Linking oxidative stress to inflammation: Toll-like receptors

Gill, Roop; Tsung, Allan; Billiar, Timothy

doi:10.1016/j.freeradbiomed.2010.01.006

Cited by 553Immune Response and InflammationNeutrophil, Myeloperoxidase and Oxidative MechanismsInflammation biomarkers and pathways

Linking oxidative stress to inflammation: Toll-like receptors

Open access

Gill, Roop, Tsung, Allan, Billiar, Timothy·2010·Free Radical Biology and Medicine

DOI 10.1016/j.freeradbiomed.2010.01.006PMC PMC3423196

Open this paper in CoChat — free account

Abstract

Injury caused by oxidative stress occurs in many clinical scenarios involving ischemia and reperfusion such as organ transplantation, hemorrhagic shock (HS), myocardial infarction, and cerebral vascular accidents. Activation of the immune system as a result of disturbances in the redox state of cells seems to contribute to tissue and organ damage in these conditions. The link between oxidative stress and inflammatory pathways is poorly understood. Recently, Toll-like receptors (TLRs) have been shown to mediate the inflammatory response seen in experimental ischemia and reperfusion (I/R). The TLR family of receptors involved in alerting the innate immune system of danger seems to be activated by damage-associated molecular pattern molecules (DAMPs) that are released during conditions of oxidative stress. In this review, we examine the role of TLRs in various experimental models of oxidative stress such as HS and I/R. We also report on potential DAMPs that may interact with TLRs in mediating injury. Finally, potential mechanisms by which reactive oxygen species from NADPH oxidase can signal the commencement of inflammatory pathways through TLRs are explored.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.freeradbiomed.2010.01.006

