Cited by 268Nanoparticles: synthesis and applicationsAutophagy in Disease and TherapyHeavy Metal Exposure and Toxicity

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Zinc oxide nanoparticle induced autophagic cell death and mitochondrial damage via reactive oxygen species generation

Yu, Kyeong-Nam, Yoon, Tae-Jong, Minai-Tehrani, Arash, Kim, Ji-Eun, Park, Soo Jin, Jeong, Min Sook, Ha, Shin-Woo, Lee, Jin-Kyu, Kim, Jun Sung, Cho, Myung-Haing·2013·Toxicology in Vitro

DOI 10.1016/j.tiv.2013.02.010

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Abstract

Zinc oxide nanoparticles (ZnO-np) are used in an increasing number of industrial products such as paint, coating and cosmetics, and in other biological applications. There have been many suggestions of a ZnO-np toxicity paradigm but the underlying molecular mechanisms about the toxicity of ZnO-np remain unclear. This study was done to determine the potential toxicity of ZnO-np and to assess the toxicity mechanism in normal skin cells. Synthesized ZnO-np generated reactive oxygen species (ROS), as determined by electron spin resonance. After uptake into cells, ZnO-np induced ROS in a concentration- and time-dependent manner. To demonstrate ZnO-np toxicity mechanism related to ROS, we detected abnormal autophagic vacuoles accumulation and mitochondria dysfunction after ZnO-np treatment. Furthermore mitochondria membrane potential and adenosine-5'-triphosphate (ATP) production are decreased for culture with ZnO-np. We conclude that ZnO-np leads to cell death through autophagic vacuole accumulation and mitochondria damage in normal skin cells via ROS induction. Accordingly, ZnO-np may cause toxicity and the results highlight and need for careful regulation of ZnO-np production and use.

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Authors: Yu, K.-N., Yoon, T.-J., Minai-Tehrani, A., Kim, J.-E., Park, S. J., Jeong, M. S., Ha, S.-W., Lee, J.-K., Kim, J. S., & Cho, M.-H.
Affiliations: Seoul National University (KR)
CHA University (KR)
Emory University (US)
Corresponding author: Kim, Jun Sung
Cho, Myung-Haing
ORCID: Yoon, Tae-Jong
Kim, Ji-Eun
Lee, Jin-Kyu
Venue: Toxicology in Vitro
Publisher: Elsevier BV
Published: 2013-06
Volume: 27
Issue: 4
Pages: 1187-1195
ISSN: 0887-2333 (ISSN-L)
DOI: 10.1016/j.tiv.2013.02.010
OpenAlex: W1966626824
Cited by: 268
References: 43
Citations by year: 2026: 8 · 2025: 14 · 2024: 15 · 2023: 16 · 2022: 17 · 2021: 20 · 2020: 28 · 2019: 31 · 2018: 26 · 2017: 16 · 2016: 26 · 2015: 25 · 2014: 21 · 2013: 5
FWCI: 11.58
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Toxicology in Vitro (publishedVersion)
PubMed (publishedVersion)
Seoul National University Open Repository (Seoul National University) (submittedVersion)
Funders: Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University
National Research Foundation of Korea
Ministry of Education, Science and Technology (2009-0082737, 2010-0019991, 2011-0019175)
Topics: Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
Keywords: zinc oxide nanoparticles, nanoparticle toxicity, autophagic cell death, mitochondrial damage, mitochondrial dysfunction, reactive oxygen species, mitochondrial membrane potential, ATP production, skin cells, nanoparticle uptake
MeSH terms: Adenosine Triphosphate, Animals, Autophagy, Cell Line, Mitochondria, Zinc Oxide, Reactive Oxygen Species, Microscopy, Electron, Transmission, Mice, Membrane Potential, Mitochondrial, Metal Nanoparticles

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Zinc oxide nanoparticle induced autophagic cell death and mitochondrial damage via reactive oxygen species generation

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