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Magnetic iron oxide nanoparticles induce autophagy preceding apoptosis through mitochondrial damage and {ER} stress in {RAW264}.7 cells

Park, Eun-Jung, Choi, Dong-Hyuk, Kim, Younghun, Lee, Eun-Woo, Song, Jaewhan, Cho, Myung-Haing, Kim, Jae-Ho, Kim, Sang-Wook·2014·Toxicology in Vitro
DOI 10.1016/j.tiv.2014.07.010
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Abstract

Magnetic nanoparticles have been widely used in a broad range of disciplines owing to their unique properties. However, many unexpected risks have been reported in their use. In this study, we investigated the uptake process and toxic mechanism of magnetic iron oxide nanoparticles (M-FeNPs) using RAW264.7 cells, a murine peritoneal macrophage cell line. M-FeNPs markedly enhanced the mobility of cells. At 24h after exposure, M-FeNPs were located freely in the cytosol or within autolysosomes containing various organelles, especially the endoplasmic reticulum (ER). Cell viability decreased in a dose-dependent manner in conjunction with the arrest in S phase. ATP production also rapidly decreased together with mitochondrial damage, the number of cells that generate ROS increased, and the secretions of pro-inflammatory cytokines enhanced. The levels of oxidative stress- and ER stress-related genes were up-regulated, whereas the levels of transcription-related genes were down-regulated. Additionally, the levels of autophagy- and ER stress-related proteins increased, and the number of apoptotic cells increased with time. We also investigated the function of the autolysosome in the cellular response after exposure of M-FeNPs. When cells were exposed to M-FeNPs for 24h with BaFA1 pretreatment, the plasma membrane disintegrated, cytosolic components disappeared, and the number of apoptotic cells significantly increased. Taken together, these results show that M-FeNPs induce autophagy p…

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Research works printed but not linked: 62