Cites

134 of 134 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Inflammation enhances oxidative stress by upregulating expression of reactive oxygen species-producing enzymes and downregulating antioxidant defenses.
“Inflammation, in turn, enhances oxidative stress by upregulating the expression of reactive oxygen species–producing enzymes and downregulating antioxidant defenses.126”
From Vascular Contributions to Cognitive Impairment and Dementia: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association (2011) · cites this paper as [126]
The “Interactions between TLR4 and NADPH oxidase” section reports increased NADPH oxidase subunits after dendritic cells were stimulated with TLR-activating substances, supporting the ROS-producing-enzyme part in that setting. It does not report that inflammation downregulates antioxidant defenses, and its evidence does not establish the full mechanism as a general effect of inflammation. No page number is available in our copy. (LLM, conf=0.86)
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Oxidants, oxidative stress and the biology of ageing
Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413 · see citing works
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in <i>Tlr4</i> Gene
Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631 · see citing works
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
Medzhitov, R., Preston-Hurlburt, P., & Janeway, C. A. J. (1997) · Nature · doi:10.1038/41131 · Cited by 6,137 · see citing works
Tolerance, Danger, and the Extended Family
Matzinger, P. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.005015 · Cited by 4,848 · see citing works
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
Scaffidi, P., Misteli, T., & Bianchi, M. E. (2002) · Nature · doi:10.1038/nature00858 · Cited by 4,221 · see citing works
The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults
Lemaître, B., Nicolas, E., Michaut, L., Reichhart, J., & Hoffmann, J. A. (1996) · Cell · doi:10.1016/s0092-8674(00)80172-5 · Cited by 4,027 · see citing works
CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein
Wright, S. D., Ramos, R., Tobias, P. S., Ulevitch, R. J., & Mathison, J. C. (1990) · Science · doi:10.1126/science.1698311 · Cited by 3,986 · see citing works
Approaching the asymptote? Evolution and revolution in immunology.Preprint
Janeway, C. (1989) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1989.054.01.003 · Cited by 3,396 · see citing works
HMG-1 as a Late Mediator of Endotoxin Lethality in Mice
Wang, H., Bloom, O., Zhang, M., Vishnubhakat, J. M., Ombrellino, M., Che, J., Frazier, A., Yang, H., Ivanova, S., Borovikova, L. V., et al. (1999) · Science · doi:10.1126/science.285.5425.248 · Cited by 3,386 · see citing works
NOX enzymes and the biology of reactive oxygen
Lambeth, J. D. (2004) · Nature Reviews Immunology · doi:10.1038/nri1312 · Cited by 3,125 · see citing works
Heart-Lung Transplantation
Yarbrough, W. M., Robbins, R. C., & Mallidi, H. R. (2016) · CRC Press eBooks · doi:10.3109/9781439802571-25 · Cited by 2,158 · see citing works
Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex
Ohashi, K., Burkart, V., Flohé, S. B., & Kolb, H. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.2.558 · Cited by 1,607 · see citing works
Natural adjuvants: Endogenous activators of dendritic cells
Gallucci, S., Lolkema, M. P., & Matzinger, P. (1999) · Nature Medicine · doi:10.1038/15200 · Cited by 1,601 · see citing works
Involvement of Toll-like Receptors 2 and 4 in Cellular Activation by High Mobility Group Box 1 Protein
Park, J. S., Svetkauskaite, D., He, Q., Kim, J., Strassheim, D., Ishizaka, A., & Abraham, E. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m306793200 · Cited by 1,560 · see citing works
Regulation of lung injury and repair by Toll-like receptors and hyaluronan
Jiang, D., Liang, J., Fan, J., Yu, S., Chen, S., Luo, Y., Prestwich, G. D., Mascarenhas, M. M., Garg, H. G., Quinn, D. A., et al. (2005) · Nature Medicine · doi:10.1038/nm1315 · Cited by 1,401 · see citing works
Toll-like receptor 9–dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE
Tian, J., Avalos, A. M., Mao, S.-Y., Chen, B., Senthil, K., Wu, H., Parroche, P., Drabic, S., Golenbock, D., Sirois, C., et al. (2007) · Nature Immunology · doi:10.1038/ni1457 · Cited by 1,372 · see citing works
Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury
Imai, Y., Kuba, K., Neely, G. G., Yaghubian-Malhami, R., Perkmann, T., van Loo, G., Ermolaeva, M., Veldhuizen, R., Leung, Y. H. C., Wang, H., et al. (2008) · Cell · doi:10.1016/j.cell.2008.02.043 · Cited by 1,356 · see citing works
Innate immunity: an overview
Beutler, B. (2003) · Molecular Immunology · doi:10.1016/j.molimm.2003.10.005 · Cited by 1,276 · see citing works
Crystal Structure of the TLR4-MD-2 Complex with Bound Endotoxin Antagonist Eritoran
Kim, H. M., Park, B. S., Kim, J.-I., Kim, S. E., Lee, J., Oh, S. C., Enkhbayar, P., Matsushima, N., Lee, H., Yoo, O. J., et al. (2007) · Cell · doi:10.1016/j.cell.2007.08.002 · Cited by 1,180 · see citing works
Oxygen radicals and signaling
Finkel, T. (1998) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(98)80147-6 · Cited by 1,170 · see citing works
The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion
Tsung, A., Sahai, R., Tanaka, H., Nakao, A., Fink, M. P., Lotze, M. T., Yang, H., Li, J., Tracey, K. J., Geller, D. A., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20042614 · Cited by 1,113 · see citing works
Self-citation
HSP70 as Endogenous Stimulus of the Toll/Interleukin-1 Receptor Signal Pathway
Vabulas, R. M., Ahmad‐Nejad, P., Ghose, S., Kirschning, C. J., Issels, R. D., & Wagner, H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111204200 · Cited by 949 · see citing works
TLR4 activation mediates kidney ischemia/reperfusion injury
Wu, H., Chen, G., Wyburn, K., Yin, J. L., Bertolino, P., Eris, J., Alexander, S. I., Sharland, A. F., & Chadban, S. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31008 · Cited by 838 · see citing works
CD24 and Siglec-10 Selectively Repress Tissue Damage–Induced Immune Responses
Chen, G.-Y., Tang, J., Zheng, P., & Liu, Y. (2009) · Science · doi:10.1126/science.1168988 · Cited by 786 · cited 1× · see citing works
“CD24 co-immunoprecipitates with DAMPs Hsp70, Hsp90, and HMGB1, which can reduce DAMP activation of TLR4, and a germline mutation of CD24 increased susceptibility to hepatocyte necrosis in an acetoaminophen-induced liver injury model [22, 23].”
Background
Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function.
Fialkow, L., Wang, Y.-C., & Downey, G. (2007) · Free Radical Biology & Medicine · doi:10.1016/j.freeradbiomed.2006.09.030 · Cited by 722 · see citing works
IRAK-4: A novel member of the IRAK family with the properties of an IRAK-kinase
Li, S., Strelow, A., Fontana, E. J., & Wesche, H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.082100399 · Cited by 714 · see citing works
Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits
Tang, S.-C., Arumugam, T. V., Xu, X., Cheng, A., Mughal, M. R., Jo, D. G., Lathia, J. D., Siler, D. A., Chigurupati, S., Ouyang, X., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702553104 · Cited by 672 · see citing works
Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium
Frantz, S., Kobzik, L., Kim, Y., Fukazawa, R., Medzhitov, R. M., Lee, R. T., & Kelly, R. A. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6709 · Cited by 645 · see citing works
Cutting Edge: Direct Interaction of TLR4 with NAD(P)H Oxidase 4 Isozyme Is Essential for Lipopolysaccharide-Induced Production of Reactive Oxygen Species and Activation of NF-κB
Park, H. S., Jung, H. Y., Park, E. Y., Kim, J., Lee, W. J., & Bae, Y. S. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.6.3589 · Cited by 635 · see citing works
Induction of Immunological Tolerance by Apoptotic Cells Requires Caspase-Dependent Oxidation of High-Mobility Group Box-1 Protein
Kazama, H., Ricci, J.-E., Herndon, J. M., Hoppe, G., Green, D. R., & Ferguson, T. A. (2008) · Immunity · doi:10.1016/j.immuni.2008.05.013 · Cited by 627 · see citing works
Reduced Myocardial Ischemia-Reperfusion Injury in Toll-Like Receptor 4-Deficient Mice
Oyama, J., Blais, C., Liu, X., Pu, M., Kobzik, L., Kelly, R. A., & Bourcier, T. (2004) · Circulation · doi:10.1161/01.cir.0000112575.66565.84 · Cited by 620 · see citing works
HMGB1 release induced by liver ischemia involves Toll-like receptor 4–dependent reactive oxygen species production and calcium-mediated signaling
Tsung, A., Klune, J. R., Zhang, X., Jeyabalan, G., Cao, Z., Peng, X., Stolz, D. B., Geller, D. A., Rosengart, M. R., & Billiar, T. R. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070247 · Cited by 617 · see citing works
Self-citation
Toll-Like Receptor 4 Is Involved in Brain Damage and Inflammation After Experimental Stroke
Caso, J. R., Pradillo, J. M., Hurtado, O., Lorenzo, P. L., Moro, M. Á., & Lizasoaín, I. (2007) · Circulation · doi:10.1161/circulationaha.106.603431 · Cited by 606 · see citing works
Involvement of Reactive Oxygen Species in Toll-Like Receptor 4-Dependent Activation of NF-κB
Asehnoune, K., Strassheim, D., Mitra, S., Kim, J. Y., & Abraham, E. H. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.4.2522 · Cited by 564 · see citing works
Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney
Leemans, J. C., Stokman, G., Claessen, N., Rouschop, K. M. A., Teske, G. J. D., Kirschning, C. J., Akira, S., van der Poll, T., Weening, J. J., & Florquin, S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci22832 · Cited by 563 · see citing works
