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Cited by 324

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Strongyloides hyperinfection syndrome: an emerging global infectious disease

Marcos, Luis A., Terashima, Angelica, DuPont, Herbert L., Gotuzzo, Eduardo·2008·Transactions of the Royal Society of Tropical Medicine and Hygiene
DOI 10.1016/j.trstmh.2008.01.020
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Abstract

The hyperinfection syndrome (HS) caused by Strongyloides stercoralis has a high mortality rate (15% to 87%). A variety of risk factors and predisposing conditions have been described, including new immunosuppressive therapies; HTLV-1 infection; cadaveric transplantation; immune reconstitution syndrome; haematological malignancies (especially lymphoma); tuberculosis; malnutrition secondary to chronic Strongyloides diarrhoea; international travel and immigration. Inhibition of Th2 cell-mediated, humoral or mucosal immunity is associated with HS. HS is more frequently seen in HTLV-1 than HIV patients. In AIDS, there is an increase in Th2 cytokines, while in HTLV-1 infection there is a decrease in the Th2 response, leading to an increased risk of autoinfection. Corticosteroid use remains the most frequent risk factor for HS. A number of ELISAs are useful for diagnosis and post-treatment evaluation. Once diagnosed, the disease may be managed effectively with anthelminthic drugs, including ivermectin. HS causes diverse symptoms and signs, with unusual manifestations leading to misdiagnosis and medical errors related to healthcare providers' lack of familiarity with the condition. HS is an example of an emerging tropical infection migrating to developed countries and requiring greater clinician awareness.

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Metadata

Authors
Marcos, L. A., Terashima, A., DuPont, H. L., & Gotuzzo, E.
Venue
Transactions of the Royal Society of Tropical Medicine and Hygiene
Publisher
Oxford University Press (OUP)
Published
2008-04
Volume
102
Issue
4
Pages
314-318
ISSN
0035-9203 (ISSN-L)
DOI
10.1016/j.trstmh.2008.01.020
OpenAlex
W2036253433
Cited by
324
References
23
FWCI
16.76
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Strongyloides hyperinfection syndrome: an emerging global infectious disease. https://app.cochat.ai/papers/10.1016/j.trstmh.2008.01.020
The paper
Marcos, L. A., Terashima, A., DuPont, H. L., & Gotuzzo, E. (2008). Strongyloides hyperinfection syndrome: an emerging global infectious disease. Transactions of the Royal Society of Tropical Medicine and Hygiene. https://doi.org/10.1016/j.trstmh.2008.01.020

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.