  1. Afeseh Ngwaq, 2011, Manganese nanoparticle activates mitochondrial dependent apoptotic signaling and autophagy in dopaminergic neuronal cells, Toxicol. Appl. Pharmacol., 256, 227, 10.1016/j.taap.2011.07.018 · DOI
  2. Alzhanova, 2006, A trans-Golgi network resident protein, golgin-97, accumulates in viral factories and incorporates into virious during poxvirus infection, J. Virol., 80, 11520, 10.1128/JVI.00287-06 · DOI
  3. Andón, 2013, Programmed cell death: molecular mechanisms and implications for safety assessment of nanomaterials, Acc. Chem. Res., 46, 733, 10.1021/ar300020b · DOI
  4. Basu, 1998, The relationship between Bcl2, Bax and p53: consequences for cell cycle progression and cell death, Mol. Hum. Reprod., 4, 1099, 10.1093/molehr/4.12.1099 · DOI
  5. Bernales, 2007, ER-phagy. Selective autophagy of the endoplasmic reticulum, Autophagy, 3, 285, 10.4161/auto.3930 · DOI
  6. Bernd, 2009, Safety and tolerability of ultrasmall superparamagnetic iron oxide contrast agent: comprehensive analysis of a clinical development program, Invest. Radiol., 44, 336, 10.1097/RLI.0b013e3181a0068b · DOI · Paper page
  7. Brady, 1998, Bax. The pro-apoptotic Bcl-2 family member, Bax, Int. J. Biochem. Cell Biol., 30, 647, 10.1016/S1357-2725(98)00006-5 · DOI
  8. Centers for Disease Control and Prevention, 2007, Nephrogenic fibrosing dermopathy associated with exposure to gadolinium-containing contrast agents—St. Louis, Missouri, 2002–2006, MMWR Morb. Mortal. Wkly Rep., 56, 137
  9. Chaturvedi, 2009, Autophagy in immune cell regulation and dysregulation, Curr. Allergy Asthma Rep., 9, 341, 10.1007/s11882-009-0050-1 · DOI
  10. Chen, 2010, Application and advancement of magnetic iron-oxide nanoparticles in tumor-targeted therapy, Chin. J. Cancer, 29, 125, 10.5732/cjc.009.10153 · DOI
  11. Cheong, 2012, Therapeutic targets in cancer cell metabolism and autophagy, Nat. Biotechnol., 30, 671, 10.1038/nbt.2285 · DOI
  12. Christen, 2012, Silica nanoparticles and silver-doped silica nanoparticles induce endoplasmatic reticulum stress response and alter cytochrome P4501A activity, Chemosphere, 87, 423, 10.1016/j.chemosphere.2011.12.046 · DOI
  13. Crapo, 2003, Oxidative stress as an initiator of cytokine release and cell damage, Eur. Respir. J., 44, 4s, 10.1183/09031936.03.00000203a · DOI
  14. Deegan, 2013, Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic retivulum stress, Cell. Mol. Life Sci., 70, 2425, 10.1007/s00018-012-1173-4 · DOI
  15. Dempsey, 2003, The signaling adaptors and pathways activated by TNF superfamily, Cytokine Growth Factor Rev., 14, 193, 10.1016/S1359-6101(03)00021-2 · DOI
  16. Ferri, 2001, Organelle-specific initiation of cell death pathways, Nat. Cell. Biol., 3, E255, 10.1038/ncb1101-e255 · DOI
  17. Filao, 2011, Superoxide dismutases: role in redox signaling, vascular function, and diseases, Antioxid. Redox Signal., 15, 1583, 10.1089/ars.2011.3999 · DOI
  18. Gustafsson, 2008, Recycle or die: the role of autophagy in cardioprotection, J. Mol. Cell. Cardiol., 44, 654, 10.1016/j.yjmcc.2008.01.010 · DOI
  19. Hale, 1996, Apoptosis: molecular regulation of cell death, Eur. J. Biochem., 236, 1, 10.1111/j.1432-1033.1996.00001.x · DOI
  20. Hamasaki, 2005, Starvation triggers the delivery of the endoplasmic reticulum to the vacuole via autophagy in yeast, Traffic, 6, 56, 10.1111/j.1600-0854.2004.00245.x · DOI
  21. Harris, 2011, Autophagy and cytokines, Cytokine, 56, 140, 10.1016/j.cyto.2011.08.022 · DOI
  22. Haspel, 2011, Autophagy: a core cellular process with emerging links to pulmonary disease, Am. J. Respir. Crit. Care Med., 184, 1237, 10.1164/rccm.201106-0966CI · DOI
  23. Heath-Engel, 2008, The endoplasmic reticulum in apoptosis and autophagy: role of the BCL-2 protein family, Oncogene, 27, 6419, 10.1038/onc.2008.309 · DOI
  24. Hussain, 2013, Interplay between apoptotic and autophagy pathways after exposure to cerium dioxide nanoparticles in human monocytes, Autophagy, 9, 101, 10.4161/auto.22266 · DOI
  25. Hussain, 2012, Cerium dioxide nanoparticles induce apoptosis and autophagy in human peripheral blood monocytes, ACS Nano, 6, 5820, 10.1021/nn302235u · DOI
  26. Jones, 2013, Autophagy and inflammatory diseases, Immunol. Cell Biol., 91, 250, 10.1038/icb.2012.82 · DOI
  27. Klionsky, 2008, Does bafilomycin A1 block the fusion of autophagosomes with lysosomes?, Autophagy, 4, 849, 10.4161/auto.6845 · DOI · Paper page
  28. Kroll, 2009, Current in vitro methods in nanoparticle risk assessment: limitations and challenges, Eur. J. Pharm. Biopharm., 72, 370, 10.1016/j.ejpb.2008.08.009 · DOI
  29. Kroll, 2012, Interference of engineered nanoparticles with in vitro toxicity assays, Arch. Toxicol., 86, 1123, 10.1007/s00204-012-0837-z · DOI
  30. Li, 2013, Rapamycin induces autophagy in the melanoma cell line M14 via regulation of the expression levels of Bcl-2 and Bax, Oncol. Lett., 5, 167, 10.3892/ol.2012.986 · DOI
  31. Logue, 2013, New directions in ER stress-induced cell death, Apoptosis, 18, 537, 10.1007/s10495-013-0818-6 · DOI
  32. Madeo, 2009, Autophagy for the avoidance of neurodegeneration, Genes Dev., 23, 2253, 10.1101/gad.1858009 · DOI
