The pathobiome in animal and plant diseases.
Open accessAbstract
A growing awareness of the diversity and ubiquity of microbes (eukaryotes, prokaryotes, and viruses) associated with larger 'host' organisms has led to the realisation that many diseases thought to be caused by one primary agent are the result of interactions between multiple taxa and the host. Even where a primary agent can be identified, its effect is often moderated by other symbionts. Therefore, the one pathogen-one disease paradigm is shifting towards the pathobiome concept, integrating the interaction of multiple symbionts, host, and environment in a new understanding of disease aetiology. Taxonomically, pathobiomes are variable across host species, ecology, tissue type, and time. Therefore, a more functionally driven understanding of pathobiotic systems is necessary, based on gene expression, metabolic interactions, and ecological processes.
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In an analogous situation in the wild, dietary shifts or a reduction in forage diversity can contribute to a change in gut microflora, setting up the potential for a dysbiosis and pathobiome.
“In an analogous situation in the wild, dietary shifts or a reduction in forage diversity can contribute to a change in gut microflora, setting up the potential for a dysbiosis and pathobiome (Stecher et al., 2013;Bass et al., 2019).”
From Novel Lethal Clostridial Infection in Florida Manatees (Trichechus manatus latirostris): Cause of the 2013 Unusual Mortality Event in the Indian River Lagoon (2022) · cites this paper as Bass et al., 2019
Cites
The Human Intestinal Microbiome in Health and Disease
Lynch, S. V., & Pedersen, O. (2016) · New England Journal of Medicine · doi:10.1056/nejmra1600266 · Cited by 3,637 · see citing works
Mitra, A., MacIntyre, D. A., Lee, Y. S., Smith, A., Marchesi, J. R., Lehne, B., Bhatia, R., Lyons, D., Paraskevaidis, E., Li, J. V., et al. (2015) · Scientific Reports · doi:10.1038/srep16865 · Cited by 498 · see citing works
Role of priority effects in the early-life assembly of the gut microbiota
Sprockett, D., Fukami, T., & Relman, D. A. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.173 · Cited by 419 · see citing works
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A review of reported seaweed diseases and pests in aquaculture in Asia.
Ward, G. M., Faisan, J. P., Cottier‐Cook, E. J., Gachon, C., Hurtado, A. Q., Lim, P. E., Matoju, I., Msuya, F. E., Bass, D., & Brodie, J. (2020) · Journal of the World Aquaculture Society · doi:10.1111/jwas.12649 · Cited by 177 · see citing works
Self-citationBuller, H., Adam, K., Bard, A., Bruce, A., (Ray) Chan, K. W., Hinchliffe, S., Morgans, L., Rees, G., & Reyher, K. K. (2020) · Frontiers in Veterinary Science · doi:10.3389/fvets.2020.569545 · Cited by 39 · see citing works
Landsberg, J. H., Tabuchi, M., Rotstein, D. S., Subramaniam, K., Rodrigues, T. C. S., Waltzek, T. B., Stacy, N. I., Wilson, P. W., Kiryu, Y., Uzal, F. A., et al. (2022) · Frontiers in Marine Science · doi:10.3389/fmars.2022.841857 · Cited by 20 · see citing works
“In an analogous situation in the wild, dietary shifts or a reduction in forage diversity can contribute to a change in gut microflora, setting up the potential for a dysbiosis and pathobiome (Stecher et al., 2013; Bass et al., 2019).”
Background
- Authors
- Bass, D., Stentiford, G. D., Wang, H.-C., Koskella, B., & Tyler, C. R.
- Affiliations
- Centre for Environment, Fisheries and Aquaculture Science (GB)
- National Cheng Kung University (TW)
- University of California, Berkeley (US)
- University of Exeter (GB)
- Corresponding author
- Bass, David
- Venue
- Trends in Ecology & Evolution
- Publisher
- Elsevier BV
- Published
- 2019-11
- Volume
- 34
- Issue
- 11
- Pages
- 996-1008
- ISSN
- 0169-5347 (ISSN-L)
- PMC
- PMC7479508
- OpenAlex
- W2973113033
- Cited by
- 376
- References
- 3
- Citations by year
- 2026: 47 · 2025: 52 · 2024: 63 · 2023: 70 · 2022: 51 · 2021: 53 · 2020: 35 · 2019: 5
- FWCI
- 3.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Trends in Ecology & Evolution (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Defra (FC1214)
- Newton Fund (BB/N00504X/1)
- Ministry of Science and Technology (108-2314-B-006-096-MY3)
- NSF (IOS-1838299)
- EU H2020 (678589)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant-Microbe Interactions and Immunity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Physical Sciences › Environmental Science › Ecology › Parasite Biology and Host Interactions
- Keywords
- pathobiome, host-microbe interactions, etiology, microbial symbionts, plant disease, animal diseases, host-microbe coevolution, microbial diversity, host-microbe metabolic interactions
- MeSH terms
- Animals, Ecology, Plant Diseases, Symbiosis, Eukaryota
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