The DOI matches its Crossref record; 126 of the 126 references it cites were found in a registry or an index.
Snake venom metalloproteinases
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Díaz‐Perales, A., Quesada, V., Peinado, J. R., Ugalde, A. P., Álvarez, J., Suárez, M. F., Gomis‐Rüth, F. X., & López-Otı́n, C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504533200 · Cited by 29
RetractedBode, W., Gomis-Rüth, F.-X., & Stöckler, W. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80312-i · Cited by 757
Snake venoms and the hemostatic system
Markland, F. S. (1998) · Toxicon · doi:10.1016/s0041-0101(98)00126-3 · Cited by 703
Self-citationHemorrhagic metalloproteinases from snake venoms
Bjarnason, J. B., & Fox, J. W. (1994) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(94)90049-3 · Cited by 619
Fox, J. W., & Serrano, S. M. T. (2005) · Toxicon · doi:10.1016/j.toxicon.2005.02.012 · Cited by 587
Baumann, U., Wu, S., Flaherty, K. M., & McKay, D. B. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06009.x · Cited by 473
Gutiérrez, J. M., Rucavado, A., Escalante, T., & Díaz, C. (2005) · Toxicon · doi:10.1016/j.toxicon.2005.02.029 · Cited by 473
Matrix metalloproteinases: Fold and function of their catalytic domains
Tallant, C., Marrero, A., & Gomis-Rüth, F. X. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2009.04.003 · Cited by 463
Handbook of Venoms and Toxins of Reptiles
(2016) · CRC Press eBooks · doi:10.1201/9781420008661 · Cited by 462
Fox, J. W., & Serrano, S. M. T. (2008) · The FEBS Journal · doi:10.1111/j.1742-4658.2008.06466.x · Cited by 452
Research works printed but not linked: 66
- Adler, 1991, Solution structure of kistrin, a potent platelet aggregation inhibitor and Gp IIb-IIIa antagonist, Science, 253, 445, 10.1126/science.1862345 · doi:10.1126/science.1862345
- Anderson, 1997, Systemic hemorrhage induced by proteinase H from Crotalus adamanteus (eastern diamondback rattlesnake) venom, Toxicon, 35, 1301, 10.1016/S0041-0101(97)00012-3 · doi:10.1016/s0041-0101(97)00012-3
- Arakawa, 1989, Alpha 2-Macroglobulin traps a proteinase in the midregion of its arms. An immunoelectron microscopic study, J. Biol. Chem., 264, 2350, 10.1016/S0021-9258(18)94183-9 · doi:10.1016/s0021-9258(18)94183-9
- Au, 1993, Nucleotide sequence of a full-length cDNA encoding a common precursor of platelet aggregation inhibitor and hemorrhagic protein from Calloselasma rhodostoma venom, Biochim. Biophys. Acta, 1173, 243, 10.1016/0167-4781(93)90190-O · doi:10.1016/0167-4781(93)90190-o
- Bajwa, 1980, Fibrinolytic enzyme(s) in western diamondback rattlesnake (Crotalus atrox) venom, Toxicon, 18, 285, 10.1016/0041-0101(80)90007-0 · doi:10.1016/0041-0101(80)90007-0
- Bajwa, 1981, Fibrinolytic and fibrinogen clotting enzymes present in the venoms of western diamondback rattlesnake, Crotalus atrox, eastern diamondback rattlesnake, Crotalus adamanteus, and southern Pacific rattlesnake, Crotalus viridis helleri, Toxicon, 19, 53, 10.1016/0041-0101(81)90117-3 · doi:10.1016/0041-0101(81)90117-3
- Bajwa, 1981, Clinical potential of fibrinolytic enzyme(s) of western diamondback rattlesnake (Crotalus atrox) venom, Proc. West. Pharmacol. Soc., 24, 165
