The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
CAF Subpopulations: A New Reservoir of Stromal Targets in Pancreatic Cancer
Open accessAbstract
Cancer-associated fibroblasts (CAFs) are one of the most significant components in the tumour microenvironment (TME), where they can perform several protumourigenic functions. Several studies have recently reported that CAFs are more heterogenous and plastic than was previously thought. As such, there has been a shift in the field to study CAF subpopulations and the emergent functions of these subsets in tumourigenesis. In this review, we explore how different aspects of CAF heterogeneity are defined and how these manifest in multiple cancers, with a focus on pancreatic ductal adenocarcinoma (PDAC). We also discuss therapeutic approaches to selectively target protumourigenic CAF functions, while avoiding normal fibroblasts, providing insight into the future of stromal targeting for the treatment of PDAC and other solid tumours.
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Cites
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Genomic analyses identify molecular subtypes of pancreatic cancer
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“Furthermore, TAMs have been implicated in determining the subtype of PDAC tumours, where a high number of TAMs promotes a dense stroma and low T cell infiltrate, characteristic of the squamous subtype [134], which has worse prognosis [50].”
BackgroundSelf-citationTargeting the IL-6/JAK/STAT3 signalling axis in cancer
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Whole genomes redefine the mutational landscape of pancreatic cancer
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Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer
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Cited by
Immunotherapy for pancreatic cancer: A 2020 update
Schizas, D., Charalampakis, N., Kole, C., Economopoulou, P., Koustas, E., Gkotsis, E., Ziogas, D., Psyrri, A., & Karamouzis, M. V. (2020) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2020.102016 · Cited by 458
Targeting TGFβ signal transduction for cancer therapy
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Cancer-associated fibroblasts: overview, progress, challenges, and directions
Ping, Q., Yan, R., Cheng, X., Wang, W., Zhong, Y., Hou, Z., Shi, Y., Wang, C., & Li, R. (2021) · Cancer Gene Therapy · doi:10.1038/s41417-021-00318-4 · Cited by 285
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Cui Zhou, D., Jayasinghe, R. G., Chen, S., Herndon, J. M., Iglesia, M. D., Navale, P., Wendl, M. C., Caravan, W., Sato, K., Storrs, E., et al. (2022) · Nature Genetics · doi:10.1038/s41588-022-01157-1 · Cited by 284
Metadata
- Authors
- Pereira, B. A., Vennin, C., Papanicolaou, M., Chambers, C. R., Herrmann, D., Morton, J. P., Cox, T. R., & Timpson, P.
- Venue
- Trends in Cancer
- Publisher
- Elsevier BV
- Published
- 2019-11
- Volume
- 5
- Issue
- 11
- Pages
- 724-741
- ISSN
- 2405-8025 (ISSN-L)
- 2405-8033
- OpenAlex
- W2981546796
- Cited by
- 314
- References
- 31
- FWCI
- 4.89
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- The paper
- Pereira, B. A., Vennin, C., Papanicolaou, M., Chambers, C. R., Herrmann, D., Morton, J. P., Cox, T. R., & Timpson, P. (2019). CAF Subpopulations: A New Reservoir of Stromal Targets in Pancreatic Cancer. Trends in Cancer. https://doi.org/10.1016/j.trecan.2019.09.010
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
