An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus
Open accessAbstract
With continued debate over the functional significance of adult neurogenesis, identifying an in vivo correlate of neurogenesis has become an important goal. Here we rely on the coupling between neurogenesis and angiogenesis and test whether MRI measurements of cerebral blood volume (CBV) provide an imaging correlate of neurogenesis. First, we used an MRI approach to generate CBV maps over time in the hippocampal formation of exercising mice. Among all hippocampal subregions, exercise was found to have a primary effect on dentate gyrus CBV, the only subregion that supports adult neurogenesis. Moreover, exercise-induced increases in dentate gyrus CBV were found to correlate with postmortem measurements of neurogenesis. Second, using similar MRI technologies, we generated CBV maps over time in the hippocampal formation of exercising humans. As in mice, exercise was found to have a primary effect on dentate gyrus CBV, and the CBV changes were found to selectively correlate with cardiopulmonary and cognitive function. Taken together, these findings show that dentate gyrus CBV provides an imaging correlate of exercise-induced neurogenesis and that exercise differentially targets the dentate gyrus, a hippocampal subregion important for memory and implicated in cognitive aging.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A potential indirect measurement is the correlation between cerebral blood volume in the dentate gyrus, cognitive enhancements, and adult neurogenesis as a function of exercise.
“A potential indirect measurement that has been established is the correlation between cerebral blood volume in the dentate gyrus, cognitive enhancements, and adult neurogenesis as a function of exercise (Pereira et al., 2007).”
From Exercise-Mediated Neurogenesis in the Hippocampus via BDNF (2018) · cites this paper as Pereira et al., 2007
In rodents, aerobic exercise raises dentate gyrus neurogenesis, and in humans it raises cerebral blood volume in that region.
“For example, it has been shown that aerobic exercise increases the rate of neurogenesis in the dentate gyrus region of the rodent hippocampus and increases cerebral blood volume (CBV) in the same region in humans (Pereira et al., 2007; van Praag et al., 1999a,b).”
From Multi-modal characterization of rapid anterior hippocampal volume increase associated with aerobic exercise (2016) · cites this paper as Pereira et al., 2007
Pereira et al. (2007) reported a significant CBV increase in the dentate gyrus after three months of aerobic exercise in eleven healthy adults.
“A previous human study by Pereira et al. (2007) reported a significant increase in CBV specifically in the dentate gyrus region of the hippocampus after three months of regular aerobic exercise in a group of eleven healthy adults.”
From Multi-modal characterization of rapid anterior hippocampal volume increase associated with aerobic exercise (2016) · cites this paper as Pereira et al., 2007
Rodent studies have shown robust hippocampal vascular change after prolonged exercise.
“previously published studies in rodents that have shown a robust vascular change within the hippocampus after a prolonged period of exercise (Pereira et al., 2007; Van der Borght et al., 2009; van Praag et al., 2005).”
From Multi-modal characterization of rapid anterior hippocampal volume increase associated with aerobic exercise (2016) · cites this paper as Pereira et al., 2007
Pereira et al.'s intervention was twice as long as the present one (3 months vs. 6 weeks).
“the intervention in Pereira et al. (2007) is twice as long (3 months vs. 6 weeks).”
From Multi-modal characterization of rapid anterior hippocampal volume increase associated with aerobic exercise (2016) · cites this paper as Pereira et al., 2007
Increased hippocampal volume may in part be explained by exercise-associated increases in neurogenesis in the dentate gyrus subfield of the hippocampus, which is negatively impacted in PTSD.
“Increased hippocampal volume may in part be explained by exercise associated increases in neurogenesis in the dentate gyrus subfield of the hippocampus (97, 98), which is negatively impacted in PTSD (84).”
From Exercise Intervention in PTSD: A Narrative Review and Rationale for Implementation (2019) · cites this paper as [98]
Aerobic exercise may also stimulate cell proliferation and dentate gyrus volume growth in the human brain.
“AE increases the rate of hippocampal neurogenesis, i.e., both the rate of cell proliferation as well as the survival of newborn granule cells (Cotman et al., 2007; Kempermann et al., 2010; Lucassen et al., 2010; Vivar et al., 2013) and despite being difficult to study in humans (Manganas et al., 2007; Ho et al., 2013; Jessberger and Gage, 2014), AE may also stimulate cell proliferation and DG”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Pereira et al., 2007
Increases in cerebral blood flow in the human hippocampus have been correlated with improved performance on episodic memory tasks.
“This coincides with studies that have demonstrated a greater cerebral blood flow in the human hippocampus (Pereira et al., 2007; Burdette et al., 2010; Maass et al., 2015), some of which have correlated this increase with improved performance on episodic memory tasks (Pereira et al., 2007; Maass et al., 2015).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Pereira et al., 2007
Greater cerebral blood flow in the human hippocampus has been demonstrated.
