The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Current strategies to minimize hepatic ischemia–reperfusion injury by targeting reactive oxygen species
Open accessAbstract
Ischemia–reperfusion is a major component of injury in vascular occlusion both during liver surgery and during liver transplantation. The pathophysiology of hepatic ischemia–reperfusion includes a number of mechanisms including oxidant stress that contribute to various degrees to the overall organ damage. A large volume of recent research has focused on the use of antioxidants to ameliorate this injury, although results in experimental models have not translated well to the clinic. This review focuses on critical sources and mediators of oxidative stress during hepatic ischemia–reperfusion, the status of current antioxidant interventions, and emerging mechanisms of protection by preconditioning. While recent advances in regulation of antioxidant systems by Nrf2 provide interesting new potential therapeutic targets, an increased focus must be placed on more in-depth mechanistic investigations in hepatic ischemia–reperfusion injury and translational research in order to refine current strategies in disease management.
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Cites
How mitochondria produce reactive oxygen species
Murphy, M. P. (2009) · Biochemical Journal · doi:10.1042/bj20081386 · Cited by 8,207
Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE Pathway
Kensler, T. W., Wakabayashi, N., & Biswal, S. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.46.120604.141046 · Cited by 3,630
Selective degradation of mitochondria by mitophagy
Kim, I., Rodriguez-Enriquez, S., & Lemasters, J. J. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.03.034 · Cited by 1,558
Linking oxidative stress to inflammation: Toll-like receptors
Gill, R., Tsung, A., & Billiar, T. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.01.006 · Cited by 553
Hanawa, N., Shinohara, M., Saberi, B., Gaarde, W. A., Han, D., & Kaplowitz, N. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708916200 · Cited by 527
Saito, C., Zwingmann, C., & Jaeschke, H. (2010) · Hepatology · doi:10.1002/hep.23267 · Cited by 430
Self-citation
Cited by
A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury
Chouchani, E. T., Pell, V. R., James, A. M., Work, L. M., Saeb-Parsy, K., Frezza, C., Krieg, T., & Murphy, M. P. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.12.009 · Cited by 752
Protective mechanisms of end-ischemic cold machine perfusion in DCD liver grafts
Schlegel, A., Rougemont, O. D., Graf, R., Clavien, P.-A., & Dutkowski, P. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2012.10.004 · Cited by 274
Challenges to Liver Transplantation and Strategies to Improve Outcomes
Dutkowski, P., Linecker, M., DeOliveira, M. L., Müllhaupt, B., & Clavien, P.-A. (2015) · Gastroenterology · doi:10.1053/j.gastro.2014.08.045 · Cited by 270
Moles, A., Murphy, L., Wilson, C. L., Chakraborty, J. B., Fox, C., Park, E. J., Mann, J., Oakley, F., Howarth, R., Brain, J., et al. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2013.12.005 · Cited by 169
Metadata
- Authors
- Jaeschke, H., & Woolbright, B. L.
- Venue
- Transplantation Reviews
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 26
- Issue
- 2
- Pages
- 103-114
- ISSN
- 0955-470X (ISSN-L)
- OpenAlex
- W2168540880
- Cited by
- 292
- References
- 6
- FWCI
- 22.85
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
