Role of priority effects in the early-life assembly of the gut microbiota
Open accessAbstract
Understanding how microbial communities develop is essential for predicting and directing their future states. Ecological theory suggests that community development is often influenced by priority effects, in which the order and timing of species arrival determine how species affect one another. Priority effects can have long-lasting consequences, particularly if species arrival history varies during the early stage of community development, but their importance to the human gut microbiota and host health remains largely unknown. Here, we explore how priority effects might influence microbial communities in the gastrointestinal tract during early childhood and how the strength of priority effects can be estimated from the composition of the microbial species pool. We also discuss factors that alter microbial transmission, such as delivery mode, diet and parenting behaviours such as breastfeeding, which can influence the likelihood of priority effects. An improved knowledge of priority effects has the potential to inform microorganism-based therapies, such as prebiotics and probiotics, which are aimed at guiding the microbiota towards a healthy state.
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The decrease in Enterococcus could potentially be attributed to carbon source depletion promoted by Bifidobacterium specialised human milk oligosaccharide utilisation in the human milk-fed gut environment, which may inhibit pathobiont colonisation and growth.
“This decrease could potentially be attributed to the carbon source depletion promoted by Bifidobacterium specialised HMO utilisation in human milk-fed gut environment, which may inhibit pathobiont colonisation and growth39,40.”
From Impact of early life antibiotic and probiotic treatment on gut microbiome and resistome of very-low-birth-weight preterm infants. (2025) · cites this paper as [39]
In “Priority effects in the infant gut” (page unavailable), the paper says Bifidobacterium consumes breast-milk HMOs and likely depletes those carbon sources, limiting later species’ colonization. It does not identify Enterococcus as an affected species or show that this mechanism explains its decrease or inhibits pathobiont growth specifically. (LLM, conf=0.86)
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- Authors
- Sprockett, D., Fukami, T., & Relman, D. A.
- Affiliations
- Stanford Medicine (US)
- Stanford University (US)
- VA Palo Alto Health Care System (US)
- Corresponding author
- Relman, David A.
- Venue
- Nature Reviews Gastroenterology & Hepatology
- Published
- 2018-01-24
- Volume
- 15
- Issue
- 4
- Pages
- 197-205
- ISSN
- 1759-5045 (ISSN-L)
- 1759-5053
- PMC
- PMC6813786
- OpenAlex
- W2784989009
- Cited by
- 419
- References
- 134
- Citations by year
- 2026: 38 · 2025: 52 · 2024: 58 · 2023: 44 · 2022: 59 · 2021: 66 · 2020: 56 · 2019: 33 · 2018: 12 · 2017: 1
- FWCI
- 4.09
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Gastroenterology & Hepatology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (T32GM007276)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
- Keywords
- priority effects, microbial transmission, mode of delivery, diet, breastfeeding, parenting behaviour, prebiotics, probiotics, early childhood
- MeSH terms
- Gastrointestinal Microbiome, Host Microbial Interactions, Child Development, Biological Evolution, Female, Humans, Infant, Infant, Newborn, Labor, Obstetric, Maternal-Fetal Exchange, Pregnancy, Selection, Genetic, Time Factors, Genetic Drift, Biodiversity
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