“This coincides with studies that have demonstrated a greater cerebral blood flow in the human hippocampus (Pereira et al., 2007; Burdette et al., 2010; Maass et al., 2015), some of which have correlated this increase with improved performance on episodic memory tasks (Pereira et al., 2007; Maass et al., 2015).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Pereira et al., 2007
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859 · see citing works
Neurogenesis in the adult human hippocampus
Eriksson, P. S., Perfilieva, E., Björk-Eriksson, T., Alborn, A.-M., Nordborg, C., Peterson, D. A., & Gage, F. H. (1998) · Nature Medicine · doi:10.1038/3305 · Cited by 6,369 · see citing works
Self-citationRequirement of hippocampal neurogenesis for the behavioral effects of antidepressants
Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321 · see citing works
Self-citationAngiogenesis in health and disease
Carmeliet, P. (2003) · Nature Medicine · doi:10.1038/nm0603-653 · Cited by 4,258 · see citing works
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
van Praag, H., Kempermann, G., & Gage, F. H. (1999) · Nature Neuroscience · doi:10.1038/6368 · Cited by 3,880 · see citing works
Self-citationAutoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats
Altman, J., & Das, G. D. (1965) · Journal of Comparative Neurology · doi:10.1002/cne.901240303 · Cited by 3,592 · see citing works
The Neuroendocrinology of Stress: A Never Ending Story
Lightman, S. L. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01711.x · Cited by 3,570 · see citing works
L’examen Clinique en Psychologie
Rubé, P. (1959) · American Journal of Psychotherapy · doi:10.1176/appi.psychotherapy.1959.13.4.989 · Cited by 3,299 · see citing works
Running enhances neurogenesis, learning, and long-term potentiation in mice
van Praag, H., Christie, B. R., Sejnowski, T. J., & Gage, F. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13427 · Cited by 2,904 · see citing works
Self-citationExercise: a behavioral intervention to enhance brain health and plasticity
Cotman, C. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02143-4 · Cited by 2,739 · see citing works
Squire, L. R., Stark, C. E. L., & Clark, R. E. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144130 · Cited by 2,680 · see citing works
Exercise enhances learning and hippocampal neurogenesis in aged mice
van Praag, H., Shubert, T., Zhao, C., & Gage, F. H. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1731-05.2005 · Cited by 2,078 · see citing works
Self-citationQualitative Assessment of Verbal Fluency Performance in Frontotemporal Dementia
van den Berg, E., Jiskoot, L. C., Grosveld, M. J. H., Swieten, J. C. V., & Papma, J. M. (2017) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000477538 · Cited by 2,061 · see citing works
Neurogenesis in the Adult Rat: Electron Microscopic Analysis of Light Radioautographs
Kaplan, M., & Hinds, J. W. (1977) · Science · doi:10.1126/science.887941 · Cited by 1,478 · see citing works
Post-Stroke Fatigue: Epidemiology, Clinical Characteristics and Treatment
Acciarresi, M., Bogousslavsky, J., & Paciaroni, M. (2014) · European Neurology · doi:10.1159/000363763 · Cited by 1,423 · see citing works
Ageing, fitness and neurocognitive function
Kramer, A. F., Hahn, S., Cohen, N. J., Banich, M. T., McAuley, E., Harrison, C. R., Chason, J., Vakil, E., Bardell, L., Boileau, R. A., et al. (1999) · Nature · doi:10.1038/22682 · Cited by 1,394 · see citing works
Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease
West, M. J., Coleman, P. D., Flood, D. G., & Troncoso, J. C. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92338-8 · Cited by 1,267 · see citing works
Physical Activity, Including Walking, and Cognitive Function in Older Women
Weuve, J. (2004) · JAMA · doi:10.1001/jama.292.12.1454 · Cited by 1,175 · see citing works
Sugahara, T., Korogi, Y., Kochi, M., Ikushima, I., Shigematu, Y., Hirai, T., Okuda, T., Liang, L., Ge, Y., Komohara, Y., et al. (1999) · Journal of Magnetic Resonance Imaging · doi:10.1002/(sici)1522-2586(199901)9:1 · Cited by 1,151 · see citing works
Imaging of angiogenesis: from microscope to clinic
McDonald, D. M., & Choyke, P. L. (2003) · Nature Medicine · doi:10.1038/nm0603-713 · Cited by 1,020 · see citing works
Neeper, S. A., Gómez‐Pinilla, F., Choi, J., & Cotman, C. W. (1996) · Brain Research · doi:10.1016/0006-8993(96)00273-9 · Cited by 1,015 · see citing works
Dishman, R. K., Berthoud, H., Booth, F. W., Cotman, C. W., Edgerton, V. R., Fleshner, M. R., Gandevia, S. C., Gomez‐Pinilla, F., Greenwood, B. N., Hillman, C. H., et al. (2006) · Obesity · doi:10.1038/oby.2006.46 · Cited by 958 · see citing works
Coordinated Interaction of Neurogenesis and Angiogenesis in the Adult Songbird Brain
Louissaint, A., Rao, S., Leventhal, C., & Goldman, S. A. (2002) · Neuron · doi:10.1016/s0896-6273(02)00722-5 · Cited by 735 · see citing works
Exercise standards. A statement for health professionals from the American Heart Association.
