The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Plant-made vaccine antigens and biopharmaceuticals
Open accessAbstract
Plant cells are ideal bioreactors for the production and oral delivery of vaccines and biopharmaceuticals, eliminating the need for expensive fermentation, purification, cold storage, transportation and sterile delivery. Plant-made vaccines have been developed for two decades but none has advanced beyond Phase I. However, two plant-made biopharmaceuticals are now advancing through Phase II and Phase III human clinical trials. In this review, we evaluate the advantages and disadvantages of different plant expression systems (stable nuclear and chloroplast or transient viral) and their current limitations or challenges. We provide suggestions for advancing this valuable concept for clinical applications and conclude that greater research emphasis is needed on large scale production, purification, functional characterization, oral delivery and preclinical evaluation.
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Citations
Cites
1 retracted
Voinnet, O., Rivas, S., Mestre, P., & Baulcombe, D. (2003) · The Plant Journal · doi:10.1046/j.1365-313x.2003.01676.x · Cited by 1,734
RetractedThe challenge of emerging and re-emerging infectious diseases
Morens, D. M., Folkers, G. K., & Fauci, A. S. (2004) · Nature · doi:10.1038/nature02759 · Cited by 2,103
Protecting Households From Catastrophic Health Spending
Xu, K., Evans, D. B., Carrin, G., Aguilar-Rivera, A. M., Musgrove, P., & Evans, T. (2007) · Health Affairs · doi:10.1377/hlthaff.26.4.972 · Cited by 1,071
Immunogenicity in humans of a recombinant bacterial antigen delivered in a transgenic potato
Tacket, C. O., Mason, H. S., Losonsky, G., Clements, J. D., Levine, M. M., & Arntzen, C. J. (1998) · Nature Medicine · doi:10.1038/nm0598-607 · Cited by 581
Self-citationStrasser, R., Stadlmann, J., Schähs, M., Stiegler, G., Quendler, H., Mach, L., Glössl, J., Weterings, K., Pabst, M., & Steinkellner, H. (2008) · Plant Biotechnology Journal · doi:10.1111/j.1467-7652.2008.00330.x · Cited by 520
Molecular strategies for gene containment in transgenic crops
Daniell, H. (2002) · Nature Biotechnology · doi:10.1038/nbt0602-581 · Cited by 496
Self-citationHigh-yield production of a human therapeutic protein in tobacco chloroplasts
Staub, J. M., Garcia, B., Graves, J., Hajdukiewicz, P. T. J., Hunter, P., Nehra, N., Paradkar, V., Schlittler, M., Carroll, J. A., Spatola, L., et al. (2000) · Nature Biotechnology · doi:10.1038/73796 · Cited by 486
Human Immune Responses to a Novel Norwalk Virus Vaccine Delivered in Transgenic Potatoes
Tacket, C. O., Mason, H. S., Losonsky, G., Estes, M. K., Levine, M. M., & Arntzen, C. J. (2000) · The Journal of Infectious Diseases · doi:10.1086/315653 · Cited by 481
Self-citationShaaltiel, Y., Bartfeld, D., Hashmueli, S., Baum, G., Brill‐Almon, E., Galili, G., Dym, O., Boldin‐Adamsky, S. A., Silman, I., Sussman, J. L., et al. (2007) · Plant Biotechnology Journal · doi:10.1111/j.1467-7652.2007.00263.x · Cited by 425
Giritch, A., Marillonnet, S., Engler, C., van Eldik, G., Botterman, J., Klimyuk, V., & Gleba, Y. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606631103 · Cited by 419
Cited by
The Future of Aquatic Protein: Implications for Protein Sources in Aquaculture Diets
Hua, K., Cobcroft, J. M., Cole, A., Condon, K., Jerry, D. R., Mangott, A., Praeger, C., Vucko, M. J., Zeng, C., Zenger, K., et al. (2019) · One Earth · doi:10.1016/j.oneear.2019.10.018 · Cited by 851
Metadata
- Authors
- Daniell, H., Singh, N. D., Mason, H., & Streatfield, S. J.
- Venue
- Trends in Plant Science
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 14
- Issue
- 12
- Pages
- 669-679
- ISSN
- 1360-1385 (ISSN-L)
- OpenAlex
- W2065035248
- Cited by
- 405
- References
- 78
- FWCI
- 3.61
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Daniell, H., Singh, N. D., Mason, H., & Streatfield, S. J. (2009). Plant-made vaccine antigens and biopharmaceuticals. Trends in Plant Science. https://doi.org/10.1016/j.tplants.2009.09.009
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
