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Hepatotoxicity from antituberculous therapy in the elderly: A systematic review
Open accessAbstract
Background Elderly persons have the highest rates of tuberculosis (TB) in the United States compared to all other age groups. A systematic literature review was conducted to determine if older age was a risk factor for hepatotoxicity resulting from treatment with first-line drugs used to treat active (TB) and latent tuberculosis (LTBI).Methods A systematic review of MEDLINE, Cochrane Controlled Trial Registry, CINAHL(®), and Science Citation Index Expanded (from 1970 to 2011) was performed to determine the risk of hepatotoxicity, comparing those over 60 with those under 60. A meta-analysis was performed using a random effects model along with log odds ratios and the chi-square test.Findings Thirty-eight studies (40,034 participants; 1208 cases of hepatotoxicity) met the selection criteria. For active TB, an overall mean effect of 0.277 (p = 0.024, 95% CI: 0.037-0.517) was observed, which is equivalent to an odds ratio of 1.32 (95% CI: 1.04-1.68). For LTBI, an overall mean effect of 1.42 (p < 0.001, 95% CI: 0.794-2.05) was observed, which translates to an odds ratio of 4.14 (95% CI: 2.21-7.74).Interpretation Our analysis revealed that patients older than 60 had significantly more risk of hepatotoxicity. These studies suggest that a gentler regimen of treatment for older individuals could benefit health outcomes in this population of TB patients and minimize risks to the public's health.
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Cites
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000100 · Cited by 28,164
Griffith, D. E., Aksamit, T., Brown-Elliott, B. A., Catanzaro, A., Daley, C., Gordin, F., Holland, S. M., Horsburgh, R., Huitt, G., Iademarco, M. F., et al. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200604-571st · Cited by 6,110
Blumberg, H. M., Burman, W. J., Chaisson, R. E., Daley, C. L., Etkind, S. C., Friedman, L. N., Fujiwara, P., Grzemska, M., Hopewell, P. C., Iseman, M. D., et al. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.167.4.603 · Cited by 1,936
An Official ATS Statement: Hepatotoxicity of Antituberculosis Therapy
Saukkonen, J. J., Cohn, D. L., Jasmer, R. M., Schenker, S., Jereb, J., Nolan, C. M., Peloquin, C. A., Gordin, F. M., Nunes, D., Strader, D. B., et al. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200510-1666st · Cited by 1,171
Data analysis 2Preprint
Wagemans, F. M. A., Brandt, M. J., & Zeelenberg, M. (2016) · Cited by 952
Hepatotoxicity Associated With Isoniazid Preventive Therapy
Nolan, C. M., GOLDBERG, S. V., & Buskin, S. E. (1999) · JAMA · doi:10.1001/jama.281.11.1014 · Cited by 463
(1923) · Public Health · doi:10.1016/s0033-3506(23)80379-1 · Cited by 459
Schaberg, T., Rebhan, K., & Lode, H. M. (1996) · European Respiratory Journal · doi:10.1183/09031936.96.09102026 · Cited by 384
McGuire, S. (2014) · Advances in Nutrition · doi:10.3945/an.114.005900 · Cited by 365
Samandari, T., Agizew, T., Nyirenda, S., Tedla, Z., Sibanda, T., Shang, N., Mosimaneotsile, B., Motsamai, O. I., Bozeman, L., Davis, M. K., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60204-3 · Cited by 354
Isoniazid-Associated Hepatitis
Garibaldi, R. A., DRUSIN, R. E., Ferebee, S. H., & Gregg, M. B. (1972) · American Review of Respiratory Disease · doi:10.1164/arrd.1972.106.3.357 · Cited by 233
Menzies, D., Long, R., Trajman, A., Dion, M.-J., Yang, J., Jahdali, H. A., Memish, Z. A., Khan, K., Gardam, M. A., Hoeppner, V., et al. (2008) · Annals of Internal Medicine · doi:10.7326/0003-4819-149-10-200811180-00003 · Cited by 217
(2003) · PsycEXTRA Dataset · doi:10.1037/e359142004-001 · Cited by 205
Frequency and type of reactions to antituberculosis drugs: Observations in routine treatment
Ormerod, L. P., & Horsfield, N. (1996) · Tubercle and Lung Disease · doi:10.1016/s0962-8479(96)90073-8 · Cited by 158
Shang, P., Xia, Y., Liu, F., Wang, X., Yuan, Y., Hu, D., Tu, D., Chen, Y., Deng, P., Cheng, S., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021836 · Cited by 129
Possuelo, L. G., Castelan, J. A., de Brito, T. C., Ribeiro, A. W., Cafrune, P. I., Picon, P. D., Santos, A. R., Teixeira, R. L. F., Gregianini, T. S., Hutz, M. H., et al. (2008) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-008-0484-8 · Cited by 127
Evaluation of risk factors for antituberculosis treatment induced hepatotoxicity.
Singla, R., Sharma, S. K., Mohan, A., Makharia, G. K., Sreenivas, V., Jha, B. K., Kumar, S., Sarda, P., & Singh, S. (2010) · PubMed · Cited by 126
Thulin, P., Nordahl, G., Gry, M., Yimer, G., Aklillu, E., Makonnen, E., Aderaye, G., Lindquist, L., Mattsson, C. M., Ekblom, B. T., et al. (2013) · Liver International · doi:10.1111/liv.12322 · Cited by 123
Rb, B. (1979) · JAMA · doi:10.1001/jama.241.12.1239 · Cited by 123
Hepatotoxicity of tuberculosis chemotherapy under general programme conditions in Singapore.
Teleman, M. D., Chee, C. B. E., Earnest, A., & Wang, Y. T. (2002) · PubMed · Cited by 111
Results of contact examination in Rotterdam, 1967-1969.
van Geuns, H. A., Meijer, J., & Styblo, K. (1975) · PubMed · Cited by 106
Identification of Serum microRNA Biomarkers for Tuberculosis Using RNA-seq
Zhang, H., Sun, Z., Wei, W., Liu, Z., Fleming, J., Zhang, S., Lin, N., Wang, M., Chen, M., Xu, Y., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088909 · Cited by 89
Transmission of Mycobacterium tuberculosis Depending on the Age and Sex of Source Cases
Borgdorff, M. W. (2001) · American Journal of Epidemiology · doi:10.1093/aje/154.10.934 · Cited by 89
Risk factors of hepatitis during Anti-tuberculous treatment and implications of hepatitis virus load
Wang, J., Liu, C., Hu, F., Chang, H.-C., Liu, J.-L., Chen, J., Yu, C., Lee, L., Kao, J., & Yang, P. (2011) · Journal of Infection · doi:10.1016/j.jinf.2011.04.005 · Cited by 88
Diagnostic and Therapeutic Problems of Pulmonary Tuberculosis in Elderly Patients
Lee, J. H., Han, D. H., Song, J., & Chung, H. S. (2005) · Journal of Korean Medical Science · doi:10.3346/jkms.2005.20.5.784 · Cited by 83
Meyers, B. R., Papanicolaou, G. A., Sheiner, P. A., Emre, S., & Miller, C. M. (2000) · Transplantation · doi:10.1097/00007890-200001150-00013 · Cited by 83
Hepatobiliary Tuberculosis: A Review of Presentations and Outcomes
Chong, V. H. (2008) · Southern Medical Journal · doi:10.1097/smj.0b013e318164ddbb · Cited by 82
Safety of 2 Months of Rifampin and Pyrazinamide for Treatment of Latent Tuberculosis
Stout, J. E., Engemann, J. J., Cheng, A. C., Fortenberry, E. R., & HAMILTON, C. D. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200209-998oc · Cited by 80
Kunst, H., & Khan, K. S. (2010) · PubMed · Cited by 79
Jahng, A. W., Tran, T. T., Bui, L. L., & Joyner, J. L. (2007) · Transplantation · doi:10.1097/01.tp.0000266578.45634.4f · Cited by 68
Sotsuka, T., Sasaki, Y., Hirai, S., Yamagishi, F., & Ueno, K. (2011) · PubMed · Cited by 68
Adverse events associated with treatment of latent tuberculosis in the general population
Smith, B. M., Schwartzman, K., Bartlett, G., & Menzies, D. (2011) · Canadian Medical Association Journal · doi:10.1503/cmaj.091824 · Cited by 60
Hepatitis C virus infection increases hepatitis risk during anti-tuberculosis treatment.
Chien, J.-Y., Huang, R.-M., Wang, J.-Y., Ruan, S.-Y., Chien, Y.-J., Yu, C., & Yang, P.-C. (2010) · PubMed · Cited by 60
Antituberculous drug-induced liver injury: current perspective.
Devarbhavi, H. C. (2012) · PubMed · Cited by 57
Aging and Hepatotoxicity of Isoniazid and Rifampin in Pulmonary Tuberculosis
den Brande, P. V., Steenbergen, W. V., Vervoort, G., & DEMEDTS, M. G. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.152.5.7582317 · Cited by 56
Lorent, N., Sebatunzi, O. R., Mukeshimana, G., den Ende, J. V., & Clerinx, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019566 · Cited by 54
Baghaei, P., Tabarsi, P., Chitsaz, E., Saleh, M., Marjani, M., Shemirani, S., Pooramiri, M. V., Dizaji, M. K., Farnia, P., Fahimi, F., et al. (2010) · American Journal of Therapeutics · doi:10.1097/mjt.0b013e31818f9eae · Cited by 53
Reported tuberculosis in the United States, 2004
Armstrong, L., Hart, M., Jeffries, C. D., Magee, E., Manangan, L. P., Miner, C. E., Miramontes, R., Newell, G. T., Pratt, R. H., Winston, C. A., et al. (2005) · Cited by 53
Sharifzadeh, M. S., Rasoulinejad, M., Valipour, F., Nouraie, M. S., & Vaziri, S. (2005) · Pharmacological Research · doi:10.1016/j.phrs.2004.10.009 · Cited by 50
Bartacek, A., Schütt, D., Panosch, B., & Borek, M. (2009) · PubMed · Cited by 46
Isoniazid hepatotoxicity after orthotopic liver transplantation.
Schluger, L. K., Sheiner, P. A., Jonas, M., Guarrera, J. V., Fiel, I., Meyers, B. F., & Berk, P. D. (1996) · PubMed · Cited by 46
Zabana, Y., Domènech, E., López–Sanromán, A., Beltrán, B., Cabriada, J. L., Saro, C. M., Araméndiz, R., Ginard, D., Hinojosa, J., Gisbert, J. P., et al. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20496 · Cited by 46
Hepatitis C Virus Infection and Hepatotoxicity During Antituberculosis Chemotherapy
Kwon, Y. S., Koh, W., Suh, G. Y., Chung, M. P., Kim, H., & Kwon, O. J. (2007) · CHEST Journal · doi:10.1378/chest.06-2042 · Cited by 44
Şen, N., Turunç, T., Karataşli, M., Sezer, S., Demıroğlu, Y. Z., & Eyüboğlu, F. Ö. (2008) · Transplantation Proceedings · doi:10.1016/j.transproceed.2007.12.003 · Cited by 40
Safety and Completion Rate of Short‐Course Therapy for Treatment of Latent Tuberculosis Infection
Cook, P., Maldonado, R. A., Yarnell, C. T., & Holbert, D. (2006) · Clinical Infectious Diseases · doi:10.1086/505398 · Cited by 38
Side-effects of antituberculosis drug treatment in patients with chronic renal failure
Quantrill, S. J., Woodhead, M. A., Bell, C. E., Hardy, C., Hutchison, A. J., & Gokal, R. (2002) · European Respiratory Journal · doi:10.1183/09031936.02.00298002 · Cited by 34
Nader, L. A., de Mattos, Â. A., Picon, P. D., Bassanesi, S. L., de Mattos, Â. Z., & Rodriguez, M. P. (2010) · Annals of Hepatology · doi:10.1016/s1665-2681(19)31682-5 · Cited by 33
Sun, H., Chen, I.-L., Gau, C., Chang, S., & Luh, K. (2009) · Journal of the Formosan Medical Association · doi:10.1016/s0929-6646(09)60040-1 · Cited by 29
Young, H. L., Wessolossky, M., Ellis, J., Kaminski, M., & Daly, J. S. (2009) · Clinical Infectious Diseases · doi:10.1086/600394 · Cited by 27
Successful use of rifampicin for Hispanic foreign-born patients with latent tuberculosis infection.
Haley, C. A., Stephan, S., Vossel, L. F., Sherfy, E. A., Laserson, K. F., & Kainer, M. A. (2008) · PubMed · Cited by 25
Frequency of anti-tuberculous therapy-induced hepatotoxicity in patients and their outcome.
Tariq, S., Khan, T. S., Malik, S., Anwar, M., & Rashid, A. (2009) · PubMed · Cited by 19
Sistanizad, M., Azizi, E., Khalili, H. A., Hajiabdolbaghi, M., Gholami, K., & Mahjub, R. (2011) · Europe PMC (PubMed Central) · Cited by 16
Various clinical presentations of tuberculosis in heart transplant recipients
Chou, N., Liu, L.-T., Ko, W.-J., Hsu, R.-B., Chen, Y., Yu, H., Chi, N.-H., Chang, S., & Wang, S. (2004) · Transplantation Proceedings · doi:10.1016/j.transproceed.2004.08.114 · Cited by 15
Absence of Transaminase Elevation During Concomitant Methotrexate and Isoniazid Therapy
EKOCHIN, L. H., Manadan, A. M., Aggarwal, R., Sequeira, W., & Block, J. A. (2009) · The Journal of Rheumatology · doi:10.3899/jrheum.090149 · Cited by 3
Flagged first, then by citations
1 of the 55 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Khan, 2010, Anti-tubercular chemotherapy and drug induced hepatitis, Healthmed, 4, 536
Cited by
Sorted by citations
Does tuberculosis threaten our ageing populations?
Byng-Maddick, R., & Noursadeghi, M. (2016) · BMC Infectious Diseases · doi:10.1186/s12879-016-1451-0 · Cited by 149
Ledesma, J. R., Ma, J., Zhang, M., Basting, A. V. L., Chu, H. T., Vongpradith, A., Novotney, A., LeGrand, K. E., Xu, Y. Y., Dai, X., et al. (2024) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(24)00007-0 · Cited by 146
Abbara, A., Chitty, S., Roe, J. K., Ghani, R., Collin, S. M., Ritchie, A., Kon, O. M., Dzvova, J., Davidson, H., Edwards, T. E., et al. (2017) · BMC Infectious Diseases · doi:10.1186/s12879-017-2330-z · Cited by 100
Safety and Tolerability of Antimicrobial Agents in the Older Patient
Soraci, L., Cherubini, A., Paoletti, L., Filippelli, G., Luciani, F., Laganà, P., Gambuzza, M. E., Filicetti, E., Corsonello, A., & Lattanzio, F. (2023) · Drugs & Aging · doi:10.1007/s40266-023-01019-3 · Cited by 85
Hepatotoxicity mechanisms of isoniazid: A mini‐review
Hassan, H. M., Guo, H., Yousef, B. A., Luyong, Z., & Jiang, Z. (2015) · Journal of Applied Toxicology · doi:10.1002/jat.3175 · Cited by 73
Clinical standards for the dosing and management of TB drugs
Alffenaar, J. C., STOCKER, S. L., Forsman, L. D., Garcia‐Prats, A. J., Heysell, S. K., Aarnoutse, R. E., Akkerman, O. W., Aleksa, A., van Altena, R., de Oñata, W. A., et al. (2022) · The International Journal of Tuberculosis and Lung Disease · doi:10.5588/ijtld.22.0188 · Cited by 69
Jadhavar, P. S., Dhameliya, T. M., Vaja, M. D., Kumar, D., Sridevi, J. P., Yogeeswari, P., Sriram, D., & Chakraborti, A. K. (2016) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2016.04.012 · Cited by 59
A partially randomised trial of pretomanid, moxifloxacin and pyrazinamide for pulmonary TB
Tweed, C., Wills, G. H., Crook, A. M., Amukoye, E., Balanag, V. M., Ban, A. Y. L., Bateson, A. L. C., Betteridge, M., Brumskine, W., Caoili, J., et al. (2021) · The International Journal of Tuberculosis and Lung Disease · doi:10.5588/ijtld.20.0513 · Cited by 58
Martínez, L., Seddon, J. A., Horsburgh, C. R., Lange, C. G., Mandalakas, A. M., Martinez, L., Seddon, J. A., Liu, Q., Acuña-Villaorduña, C., Bonnet, M., et al. (2024) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(24)00083-3 · Cited by 56
Bhagat, S., Supriya, M., Pathak, S., Sriram, D., & Chakraborti, A. K. (2018) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2018.09.023 · Cited by 35
Tuberculosis in Older Adults: Seattle and King County, Washington
Toren, K. G., Spitters, C., Pecha, M., Bhattarai, S., Horne, D. J. D. L., & Narita, M. (2019) · Clinical Infectious Diseases · doi:10.1093/cid/ciz306 · Cited by 36
Zhou, S.-F., Niu, N., Yin, J., Yang, Y., Wang, Z., Zhou, Z.-W., He, Z., Chen, X., Zhang, X., Duan, W., et al. (2015) · Drug Design Development and Therapy · doi:10.2147/dddt.s79369 · Cited by 34
An Insight on the Prospect of Quinazoline and Quinazolinone Derivatives as Anti-tubercular Agents
Kushwaha, N., Sahu, A., Mishra, J., Soni, A., & Dorwal, D. (2023) · Current Organic Synthesis · doi:10.2174/1570179420666230316094435 · Cited by 30
Xiao, Y., Chen, Y., Huang, R., Jiang, F., Zhou, J., & Yang, T. (2024) · BMC Medical Research Methodology · doi:10.1186/s12874-024-02214-5 · Cited by 34
Clinical and experimental research in antituberculosis drug-induced hepatotoxicity: a review
Baskaran, U. L., & Prince, S. E. (2017) · Journal of Chinese Integrative Medicine · doi:10.1016/s2095-4964(17)60319-4 · Cited by 28
Completion rate of latent tuberculosis infection treatment in patients aged 65 years and older
Noh, C. S., Kim, H. I., Choi, H., Kim, Y., Kim, C.-H., Choi, J., Hyun, I. G., & Baek, M. S. (2019) · Respiratory Medicine · doi:10.1016/j.rmed.2019.09.004 · Cited by 27
Cohen, E. B., Patwardhan, M. B., Raheja, R., Alpers, D., Andrade, R. J., Avigan, M., Lewis, J. H., Rockey, D. C., Chui, F., Iacob, A. M., et al. (2024) · Drug Safety · doi:10.1007/s40264-023-01390-5 · Cited by 32
Song, J. H., Yoon, S.-Y., Park, T. Y., Heo, E. Y., Kim, D. K., Chung, H. S., & Lee, J. (2019) · Respiratory Research · doi:10.1186/s12931-019-1256-y · Cited by 26
Zhong, T., Zhuang, Z., Dong, X., Wong, K., Wong, W., Wang, J., He, D., & Liu, S. (2021) · JMIR Medical Informatics · doi:10.2196/29226 · Cited by 26
Rapamycin modulates pulmonary pathology in a murine model of Mycobacterium tuberculosis infection
Bhatt, K., Bhagavathula, M., Verma, S., Timmins, G. S., Deretic, V. P., Ellner, J. J., & Salgame, P. (2021) · Disease Models & Mechanisms · doi:10.1242/dmm.049018 · Cited by 26
A narrative review of tuberculosis in the United States among persons aged 65 years and older
Wu, I., Chitnis, A. S., & Jaganath, D. (2022) · Journal of Clinical Tuberculosis and Other Mycobacterial Diseases · doi:10.1016/j.jctube.2022.100321 · Cited by 25
The role of regular liver function monitoring in antituberculosis drug-induced liver injury
Chang, T.-E., Huang, Y., Su, W., Perng, C., Huang, Y., & Hou, M. (2019) · Journal of the Chinese Medical Association · doi:10.1097/jcma.0000000000000119 · Cited by 24
Lin, H.-S., Cheng, C.-W., Lin, M., Chang, P., Lin, J.-C., Ye, J.-J., & Chou, Y. (2016) · Clinical Interventions in Aging · doi:10.2147/cia.s95411 · Cited by 23
Patterson, B., Abbara, A., Collin, S. M., Henderson, M., Shehata, M., Gorgui-Naguib, H., Lynn, W. A., Kon, O. M., & John, L. (2020) · Journal of Infection · doi:10.1016/j.jinf.2020.09.038 · Cited by 22
Mhimbira, F., Hella, J., Maroa, T., Kisandu, S., Chiryamkubi, M., Said, K., Mhalu, G., Mkopi, A., Mutayoba, B. K., Reither, K., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161171 · Cited by 21
Enoh, J. E., Cho, F. N., Manfo, F. P. T., Ako, S. E., & Akum, E. A. (2020) · BioMed Research International · doi:10.1155/2020/9631731 · Cited by 20
Tuberculous meningitis in the elderly
Rahman, N., Pannu, A. K., Yadav, R., Sethi, S., Saroch, A., Garg, M. K., Kumar, D., & Bhalla, A. (2021) · QJM · doi:10.1093/qjmed/hcab162 · Cited by 15
Beck‐Friis, J., Studahl, M., Yilmaz, A., Andersson, R., & Lönnermark, E. (2020) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2020.06.069 · Cited by 12
Diagnosing Pulmonary Tuberculosis in the Elderly
Symes, M. J., Probyn, B., Daneshvar, C., & Telisinghe, L. (2020) · Current Geriatrics Reports · doi:10.1007/s13670-020-00319-5 · Cited by 11
Zhang, F., Zhang, F., Qin, M., & Li, L. (2024) · Microbial Pathogenesis · doi:10.1016/j.micpath.2024.107003 · Cited by 11
Liu, J., Zhou, Y., Guan, J., Liu, Y., Weijian, S., Liu, W., Yin, X., Liu, Y., Li, T., Jin, L. G., et al. (2025) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2025.107966 · Cited by 10
Chapter 10: Treatment of active tuberculosis in special populations
Cooper, R. D., Houston, S. C., Hughes, C. A., & Johnston, J. C. (2022) · Canadian Journal of Respiratory Critical Care and Sleep Medicine · doi:10.1080/24745332.2022.2039500 · Cited by 10
Hepatotoxicity induced by isoniazid in patients with latent tuberculosis infection: a meta-analysis.
Oscanoa, T. J., Vidal, X., Luque, J., Julca-Marín, D., & Romero‐Ortuño, R. (2023) · Gastroenterology and hepatology from bed to bench. · doi:10.22037/ghfbb.v16i1.2685 · Cited by 13
A closer look at the spectrum of drug-induced liver injury in sub-Saharan Africa
Riebensahm, C., Kà, D., Sow, A., Semmo, N., & Wandeler, G. (2019) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2019.1638251 · Cited by 8
Ilaiwy, G., & Dowdy, D. W. (2021) · Journal of Clinical Tuberculosis and Other Mycobacterial Diseases · doi:10.1016/j.jctube.2021.100262 · Cited by 7
ANTITUBERCULOSIS DRUG-INDUCED HEPATOTOXICITY
Dolgushina, A. I., Волчегорский, И. А., Novoselov, P. N., Ushkareva, E. V., Olevskaya, E. R., & Кузнецова, А. С. (2018) · Экспериментальная и клиническая гастроэнтерология · doi:10.31146/1682-8658-ecg-156-8-116-124 · Cited by 7
Du, R., Rao, L., Xiao, X., Zhao, Q., Shen, X., & Xu, B. (2025) · Aging Clinical and Experimental Research · doi:10.1007/s40520-025-03070-z · Cited by 5
Medrano, B. A., Lee, M., Gemeinhardt, G. L., Yamba, L., & Restrepo, B. I. (2024) · Epidemiology and Infection · doi:10.1017/s0950268824000669 · Cited by 5
Monitoring tuberculosis contact tracing outcomes in Western Sydney, Australia
Parvaresh, L., Bag, S. K., Cho, J., Heron, N., Assareh, H., Norton, S., Corbett, S. J., & Marais, B. J. (2018) · BMJ Open Respiratory Research · doi:10.1136/bmjresp-2018-000341 · Cited by 5
Gangarapu, N. R., Ranganatham, A., Reddy, E. K., Yellappa, S., & Chandrasekhar, K. B. (2020) · Archiv der Pharmazie · doi:10.1002/ardp.201900368 · Cited by 4
Oscanoa, T. J., Moscol, S., & Amado, J. (2020) · Revista Peruana de Medicina Experimental y Salud Pública · doi:10.17843/rpmesp.2020.373.4684 · Cited by 4
Chaves, E. C., Carneiro, I. C. D. R. S., & Santos, M. I. P. D. O. (2017) · Revista Baiana Saúde Pública · doi:10.22278/2318-2660.2016.v40.n3.a2445 · Cited by 4
Enquête autour d’un cas de tuberculose
Antoun, F., Haustraete, E., & Charlois-Ou, C. (2018) · Revue des Maladies Respiratoires · doi:10.1016/j.rmr.2018.03.003 · Cited by 4
Sanni, S., Sina, H., & Baba‐Moussa, L. (2022) · Journal of Tuberculosis Research · doi:10.4236/jtr.2022.103010 · Cited by 3
Starshinova, A. A., Belyaeva, E., Пантелеев, А. М., & Pavlova, M. V. (2018) · Tuberculosis and lung diseases · doi:10.21292/2075-1230-2018-96-10-63-69 · Cited by 3
B cell responses in older adults with latent tuberculosis: Considerations for vaccine development
Helbig, S., Rekhtman, S., Dostie, K., Casler, A., Schneider, T., Hochberg, N. S., & Ganley-Leal, L. M. (2016) · Global Vaccines and Immunology · doi:10.15761/gvi.1000112 · Cited by 2
Jordan, H. T., Calderon, M., Pichardo, C., & Ahuja, S. D. (2020) · Journal of Applied Gerontology · doi:10.1177/0733464820960924 · Cited by 2
Gualano, G., Zaçe, D., Mosti, S., Mencarini, P., Musso, M., Libertone, R., Cerva, C., Goletti, D., Rianda, A., Nonno, F. D., et al. (2023) · Infectious Disease Reports · doi:10.3390/idr15060066 · Cited by 2
Pedrosa, D. M. A. S. (2016) · doi:10.26512/2016.09.d.22819 · Cited by 2
Chapitre 10: Le traitement de la tuberculose active chez les populations particulières
Cooper, R. D., Houston, S. C., Hughes, C. A., & Johnston, J. C. (2023) · Canadian Journal of Respiratory Critical Care and Sleep Medicine · doi:10.1080/24745332.2023.2226009 · Cited by 1
Früh, J., Stich, A., & Müller, A. (2021) · DMW - Deutsche Medizinische Wochenschrift · doi:10.1055/a-1377-4860 · Cited by 1
Adverse Drug Reactions and Their Impact on the Treatment of Pulmonary Tuberculosis
Kaki, T., Minakata, Y., Nakanishi, Y., Sasaki, S., Azuma, Y., Kawabe, K., & Ono, H. (2021) · Journal of Pulmonology Research & Reports · doi:10.47363/jprr/2021(3)112 · Cited by 1
Uqaili, A. A., Gurbakhshani, M., Shaikh, Z. A., Ansari, I. A., & Gurbakhshani, K. (2020) · International Journal Of Medical Science And Clinical Invention · doi:10.18535/ijmsci/v7i08.02 · Cited by 1
Tuberculosis in pregnancy and the elderly
Repossi, A. C., & Bothamley, G. H. (2018) · European Respiratory Society eBooks · doi:10.1183/2312508x.10021917 · Cited by 1
Jung, N., Mayet, W.-J., Mertens, P. R., (federführend), J. M., Müller, O.-A., Pfeifer, M., Schellinger, P. D., Weiss, N., & Wendtner, C. (2020) · Elsevier eBooks · doi:10.1016/b978-3-437-06282-7.50018-8 · Cited by 1
Tuberculosis diseminada en anciano de edad avanzada
Gil, A., Mateos, I., Zurita, A. J. S., & Ramos, J. M. (2015) · Medicina de Familia SEMERGEN · doi:10.1016/j.semerg.2015.07.010
Laoveeravat, P., Wongjarupong, N., Phathong, C., Hurst, C. P., Treeprasertsuk, S., Rerknimitr, R., & Chaiteerakij, R. (2018) · Asian Biomedicine · doi:10.1515/abm-2019-0003
Laundy, N., Colley, S., Fawcett, J., Ryder, L., Vedio, A., Cohen, D., & Collini, P. (2022) · Clinical Infection in Practice · doi:10.1016/j.clinpr.2022.100136
Medication Use in Infectious Diseases
Bilder, G. E., & Brown-O’Hara, P. (2025) · Springer eBooks · doi:10.1007/978-3-031-84831-5_6
Xiao, Y., Chen, Y. L., Huang, R., Jiang, F., Zhou, J., & Yang, T. (2024) · Figshare · doi:10.6084/m9.figshare.25658557
Xiao, Y., Chen, Y. L., Huang, R., Jiang, F., Zhou, J., & Yang, T. (2024) · Figshare · doi:10.6084/m9.figshare.25658683
Bronchiectasis and Mycobacterial Infections in Older Adults
Peterson, J., Jones, M., & Losier, A. (2026) · Respiratory medicine · doi:10.1007/978-3-032-29861-4_14
Stanley, J., Marambire, E. T., Calderwood, C., Gregson, C. L., de Wilton, A., Kavenga, F., Falayi, M., Corbett, E. L., Timire, C., Chipinduro, M., et al. (2026) · The Lancet Regional Health - Africa · doi:10.1016/j.lanafr.2026.100138
Metadata
- Authors
- Hosford, J. D., von Fricken, M. E., Lauzardo, M., Chang, M., Dai, Y., Lyon, J. A., Shuster, J., & Fennelly, K. P.
- Affiliations
- University of Florida Health (US)
- University of Florida (US)
- Corresponding author
- Fennelly, Kevin P.
- Venue
- Tuberculosis
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 95
- Issue
- 2
- Pages
- 112-122
- ISSN
- 1472-9792 (ISSN-L)
- PMC
- PMC4640443
- OpenAlex
- W1995346822
- Cited by
- 63
- References
- 55
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 8 · 2023: 5 · 2022: 5 · 2021: 7 · 2020: 9 · 2019: 5 · 2018: 7 · 2017: 3 · 2016: 6 · 2015: 3
- FWCI
- 0.72
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Tuberculosis (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR001427, UL1TR000064)
- Centers for Disease Control and Prevention
- Emerging Pathogens Institute, University of Florida
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Health Sciences › Medicine › Ophthalmology › Drug-Induced Ocular Toxicity
- Keywords
- hepatotoxicity, antitubercular agents, elderly patients, latent tuberculosis infection, active tuberculosis, age as risk factor, drug-induced liver injury
- MeSH terms
- Age Factors, Aged, Antitubercular Agents, Humans, Risk Factors, Tuberculosis, Latent Tuberculosis, Chemical and Drug Induced Liver Injury
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