Fletcher, G. F., Froelicher, V. F., Hartley, L. H., Haskell, W. L., & Pollock, M. L. (1990) · Circulation · doi:10.1161/01.cir.82.6.2286 · Cited by 724 · see citing works
der Elst, W. V., van Boxtel, M. P. J., van Breukelen, G., & Jolles, J. (2005) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617705050344 · Cited by 710 · see citing works
Fletcher, G. F., Balady, G. J., Froelicher, V. F., Hartley, L. H., Haskell, W. L., & Pollock, M. L. (1995) · Circulation · doi:10.1161/01.cir.91.2.580 · Cited by 561 · see citing works
THE PHYSIOLOGICAL MEANING OF THE MAXIMAL OXYGEN INTAKE TEST1
Mitchell, J. H., Sproule, B. J., & Chapman, C. B. (1958) · Journal of Clinical Investigation · doi:10.1172/jci103636 · Cited by 516 · see citing works
Sugahara, T., Korogi, Y., Kochi, M., Ikushima, I., Hirai, T., Okuda, T., Shigematsu, Y., Liang, L., Ge, Y., Ushio, Y., et al. (1998) · American Journal of Roentgenology · doi:10.2214/ajr.171.6.9843274 · Cited by 456 · see citing works
Determinants of maximal oxygen transport and utilization
Wagner, P. D. (1996) · Annual Review of Physiology · doi:10.1146/annurev.ph.58.030196.000321 · Cited by 421 · see citing works
Key factors in the acquisition of contrast kinetic data for oncology
Evelhoch, J. L. (1999) · Journal of Magnetic Resonance Imaging · doi:10.1002/(sici)1522-2586(199909)10:3 · Cited by 366 · see citing works
Kerwin, W. S., Hooker, A. C., Spilker, M. E., Vicini, P., Ferguson, M. S., Hatsukami, T. S., & Yuan, C. (2003) · Circulation · doi:10.1161/01.cir.0000048145.52309.31 · Cited by 353 · see citing works
NMR imaging of changes in vascular morphology due to tumor angiogenesis
Dennie, J., Mandeville, J. B., Boxerman, J. L., Packard, S. D., Rosen, B. R., & Weisskoff, R. M. (1998) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910400602 · Cited by 336 · see citing works
D'Amore, P. A., & Thompson, R. W. (1987) · Annual Review of Physiology · doi:10.1146/annurev.ph.49.030187.002321 · Cited by 301 · see citing works
Small, S. A., Chawla, M. K., Buonocore, M. H., Rapp, P. R., & Barnes, C. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400285101 · Cited by 281 · see citing works
Self-citationThe neurobiology of memory changes in normal aging
Erickson, C. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00160-2 · Cited by 267 · see citing works
Emerging principles of intrinsic hippocampal organization
Amaral, D. G. (1993) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(93)90214-j · Cited by 249 · see citing works
MR imaging of tumor microcirculation: Promise for the new millenium
Taylor, J. S., Tofts, P. S., Port, R. E., Evelhoch, J. L., Knopp, M. V., Reddick, W. E., Runge, V. M., & Mayr, N. A. (1999) · Journal of Magnetic Resonance Imaging · doi:10.1002/(sici)1522-2586(199912)10:6 · Cited by 223 · see citing works
Selective decline in memory function among healthy elderly
Small, S. A., Stern, Y., Tang, M. X., & Mayeux, R. P. (1999) · Neurology · doi:10.1212/wnl.52.7.1392 · Cited by 219 · see citing works
Self-citationMaia, A. C. M., Malheiros, S. M. F., da Rocha, A. J., da Silva, C. J., Gabbai, A. A., Ferraz, F. A. P., & Stávale, J. N. (2005) · PubMed Central · Cited by 213 · see citing works
van Dijke, C. F., Brasch, R. C., Roberts, T. P. L., Weidner, N., Mathur, A., Shames, D. M., Mann, J. S., Demšar, F., Lang, P. K., & Schwickert, H. C. (1996) · Radiology · doi:10.1148/radiology.198.3.8628876 · Cited by 207 · see citing works
Imaging hippocampal function across the human life span: Is memory decline normal or not?
Small, S. A., Tsai, W. Y., DeLaPaz, R., Mayeux, R., & Stern, Y. (2002) · Annals of Neurology · doi:10.1002/ana.10105 · Cited by 205 · see citing works
Self-citationDynamic, contrast‐enhanced perfusion MRI in mouse gliomas: Correlation with histopathology
Cha, S., Johnson, G., Wadghiri, Y. Z., Jin, O., Babb, J., Zagzag, D., & Turnbull, D. H. (2003) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10446 · Cited by 198 · see citing works
Gazzaley, A. H., Siegel, S. J., Kordower, J. H., Mufson, E. J., & Morrison, J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.7.3121 · Cited by 177 · see citing works
Exercise-Induced Changes in Local Cerebral Glucose Utilization in the Rat
Vissing, J., Andersen, M., & Diemer, N. H. (1996) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199607000-00025 · Cited by 171 · see citing works
Spatial and temporal expression of short, long/medium, or both opsins in human fetal cones
Xiao, M., & Hendrickson, A. E. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20001002)425:4 · Cited by 165 · see citing works
Aronen, H. J., Pardo, F. S., Kennedy, D. N., Belliveau, J. W., Packard, S. D., Hsu, D. W., Hochberg, F., Fischman, A. J., & Rosen, B. R. (2000) · PubMed · Cited by 160 · see citing works
MRI detects white matter reorganization after neural progenitor cell treatment of stroke
Jiang, Q., Zhang, Z. G., Ding, G., Silver, B., Zhang, L., Meng, H., Lü, M., Pourabdillah-Nejed-D., S., Wang, L., Savant‐Bhonsale, S., et al. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.05.025 · Cited by 152 · see citing works
Development and differentiation of endothelium
Risau, W. (1998) · Kidney International · doi:10.1046/j.1523-1755.1998.06701.x · Cited by 152 · see citing works
Lei, H. C., Grinberg, O. Y., Nwaigwe, C. I., Hou, H. G., Williams, H. J., Swartz, H. M., & Dunn, J. F. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02786-x · Cited by 133 · see citing works
Lin, T., Sun, S., Cheung, W., Li, F., & Chang, C. (2002) · Stroke · doi:10.1161/01.str.0000037675.97888.9d · Cited by 129 · see citing works
Bremer, C., Mustafa, M., Bogdanov, A. A., Jr., Ntziachristos, V., Petrovsky, A., & Weissleder, R. (2003) · Radiology · doi:10.1148/radiol.2261012140 · Cited by 84 · see citing works
Association Between Mind‐Body and Cardiovascular Exercises and Memory in Older Adults
Chan, A. S.-Y., Ho, Y., Cheung, M., Albert, M., Chiu, H. F. K., & Lam, L. C. W. (2005) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.53513.x · Cited by 79 · see citing works
Paracrine control of vascularization and neurogenesis by neurotrophins
Emanueli, C., Schratzberger, P., Kirchmair, R., & Madeddu, P. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705458 · Cited by 62 · see citing works
Shetty, A. K., & Turner, D. A. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7107 · Cited by 61 · see citing works
Cerebral blood flow and metabolism during exercise.
Ide, K., & Secher, N. (2000) · Progress in neurobiology · doi:10.1016/s0301-0082(99)00057-x · Cited by 60 · see citing works
Monitoring angiogenesis in brain using steady‐state quantification of ΔR2 with MION infusion
Dunn, J. F., Roche, M. A., Springett, R., Abajian, M. A., Merlis, J., Daghlian, C. P., Lu, S. Y., & Makki, M. (2003) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10660 · Cited by 53 · see citing works
Longitudinal mapping of mouse cerebral blood volume with MRI
Moreno, H., Hua, F., Brown, T. R., & Small, S. A. (2006) · NMR in Biomedicine · doi:10.1002/nbm.1022 · Cited by 52 · see citing works
Self-citationPathak, A. P., Rand, S. D., & Schmainda, K. M. (2003) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.10371 · Cited by 49 · see citing works
Cediel, E., Heras, N. D. L., Sanz‐Rosa, D., Velasco, O., Cachofeiro, V., & Lahera, V. (2004) · Kidney International · doi:10.1111/j.1523-1755.2005.09302.x · Cited by 17 · see citing works
Flagged first, then by citations
Research works printed but not linked: 4
- [24]Maia AC, Jr, Malheiros SM, da Rocha AJ, da Silva CJ, Gabbai AA, Ferraz FA, Stavale JN. Am J Neuroradiol. 2005;26:777–783. [PMC free article] [PubMed] [Google Scholar]
- [25]Aronen HJ, Pardo FS, Kennedy DN, Belliveau JW, Packard SD, Hsu DW, Hochberg FH, Fischman AJ, Rosen BR. Clin Cancer Res. 2000;6:2189–2200. [PubMed] [Google Scholar]
- [48]Neeper SA, Gomez-Pinilla F, Choi J, Cotman CW. Brain Res. 1996;726:49–56. [PubMed] [Google Scholar]
- [55]Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S, Weisstaub N, Lee J, Duman R, Arancio O, et al. Science. 2003;301:805–809. doi: 10.1126/science.1083328. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
Cited by
Sorted by citations
Exercise training increases size of hippocampus and improves memory
Erickson, K. I., Voss, M. W., Prakash, R. S., Basak, C., Szabo, A., Chaddock, L., Kim, J. S., Heo, S., Alves, H., White, S. M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015950108 · Cited by 4,855 · see citing works
The Neuroendocrinology of Stress: A Never Ending Story
Lightman, S. L. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01711.x · Cited by 3,570 · see citing works
Be smart, exercise your heart: Exercise effects on brain and cognition
Hillman, C. H., Erickson, K. I., & Kramer, A. F. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2298 · Cited by 3,563 · see citing works
Mechanisms and Functional Implications of Adult Neurogenesis
Zhao, C., Deng, W., & Gage, F. H. (2008) · Cell · doi:10.1016/j.cell.2008.01.033 · Cited by 3,007 · see citing works
Self-citationRoss, R., Blair, S. N., Arena, R., Church, T. S., Després, J.-P., Franklin, B. A., Haskell, W. L., Kaminsky, L. A., Levine, B. D., Lavie, C. J., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000461 · Cited by 2,486 · see citing works
Exercise builds brain health: key roles of growth factor cascades and inflammation
Cotman, C. W., Berchtold, N. C., & Christie, L.-A. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.06.011 · Cited by 2,268 · see citing works
New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?
Deng, W., Aimone, J. B., & Gage, F. H. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2822 · Cited by 2,120 · see citing works
Self-citationPlasticity in gray and white: neuroimaging changes in brain structure during learning
Zatorre, R. J., Fields, R. D., & Johansen-Berg, H. (2012) · Nature Neuroscience · doi:10.1038/nn.3045 · Cited by 1,685 · see citing works
McEwen, B. S., & Gianaros, P. J. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05331.x · Cited by 1,715 · see citing works
Smith, P. J., Blumenthal, J. A., Hoffman, B. M., Cooper, H., Strauman, T. A., Welsh-Bohmer, K., Browndyke, J. N., & Sherwood, A. (2010) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181d14633 · Cited by 1,714 · see citing works
Pattern separation in the hippocampus
Yassa, M. A., & Stark, C. E. L. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.06.006 · Cited by 1,544 · see citing works
Hertzog, C., Kramer, A. F., Wilson, R. S., & Lindenberger, U. (2008) · Psychological Science in the Public Interest · doi:10.1111/j.1539-6053.2009.01034.x · Cited by 1,495 · see citing works
Brain foods: The effects of nutrients on brain function.
Gómez-Pinilla, F. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2421 · Cited by 1,372 · see citing works
Human Hippocampal Neurogenesis Persists throughout Aging
Boldrini, M., Fulmore, C. A., Tartt, A. N., Simeon, L. R., Pavlova, I., Poposka, V., Rosoklija, G. B., Stankov, A., Arango, V., Dwork, A. J., et al. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.03.015 · Cited by 1,345 · see citing works
Self-citationKandola, A., Ashdown-Franks, G., Hendrikse, J., Sabiston, C. M., & Stubbs, B. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.09.040 · Cited by 1,309 · see citing works
Harnessing neuroplasticity for clinical applications
Cramer, S. C., Sur, M., Dobkin, B. H., O'Brien, C., Sanger, T. D., Trojanowski, J. Q., Rumsey, J. M., Hicks, R., Cameron, J., Chen, D., et al. (2011) · Brain · doi:10.1093/brain/awr039 · Cited by 1,259 · see citing works
Adult hippocampal neurogenesis in depression
Sahay, A., & Hen, R. (2007) · Nature Neuroscience · doi:10.1038/nn1969 · Cited by 1,206 · see citing works
Self-citationStress- and Allostasis-Induced Brain Plasticity
McEwen, B. S., & Gianaros, P. J. (2011) · Annual Review of Medicine · doi:10.1146/annurev-med-052209-100430 · Cited by 1,171 · see citing works
Nagamatsu, L. S., Chan, A., Davis, J. C., Beattie, B. L., Graf, P., Voss, M. W., Sharma, D., & Liu-Ambrose, T. Y. L. (2013) · Journal of Aging Research · doi:10.1155/2013/861893 · Cited by 1,090 · see citing works
Best, J. R. (2010) · Developmental Review · doi:10.1016/j.dr.2010.08.001 · Cited by 1,078 · see citing works
Mandolesi, L., Polverino, A., Montuori, S., Foti, F., Ferraioli, G., Sorrentino, P., & Sorrentino, G. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.00509 · Cited by 1,038 · see citing works
Adult hippocampal neurogenesis and cognitive flexibility — linking memory and mood
Anacker, C., & Hen, R. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.45 · Cited by 1,014 · see citing works
Self-citationBridging animal and human models of exercise-induced brain plasticity
Voss, M. W., Vivar, C., Kramer, A. F., & van Praag, H. (2013) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2013.08.001 · Cited by 1,030 · see citing works
Aerobic fitness is associated with hippocampal volume in elderly humans
Erickson, K. I., Prakash, R. S., Voss, M. W., Chaddock, L., Hu, L., Morris, K. S., White, S. M., Wójcicki, T. R., McAuley, E., & Kramer, A. F. (2009) · Hippocampus · doi:10.1002/hipo.20547 · Cited by 1,007 · see citing works
A pathophysiological framework of hippocampal dysfunction in ageing and disease
Small, S. A., Schobel, S., Buxton, R. B., Witter, M. P., & Barnes, C. A. (2011) · Nature reviews. Neuroscience · doi:10.1038/nrn3085 · Cited by 920 · see citing works
Self-citationPhysical Activity, Diet, and Risk of Alzheimer Disease
Scarmeas, N. (2009) · JAMA · doi:10.1001/jama.2009.1144 · Cited by 916 · see citing works
Physical Exercise as a Preventive or Disease-Modifying Treatment of Dementia and Brain Aging
Ahlskog, J. E., Geda, Y. E., Graff-Radford, N. R., & Petersen, R. C. (2011) · Mayo Clinic Proceedings · doi:10.4065/mcp.2011.0252 · Cited by 885 · see citing works
Exercise and Children’s Intelligence, Cognition, and Academic Achievement
Tomporowski, P. D., Davis, C. L., Miller, P. H., & Naglieri, J. A. (2008) · Educational Psychology Review · doi:10.1007/s10648-007-9057-0 · Cited by 874 · see citing works
Plasticity of brain networks in a randomized intervention trial of exercise training in older adults
Voss (2010) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2010.00032 · Cited by 841 · see citing works
Capitalizing on cortical plasticity: influence of physical activity on cognition and brain function
Kramer, A. F., & Erickson, K. I. (2007) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2007.06.009 · Cited by 741 · see citing works
Ruegsegger, G. N., & Booth, F. W. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a029694 · Cited by 690 · see citing works
Chaddock, L., Erickson, K. I., Prakash, R. S., Kim, J. S., Voss, M. W., VanPatter, M., Pontifex, M. B., Raine, L. B., Konkel, A., Hillman, C. H., et al. (2010) · Brain Research · doi:10.1016/j.brainres.2010.08.049 · Cited by 687 · see citing works
MacQueen, G., & Frodl, T. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.80 · Cited by 665 · see citing works
Training-Induced Brain Structure Changes in the Elderly
Boyke, J., Driemeyer, J., Gaser, C., Büchel, C., & May, A. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.0742-08.2008 · Cited by 681 · see citing works
Davis, C. L., Tomporowski, P. D., McDowell, J. E., Austin, B. P., Miller, P. H., Yanasak, N. E., Allison, J. D., & Naglieri, J. A. (2011) · Health Psychology · doi:10.1037/a0021766 · Cited by 911 · see citing works
Pedersen, B. K. (2011) · Journal of Experimental Biology · doi:10.1242/jeb.048074 · Cited by 668 · see citing works
Yankner, B. A., Lu, T., & Loerch, P. (2008) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathmechdis.2.010506.092044 · Cited by 677 · see citing works
Exercising your brain: A review of human brain plasticity and training-induced learning.