- Bajwa, 1982, Thrombin-like and fibrinolytic enzymes in the venoms from the gaboon viper (Bitis gabonica), eastern cottonmouth moccasin (Agkistrodon p. piscivorus) and southern copperhead (Agkistrodon c. contortrix) snakes, Toxicon, 20, 427, 10.1016/0041-0101(82)90005-8 · doi:10.1016/0041-0101(82)90005-8
- Bee, 2001, Novel in vitro assays for assessing the haemorrhagic activity of snake venoms and for demonstration of venom metalloproteinase inhibitors, Toxicon, 39, 1429, 10.1016/S0041-0101(01)00103-9 · doi:10.1016/s0041-0101(01)00103-9
- Berger, 2008, Purification and functional characterization of bothrojaractivase, a prothrombin-activating metalloproteinase isolated from Bothrops jararaca snake venom, Toxicon, 51, 488, 10.1016/j.toxicon.2007.09.005 · doi:10.1016/j.toxicon.2007.09.005
- Bolger, 2001, Three-dimensional structure of fibrolase, the fibrinolytic enzyme from southern copperhead venom, modeled from the x-ray structure of adamalysin II and atrolysin C, Aaps Pharmsci., 3, E16, 10.1208/ps030216 · doi:10.1208/ps030216
- Bovill, 1995, Evidence that meizothrombin is an intermediate product in the clotting of whole blood, Arterioscler. Thromb. Vasc. Biol., 15, 754, 10.1161/01.ATV.15.6.754 · doi:10.1161/01.atv.15.6.754
- Chen, 1991, Proton NMR assignments and secondary structure of the snake venom protein echistatin, Biochemistry, 30, 11625, 10.1021/bi00114a004 · doi:10.1021/bi00114a004
- Cooke, 1991, Nuclear magnetic resonance studies of the snake toxin echistatin. 1H resonance assignments and secondary structure, Eur. J. Biochem., 202, 323, 10.1111/j.1432-1033.1991.tb16379.x · doi:10.1111/j.1432-1033.1991.tb16379.x
- Dalvit, 1991, 1H NMR studies of echistatin in solution. sequential resonance assignments and secondary structure, Eur. J. Biochem., 202, 315, 10.1111/j.1432-1033.1991.tb16378.x · doi:10.1111/j.1432-1033.1991.tb16378.x
- Deitcher, 2006, Alfimeprase: a novel recombinant direct-acting fibrinolytic, Expert Opin. Biol. Ther., 6, 1361, 10.1517/14712598.6.12.1361 · doi:10.1517/14712598.6.12.1361
- Didisheim, 1956, Fibrinolytic and coagulant activities of certain snake venoms and proteases, Proc. Soc. Exp. Biol. Med., 93, 10, 10.3181/00379727-93-22647 · doi:10.3181/00379727-93-22647
- Guan, 1991, Purification and characterization of a fibrinolytic enzyme from venom of the southern copperhead snake (Agkistrodon contortrix contortrix), Arch. Biochem. Biophys., 289, 197, 10.1016/0003-9861(91)90462-R · doi:10.1016/0003-9861(91)90462-r
- Han, 2010, Efficacy and safety of alfimeprase in patients with acute peripheral arterial occlusion (Pao), J. Vasc. Surg., 51, 600, 10.1016/j.jvs.2009.08.053 · doi:10.1016/j.jvs.2009.08.053
- Hofmann, 1987, Blood coagulation induced by the venom of Bothrops atrox. 1. Identification, purification, and properties of a prothrombin activator, Biochemistry, 26, 772, 10.1021/bi00377a018 · doi:10.1021/bi00377a018
- Huang, 1989, Trigramin: primary structure and its inhibition of Von Willebrand factor binding to glycoprotein IIb/IIIa complex on human Platelets, Biochemistry, 28, 661, 10.1021/bi00428a037 · doi:10.1021/bi00428a037
- Huang, 1984, Action mechanism of the potent platelet aggregation inhibitor from Trimeresurus gramineus snake venom, Thromb. Res., 33, 125, 10.1016/0049-3848(84)90173-7 · doi:10.1016/0049-3848(84)90173-7
- Huang, 1987, Characterization of a potent platelet aggregation inhibitor from Agkistrodon rhodostoma snake venom, Biochim. Biophys. Acta, 925, 248, 10.1016/0304-4165(87)90189-9 · doi:10.1016/0304-4165(87)90189-9
- Joseph, 2001, Snake venom prothrombin activators homologous to blood coagulation factor Xa, Haemostasis, 31, 234
- Kashyap, 2010, Invited commentary. Efficacy and safety of alfimeprase in patients with acute peripheral arterial occlusion (Pao), J. Vasc. Surg., 51, 609, 10.1016/j.jvs.2009.08.054 · doi:10.1016/j.jvs.2009.08.054
- Kini, 1990, Effects of snake venom proteins on blood platelets, Toxicon, 28, 1387, 10.1016/0041-0101(90)90155-Z · doi:10.1016/0041-0101(90)90155-z
- Kornalik, 1967, Fibrinolytic proteases in snake venoms, Experientia, 23, 999, 10.1007/BF02136407 · doi:10.1007/bf02136407
- Kress, 1980, Enzymatic inactivation of human antithrombin III. Limited proteolysis of the inhibitor by snake venom proteinases in the presence of heparin, Biochim. Biophys. Acta, 615, 178, 10.1016/0005-2744(80)90021-2 · doi:10.1016/0005-2744(80)90021-2
- Kress, 1981, Identification of the cleavage sites resulting from enzymatic inactivation of human antithrombin Iii by Crotalus adamanteus proteinase II in the the presence and absence of heparin, Biochemistry, 20, 7432, 10.1021/bi00529a017 · doi:10.1021/bi00529a017
- Kress, 1984, Enzymatic inactivation of human alpha 1-antichymotrypsin by metalloproteinases in snake venoms of the family Elapidae, Comp. Biochem. Physiol. B, 77, 431, 10.1016/0305-0491(84)90255-4 · doi:10.1016/0305-0491(84)90255-4
- Kress, 1980, Studies on the complex between human alpha 2-macroglobulin and Crotalus adamanteus proteinase II. Release of active proteinase from the complex, Biochim. Biophys. Acta, 613, 469, 10.1016/0005-2744(80)90101-1 · doi:10.1016/0005-2744(80)90101-1
- Macfarlane, 1961, The coagulant action of russell's viper venom; the use of antivenom in defining its reaction with s serum factor, Br. J. Haematol., 7, 496, 10.1111/j.1365-2141.1961.tb00358.x · doi:10.1111/j.1365-2141.1961.tb00358.x
- Maeno, 1960, Studies on habu snake venom. 2c. Studies on H beta-proteinase of habu venom, Jpn. J. Microbiol., 4, 173, 10.1111/j.1348-0421.1960.tb00165.x · doi:10.1111/j.1348-0421.1960.tb00165.x
- Markland, 1994, Thrombolytic effects of recombinant fibrolase or apsac in a canine model of carotid artery thrombosis, Circulation, 90, 2448, 10.1161/01.CIR.90.5.2448 · doi:10.1161/01.cir.90.5.2448
- Markland, 2010, Fibrolase: trials and tribulations, Toxins (Basel), 2, 793, 10.3390/toxins2040793 · doi:10.3390/toxins2040793
- Moise, 2008, Alfimeprase for the treatment of acute peripheral arterial occlusion, Expert Opin. Biol. Ther., 8, 683, 10.1517/14712598.8.5.683 · doi:10.1517/14712598.8.5.683
- Musial, 1990, Inhibition of platelet adhesion to surfaces of extracorporeal circuits by disintegrins. RGD-containing peptides from viper venoms, Circulation, 82, 261, 10.1161/01.CIR.82.1.261 · doi:10.1161/01.cir.82.1.261
- Neeper, 1990, Sequence of a cDNA encoding the platelet aggregation inhibitor trigramin, Nucleic Acids Res., 18, 4255, 10.1093/nar/18.14.4255 · doi:10.1093/nar/18.14.4255
- Nelsestuen, 1972, The purification and properties of an abnormal prothrombin protein produced by dicumarol-treated cows. A comparison to normal prothrombin, J. Biol. Chem., 247, 8176, 10.1016/S0021-9258(20)81825-0 · doi:10.1016/s0021-9258(20)81825-0
