietraszek, G., Annangi, B., Domenech, J., Velázquez, A., Marcos, R., & Hernández, A. (2020) · Archives of Toxicology · doi:10.1007/s00204-020-02737-y · Cited by 11
Quercetin ameliorates cytotoxic effects of zinc oxide nanoparticles on sertoli cells by enhancing autophagy and suppressing oxidative stress
Zeinvand‐Lorestani, M., Karimi, S., & Khorsandi, L. (2021) · Andrologia · doi:10.1111/and.13988 · Cited by 12
NRF2 deficiency sensitizes human keratinocytes to zinc oxide nanoparticles-induced autophagy and cytotoxicity
Yin, Y., Peng, H., Shao, J., Zhang, J., Li, Y., Pi, J., & Guo, J. (2021) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2021.103721 · Cited by 11
The interaction between lead sulfide nano-dendrites and Saccharomyce cerevisiae is involved in nanotoxicity
Yu, Q., Sun, M., Wang, Y., Li, M., & Liu, L. (2014) · RSC Advances · doi:10.1039/c4ra01861c · Cited by 11
Unveiling the structural dynamics and anticancer potential of zinc and iron oxide nanoparticles derived from Allium cepa peels
Mustafa, R., Nazir, A., Abbas, M., & Iqbal, M. (2025) · New Journal of Chemistry · doi:10.1039/d5nj00264h · Cited by 10
Electrochemical Impedance Spectroscopy of Zinc Oxide Nanoparticles After Deposition on Screen Printed Electrode
Wang, K., Zhang, W., & Lai, E. P. C. (2021) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2021.19366 · Cited by 9
Epigenetic Mechanisms in Understanding Nanomaterial-Induced Toxicity
Ghosh, M., Godderis, L., & Hoet, P. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-88071-2_9 · Cited by 9
Recent advances of nanotechnology in COVID 19: A critical review and future perspective
Chaudhary, K. R., Kujur, S., & Singh, K. (2022) · OpenNano · doi:10.1016/j.onano.2022.100118 · Cited by 9
The Vast Biomedical Applications of Zinc Oxide Nanoparticles
Abd-Elmaqsoud, I., El-saadawy, H. A., Ahmed, A., Abdelkhalek, A., & Arisha, A. (2022) · Zagazig Veterinary Journal/Zagazig Veterinary Journal (Online) · doi:10.21608/zvjz.2022.144910.1182 · Cited by 9

Authors: Yu, K.-N., Yoon, T.-J., Minai-Tehrani, A., Kim, J.-E., Park, S. J., Jeong, M. S., Ha, S.-W., Lee, J.-K., Kim, J. S., & Cho, M.-H.
Affiliations: Seoul National University (KR)
CHA University (KR)
Emory University (US)
Corresponding author: Kim, Jun Sung
Cho, Myung-Haing
ORCID: Yoon, Tae-Jong
Kim, Ji-Eun
Lee, Jin-Kyu
Venue: Toxicology in Vitro
Publisher: Elsevier BV
Published: 2013-06
Volume: 27
Issue: 4
Pages: 1187-1195
ISSN: 0887-2333 (ISSN-L)
DOI: 10.1016/j.tiv.2013.02.010
OpenAlex: W1966626824
Cited by: 268
References: 43
Citations by year: 2026: 8 · 2025: 14 · 2024: 15 · 2023: 16 · 2022: 17 · 2021: 20 · 2020: 28 · 2019: 31 · 2018: 26 · 2017: 16 · 2016: 26 · 2015: 25 · 2014: 21 · 2013: 5
FWCI: 11.58
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Toxicology in Vitro (publishedVersion)
PubMed (publishedVersion)
Seoul National University Open Repository (Seoul National University) (submittedVersion)
Funders: Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University
National Research Foundation of Korea
Ministry of Education, Science and Technology (2009-0082737, 2010-0019991, 2011-0019175)
Topics: Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
Keywords: zinc oxide nanoparticles, nanoparticle toxicity, autophagic cell death, mitochondrial damage, mitochondrial dysfunction, reactive oxygen species, mitochondrial membrane potential, ATP production, skin cells, nanoparticle uptake
MeSH terms: Adenosine Triphosphate, Animals, Autophagy, Cell Line, Mitochondria, Zinc Oxide, Reactive Oxygen Species, Microscopy, Electron, Transmission, Mice, Membrane Potential, Mitochondrial, Metal Nanoparticles

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Zinc oxide nanoparticle induced autophagic cell death and mitochondrial damage via reactive oxygen species generation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks