The DOI matches its Crossref record; 90 of the 90 references it cites were found in a registry or an index.
Cancer Epigenetics, Tumor Immunity, and Immunotherapy
Open accessAbstract
Epigenetic mechanisms, including DNA methylation, histone post-translational modifications, and chromatin structure regulation, are critical for the interactions between tumor and immune cells. Emerging evidence shows that tumors commonly hijack various epigenetic mechanisms to escape immune restriction. As a result, the pharmaceutical modulation of epigenetic regulators, including ‘writers’, ‘readers’, ‘erasers’, and ‘remodelers’, is able to normalize the impaired immunosurveillance and/or trigger antitumor immune responses. Thus, epigenetic targeting agents are attractive immunomodulatory drugs and will have major impacts on immuno-oncology. Here, we discuss epigenetic regulators of the cancer–immunity cycle and current advances in developing epigenetic therapies to boost anticancer immune responses, either alone or in combination with current immunotherapies.
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Cites
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Cited by
Immune evasion in cancer: mechanisms and cutting-edge therapeutic approaches
Tufail, M., Jiang, C.-H., & Li, N. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02280-1 · Cited by 363
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KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements
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Metadata
- Authors
- Cao, J., & Yan, Q.
- Venue
- Trends in Cancer
- Publisher
- Elsevier BV
- Published
- 2020-07
- Volume
- 6
- Issue
- 7
- Pages
- 580-592
- ISSN
- 2405-8025 (ISSN-L)
- 2405-8033
- OpenAlex
- W3015068997
- Cited by
- 346
- References
- 90
- FWCI
- 3.50
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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