- Ohsaka, 1960, Fractionation of habu snake venom by chromatography on cm-cellulose with special reference to biological activities, Jpn. J. Med. Sci. Biol., 13, 199, 10.7883/yoken1952.13.199 · doi:10.7883/yoken1952.13.199
- Okonogi, 1960, Studies on the habu snake venom. 3–2. A comparative study of histopathological changes caused by crude venom, purified habu-proteinase and other proteinases, Jpn. J. Microbiol., 4, 189, 10.1111/j.1348-0421.1960.tb00167.x · doi:10.1111/j.1348-0421.1960.tb00167.x
- Omori, 1962, Toxic action of mamushi venom with special reference to hemorrhage, Nisin Igaku, 49, 770
- Ouyang, 1983, Potent platelet aggregation inhibitor from Trimeresurus gramineus snake venom, Biochim. Biophys. Acta, 757, 332, 10.1016/0304-4165(83)90059-4 · doi:10.1016/0304-4165(83)90059-4
- Ouyang, 1992, Characterization of snake venom components acting on blood coagulation and platelet function, Toxicon, 30, 945, 10.1016/0041-0101(92)90040-C · doi:10.1016/0041-0101(92)90040-c
- Ouyang, 1983, A potent platelet aggregation inhibitor purified from Agkistrodon halys (Mamushi) snake venom, Toxicon, 21, 797, 10.1016/0041-0101(83)90068-5 · doi:10.1016/0041-0101(83)90068-5
- Ouyang, 1985, Characterization of the platelet aggregation inducer and inhibitor from Echis carinatus snake venom, Biochim. Biophys. Acta, 841, 1, 10.1016/0304-4165(85)90267-3 · doi:10.1016/0304-4165(85)90267-3
- Ownby, 1974, Pathogenesis of hemorrhage induced by rattlesnake venom. An electron microscopic study, Am. J. Pathol., 76, 401
- Ownby, 1990, Pathogenesis of hemorrhage induced by bilitoxin, a hemorrhagic toxin isolated from the venom of the common cantil (Agkistrodon bilineatus bilineatus), Toxicon, 28, 837, 10.1016/S0041-0101(09)80006-8 · doi:10.1016/s0041-0101(09)80006-8
- Quinton, 2005, Characterization of toxins within crude venoms by combined use of fourier transform mass spectrometry and cloning, Anal. Chem., 77, 6630, 10.1021/ac050575k · doi:10.1021/ac050575k
- Randolph, 1992, Amino acid sequence of fibrolase, a direct-acting fibrinolytic enzyme from Agkistrodon contortrix contortrix venom, Protein Sci., 1, 590, 10.1002/pro.5560010505 · doi:10.1002/pro.5560010505
- Retzios, 1988, A direct-acting fibrinolytic enzyme from the venom of Agkistrodon contortrix contortrix: effects on various components of the human blood coagulation and fibrinolysis systems, Thromb. Res., 52, 541, 10.1016/0049-3848(88)90127-2 · doi:10.1016/0049-3848(88)90127-2
- Rosing, 1992, Structural and functional properties of snake venom prothrombin activators, Toxicon, 30, 1515, 10.1016/0041-0101(92)90023-X · doi:10.1016/0041-0101(92)90023-x
- Saudek, 1991, The secondary structure of echistatin from 1H-NMR, circular-dichroism and Raman spectroscopy, Eur. J. Biochem., 202, 329, 10.1111/j.1432-1033.1991.tb16380.x · doi:10.1111/j.1432-1033.1991.tb16380.x
- Siigur, 1996, cDNA cloning and deduced amino acid sequence of fibrinolytic enzyme (lebetase) from Vipera lebetina snake venom, Biochem. Biophys. Res. Commun., 224, 229, 10.1006/bbrc.1996.1012 · doi:10.1006/bbrc.1996.1012
- Sottrup-Jensen, 1981, Sequence location of the reactive thiol ester in human alpha 2-macroglobulin, FEBS Lett., 123, 145, 10.1016/0014-5793(81)80039-7 · doi:10.1016/0014-5793(81)80039-7