Functional Diversity and Regulation of Different Interleukin-1 Receptor-Associated Kinase (IRAK) Family Members
Janssens, S., & Beyaert, R. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00053-4 · Cited by 559 · see citing works
TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events
Cavassani, K. A., Ishii, M., Wen, H., Schaller, M. A., Lincoln, P., Lukacs, N. W., Hogaboam, C. M., & Kunkel, S. L. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20081370 · Cited by 447 · see citing works
Cutting Edge: TLR4 Activation Mediates Liver Ischemia/Reperfusion Inflammatory Response via IFN Regulatory Factor 3-Dependent MyD88-Independent Pathway
Zhai, Y., Shen, X., O’Connell, R. M., GAO, F. G., Lassman, C., Busuttil, R. W., Cheng, G., & Kupiec‐Weglinski, J. W. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.12.7115 · Cited by 445 · see citing works
In Vivo Expression of Toll-Like Receptor 2 and 4 by Renal Epithelial Cells: IFN-γ and TNF-α Mediated Up-Regulation During Inflammation
Wolfs, T. G. A. M., Buurman, W. A., van Schadewijk, A. M., de Vries, B., Daemen, M. A. R. C., Hiemstra, P. S., & Veer, C. V. ′. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.3.1286 · Cited by 441 · see citing works
HMGB1 Develops Enhanced Proinflammatory Activity by Binding to Cytokines
Sha, Y., Zmijewski, J. W., Xu, Z., & Abraham, E. H. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.4.2531 · Cited by 393 · see citing works
Toll-like receptor stimulation in cardiomyoctes decreases contractility and initiates an NF-κB dependent inflammatory response☆
BOYD, J., MATHUR, S., WANG, Y., Bateman, R. M., & Walley, K. R. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.09.011 · Cited by 371 · see citing works
Inflammatory Response After Open Heart Surgery
Dybdahl, B., Wahba, A., Lien, E., Flo, T. H., Waage, A., Qureshi, N., Sellevold, O. F. M., Espevik, T., & Sundan, A. (2002) · Circulation · doi:10.1161/hc0602.103617 · Cited by 362 · see citing works
Hepatic Ischemia/Reperfusion Injury Involves Functional TLR4 Signaling in Nonparenchymal Cells
Tsung, A., Hoffman, R. A., Izuishi, K., Critchlow, N. D., Nakao, A., Chan, M., Lotze, M. T., Geller, D. A., & Billiar, T. R. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.11.7661 · Cited by 362 · see citing works
Self-citation
Toll-Like Receptor-2 Modulates Ventricular Remodeling After Myocardial Infarction
Shishido, T., Nozaki, N., Yamaguchi, S., Shibata, Y., Nitobe, J., Miyamoto, T., Takahashi, H., Arimoto, T., Maeda, K., Yamakawa, M., et al. (2003) · Circulation · doi:10.1161/01.cir.0000101921.93016.1c · Cited by 303 · see citing works
S100A8 and S100A9 Mediate Endotoxin-Induced Cardiomyocyte Dysfunction via the Receptor for Advanced Glycation End Products
Boyd, J. H., Kan, B., Roberts, H., Wang, Y., & Walley, K. R. (2008) · Circulation Research · doi:10.1161/circresaha.107.167544 · Cited by 292 · see citing works
Inhibition of Toll-like Receptor 4 With Eritoran Attenuates Myocardial Ischemia-Reperfusion Injury
Shimamoto, A., Chong, A. J., Yada, M., Shomura, S., Takayama, H., Fleisig, A. J., Agnew, M. L., Hampton, C. R., Rothnie, C. L., Spring, D. J., et al. (2006) · Circulation · doi:10.1161/circulationaha.105.000901 · Cited by 283 · see citing works
Ischemia-Reperfusion Injury: Processes in Pathogenetic Networks: A Review
de GROOT, H., & Rauen, U. (2007) · Transplantation Proceedings · doi:10.1016/j.transproceed.2006.12.012 · Cited by 275 · see citing works
TLR2 Is Constitutively Expressed within the Kidney and Participates in Ischemic Renal Injury through Both MyD88-Dependent and -Independent Pathways
Shigeoka, A. A., Holscher, T. D., King, A. J., Hall, F. W., Kiosses, W. B., Tobias, P. S., Mackman, N., & McKay, D. B. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.10.6252 · Cited by 273 · see citing works
Identification of Proteins Containing Cysteine Residues That Are Sensitive to Oxidation by Hydrogen Peroxide at Neutral pH
Kim, J.-R., Yoon, H. W., Kwon, K., Lee, S.-R., & Rhee, S. G. (2000) · Analytical Biochemistry · doi:10.1006/abio.2000.4623 · Cited by 273 · see citing works
The non-provitamin A carotenoid, lutein, inhibits NF-κB-dependent gene expression through redox-based regulation of the phosphatidylinositol 3-kinase/PTEN/Akt and NF-κB-inducing kinase pathways: Role of H2O2 in NF-κB activation
Kim, J.-H., Na, H.-J., Kim, C.-K., Kim, J.-Y., Ha, K.-S., Lee, H., Chung, H.-T., Kwon, H. J., Kwon, Y.-G., & Kim, Y.-M. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.06.019 · Cited by 273 · see citing works
Toll-like receptor-4 (TLR4) signaling augments chemokine-induced neutrophil migration by modulating cell surface expression of chemokine receptors
Fan, J., & Malik, A. B. (2003) · Nature Medicine · doi:10.1038/nm832 · Cited by 265 · see citing works
Toll-like receptor 2 mediates CNS injury in focal cerebral ischemia
Lehnardt, S., Lehmann, S., Kaul, D., Tschimmel, K., Hoffmann, O. M., Cho, S., Krueger, C., Nitsch, R., Meisel, A., & Weber, J. R. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2007.07.023 · Cited by 252 · see citing works
Differential liver sensitization to Toll-like receptor pathways in mice with alcoholic fatty liver
Gustot, T., Lemmers, A., Moreno, C., Nagy, N., Quertinmont, E., Nicaise, C., Franchimont, D. P., Louis, H., Deviere, J. M., & Moine, O. L. (2006) · Hepatology · doi:10.1002/hep.21138 · Cited by 244 · see citing works
Post-translational Methylation of High Mobility Group Box 1 (HMGB1) Causes Its Cytoplasmic Localization in Neutrophils
Ito, I., Fukazawa, J., & Yoshida, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608467200 · Cited by 243 · see citing works
Toll-like receptor signaling: a critical modulator of cell survival and ischemic injury in the heart
Chao, W. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00995.2008 · Cited by 242 · see citing works
The intracellular distribution and function of the high mobility group chromosomal proteins
Einck, L., & Bustin, M. (1985) · Experimental Cell Research · doi:10.1016/0014-4827(85)90539-7 · Cited by 240 · see citing works
Reduced cerebral ischemia-reperfusion injury in Toll-like receptor 4 deficient mice
Can-xiang, C., Yang, Q., Lv, F., Cui, J., Fu, H.-B., & Wang, J. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.12.057 · Cited by 239 · see citing works
Oxidants and Antioxidants in Viral Diseases: Disease Mechanisms and Metabolic Regulation
Peterhans, E. (1997) · Journal of Nutrition · doi:10.1093/jn/127.5.962s · Cited by 238 · see citing works
TLR2 has a detrimental role in mouse transient focal cerebral ischemia
Ziegler, G., Harhausen, D., Schepers, C., Hoffmann, O. M., Röhr, C., Prinz, V., König, J., Lehrach, H. R., Nietfeld, W., & Trendelenburg, G. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.05.157 · Cited by 235 · see citing works
Toll-Like Receptor-4 Coordinates the Innate Immune Response of the Kidney to Renal Ischemia/Reperfusion Injury
Pulskens, W. P. C., Teske, G. J. D., Butter, L. M., Roelofs, J. J. T. H., van der Poll, T., Florquin, S., & Leemans, J. C. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003596 · Cited by 233 · see citing works
Cutting Edge: An Endogenous Pathway to Systemic Inflammatory Response Syndrome (SIRS)-Like Reactions through Toll-Like Receptor 4
Johnson, G. B., Brunn, G. J., & Platt, J. L. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.1.20 · Cited by 232 · see citing works
Systemic inflammation and remote organ injury following trauma require HMGB1
Levy, R. M., Mollen, K. P., Prince, J. M., Kaczorowski, D. J., Vallabhaneni, R., Liu, S., Tracey, K. J., Lotze, M. T., Hackam, D. J., Fink, M. P., et al. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00272.2007 · Cited by 230 · see citing works
Self-citation
IRAK-4 as the central TIR signaling mediator in innate immunity.
Suzuki, N., Suzuki, S., & Yeh, W. (2002) · Trends in immunology · doi:10.1016/s1471-4906(02)02298-6 · Cited by 228 · see citing works
Cell injury releases endogenous adjuvants that stimulate cytotoxic T cell responses
Shi, Y., Zheng, W., & Rock, K. L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.260497597 · Cited by 226 · see citing works
Toll-like receptor 4 mediates ischemia/reperfusion injury of the heart
Chong, A. J., Shimamoto, A., Hampton, C. R., Takayama, H., Spring, D. J., Rothnie, C. L., Yada, M., Pohlman, T. H., & Verrier, E. D. (2004) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2003.11.036 · Cited by 222 · see citing works
Anti-HMGB1 Neutralizing Antibody Ameliorates Gut Barrier Dysfunction and Improves Survival after Hemorrhagic Shock
Yang, R., Harada, T., Mollen, K. P., Prince, J. M., Levy, R. M., Englert, J. A., Gallowitsch‐Puerta, M., Yang, L., Yang, H., Tracey, K. J., et al. (2006) · Molecular Medicine · doi:10.2119/2006-00010.yang · Cited by 221 · see citing works
Self-citation
Reactive oxygen species: toxic molecules or spark of life?
Magder, S. A. (2006) · Critical Care · doi:10.1186/cc3992 · Cited by 211 · see citing works
The strength of receptor signaling is centrally controlled through a cooperative loop between Ca2+ and an oxidant signal
Singh, D. K., Kumar, D., Siddiqui, Z., Basu, S. K., Kumar, V., & Rao, K. V. S. (2005) · Cell · doi:10.1016/j.cell.2005.02.036 · Cited by 206 · see citing works
Oxidative stress generated by hemorrhagic shock recruits Toll-like receptor 4 to the plasma membrane in macrophages
Powers, K. A., Szászi, K., Khadaroo, R. G., Tawadros, P. S., Marshall, J. C., Kapùs, A., & Rotstein, O. D. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060943 · Cited by 203 · see citing works
Activation of Toll-like receptor 4 signaling contributes to hippocampal neuronal death following global cerebral ischemia/reperfusion