  33. Maier, 2002, Role of superoxide dismutases in oxidative damage and neurodegenerative disorders, Neuroscientist, 8, 323, 10.1177/107385840200800408 · DOI
  34. Marquez, 2012, Bcl-2: Beclin 1 complex: multiple, mechanisms regulating autophagy/apoptosis toggle switch, Am. J. Cancer Res., 2, 214
  35. Matsumoto, 1996, Ectopic expression of CHOP(GADD153) induces apoptosis in M1 myeloblastic leukemia cells, FEBS Lett., 395, 143, 10.1016/0014-5793(96)01016-2 · DOI
  36. Mehrpour, 2010, Autophagy in health and disease. 1. Regulation and significance of autophagy: an overview, Am. J. Physiol. Cell Physiol., 298, C776, 10.1152/ajpcell.00507.2009 · DOI
  37. Moretti, 2007, Switch between apoptosis and autophagy: radiation-induced endoplasmic reticulum stress?, Cell Cycle, 6, 793, 10.4161/cc.6.7.4036 · DOI
  38. Moscat, 2009, P62 at the crossroads of autophagy, apoptosis, and cancer, Cell, 137, 1001, 10.1016/j.cell.2009.05.023 · DOI · Paper page
  39. Nel, 2009, Understanding biophysicochemical interactions at the nano-bio interface, Nat. Mater., 8, 543, 10.1038/nmat2442 · DOI · Paper page
  40. Ni, 2007, ER chaperones in mammalian development and human diseases, FEBS Lett., 581, 3641, 10.1016/j.febslet.2007.04.045 · DOI
  41. Ni, 2012, Targeting autophagy for the treatment of liver diseases, Pharmacol. Res., 66, 463, 10.1016/j.phrs.2012.07.003 · DOI
  42. Ouimet, 2013, Autophagy in obesity and atherosclerosis: interrelationships between cholesterol homeostasis, lipoprotein metabolism and autophagy in macrophages and other systems, Biochim. Biophys. Acta, 1831, 1124, 10.1016/j.bbalip.2013.03.007 · DOI
  43. Park, 2008, Oxidative stress and apoptosis induced by titanium dioxide nanoparticles in cultured BEAS-2B cells, Toxicol. Lett., 180, 222, 10.1016/j.toxlet.2008.06.869 · DOI
  44. Park, 2013, Comparison of toxicity between the different-type TiO2 nanowires in vivo and in vitro, Arch. Toxicol., 87, 1219, 10.1007/s00204-013-1019-3 · DOI
  45. Park, 2014, ERK pathway is activated in bare-FeNPs-induced autophagy, Arch. Toxicol., 88, 323, 10.1007/s00204-013-1134-1 · DOI
  46. Park, 2014, Magnetite and maghemite induced different toxicity in murine alveolar macrophage cells, Arch. Toxicol., 88, 1607, 10.1007/s00204-014-1210-1 · DOI
  47. Puppi, 2011, Use of a clinically approved iron oxide MRI contrast agent to label human hepatocytes, Cell Transplant., 20, 963, 10.3727/096368910X543367 · DOI
  48. Puthalakath, 2007, ER stress triggers apoptosis by activating BH3-only protein Bim, Cell, 129, 1337, 10.1016/j.cell.2007.04.027 · DOI
  49. Rikiishi, 2012, Novel insights into the interplay between apoptosis and autophagy, Int. J. Cell Biol., 317645
  50. Runge, 2001, Safety of magnetic resonance contrast media, Top. Magn. Reson. Imaging, 12, 309, 10.1097/00002142-200108000-00007 · DOI
  51. Sano, 2013, ER stress-induced cell death mechanisms, Biochim. Biophys. Acta, 1833, 3460, 10.1016/j.bbamcr.2013.06.028 · DOI · Paper page
  52. Sharma, 2002, Cytokines, apoptosis and cachexia: the potential for TNF antagonism, Int. J. Cardiol., 85, 161, 10.1016/S0167-5273(02)00244-9 · DOI
  53. Sperandio, 2000, An alternative, nonapoptotic form of programmed cell death, Proc. Natl. Acad. Sci. USA, 97, 14376, 10.1073/pnas.97.26.14376 · DOI
  54. Stern, 2012, Autophagy and lysosomal dysfunction as emerging mechanisms of nanomaterial toxicity, Part. Fibre Toxicol., 9, 20, 10.1186/1743-8977-9-20 · DOI
  55. Thorek, 2006, Superparamagnetic iron oxide nanoparticle probes for molecular imaging, Ann. Biomed. Eng., 34, 23, 10.1007/s10439-005-9002-7 · DOI
  56. Verma, 2010, Effect of surface properties on nanoparticle-cell interactions, Small, 6, 12, 10.1002/smll.200901158 · DOI
  57. Wang, 2011, Superparamagnetic iron oxide based MRI contrast agents. Current status of clinical application, Quant. Imaging Med. Surg., 1, 35
  58. Wang, 2013, Autophagy regulates inflammation following oxidative injury in diabetes, Autophagy, 9, 272, 10.4161/auto.23628 · DOI
  59. Xie, 2012, Autophagy is induced through the ROS-TP53-DRAM1 pathway in response to mitochondrial protein synthesis inhibition, Autophagy, 8, 1071, 10.4161/auto.20250 · DOI
  60. Yang, 2010, Dysregulation of autophagy and Parkinson’s disease: the MEF2D link, Apoptosis, 15, 1410, 10.1007/s10495-010-0475-y · DOI
  61. Yoshimori, 1991, Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells, J. Biol. Chem., 266, 17707, 10.1016/S0021-9258(19)47429-2 · DOI
  62. Zhang, 2013, DRAM1 regulates autophagy flux through lysosomes, PLoS ONE, 8, e63245, 10.1371/journal.pone.0063245 · DOI

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Metadata

Authors
Park, E.-J., Choi, D.-H., Kim, Y., Lee, E.-W., Song, J., Cho, M.-H., Kim, J.-H., & Kim, S.-W.
Venue
Toxicology in Vitro
Publisher
Elsevier BV
Published
2014-12
Volume
28
Issue
8
Pages
1402-1412
ISSN
0887-2333
DOI
10.1016/j.tiv.2014.07.010
Cited by
104
References
2
Language
en
Licence
Funders
  • Ministry of Education, Science and Technology (2011-35B-E00011)
  • National Research Foundation of Korea

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