- Sottrup-Jensen, 1981, Primary structure of the ‘Bait’ region for proteinases in alpha 2-macroglobulin. Nature of the complex, FEBS Lett., 127, 167, 10.1016/0014-5793(81)80197-4 · doi:10.1016/0014-5793(81)80197-4
- Sottrup-Jensen, 1981, Mechanism of proteinase complex formation with alpha 2-macroglobulin. Three modes of trypsin binding, FEBS Lett., 128, 127, 10.1016/0014-5793(81)81097-6 · doi:10.1016/0014-5793(81)81097-6
- St Pierre, 2007, Diversity of toxic components from the venom of the evolutionarily distinct black whip snake, Demansia vestigiata, J. Proteome Res., 6, 3093, 10.1021/pr0701613 · doi:10.1021/pr0701613
- Swenson, 2005, Snake venom fibrin(ogen)olytic enzymes, Toxicon, 45, 1021, 10.1016/j.toxicon.2005.02.027 · doi:10.1016/j.toxicon.2005.02.027
- Teng, 1985, Action mechanism of the platelet aggregation inducer and inhibitor from Echis carinatus snake venom, Biochim. Biophys. Acta, 841, 8, 10.1016/0304-4165(85)90268-5 · doi:10.1016/0304-4165(85)90268-5
- Toombs, 2001, Alfimeprase: pharmacology of a novel fibrinolytic metalloproteinase for thrombolysis, Haemostasis, 31, 141
- Toombs, 2001, New directions in thrombolytic therapy, Curr. Opin. Pharmacol., 1, 164, 10.1016/S1471-4892(01)00030-3 · doi:10.1016/s1471-4892(01)00030-3
- Tu, 1996, Biochemical characterization of atroxase and nucleotide sequence encoding the fibrinolytic enzyme, Toxicon, 34, 1295, 10.1016/S0041-0101(96)00106-7 · doi:10.1016/s0041-0101(96)00106-7
- Waltersperger, 2010, Crystal structure of archaemetzincin AmzA from Methanopyrus kandleri at 1.5 A resolution, Proteins, 78, 2720, 10.1002/prot.22777 · doi:10.1002/prot.22777
- Wang, 2005, Primary structure and antiplatelet mechanism of a snake venom metalloproteinase, acurhagin, from Agkistrodon acutus venom, Biochimie, 87, 1065, 10.1016/j.biochi.2005.06.002 · doi:10.1016/j.biochi.2005.06.002
- Yamada, 1997, Purification and characterization of a Ca2+-dependent prothrombin activator, multactivase, from the venom of Echis multisquamatus, J. Biochem., 122, 991, 10.1093/oxfordjournals.jbchem.a021862 · doi:10.1093/oxfordjournals.jbchem.a021862
Cited by
Eble, J. A. (2019) · Toxins · doi:10.3390/toxins11030136 · Cited by 82
Chromosome-level reference genome of the jellyfish Rhopilema esculentum
Li, Y., Gao, L., Pan, Y., Tian, M., Li, Y., He, C., Dong, Y., Sun, Y., & Zhou, Z. (2020) · GigaScience · doi:10.1093/gigascience/giaa036 · Cited by 31
Wei, Y., Lu, Q.-Y., Zhong, X.-J., Guo, L., Zeng, F.-Y., & Sun, Q.-Y. (2023) · Toxicon · doi:10.1016/j.toxicon.2023.107210 · Cited by 5
Alangode, A., Rajasekhar, A., Sabu, J. J., Krishna, S., Anuja, D., Sreeja, A., Remesh, G., Kaladevi, A., & Nair, B. G. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27156830
Metadata
- Authors
- Markland, F. S., & Swenson, S.
- Venue
- Toxicon
- Publisher
- Elsevier BV
- Published
- 2013-02
- Volume
- 62
- Pages
- 3-18
- ISSN
- 0041-0101 (ISSN-L)
- OpenAlex
- W1977229831
- Cited by
- 345
- References
- 126
- FWCI
- 11.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Snake venom metalloproteinases. https://app.cochat.ai/papers/10.1016/j.toxicon.2012.09.004
- The paper
- Markland, F. S., & Swenson, S. (2013). Snake venom metalloproteinases. Toxicon. https://doi.org/10.1016/j.toxicon.2012.09.004
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.