Green, C. S., & Bavelier, D. (2008) · Psychology and Aging · doi:10.1037/a0014345 · Cited by 660 · see citing works
Neurogenesis and Exercise: Past and Future Directions
van Praag, H. (2008) · NeuroMolecular Medicine · doi:10.1007/s12017-008-8028-z · Cited by 645 · see citing works
Regulation and function of adult neurogenesis: from genes to cognition.
Aimone, J. B., Li, Y., Lee, S. W., Clemenson, G. D., Deng, W., & Gage, F. H. (2014) · Physiological Reviews · doi:10.1152/physrev.00004.2014 · Cited by 635 · see citing works
Self-citationExercise and Mental Health: Many Reasons to Move
Deslandes, A., Moraes, H., Ferreira, C., Veiga, H., Silveira, H., Mouta, R., Pompeu, F. A. M. S., Coutinho, E. S. F., & Laks, J. (2009) · Neuropsychobiology · doi:10.1159/000223730 · Cited by 609 · see citing works
Exercise, brain, and cognition across the life span.
Voss, M. W., Nagamatsu, L. S., Liu-Ambrose, T., & Kramer, A. F. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00210.2011 · Cited by 601 · see citing works
The Influence of Exercise on Cognitive Abilities
Gómez‐Pinilla, F., & Hillman, C. H. (2012) · Comprehensive physiology · doi:10.1002/cphy.c110063 · Cited by 683 · see citing works
Hippocampal Plasticity in Response to Exercise in Schizophrenia
Pajonk, F.-G., Wobrock, T., Gruber, O., Scherk, H., Berner, D., Kaizl, I., Kierer, A., Müller, S., Oest, M., Meyer, T., et al. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.193 · Cited by 592 · see citing works
Physical exercise in the prevention and treatment of Alzheimer's disease
la Rosa, A. D., González, G. O., Arc‐Chagnaud, C., Millán-Domingo, F., Salvador‐Pascual, A., García-Lucerga, C., Blasco-Lafarga, C., García-Domínguez, E., Carretero, A., Correas, Á. G., et al. (2020) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2020.01.004 · Cited by 617 · see citing works
Exercise and the brain: something to chew on
van Praag, H. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2008.12.007 · Cited by 599 · see citing works
Caloric restriction improves memory in elderly humans
Witte, A. V., Fobker, M., Gellner, R., Knecht, S., & Flöel, A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808587106 · Cited by 574 · see citing works
Running enhances spatial pattern separation in mice
Creer, D. J., Romberg, C., Saksida, L. M., van Praag, H., & Bussey, T. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911725107 · Cited by 553 · see citing works
Exercise-Mediated Neurogenesis in the Hippocampus via BDNF
Liu, P. Z., & Nusslock, R. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00052 · Cited by 533 · see citing works
The Antidepressive Effects of Exercise: A Meta-Analysis of Randomized Trials
Rethorst, C. D., Wipfli, B. M., & Landers, D. M. (2009) · Sports Medicine · doi:10.2165/00007256-200939060-00004 · Cited by 541 · see citing works
Effect of aerobic exercise on hippocampal volume in humans: A systematic review and meta-analysis
Firth, J., Stubbs, B., Vancampfort, D., Schuch, F., Lagopoulos, J., Rosenbaum, S., & Ward, P. B. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2017.11.007 · Cited by 526 · see citing works
Depression and Hippocampal Neurogenesis: A Road to Remission?
Eisch, A. J., & Petrik, D. (2012) · Science · doi:10.1126/science.1222941 · Cited by 516 · see citing works
Experience-dependent structural plasticity in the adult human brain
May, A. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.08.002 · Cited by 512 · see citing works
Physical activity and memory functions: An interventional study
Ruscheweyh, R., Willemer, C., Krüger, K., Duning, T., Warnecke, T., Sommer, J., Völker, K., Ho, H. V., Mooren, F., Knecht, S., et al. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.08.001 · Cited by 499 · see citing works
AMPK and the biochemistry of exercise: implications for human health and disease
Richter, E. A., & Ruderman, N. B. (2009) · Biochemical Journal · doi:10.1042/bj20082055 · Cited by 481 · see citing works
Does vigorous exercise have a neuroprotective effect in Parkinson disease?
Ahlskog, J. E. (2011) · Neurology · doi:10.1212/wnl.0b013e318225ab66 · Cited by 463 · see citing works
Aerobic exercise effects on cognitive and neural plasticity in older adults
Erickson, K. I., & Kramer, A. F. (2008) · British Journal of Sports Medicine · doi:10.1136/bjsm.2008.052498 · Cited by 456 · see citing works
Structural Plasticity and Hippocampal Function
Leuner, B., & Gould, E. (2009) · Annual Review of Psychology · doi:10.1146/annurev.psych.093008.100359 · Cited by 452 · see citing works
Phillips, C. (2017) · Neural Plasticity · doi:10.1155/2017/7260130 · Cited by 456 · see citing works
Age-related memory deficits linked to circuit-specific disruptions in the hippocampus
Yassa, M. A., Mattfeld, A. T., Stark, S. M., & Stark, C. E. L. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1101567108 · Cited by 436 · see citing works
Benefits of regular aerobic exercise for executive functioning in healthy populations
Guiney, H., & Machado, L. (2012) · Psychonomic Bulletin & Review · doi:10.3758/s13423-012-0345-4 · Cited by 455 · see citing works
Changes in Gray Matter Induced by Learning—Revisited
Driemeyer, J., Boyke, J., Christian Gaser, B., Büchel, C., & May, A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002669 · Cited by 440 · see citing works
Training-induced structural changes in the adult human brain
Draganski, B., & May, A. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.02.015 · Cited by 437 · see citing works
Voelcker‐Rehage, C., & Niemann, C. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.01.028 · Cited by 442 · see citing works
Effect of Tai Chi on Cognitive Performance in Older Adults: Systematic Review and Meta‐Analysis
Wayne, P. M., Walsh, J. N., Taylor‐Piliae, R. E., Wells, R. E., Papp, K. V., Donovan, N. J., & Yeh, G. Y. (2014) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12611 · Cited by 435 · see citing works
White Matter Plasticity in the Adult Brain
Sampaio‐Baptista, C., & Johansen‐Berg, H. (2017) · Neuron · doi:10.1016/j.neuron.2017.11.026 · Cited by 414 · see citing works
Environment and Brain Plasticity: Towards an Endogenous Pharmacotherapy
Sale, A., Berardi, N., & Maffei, L. (2014) · Physiological Reviews · doi:10.1152/physrev.00036.2012 · Cited by 402 · see citing works
Cardiovascular fitness is associated with cognition in young adulthood
Åberg, M. A. I., Pedersen, N. L., Torén, K., Svartengren, M., Bäckstrand, B., Johnsson, T., Cooper-Kuhn, C. M., Åberg, N. D., Nilsson, M., & Kuhn, H. G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905307106 · Cited by 382 · see citing works
The current state of the neurogenic theory of depression and anxiety
Miller, B. R., & Hen, R. (2015) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.08.012 · Cited by 386 · see citing works
Self-citationPhysical Activity and Cognitive Vitality
Prakash, R. S., Voss, M. W., Erickson, K. I., & Kramer, A. F. (2015) · Annual Review of Psychology · doi:10.1146/annurev-psych-010814-015249 · Cited by 376 · see citing works
Vascular hippocampal plasticity after aerobic exercise in older adults.
Maass, A., Düzel, S., Goerke, M., Becke, A., Sobieray, U., Neumann, K., Lövden, M., Lindenberger, U., Bäckman, L., Braun-Dullaeus, R., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.114 · Cited by 382 · see citing works
Shorter term aerobic exercise improves brain, cognition, and cardiovascular fitness in aging
Chapman, S. B., Aslan, S., Spence, J. S., DeFina, L. F., Keebler, M. W., Didehbani, N., & Lu, H. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00075 · Cited by 381 · see citing works
All about running: synaptic plasticity, growth factors and adult hippocampal neurogenesis
Vivar, C., Potter, M. C., & van Praag, H. (2012) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2012_220 · Cited by 370 · see citing works
Signaling in Adult Neurogenesis
Suh, H., Deng, W., & Gage, F. H. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.042308.113256 · Cited by 373 · see citing works
Self-citationComputational Influence of Adult Neurogenesis on Memory Encoding
Aimone, J. B., Wiles, J., & Gage, F. H. (2009) · Neuron · doi:10.1016/j.neuron.2008.11.026 · Cited by 370 · see citing works
Self-citationChaddock, L., Pontifex, M. B., Hillman, C. H., & Kramer, A. F. (2011) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617711000567 · Cited by 369 · see citing works
Paillard, T., Rolland, Y., & Barreto, P. D. S. (2015) · Journal of Clinical Neurology · doi:10.3988/jcn.2015.11.3.212 · Cited by 366 · see citing works
Schobel, S., Lewandowski, N. M., Corcoran, C. M., Moore, H. M., Brown, T. R., Malaspina, D., & Small, S. A. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.115 · Cited by 364 · see citing works
Self-citationA review of physical and cognitive interventions in aging
Bamidis, P. D., Vivas, A. B., Styliadis, C., Frantzidis, C., Klados, M. A., Schlee, W., Σιούντας, Α., & Papageorgiou, S. G. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.03.019 · Cited by 360 · see citing works
Maaß, A., Düzel, S., Brigadski, T., Goerke, M., Becke, A., Sobieray, U., Neumann, K., Lövdén, M., Lindenberger, U., Bäckman, L., et al. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.10.084 · Cited by 358 · see citing works
Boldrini, M., Hen, R., Underwood, M. D., Rosoklija, G. B., Dwork, A. J., Mann, J. J., & Arango, V. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.04.024 · Cited by 348 · see citing works
Self-citationEnhancing dentate gyrus function with dietary flavanols improves cognition in older adults
Brickman, A. M., Khan, U., Provenzano, F. A., Yeung, L., SUZUKI, W. A., Schroeter, H., Wall, M. M., Sloan, R. P., & Small, S. A. (2014) · Nature Neuroscience · doi:10.1038/nn.3850 · Cited by 349 · see citing works
Self-citationKelly, R. E., Alexopoulos, G. S., Wang, Z., Gunning, F. M., Murphy, C. F., Morimoto, S. S., Kanellopoulos, D., Jia, Z., Lim, K. O., & Hoptman, M. J. (2010) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2010.03.028 · Cited by 345 · see citing works
Physical exercise, neuroplasticity, spatial learning and memory
Cassilhas, R. C., Tufik, S., & de Mello, M. T. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2102-0 · Cited by 340 · see citing works
Exercise effects on depression: Possible neural mechanisms
Gujral, S., Aizenstein, H., Reynolds, C. F., Butters, M. A., & Erickson, K. I. (2017) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2017.04.012 · Cited by 334 · see citing works
Law, L. L. F., Barnett, F., Yau, M. K.-S., & Gray, M. A. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.02.008 · Cited by 341 · see citing works
A primer on investigating the after effects of acute bouts of physical activity on cognition
Pontifex, M. B., McGowan, A. L., Chandler, M. C., Gwizdala, K. L., Parks, A. C., Fenn, K., & Kamijo, K. (2019) · Psychology of Sport and Exercise · doi:10.1016/j.psychsport.2018.08.015 · Cited by 339 · see citing works
Running induces widespread structural alterations in the hippocampus and entorhinal cortex
Stranahan, A. M., Khalil, D., & Gould, E. (2007) · Hippocampus · doi:10.1002/hipo.20348 · Cited by 327 · see citing works
Can physical exercise in old age improve memory and hippocampal function?