Hua, F., Ma, J., Ha, T., Xia, Y., Kelley, J., Williams, D. L., Kao, R. L., Browder, I. W., Schweitzer, J. B., Kalbfleisch, J. H., et al. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2007.08.014 · Cited by 200 · see citing works
Hemorrhagic shock primes for increased expression of cytokine‐induced neutrophil chemoattractant in the lung: role in pulmonary inflammation following lipopolysaccharide
Fan, J., Marshall, J. C., Jimenez, M., Shek, P. N., Zagorski, J., & Rotstein, O. D. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.1.440 · Cited by 193 · see citing works
Hypoxia Inducible Factor (HIF)-1 Coordinates Induction of Toll-Like Receptors TLR2 and TLR6 during Hypoxia
Kuhlicke, J., Frick, J.-S., Morote–Garcia, J. C., Rosenberger, P., & Eltzschig, H. K. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001364 · Cited by 190 · see citing works
Ischemia-Reperfusion Injury Activates Innate Immunity in Rat Kidneys
Kim, B. S., Lim, S. W., Li, C., Kim, J. S., Sun, B., Ahn, K. O., Han, S. W., Kim, J., & Yang, C. W. (2005) · Transplantation · doi:10.1097/01.tp.0000158355.83327.62 · Cited by 189 · see citing works
Alarmins Initiate Host Defense
Oppenheim, J. J., Tewary, P., de la Rosa, G., & Yang, D. (2007) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-72005-0_19 · Cited by 181 · see citing works
Endogenous signals released from necrotic cells augment inflammatory responses to bacterial endotoxin
Elmezayen, R., Gazzar, M. E., Seeds, M. C., McCall, C. E., Dreskin, S. C., & Nicolls, M. R. (2007) · Immunology Letters · doi:10.1016/j.imlet.2007.04.011 · Cited by 178 · see citing works
Toll‐Like Receptor and Heme Oxygenase‐1 Signaling in Hepatic Ischemia/Reperfusion Injury
Shen, X., Ke, B., Zhai, Y., Gao, F., Busuttil, R. W., Cheng, G., & Kupiec‐Weglinski, J. W. (2005) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2005.00932.x · Cited by 171 · see citing works
Lipopolysaccharide-induced myocardial protection against ischaemia/reperfusion injury is mediated through a PI3K/Akt-dependent mechanism
Ha, T., Hua, F., Liu, X., Ma, J., McMullen, J. R., Shioi, T., Izumo, S., Kelley, J., Gao, X., Browder, W., et al. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn037 · Cited by 165 · see citing works
N‐acetylcysteine reduces lipopolysaccharide‐sensitized hypoxic‐ischemic brain injury
Wang, X., Svedin, P., Nie, C., Lapatto, R., Zhu, C., Gustavsson, M., Sandberg, M., Karlsson, J., Romero, R. J., Hagberg, H., et al. (2007) · Annals of Neurology · doi:10.1002/ana.21066 · Cited by 161 · see citing works
Toll-Like Receptors 2-Deficient Mice Are Protected Against Postischemic Coronary Endothelial Dysfunction
Favre, J., Musette, P., Douin‐Echinard, V., Laude, K. M., Henry, J., Arnal, J., Thuillez, C., & Richard, V. J. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.140723 · Cited by 159 · see citing works
TLR-4 deficiency protects against focal cerebral ischemia and axotomy-induced neurodegeneration
Kılıç, Ü., Kılıç, E., Matter, C. M., Bassetti, C. L., & Hermann, D. M. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.03.002 · Cited by 159 · see citing works
Changes in hyaluronan production and metabolism following ischaemic stroke in man
AlQteishat, A. (2006) · Brain · doi:10.1093/brain/awl139 · Cited by 149 · see citing works
CD24-Siglec G/10 discriminates danger- from pathogen-associated molecular patterns
Liu, Y., Chen, G.-Y., & Zheng, P. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.09.006 · Cited by 147 · cited 1× · see citing works
“CD24 co-immunoprecipitates with DAMPs Hsp70, Hsp90, and HMGB1, which can reduce DAMP activation of TLR4, and a germline mutation of CD24 increased susceptibility to hepatocyte necrosis in an acetoaminophen-induced liver injury model [22, 23].”
Background
Hemorrhage-induced acute lung injury is TLR-4 dependent
Barsness, K. A., Arcaroli, J. J., Harken, A. H., Abraham, E. H., Banerjee, A. M., Reznikov, L. L., & McIntyre, R. C. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00412.2003 · Cited by 131 · see citing works
Cutting Edge: TLR4 Deficiency Confers Susceptibility to Lethal Oxidant Lung Injury
Zhang, X., Shan, P., Qureshi, S. T., Homer, R., Medzhitov, R. M., Noble, P. W., & Lee, P. J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.8.4834 · Cited by 127 · see citing works
Toll Receptor-Mediated Regulation of NADPH Oxidase in Human Dendritic Cells
Vulcano, M., Dusi, S., Lissandrini, D., Badolato, R., Mazzi, P., Riboldi, E., Borroni, E. M., Calleri, A., Donini, M., Plebani, A., et al. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.9.5749 · Cited by 124 · see citing works
Nitric Oxide-Induced Nitrative Stress Involved in Microbial Pathogenesis
Zaki, M. H., Akuta, T., & Akaike, T. (2005) · Journal of Pharmacological Sciences · doi:10.1254/jphs.crj05004x · Cited by 120 · see citing works
Activation of mouse peritoneal macrophages by lipopolysaccharide alters the kinetic parameters of the superoxide-producing NADPH oxidase.
Sasada, M., Pabst, M. J., & Johnston, R. B. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44543-1 · Cited by 119 · see citing works
Toll-like receptor 2 modulates left ventricular function following ischemia-reperfusion injury
Sakata, Y., Dong, J.-W., Vallejo, J. G., Huang, C., Baker, J. S., Tracey, K. J., Tacheuchi, O., Akira, S., & Mann, D. L. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00642.2006 · Cited by 119 · see citing works
Increasing numbers of hepatic dendritic cells promote HMGB1-mediated ischemia-reperfusion injury
Tsung, A., Zheng, N., Jeyabalan, G., Izuishi, K., Klune, J. R., Geller, D. A., Lotze, M. T., Lü, L., & Billiar, T. R. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0706468 · Cited by 118 · see citing works
Self-citation
Toll-Like Receptor 4 Mediates Lung Ischemia-Reperfusion Injury
Shimamoto, A., Pohlman, T. H., Shomura, S., Tarukawa, T., Takao, M., & Shimpo, H. (2006) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2006.06.079 · Cited by 113 · see citing works
Toll-Like Receptor-4 Signaling Mediates Hepatic Injury and Systemic Inflammation in Hemorrhagic Shock
Prince, J. M., Levy, R. M., Yang, R., Mollen, K. P., Fink, M. P., Yoram Vodovotz, B., & Billiar, T. R. (2006) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2005.11.021 · Cited by 112 · see citing works
Self-citation
Absence of toll-Like Receptor 4 (TLR4) Signaling in the Donor Organ Reduces Ischemia and Reperfusion Injury in a Murine Liver Transplantation Model
Shen, X., Ke, B., Zhai, Y., GAO, F. G., Tsuchihashi, S.-I., Lassman, C., Busuttil, R. W., & Kupiec‐Weglinski, J. W. (2007) · Liver Transplantation · doi:10.1002/lt.21251 · Cited by 111 · see citing works
Elevated Circulating Levels of Heat Shock Protein 70 are Related to Systemic Inflammatory Reaction Through Monocyte Toll Signal in Patients with Heart Failure After Acute Myocardial Infarction
Satoh, M., Shimoda, Y., Akatsu, T., Ishikawa, Y., Minami, Y., & Nakamura, M. (2006) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2006.03.004 · Cited by 107 · see citing works
Mechanisms of Toll-Like Receptor 4 (TLR4)-Mediated Inflammation After Cold Ischemia/Reperfusion in the Heart
Kaczorowski, D. J., Nakao, A., Vallabhaneni, R., Mollen, K. P., Sugimoto, R., Kohmoto, J., Zuckerbraun, B. S., McCurry, K. R., & Billiar, T. R. (2009) · Transplantation · doi:10.1097/tp.0b013e3181a36e5e · Cited by 105 · see citing works
Self-citation
Protective Mechanism of Epigallocatechin‐3‐Gallate against Helicobacter pylori‐Induced Gastric Epithelial Cytotoxicity via the Blockage of TLR‐4 Signaling
Lee, K., Yeo, M., Choue, J., Jin, J., Park, S., Cheong, J., Lee, K. J., Kim, J., & Hahm, K. (2004) · Helicobacter · doi:10.1111/j.1083-4389.2004.00281.x · Cited by 104 · see citing works
Human heat shock protein 60 stimulates vascular smooth muscle cell proliferation through Toll-like receptors 2 and 4
de GRAAF, R., Kloppenburg, G. T. L., Kitslaar, P. J. E. H. M., Bruggeman, C. A., & Stassen, F. R. M. (2006) · Microbes and Infection · doi:10.1016/j.micinf.2006.02.024 · Cited by 102 · see citing works
Both Hemopoietic and Resident Cells Are Required for MyD88-Dependent Pulmonary Inflammatory Response to Inhaled Endotoxin
Noulin, N., Quesniaux, V. F. J., Schnyder‐Candrian, S., Schnyder, B., Maillet, I., Robert, T., Vargaftig, B. B., Ryffel, B., & Couillin, I. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.10.6861 · Cited by 101 · see citing works
TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF
Takeshita, F., Ishii, K. J., Kobiyama, K., Kojima, Y., Coban, C., Sasaki, S., Ishii, N., Klinman, D. M., Okuda, K., Akira, S., et al. (2005) · European Journal of Immunology · doi:10.1002/eji.200526151 · Cited by 99 · see citing works
Toll-like receptor 4 involvement in hepatic ischemia/reperfusion injury in mice.
Wu, H., Zhang, J., Wang, L., Tian, Y., Wang, H., & Rotstein, O. D. (2004) · PubMed · Cited by 99 · see citing works
Type I, but not type II, interferon is critical in liver injury induced after ischemia and reperfusion
Zhai, Y., Qiao, B., GAO, F. G., Shen, X., Vardanian, A. J., Busuttil, R. W., & Kupiec‐Weglinski, J. W. (2007) · Hepatology · doi:10.1002/hep.21970 · Cited by 97 · see citing works
Overexpression of Human S100B Exacerbates Brain Damage and Periinfarct Gliosis After Permanent Focal Ischemia
Mori, T., Tan, J., Arendash, G. W., Koyama, N., Nojima, Y., & Town, T. (2008) · Stroke · doi:10.1161/strokeaha.107.503821 · Cited by 85 · see citing works
Hemorrhagic shock-activated neutrophils augment TLR4 signaling-induced TLR2 upregulation in alveolar macrophages: role in hemorrhage-primed lung inflammation
Fan, J., Li, Y., Yoram Vodovotz, B., Billiar, T. R., & Wilson, M. A. (2005) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00280.2005 · Cited by 82 · see citing works
Self-citation
Candida albicans Induces Selectively Transcriptional Activation of Cyclooxygenase-2 in HeLa Cells: Pivotal Roles of Toll-Like Receptors, p38 Mitogen-Activated Protein Kinase, and NF-κB
Deva, R., Shankaranarayanan, P., Ciccoli, R., & Nigam, S. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.6.3047 · Cited by 79 · see citing works
Activation of the lipopolysaccharide signaling pathway in hepatic transplantation preservation injury12
Tsoulfas, G., Takahashi, Y., Ganster, R., Yagnik, G. P., Guo, Z., Fung, J., Murase, N., & Geller, D. (2002) · Transplantation · doi:10.1097/00007890-200207150-00003 · Cited by 78 · see citing works
Cerebral Inflammatory Response After Fetal Asphyxia and Hyperoxic Resuscitation in Newborn Sheep
Markus, T., Hansson, S. R., Amer‐Wåhlin, I., Hellström-Westas, L. K., Saugstad, O. D., & Ley, D. (2007) · Pediatric Research · doi:10.1203/pdr.0b013e31811ead6e · Cited by 78 · see citing works
Toll-Like Receptor 4 Mediates the Early Inflammatory Response After Cold Ischemia/Reperfusion
Kaczorowski, D. J., Nakao, A., Mollen, K. P., Vallabhaneni, R., Sugimoto, R., Kohmoto, J., Tobita, K., Zuckerbraun, B. S., McCurry, K. R., Murase, N., et al. (2007) · Transplantation · doi:10.1097/01.tp.0000287597.87571.17 · Cited by 77 · see citing works
Self-citation
Systemic inflammation and end organ damage following trauma involves functional TLR4 signaling in both bone marrow-derived cells and parenchymal cells
Mollen, K. P., Levy, R. M., Prince, J. M., Hoffman, R. A., Scott, M. J., Kaczorowski, D. J., Vallabhaneni, R., Yoram Vodovotz, B., & Billiar, T. R. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0407201 · Cited by 77 · see citing works
Self-citation
Heme Oxygenase-1 Mediated Cytoprotection Against Liver Ischemia and Reperfusion Injury: Inhibition of Type-1 Interferon Signaling
Tsuchihashi, S.-I., Zhai, Y., Bo, Q., Busuttil, R. W., & Kupiec‐Weglinski, J. W. (2007) · Transplantation · doi:10.1097/01.tp.0000266917.39958.47 · Cited by 74 · see citing works
Toll-like receptor 4 deficiency: Smaller infarcts, but nogain in function
Kim, S.-C., Ghanem, A., Stapel, H., Tiemann, K., Knuefermann, P., Hoeft, A., Meyer, R., Grohé, C., Knowlton, A. A., & Baumgarten, G. (2007) · BMC Physiology · doi:10.1186/1472-6793-7-5 · Cited by 73 · see citing works
The transcription factor interferon regulatory factor-1 mediates liver damage during ischemia-reperfusion injury
Tsung, A., Stang, M. T., Ikeda, A., Critchlow, N. D., Izuishi, K., Nakao, A., Chan, M., Jeyabalan, G., Yim, J. H., & Geller, D. A. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00460.2005 · Cited by 71 · see citing works
Self-citation
Evidence for the Pivotal Role of Endogenous Toll-Like Receptor 4 Ligands in Liver Ischemia and Reperfusion Injury
Zhai, Y., Qiao, B., Shen, X., GAO, F. G., Busuttil, R. W., Cheng, G., Platt, J. L., Volk, H., & Kupiec‐Weglinski, J. W. (2008) · Transplantation · doi:10.1097/tp.0b013e3181684248 · Cited by 70 · see citing works
Circulating heat-shock protein 70 is associated with postoperative infection and organ dysfunction after liver resection
Kimura, F., Itoh, H., Ambiru, S., Shimizu, H., Togawa, A., Yoshidome, H., Ohtsuka, M., Shimamura, F., Kato, A., Nukui, Y., et al. (2004) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2003.08.029 · Cited by 63 · see citing works
TLR4 regulates Kupffer cell chemokine production, systemic inflammation and lung neutrophil infiltration following trauma-hemorrhage
Frink, M., Hsieh, Y.-C., Thobe, B. M., Choudhry, M. A., Schwacha, M. G., Bland, K. I., & Chaudry, I. H. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2006.12.009 · Cited by 59 · see citing works
Toll-like Receptor and Cytokine Gene Expression in the Early Phase of Human Lung Transplantation
Andrade, C., Kaneda, H., Der, S., Tsang, M. E., Lodyga, M., dos Santos, C. C., Keshavjee, S. H., & Liu, M. (2006) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2006.09.017 · Cited by 58 · see citing works
Ischemia-Induced Exocytosis of Weibel-Palade Bodies Mobilizes Stem Cells
Kuo, M., Patschan, D., Patschan, S. A., Cohen‐Gould, L., Park, H. C., Ni, J., Addabbo, F., & Goligorsky, M. S. (2008) · Journal of the American Society of Nephrology · doi:10.1681/asn.2007111200 · Cited by 57 · see citing works
Activation of hepatocytes by extracellular heat shock protein 72
Galloway, E., Shin, T., Huber, N., Eismann, T., Kuboki, S., Schuster, R. M., Blanchard, J. A., Wong, H. R., & Lentsch, A. B. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00032.2008 · Cited by 56 · see citing works
CD14 but not MD2 transmit signals from DAMP
Chun, K., & Seong, S. (2009) · International Immunopharmacology · doi:10.1016/j.intimp.2009.10.002 · Cited by 54 · see citing works
Toll-like receptor 2 is protective of ischemia–reperfusion-mediated small-bowel injury in a murine model
Aprahamian, C. J., Lorenz, R. G., Harmon, C. M., & Dimmitt, R. A. (2008) · Pediatric Critical Care Medicine · doi:10.1097/01.pcc.0000288717.44702.c0 · Cited by 54 · see citing works
Interacting Neuroendocrine and Innate and Acquired Immune Pathways Regulate Neutrophil Mobilization from Bone Marrow following Hemorrhagic Shock
Liu, Y., Yuan, Y., Li, Y., Zhang, J., Xiao, G., Yoram Vodovotz, B., Billiar, T. R., Wilson, M. A., & Fan, J. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.1.572 · Cited by 49 · see citing works
Self-citation
TLR LIGAND DECREASES MESENTERIC ISCHEMIA AND REPERFUSION INJURY-INDUCED GUT DAMAGE THROUGH TNF-α SIGNALING
Chen, L.-W., Chang, W.-J., Chen, P.-H., Liu, W., & Hsu, C.-M. (2008) · Shock · doi:10.1097/shk.0b013e31816a3458 · Cited by 46 · see citing works
The Role of Toll-Like Receptors 2 and 4 in Acute Allograft Rejection After Liver Transplantation
Deng, J., Geng, L., Qian, Y., Li, H., Wang, Y., Xie, H., Feng, X., & Zheng, S. (2007) · Transplantation Proceedings · doi:10.1016/j.transproceed.2007.02.102 · Cited by 46 · see citing works
Effect of hemorrhagic shock on gut barrier function and expression of stress-related genes in normal and gnotobiotic mice
Yang, R., Gallo, D. J., Baust, J., Watkins, S. C., Delude, R. L., & Fink, M. P. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00278.2002 · Cited by 45 · see citing works
Signaling for myocardial depression in hemorrhagic shock: roles of Toll-like receptor 4 and p55 TNF-α receptor
Meng, X., Ao, L., Song, Y., Raeburn, C. D., Fullerton, D. A., & Harken, A. H. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00182.2004 · Cited by 43 · see citing works
HEMORRHAGIC SHOCK IN ENDCTOXIN RESISTANT MICE
DeMaria, E. J., Pellicane, J. V., Lee, R. B., & Sugerman, H. J. (1992) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-199207000-00041 · Cited by 31 · see citing works
TOLL-LIKE RECEPTOR 4 REGULATES HEME OXYGENASE-1 EXPRESSION AFTER HEMORRHAGIC SHOCK INDUCED ACUTE LUNG INJURY IN MICE
Chen, C., Wang, Y., Zhang, Z., Wang, C., & Peng, M. (2009) · Shock · doi:10.1097/shk.0b013e318188f7e1 · Cited by 30 · see citing works
Differential effect of resuscitation on Toll-like receptors in a model of hemorrhagic shock without a septic challenge
Chen, H., Koustova, E., Shults, C., Sailhamer, E. A., & Alam, H. B. (2007) · Resuscitation · doi:10.1016/j.resuscitation.2007.01.031 · Cited by 28 · see citing works
POSTISCHEMIC VASCULAR PERMEABILITY REQUIRES BOTH TLR-2 AND TLR-4, BUT ONLY TLR-2 MEDIATES THE TRANSENDOTHELIAL MIGRATION OF LEUKOCYTES
Khandoga, A. G., Khandoga, A., Anders, H., & Krombach, F. (2009) · Shock · doi:10.1097/shk.0b013e318193c859 · Cited by 26 · see citing works
Exposure to Bacterial DNA Before Hemorrhagic Shock Strongly Aggravates Systemic Inflammation and Gut Barrier Loss via an IFN-γ-Dependent Route
Luyer, M. D. P., Buurman, W. A., Hadfoune, M., Wolfs, T. G. A. M., Veer, C. V. ′., Jacobs, J. A., Dejong, C. H. C., & Greve, J. W. M. (2007) · Annals of Surgery · doi:10.1097/01.sla.0000251513.59983.3b · Cited by 25 · see citing works
The impact of free radical-mediated reperfusion injury on acute and chronic rejection events following cadaveric renal transplantation.
Schneeberger, H., Schleibner, S., Illner, W.-D., Meßmer, K., & Land, W. G. (1993) · PubMed · Cited by 23 · see citing works
Recruitment of the Interleukin-1 Receptor (IL-1RI)-Associated Kinase IRAK to the IL-1RI Is Redox Regulated
Böl, G., Jurrmann, N., & Brigelius‐Flohé, R. (2003) · Biological Chemistry · doi:10.1515/bc.2003.068 · Cited by 21 · see citing works
Toll-Like Receptor 2 and 4 Expression After Severe Injury is Not Involved in the Dysregulation of the Innate Immune System
Lendemans, S., Kreuzfelder, E., Rani, M., Bayeeh, E., Schade, F. U., Flohé, S. B., Waydhas, C., & Flohé, S. (2007) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/01.ta.0000240451.42238.d1 · Cited by 18 · see citing works
Oxidative-induced calcium mobilization is dependent on annexin VI release from lipid rafts
Cuschieri, J., Bulger, E. M., Garcia, I. A., & Maier, R. V. (2005) · Surgery · doi:10.1016/j.surg.2005.03.018 · Cited by 13 · see citing works
Decreased Lactate in Endotoxin-Resistant Mice Undergoing Hemorrhage Is Independent of Tumor Necrosis Factor Availability
Pellicane, J. V., Gore, D. C., & DeMaria, E. J. (1994) · Journal of Surgical Research · doi:10.1006/jsre.1994.1056 · Cited by 5 · see citing works
[Expression of Toll-like receptor 2/4 mRNA in myocardium in mice with hemorrhagic shock].
Hang, T., Shi-sen, J., Gong, J., Lü, T.-F., Song, Y., & Zhuge, H.-H. (2006) · PubMed · Cited by 2 · see citing works

