A 4-week repeated oral dose toxicity study of fucoidan from the sporophyll of Undaria pinnatifida in Sprague-Dawley rats
Abstract
Fucoidan is extracted from brown seaweeds, which can have anti-coagulant, antithrombotic, antitumor, and antiviral activities. However, detailed studies on the toxicology of fucoidan have not been performed. Here we tested the toxicity of fucoidan in Sprague-Dawley rats. Fucoidan (1350mg/kg bw/day for 4 weeks) did not induce statistically significant differences in groups matched by gender with respect to body weight, ophthalmoscopy, urinalysis, hematology, and histopathology. Fucoidan did not change prothrombin time or activated partial thromboplastin time, indicating an inability to change blood clotting. This study demonstrated that fucoidan is not toxic under this administration paradigm.
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Fucoidans have attracted attention as practically nontoxic natural products with antitumor, immunomodulatory, and other useful properties.
“This research is necessary for the solution of problems of standardization of preparations on the basis of fucoidans, which have attracted attention as practically nontoxic natural products [25,26,27] with antitumor, immunomodulatory, and other useful properties [24,28,29,30].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [27]
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References 17 · Cited by 83
- Authors
- Kim, K.-J., Lee, O.-H., Lee, H.-H., & Lee, B.-Y.
- Affiliations
- CHA University (KR)
- Corresponding author
- Lee, Boo-Yong
- Venue
- Toxicology
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 267
- Issue
- 1-3
- Pages
- 154-158
- ISSN
- 0300-483X (ISSN-L)
- OpenAlex
- W2025539784
- Cited by
- 83
- References
- 17
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 8 · 2023: 5 · 2022: 4 · 2021: 3 · 2020: 8 · 2019: 7 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 8 · 2014: 2 · 2013: 3 · 2012: 5
- FWCI
- 8.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Korea Food and Drug Administration
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
- Keywords
- fucoidan, Undaria pinnatifida, brown algae, repeated oral toxicity, safety assessment, hematology, coagulation, prothrombin time, activated partial thromboplastin time, histopathology, Sprague-Dawley rats
- MeSH terms
- Administration, Oral, Animals, Anticoagulants, Antineoplastic Agents, Antiviral Agents, Body Weight, Drinking, Eating, Female, Fibrinolytic Agents, Male, Organ Size, Polysaccharides, Biomarkers, Rats, Sprague-Dawley, Toxicity Tests, Undaria, Rats
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