The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
The genomic rate of adaptive evolution
Open accessAbstract
The role of positive darwinian selection in evolution at the molecular level has been keenly debated for many years, with little resolution. However, a recent increase in DNA sequence data and the development of new methods of analysis have finally made this question tractable. Here, I review the current state-of-play of the field. Initial estimates in Drosophila suggest that approximately 50% of all amino acid substitutions, and a substantial fraction of substitutions in non-coding DNA, have been fixed as a consequence of adaptive evolution. Estimates in microorganisms are even higher. By contrast, there is little evidence of widespread adaptive evolution in our own species.
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Cites
Adaptive protein evolution at the Adh locus in Drosophila
McDonald, J. H., & Kreitman, M. (1991) · Nature · doi:10.1038/351652a0 · Cited by 3,283
A Map of Recent Positive Selection in the Human Genome
Voight, B. F., Kudaravalli, S., Wen, X., & Pritchard, J. K. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040072 · Cited by 2,893
The hitch-hiking effect of a favourable gene
MAYNARD, J., & HAIGH, J. (2007) · Genetics Research · doi:10.1017/s0016672308009579 · Cited by 2,643
Anderson, E. N. (1977) · eScholarship (California Digital Library) · Cited by 2,567
Initial sequence of the chimpanzee genome and comparison with the human genome
The Chimpanzee Sequencing and Analysis Consortium (2005) · Nature · doi:10.1038/nature04072 · Cited by 2,459
Statistical methods for detecting molecular adaptation
Yang, Z., & Bielawski, J. P. (2000) · Trends in Ecology & Evolution · doi:10.1016/s0169-5347(00)01994-7 · Cited by 1,806
The effect of deleterious mutations on neutral molecular variation.
Charlesworth, B., Morgan, M. T., & Charlesworth, D. (1993) · Genetics · doi:10.1093/genetics/134.4.1289 · Cited by 1,803
A Test of Neutral Molecular Evolution Based on Nucleotide Data
Hudson, R. R., Kreitman, M., & Aguadé, M. (1987) · Genetics · doi:10.1093/genetics/116.1.153 · Cited by 1,767
Nielsen, R., & Yang, Z. (1998) · Genetics · doi:10.1093/genetics/148.3.929 · Cited by 1,622
Genomic scans for selective sweeps using SNP data
Nielsen, R., Williamson, S., Kim, Y., Hubisz, M. J., Clark, A. G., & Bustamante, C. (2005) · Genome Research · doi:10.1101/gr.4252305 · Cited by 1,022
Cited by
RELAX: Detecting Relaxed Selection in a Phylogenetic Framework
Wertheim, J. O., Murrell, B., Smith, M. D., Kosakovsky Pond, S. L., & Scheffler, K. (2015) · Molecular Biology and Evolution · doi:10.1093/molbev/msu400 · Cited by 778
The faster-X effect: integrating theory and data
Meisel, R. P., & Connallon, T. (2013) · Trends in Genetics · doi:10.1016/j.tig.2013.05.009 · Cited by 238
Schelkunov, M. I., Shtratnikova, V. Y., Nuraliev, M. S., Selosse, M.-A., Penin, A. A., & Logacheva, M. D. (2015) · Genome Biology and Evolution · doi:10.1093/gbe/evv019 · Cited by 142
Natural selection shaped the rise and fall of passenger pigeon genomic diversity
Murray, G. G. R., Soares, A. E. R., Novak, B. J., Schaefer, N. K., Cahill, J. A., Baker, A. J., Demboski, J. R., Doll, A., Da Fonseca, R. R., Fulton, T. L., et al. (2017) · Science · doi:10.1126/science.aao0960 · Cited by 132
Pervasive positive selection on duplicated and nonduplicated vertebrate protein coding genes
Studer, R. A., Penel, S., Duret, L., & Robinson-Rechavi, M. (2008) · Genome Research · doi:10.1101/gr.076992.108 · Cited by 84
Metadata
- Authors
- EYREWALKER, A.
- Venue
- Trends in Ecology & Evolution
- Publisher
- Elsevier BV
- Published
- 2006-10
- Volume
- 21
- Issue
- 10
- Pages
- 569-575
- ISSN
- 0169-5347 (ISSN-L)
- OpenAlex
- W2160070700
- Cited by
- 316
- References
- 56
- FWCI
- 16.08
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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