Flagged first, then by citations

Sorted by citations

Vascular Contributions to Cognitive Impairment and Dementia: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association
Gorelick, P. B., Scuteri, A., Black, S. E., DeCarli, C., Greenberg, S. M., Iadecola, C., Launer, L. J., Laurent, S., Lopez, O. L., Nyenhuis, D., et al. (2011) · Stroke · doi:10.1161/str.0b013e3182299496 · Cited by 3,811 · see citing works
The Keap1–Nrf2–ARE Pathway As a Potential Preventive and Therapeutic Target: An Update
Lu, M., Ji, J., Jiang, Z., & You, Q. (2016) · Medicinal Research Reviews · doi:10.1002/med.21396 · Cited by 801 · see citing works
The role of oxidative stress during inflammatory processes
Lugrin, J., Rosenblatt‐Velin, N., Parapanov, R., & Liaudet, L. (2013) · Biological Chemistry · doi:10.1515/hsz-2013-0241 · Cited by 742 · see citing works
Molecular Mechanisms Linking Oxidative Stress and Diabetes Mellitus
Yaribeygi, H., Sathyapalan, T., Atkin, S. L., & Sahebkar, A. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/8609213 · Cited by 689 · see citing works
Thioredoxins, Glutaredoxins, and Peroxiredoxins—Molecular Mechanisms and Health Significance: from Cofactors to Antioxidants to Redox Signaling
Hanschmann, E., Godoy, J. R., Berndt, C., Hudemann, C., & Lillig, C. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4599 · Cited by 649 · see citing works
Nox family NADPH oxidases: Molecular mechanisms of activation.
Brandes, R., Weissmann, N., & Schröder, K. (2014) · Free Radical Biology & Medicine · doi:10.1016/j.freeradbiomed.2014.07.046 · Cited by 660 · see citing works
Temporal dynamics of cardiac immune cell accumulation following acute myocardial infarction
Yan, X., Anzai, A., Katsumata, Y., Matsuhashi, T., Ito, K., Endo, J., Yamamoto, T., Takeshima, A., Shinmura, K., Shen, W., et al. (2013) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2013.04.023 · Cited by 611 · see citing works
Basic Principles and Emerging Concepts in the Redox Control of Transcription Factors
Brigelius-Flohé, R., & Flohé, L. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3534 · Cited by 577 · see citing works
The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia
Iadecola, C. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0718-6 · Cited by 557 · see citing works
Toxicology and pharmacology of selenium: emphasis on synthetic organoselenium compounds
Nogueira, C. W., & da Rocha, J. B. T. (2011) · Archives of Toxicology · doi:10.1007/s00204-011-0720-3 · Cited by 477 · see citing works
Smoking and increased Alzheimer's disease risk: A review of potential mechanisms
Durazzo, T. C., Mattsson, N., Weiner, M. W., & Initiative, A. D. N. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2014.04.009 · Cited by 461 · see citing works
Redefining Preeclampsia Using Placenta-Derived Biomarkers
Staff, A. C., Benton, S. J., von Dadelszen, P., Roberts, J. M., Taylor, R. N., Powers, R. W., Jones, D. S., & Redman, C. W. G. (2013) · Hypertension · doi:10.1161/hypertensionaha.111.00250 · Cited by 375 · see citing works
Host-Associated Probiotics: A Key Factor in Sustainable Aquaculture
Doan, H. V., Hoseinifar, S. H., Ringø, E., Esteban, M. Á., Dadar, M., Dawood, M. A. O., & Faggio, C. (2019) · Reviews in Fisheries Science & Aquaculture · doi:10.1080/23308249.2019.1643288 · Cited by 355 · see citing works
Exercise, inflammation and aging.
(2012) · Europe PMC (PubMed Central) · Cited by 345 · see citing works
Models and Mechanisms of Vascular Dementia
Venkat, P., Chopp, M., & Chen, J.-L. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.05.006 · Cited by 323 · see citing works
Cellular stress response and innate immune signaling: integrating pathways in host defense and inflammation
Muralidharan, S., & Mandrekar, P. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.0313153 · Cited by 329 · see citing works
ROS and Brain Diseases: The Good, the Bad, and the Ugly
Popa-Wagner, A., Mitran, S., Sivanesan, S., Chang, E., & Buga, A.-M. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/963520 · Cited by 427 · see citing works
Role of reactive oxygen and nitrogen species in the vascular responses to inflammation
Kvietys, P. R., & Granger, D. N. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.11.002 · Cited by 313 · see citing works
Role of Microglia TLRs in Neurodegeneration
Fiebich, B. L., Batista, C. R. A., Saliba, S. W., Yousif, N. M., & de Oliveira, A. C. P. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00329 · Cited by 291 · see citing works
Oxidative stress, inflamm-aging and immunosenescence
Cannizzo, E. S., Clement, C. C., Sahu, R. K., Follo, C., & Santambrogio, L. (2011) · Journal of Proteomics · doi:10.1016/j.jprot.2011.06.005 · Cited by 303 · see citing works
Oxidative stress and fish immune system: phagocytosis and leukocyte respiratory burst activity
Biller, J. D., & Takahashi, L. S. (2018) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765201820170730 · Cited by 299 · see citing works
Role of Oxidative Stress in Reperfusion following Myocardial Ischemia and Its Treatments
Xiang, M., Lu, Y., Xin, L., Gao, J., Shang, C., Jiang, Z., Lin, H., Fang, X., Qu, Y., Wang, Y., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6614009 · Cited by 301 · see citing works
Current strategies to minimize hepatic ischemia–reperfusion injury by targeting reactive oxygen species
Jaeschke, H., & Woolbright, B. L. (2012) · Transplantation Reviews · doi:10.1016/j.trre.2011.10.006 · Cited by 292 · see citing works
Therapeutic targets of oxidative/nitrosative stress and neuroinflammation in ischemic stroke: Applications for natural product efficacy with omics and systemic biology
Chen, H., He, Y., Chen, S., Qi, S., & Shen, J. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104877 · Cited by 282 · see citing works
Betulin and its derivatives as novel compounds with different pharmacological effects
Amiri, S., Dastghaib, S., Ahmadi, M., Mehrbod, P., Khadem, F., Behrouj, H., Aghanoori, M., Machaj, F., Ghamsari, M., Rosik, J., et al. (2019) · Biotechnology Advances · doi:10.1016/j.biotechadv.2019.06.008 · Cited by 274 · see citing works
Bipolar Disorder and Immune Dysfunction: Epidemiological Findings, Proposed Pathophysiology and Clinical Implications
Rosenblat, J., & McIntyre, R. (2017) · Brain Sciences · doi:10.3390/brainsci7110144 · Cited by 258 · see citing works
Novel development of 5-aminolevurinic acid (ALA) in cancer diagnoses and therapy.
Ishizuka, M., Abe, F., Sano, Y., Takahashi, K., Inoue, K., Nakajima, M., Kohda, T., Komatsu, N., Ogura, S.-I., & Tanaka, T. (2011) · International Immunopharmacology · doi:10.1016/j.intimp.2010.11.029 · Cited by 255 · see citing works
Blood–Brain Barrier Breakdown: An Emerging Biomarker of Cognitive Impairment in Normal Aging and Dementia
Hussain, B., Fang, C., & Chang, J. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.688090 · Cited by 251 · see citing works
Mitochondria in innate immunity
Arnoult, D., Soares, F., Tattoli, I., & Girardin, S. E. (2011) · EMBO Reports · doi:10.1038/embor.2011.157 · Cited by 246 · see citing works
Targeting Oxidative Stress for the Treatment of Liver Fibrosis
Luangmonkong, T., Suriguga, S., Mutsaers, H. A. M., Groothuis, G. M. M., Olinga, P., & Boersema, M. (2018) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/112_2018_10 · Cited by 248 · see citing works
Inhibition of curcumin on influenza A virus infection and influenzal pneumonia via oxidative stress, TLR2/4, p38/JNK MAPK and NF-κB pathways
Dai, J., Gu, L., Su, Y., Wang, Q., Zhao, Y., Chen, X.-X., Deng, H., Li, W., Wang, G., & Li, K. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.11.009 · Cited by 242 · see citing works
Lutein and zeaxanthin supplementation reduces photooxidative damage and modulates the expression of inflammation-related genes in retinal pigment epithelial cells
Bian, Q., Gao, S., Zhou, J., Qin, J., Taylor, A., Johnson, E. J., Tang, G., Sparrow, J. R., Gierhart, D. L., & Shang, F. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.06.024 · Cited by 241 · see citing works
Chemistry of Lipid A: At the Heart of Innate Immunity
Molinaro, A., Holst, O., Lorenzo, F. D., Callaghan, M., Nurisso, A., D’Errico, G., Zamyatina, A., Peri, F., Berisio, R., Jerala, R., et al. (2014) · Chemistry - A European Journal · doi:10.1002/chem.201403923 · Cited by 242 · see citing works
Effects of dietary n-3 highly unsaturated fatty acids on growth, nonspecific immunity, expression of some immune related genes and disease resistance of large yellow croaker (Larmichthys crocea) following natural infestation of parasites (Cryptocaryon irritans)
Zuo, R., Ai, Q., Mai, K., Xu, W., Wang, J., Xu, H., Liufu, Z., & Zhang, Y. (2011) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2011.11.005 · Cited by 240 · see citing works
Neuroinflammation and Oxidative Stress in the Pathogenesis of Autism Spectrum Disorder
Usui, N., Kobayashi, H., & Shimada, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065487 · Cited by 267 · see citing works
Protective effects of chlorogenic acid against ischemia/reperfusion injury in rat liver: molecular evidence of its antioxidant and anti-inflammatory properties
Yun, N., Kang, J., & Lee, S. (2011) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.06.018 · Cited by 239 · see citing works
Oxidative Stress, Inflammaging, and Immunosenescence
Bauer, M. E., & la Fuente, M. D. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-397803-5.00004-6 · Cited by 229 · see citing works
Most Oxidative Stress Response In Water Samples Comes From Unknown Chemicals: The Need For Effect-Based Water Quality Trigger Values
Escher, B. I., van Daele, C., Dutt, M., Tang, J., & Altenburger, R. (2013) · Environmental Science & Technology · doi:10.1021/es304793h · Cited by 221 · see citing works
Retinal Diseases Associated with Oxidative Stress and the Effects of a Free Radical Scavenger (Edaravone)
Masuda, T., Shimazawa, M., & Hara, H. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/9208489 · Cited by 221 · see citing works
Devilishly radical NETwork in COVID-19: Oxidative stress, neutrophil extracellular traps (NETs), and T cell suppression
Schönrich, G., Raftery, M. J., & Samstag, Y. (2020) · Advances in Biological Regulation · doi:10.1016/j.jbior.2020.100741 · Cited by 221 · see citing works
Toll-like receptor-4 mediates obesity-induced non-alcoholic steatohepatitis through activation of X-box binding protein-1 in mice
Ye, D., Li, F. Y. L., Lam, K. S. L., Li, H., Jia, W., Wang, Y., Man, K., Lo, C. M., Li, X., & Xu, A. (2012) · Gut · doi:10.1136/gutjnl-2011-300269 · Cited by 206 · see citing works
Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation
Lan, T., Kisseleva, T., & Brenner, D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129743 · Cited by 192 · see citing works
Redox Regulation of Inflammation: Old Elements, a New Story
Lei, Y., Wang, K., Deng, L., Chen, Y., Nice, E. C., & Huang, C. (2014) · Medicinal Research Reviews · doi:10.1002/med.21330 · Cited by 208 · see citing works
The inflammatory role of platelets via their TLRs and Siglec receptors
Cognasse, F. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00083 · Cited by 207 · see citing works
Perioperative Organ Injury
Bartels, K., Karhausen, J., Clambey, E. T., Grenz, A., & Eltzschig, H. K. (2013) · Anesthesiology · doi:10.1097/aln.0000000000000022 · Cited by 195 · see citing works
ROS-induced ATF3 causes susceptibility to secondary infections during sepsis-associated immunosuppression
Hoetzenecker, W., Echtenacher, B., Guenova, E., Höetzenecker, K., Woelbing, F., Brück, J., Teske, A., Valtcheva, N., Fuchs, K., Kneilling, M., et al. (2011) · Nature Medicine · doi:10.1038/nm.2557 · Cited by 195 · see citing works
Evaluation of the cytotoxic and inflammatory potential of differentially shaped zinc oxide nanoparticles
Heng, B. C., Zhao, X., Tan, E. C., Khamis, N., Assodani, A., Xiong, S., Ruedl, C., Ng, K. W., & Loo, S. C. J. (2011) · Archives of Toxicology · doi:10.1007/s00204-011-0722-1 · Cited by 194 · see citing works
Ginseng root extract attenuates inflammation by inhibiting the MAPK/NF-κB signaling pathway and activating autophagy and p62-Nrf2-Keap1 signaling in vitro and in vivo
Song, Y., Li, F., Lu, S., Ren, L., Bian, S., Liu, M., Zhao, D., Wang, S., & Wang, J. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114739 · Cited by 194 · see citing works
Toxicity of zinc oxide (ZnO) nanoparticles on human bronchial epithelial cells (BEAS-2B) is accentuated by oxidative stress
Heng, B. C., Zhao, X., Xiong, S., Ng, K. W., Boey, F. Y.-C., & Loo, S. C. J. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.04.023 · Cited by 190 · see citing works
Glaucomatous Tissue Stress and the Regulation of Immune Response through Glial Toll-like Receptor Signaling
Luo, C., Yang, X., Kain, A. D., Powell, D. W., Kuehn, M. H., & Tezel, G. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-5407 · Cited by 190 · see citing works
Increased Mitochondrial Calcium Sensitivity and Abnormal Expression of Innate Immunity Genes Precede Dopaminergic Defects in Pink1-Deficient Mice
Akundi, R. S., Huang, Z., Eason, J., Pandya, J. D., Zhi, L., Cass, W. A., Sullivan, P. G., & Büeler, H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016038 · Cited by 187 · see citing works
Vascular cognitive impairment and dementia
Gorelick, P. B., Counts, S., & Nyenhuis, D. L. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.12.015 · Cited by 187 · see citing works
The Role of Nitric Oxide and Reactive Oxygen Species in the Killing of Leishmania braziliensis by Monocytes from Patients with Cutaneous Leishmaniasis
Carneiro, P. P., Conceição, J., Macedo, M. N., Magalhães, V., Carvalho, E. M., & Bacellar, O. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148084 · Cited by 179 · see citing works
Innate Immune Regulations and Liver Ischemia-Reperfusion Injury
Lü, L., Zhou, H., Ni, M., Wang, X., Busuttil, R. W., Kupiec‐Weglinski, J. W., & Zhai, Y. (2016) · Transplantation · doi:10.1097/tp.0000000000001411 · Cited by 173 · see citing works
Oxidative Stress and Acute Kidney Injury in Critical Illness: Pathophysiologic Mechanisms—Biomarkers—Interventions, and Future Perspectives
Pavlakou, P., Liakopoulos, V., Eleftheriadis, T., Mitsis, M., & Dounousi, E. C. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/6193694 · Cited by 170 · see citing works
Oxidative Stress and Renal Fibrosis: Mechanisms and Therapies
Su, H., Wan, C., Song, A., Qiu, Y., Xiong, W., & Zhang, C. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-8871-2_29 · Cited by 168 · see citing works
Autophagy Controls Acquisition of Aging Features in Macrophages
Stranks, A. J., Hansen, A. L., Panse, I., Mortensen, M., Ferguson, D. J. P., Puleston, D. J., Shenderov, K., Watson, A., Veldhoen, M., Phadwal, K., et al. (2015) · Journal of Innate Immunity · doi:10.1159/000370112 · Cited by 168 · see citing works
The role of oxidative and inflammatory stress and persistent viral infections in immunosenescence
Bauer, M. E., & la Fuente, M. D. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.01.001 · Cited by 164 · see citing works
Reactive Oxygen Species Hydrogen Peroxide Mediates Kaposi's Sarcoma-Associated Herpesvirus Reactivation from Latency
Ye, F., Zhou, F., Bedolla, R. G., Jones, T., Lei, X., Kang, T., Guadalupe, M., & Gao, S. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002054 · Cited by 163 · see citing works
ATF6 Mediates a Pro-Inflammatory Synergy Between ER Stress and TLR Activation in the Pathogenesis of Liver Ischemia-Reperfusion Injury
Rao, J., Yue, S., Fu, Y., Zhu, J., Wang, X., Busuttil, R. W., Kupiec‐Weglinski, J. W., Lü, L., & Zhai, Y. Y. (2014) · American Journal of Transplantation · doi:10.1111/ajt.12711 · Cited by 161 · see citing works
Redox regulation of cardiovascular inflammation – Immunomodulatory function of mitochondrial and Nox-derived reactive oxygen and nitrogen species
Wenzel, P., Kossmann, S., Münzel, T. F., & Daiber, A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.01.027 · Cited by 158 · see citing works
The impact of endocrine-disrupting chemicals on oxidative stress and innate immune response in zebrafish embryos
Xu, H., Yang, M., Qiu, W., Pan, C., & Wu, M. (2013) · Environmental Toxicology and Chemistry · doi:10.1002/etc.2245 · Cited by 156 · see citing works
Lactobacillus pentosus var. plantarum C29 ameliorates memory impairment and inflammaging in a d-galactose-induced accelerated aging mouse model
Woo, J.-Y., Gu, W., Kim, K., Jang, S., Han, M. J., & Kim, D. (2014) · Anaerobe · doi:10.1016/j.anaerobe.2014.03.003 · Cited by 155 · see citing works
MIND diet and cognitive performance in older adults: a systematic review
Kheirouri, S., & Alizadeh, M. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1925220 · Cited by 145 · see citing works
Novel Therapeutic Targets in Depression and Anxiety: Antioxidants as a Candidate Treatment
Xu, Y., Wang, C., Klabnik, J., & Donnell, J. O. (2014) · Current Neuropharmacology · doi:10.2174/1570159x11666131120231448 · Cited by 139 · see citing works
Chronic unpredictable mild stress generates oxidative stress and systemic inflammation in rats
López-López, A. L., Jaime, H. B., Villanueva, M. D. C. E., Brianza-Padilla, M., Vázquez-Palacios, G., & Aguilar, F. J. A. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.03.017 · Cited by 140 · see citing works
Toll like receptor signaling in “inflammaging”: microRNA as new players
Olivieri, F., Rippo, M. R., Prattichizzo, F., Babini, L., Graciotti, L., Recchioni, R., & Procopio, A. D. (2013) · Immunity & Ageing · doi:10.1186/1742-4933-10-11 · Cited by 137 · see citing works
Inflammation in Neurological Disorders: The Thin Boundary Between Brain and Periphery
Cervellati, C., Trentini, A., Pecorelli, A., & Valacchi, G. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8076 · Cited by 138 · see citing works
Mitochondrial reactive oxygen species generation triggers inflammatory response and tissue injury associated with hepatic ischemia–reperfusion: Therapeutic potential of mitochondrially targeted antioxidants
Mukhopadhyay, P., Horváth, B., Zsengellér, Z. K., Bátkai, S., Cao, Z., Kechrid, M., Holovac, E., Erdélyi, K., Tanchian, G., Liaudet, L., et al. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.05.036 · Cited by 133 · see citing works
Antioxidative, anti-inflammatory and hepatoprotective effects of resveratrol on oxidative stress-induced liver damage in tilapia (Oreochromis niloticus)
Jia, R., Li, Y., Cao, L., Du, J., Zheng, T., Qian, H., Gu, Z., Jeney, G., Xu, P., & Yin, G. (2018) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2018.10.002 · Cited by 132 · see citing works
Nrf2 activation as target to implement therapeutic treatments
Bocci, V. A., & Valacchi, G. (2015) · Frontiers in Chemistry · doi:10.3389/fchem.2015.00004 · Cited by 130 · see citing works
Salidroside suppresses inflammation in a D-galactose-induced rat model of Alzheimer’s disease via SIRT1/NF-κB pathway
Gao, J., Zhou, R., You, X., Luo, F., He, H., Chang, X., Zhu, L., Ding, X., & Yan, T. (2016) · Metabolic Brain Disease · doi:10.1007/s11011-016-9813-2 · Cited by 127 · see citing works
Update on Vascular Cognitive Impairment Associated with Subcortical Small-Vessel Disease
Wallin, A., Román, G. C., Esiri, M. M., Kettunen, P., Svensson, J., Paraskevas, G. P., & Kapaki, E. N. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170803 · Cited by 130 · see citing works
The Role of Oxidative Stress in Intervertebral Disc Degeneration
Cao, G., Yang, S., Cao, J., Tan, Z., Wu, L., Dong, F., Ding, W., & Zhang, F. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/2166817 · Cited by 126 · see citing works
Toll-like receptors and diabetes: a therapeutic perspective
Dasu, M. R. K., Ramírez, S. M., & Isseroff, R. R. (2011) · Clinical Science · doi:10.1042/cs20110357 · Cited by 126 · see citing works
Superoxide induces Neutrophil Extracellular Trap Formation in a TLR-4 and NOX-Dependent Mechanism
Al‐Khafaji, A. B., Tohme, S. T., Yazdani, H. O., Miller, D., Huang, H., & Tsung, A. (2016) · Molecular Medicine · doi:10.2119/molmed.2016.00054 · Cited by 115 · see citing works
Self-citation
Toll-Like Receptors: New Players in Myocardial Ischemia/Reperfusion Injury
Ha, T., Liu, L., Kelley, J., Kao, R. L., Williams, D. L., & Li, C. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3723 · Cited by 114 · see citing works
Effects of dietary docosahexaenoic to eicosapentaenoic acid ratio (DHA/EPA) on growth, nonspecific immunity, expression of some immune related genes and disease resistance of large yellow croaker (Larmichthys crocea) following natural infestation of parasites (Cryptocaryon irritans)
Zuo, R., Ai, Q., Mai, K., Xu, W., Wang, J., Xu, H., Liufu, Z., & Zhang, Y. (2012) · Aquaculture · doi:10.1016/j.aquaculture.2011.12.045 · Cited by 113 · see citing works
Magnesium and vitamin C supplementation attenuates steroid-associated osteonecrosis in a rat model
Zheng, L.-Z., Wang, J.-L., Xu, J., Zhang, X.-T., Liu, B.-Y., Huang, L., Zhang, R., Zu, H., He, X. M., Mi, J., et al. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.119828 · Cited by 113 · see citing works
Intraneuronal protein aggregation as a trigger for inflammation and neurodegeneration in the aging brain
Currais, A. J. M., Fischer, W. H., Maher, P. A., & Schubert, D. A. (2016) · The FASEB Journal · doi:10.1096/fj.201601184 · Cited by 114 · see citing works
Nutraceuticals for the Treatment of Diabetic Retinopathy
Rossino, M. G., & Casini, G. (2019) · Nutrients · doi:10.3390/nu11040771 · Cited by 110 · see citing works
Effects of dietary fish meal replacement by fermented moringa (Moringa oleifera Lam.) leaves on growth performance, nonspecific immunity and disease resistance against Aeromonas hydrophila in juvenile gibel carp (Carassius auratus gibelio var. CAS III)
Zhang, X., Sun, Z., Cai, J., Wang, J., Wang, G., Zhu, Z., & Cao, F. (2020) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2020.04.051 · Cited by 110 · see citing works
Arterial stiffness, cognitive impairment and dementia: confounding factor or real risk?
Iulita, M. F., de la Colina, A. N., & Girouard, H. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14235 · Cited by 107 · see citing works
High level of dietary soybean oil depresses the growth and anti-oxidative capacity and induces inflammatory response in large yellow croaker Larimichthys crocea
Mu, H., Shen, H., Liu, J., Xie, F., Zhang, W., & Mai, K. (2018) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2018.04.017 · Cited by 108 · see citing works
Heart–kidney crosstalk and role of humoral signaling in critical illness
Virzì, G. M., Day, S., de Cal, M., Vescovo, G., & Ronco, C. (2014) · Critical Care · doi:10.1186/cc13177 · Cited by 108 · see citing works
Modulation of endothelial function by Toll like receptors
Salvador, B., Arranz, A., Francisco, S., Córdoba, L., Punzón, C., Llamas, M. Á., & Fresno, M. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.03.038 · Cited by 107 · see citing works
The roles of strawberry and honey phytochemicals on human health: A possible clue on the molecular mechanisms involved in the prevention of oxidative stress and inflammation
Battino, M. A., Giampieri, F., Cianciosi, D., Ansary, J., Chen, X., Zhang, D., Gil, E., & Forbes-Hernández, T. Y. (2020) · Phytomedicine · doi:10.1016/j.phymed.2020.153170 · Cited by 112 · see citing works
Nanotherapies for sepsis by regulating inflammatory signals and reactive oxygen and nitrogen species: New insight for treating COVID-19
Chen, L., Huang, Q., Zhao, T., Sui, L., Wang, S., Xiao, Z., Nan, Y., & Ai, K. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102046 · Cited by 98 · see citing works
Palmatine Protects Against MSU-Induced Gouty Arthritis via Regulating the NF-κB/NLRP3 and Nrf2 Pathways
Cheng, J., Ma, X., Ai, G., Yu, Q., Chen, X., Yan, F., Li, Y., Xie, J., Su, Z., & Xie, Q. (2022) · Drug Design Development and Therapy · doi:10.2147/dddt.s356307 · Cited by 98 · see citing works
Inflammation and lithium: clues to mechanisms contributing to suicide-linked traits
Beurel, E., & Jope, R. S. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.129 · Cited by 92 · see citing works
Inflammasome: A Double-Edged Sword in Liver Diseases
Luan, J., & Ju, D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02201 · Cited by 96 · see citing works
Anti-oxidative, anti-inflammatory and hepatoprotective effects of Radix Bupleuri extract against oxidative damage in tilapia (Oreochromis niloticus) via Nrf2 and TLRs signaling pathway
Jia, R., Gu, Z., He, Q., Du, J., Cao, L., Jeney, G., Xu, P., & Yin, G. (2019) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2019.07.080 · Cited by 94 · see citing works
Microbiome and intestinal ischemia/reperfusion injury
Nadatani, Y., Watanabe, T., Shimada, S., Otani, K., Tanigawa, T., & Fujiwara, Y. (2018) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.17-137 · Cited by 94 · see citing works
Hyperlipidemia induces meibomian gland dysfunction
Bu, J., Wu, Y., Cai, X., Jiang, N., Jeyalatha, M. V., Yu, J., He, X., He, H., Guo, Y., Zhang, M., et al. (2019) · The Ocular Surface · doi:10.1016/j.jtos.2019.06.002 · Cited by 93 · see citing works
Impact of maternal cigarette smoke exposure on brain inflammation and oxidative stress in male mice offspring
Chan, Y., Saad, S., Pollock, C., Oliver, B., Al-Odat, I., Zaky, A. A., Jones, N. M., & Chen, H. (2016) · Scientific Reports · doi:10.1038/srep25881 · Cited by 87 · see citing works
Probiotic yogurt offers higher immune-protection than probiotic whey beverage
Lollo, P. C. B., Moura, C. S., Morato, P. N., da Cruz, A. G., Castro, W. D. F., Cazarin, C. B. B., Nisishima, L. H., Faria, J. D. A. F., Maróstica, M. R., de Oliveira, C. A. F., et al. (2013) · Food Research International · doi:10.1016/j.foodres.2013.06.003 · Cited by 89 · see citing works
Anti-influenza A virus activity of rhein through regulating oxidative stress, TLR4, Akt, MAPK, and NF-κB signal pathways
Wang, Q., Su, Y., Sheng, J., Gu, L., Zhao, Y., Chen, X., Chen, C., Li, W., Li, K., & Dai, J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0191793 · Cited by 89 · see citing works
Oxidative stress and inflammation in a spectrum of epileptogenic cortical malformations: molecular insights into their interdependence
Arena, A., Zimmer, T., van Scheppingen, J., Korotkov, A., Anink, J., Mühlebner, A., Jansen, F., van Hecke, W., Spliet, W., van Rijen, P. V., et al. (2018) · Brain Pathology · doi:10.1111/bpa.12661 · Cited by 83 · see citing works
ZnO nanoparticles induce TNF-α expression via ROS-ERK-Egr-1 pathway in human keratinocytes
Jeong, S. H., Kim, H. J., Ryu, H. J., Ryu, W. I., Park, Y.-H., Bae, H. C., Jang, Y., & Son, S. W. (2013) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2013.08.002 · Cited by 87 · see citing works
Proteomics and Metabolomics for AKI Diagnosis
Marx, D., Metzger, J., Pejchinovski, M., Gil, R., Frantzi, M., Latosińska, A., Belczacka, I., Heinzmann, S. S., Husi, H., Zoidakis, J., et al. (2017) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2017.09.007 · Cited by 89 · see citing works

