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Cited by 55Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsPhysical Activity and Health

Patients with Alzheimer's disease who carry the APOE ε4 allele benefit more from physical exercise

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Jensen, Camilla Steen, Simonsen, Anja Hviid, Siersma, Volkert, Beyer, Nina, Frederiksen, Kristian Steen, Gottrup, Hanne, Hoffman, Kristine, Høgh, Peter +5 more·2019·Alzheimer's & Dementia: Translational Research & Clinical Interventions
DOI 10.1016/j.trci.2019.02.007PMC PMC6461575
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Abstract

Introduction: Our group has completed an exercise study of 200 patients with mild Alzheimer's disease. We found improvements in cognitive, neuropsychiatric, and physical measures in the participants who adhered to the protocol. Epidemiological studies in healthy elderly suggest that exercise preserves cognitive and physical abilities to a higher extent in AP OE ε4 carriers. Methods: In this post hoc subgroup analysis study, we investigated whether the beneficial effect of an exercise intervention in patients with mild AD was dependent on the patients' APOE genotype. Results: We found that patients who were APOE ε4 carriers benefitted more from the exercise intervention by preservation of cognitive performance and improvement in physical measures. Discussion: This exploratory study establishes a possible connection between the beneficial effects of exercise in AD and the patients' APOE genotype. These findings, if validated, could greatly impact the clinical management of patients with AD and those at risk for developing AD.

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  • Physical activity appears to decrease risk of dementia.

    “In contrast, physical activity appears to decrease risk. [119][120]0][121][122][123][124][125][126][127][128]”

    From 2023 Alzheimer's disease facts and figures (2023) · cites this paper as [126]

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Authors
Jensen, C. S., Simonsen, A. H., Siersma, V., Beyer, N., Frederiksen, K. S., Gottrup, H., Hoffman, K., Høgh, P., Frikke‐Schmidt, R., Sobol, N. A., Waldemar, G., Wermuth, L., & Hasselbalch, S. G.
Affiliations
  • Copenhagen University Hospital (DK)
  • University of Copenhagen (DK)
  • Aarhus University Hospital (DK)
  • Odense University Hospital (DK)
Corresponding author
Simonsen, Anja Hviid
ORCID
Venue
Alzheimer's & Dementia: Translational Research & Clinical Interventions
Publisher
Wiley
Published
2019-01
Volume
5
Issue
1
Pages
99-106
ISSN
2352-8737 (ISSN-L)
DOI
10.1016/j.trci.2019.02.007
PMC
PMC6461575
OpenAlex
W2937382913
Cited by
55
References
7
Citations by year
2026: 4 · 2025: 3 · 2024: 9 · 2023: 10 · 2022: 9 · 2021: 11 · 2020: 7 · 2019: 2
FWCI
5.78
Type
journal article
Language
en
Open access
Licence
Locations
  • Alzheimer s & Dementia Translational Research & Clinical Interventions (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by-nc-nd)
  • University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
Ministeriet Sundhed Forebyggelse
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
Keywords
Alzheimer's disease, APOE ε4, physical activity, exercise intervention, genetic susceptibility, cognitive performance, physical function, neuropsychiatric symptoms, mild Alzheimer's disease, post hoc subgroup analysis

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