Duzel, E., van Praag, H., & Sendtner, M. (2016) · Brain · doi:10.1093/brain/awv407 · Cited by 329 · see citing works
Jäncke, L. (2009) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-2009-0519 · Cited by 329 · see citing works
Aerobic exercise for Alzheimer's disease: A randomized controlled pilot trial
Morris, J. K., Vidoni, E. D., Johnson, D. K., Sciver, A. R. V., Mahnken, J. D., Honea, R. A., Wilkins, H., Brooks, W. M., Billinger, S. A., Swerdlow, R. H., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170547 · Cited by 331 · see citing works
Phillips, C. (2017) · Neural Plasticity · doi:10.1155/2017/3589271 · Cited by 335 · see citing works
Rooks, C. R., Thom, N. J., McCully, K. K., & Dishman, R. K. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.06.002 · Cited by 326 · see citing works
Cardiovascular risk factors and future risk of Alzheimer’s disease
de Bruijn, R. F. A. G., & Ikram, M. A. (2014) · BMC Medicine · doi:10.1186/s12916-014-0130-5 · Cited by 325 · see citing works
Using network science to evaluate exercise-associated brain changes in older adults.
Burdette (2010) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2010.00023 · Cited by 320 · see citing works
Plant-Derived Flavanol (−)Epicatechin Enhances Angiogenesis and Retention of Spatial Memory in Mice
van Praag, H., Lucero, M. J., Yeo, G. W., Stecker, K., Heivand, N., Zhao, C., Yip, E., Afanador, M., Schroeter, H., Hammerstone, J., et al. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0914-07.2007 · Cited by 303 · see citing works
Self-citationNovak, C. M., Burghardt, P. R., & Levine, J. A. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.12.012 · Cited by 308 · see citing works
Adult neurogenesis: integrating theories and separating functions
Aimone, J. B., Deng, W., & Gage, F. H. (2010) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.04.003 · Cited by 303 · see citing works
Self-citationNeuroscience of Exercise: From Neurobiology Mechanisms to Mental Health
Portugal, E. M. M., Cevada, T., Monteiro-Júnior, R. S., Guimarães, T. T., Rubini, E. D. C., Lattari, E., Blois, C., & Deslandes, A. C. (2013) · Neuropsychobiology · doi:10.1159/000350946 · Cited by 310 · see citing works
The effects of aerobic activity on brain structure.
Thomas, A. G., Dennis, A., Bandettini, P. A., & Johansen-Berg, H. (2012) · Frontiers in Psychology · doi:10.3389/fpsyg.2012.00086 · Cited by 303 · see citing works
- Authors
- Pereira, A. C., Huddleston, D. E., Brickman, A. M., Sosunov, A. A., Hen, R., McKhann, G. M., Sloan, R., Gage, F. H., Brown, T. R., & Small, S. A.
- Affiliations
- *The Taub Institute for Research on Alzheimer's Disease and the Aging Brain,
- Neurosurgery,
- Psychiatry, and
- Salk Institute for Biological Studies (US)
- Columbia University Irving Medical Center (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2007-03-27
- Volume
- 104
- Issue
- 13
- Pages
- 5638-5643
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC1838482
- OpenAlex
- W2145944042
- Cited by
- 1,353
- References
- 59
- Citations by year
- 2026: 34 · 2025: 48 · 2024: 45 · 2023: 46 · 2022: 61 · 2021: 72 · 2020: 116 · 2019: 84 · 2018: 69 · 2017: 83 · 2016: 82 · 2015: 94 · 2014: 82 · 2013: 85 · 2012: 88
- FWCI
- 18.02
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- James S. McDonnell Foundation
- National Institutes of Health
- Defense Advanced Research Projects Agency
- Advanced Research Projects Agency
- National Institute on Aging (AG025161, R01AG025161, P50AG008702)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- adult neurogenesis, physical activity, dentate gyrus, cerebral blood volume, angiogenesis, hippocampus, cardiopulmonary function, cognitive function, cognitive aging
- MeSH terms
- Adult, Aging, Animals, Brain Mapping, Female, Hippocampus, Humans, Male, Mice, Inbred C57BL, Middle Aged, Neovascularization, Pathologic, Neurons, Exercise, Dentate Gyrus, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