Toll-Like Receptors in Hepatic Ischemia/Reperfusion and Transplantation
Evankovich, J. W., Billiar, T. R., & Tsung, A. (2010) · Gastroenterology Research and Practice · doi:10.1155/2010/537263 · Cited by 36 · see citing works
Self-citation
doi:10.1155/2010/537263 Review Article
Receptors, T.-L., Evankovich, J., Billiar, T., & Tsung, A. (2010)
Self-citation
Roles of PRR-Mediated Signaling Pathways in the Regulation of Oxidative Stress and Inflammatory Diseases
Li, P., & Chang, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147688 · Cited by 139 · see citing works
The role of oxidative stress during inflammatory processes
Lugrin, J., Rosenblatt‐Velin, N., Parapanov, R., & Liaudet, L. (2013) · Biological Chemistry · doi:10.1515/hsz-2013-0241 · Cited by 742 · see citing works
Toll-like receptor 4 mediated injury after hepatic ischemia-reperfusion involves reactive oxygen species
Tsung, A., Klune, J. R., Nakao, A., Critchlow, N. D., Chan, M., Billiar, T. R., & Geller, D. A. (2006) · Journal of Surgical Research · doi:10.1016/j.jss.2005.11.036
Self-citation

Authors: Gill, R., Tsung, A., & Billiar, T.
Affiliations: University of Pittsburgh (US)
Corresponding author: Gill, Roop
ORCID: Tsung, Allan
Billiar, Timothy
Venue: Free Radical Biology and Medicine
Publisher: Elsevier BV
Published: 2010-05
Volume: 48
Issue: 9
Pages: 1121-1132
ISSN: 0891-5849 (ISSN-L)
DOI: 10.1016/j.freeradbiomed.2010.01.006
PMC: PMC3423196
OpenAlex: W2013742341
Cited by: 553
References: 134
Citations by year: 2026: 21 · 2025: 37 · 2024: 26 · 2023: 41 · 2022: 34 · 2021: 50 · 2020: 42 · 2019: 39 · 2018: 38 · 2017: 33 · 2016: 28 · 2015: 31 · 2014: 35 · 2013: 33 · 2012: 18
FWCI: 2.50
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Free Radical Biology and Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of General Medical Sciences (R01GM050441)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Keywords: oxidative stress, Toll-like receptors, inflammation, ischemia-reperfusion injury, hemorrhagic shock, damage-associated molecular patterns, reactive oxygen species, NADPH oxidase, innate immunity, organ transplantation, myocardial infarction, stroke
MeSH terms: Animals, Humans, Inflammation, Reperfusion Injury, Oxidative Stress, Toll-Like Receptors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Linking oxidative stress to inflammation: Toll-like receptors

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks