Computer analysis of three-dimensional power angiography images of foetal cerebral, lung and placental circulation in normal and high-risk pregnancy
Abstract
Three-dimensional (3-D) ultrasound (US) has greatly improved evaluation of organ circulation. The aim of this study was to explore the possible use of this new technique in normal and high-risk pregnancies. Fetal brain, lung and placenta 3-D power Doppler signal intensity were recorded in 115 normal singleton pregnancies (24 to 42 weeks gestation) and in 67 high-risk pregnancies. Mean image pixel signal intensity was calculated for each organ and a brain-lung ratio. In normal pregnancy, placental and lung signal intensity increased until 33, with a rapid decrease after 38, weeks of gestation. Fetal cerebral signal intensity increased with gestational age. Placental and fetal lung signal intensity was significantly lower in high-risk pregnancies than in the control group, with increased fetal brain and brain-lung ratios. The present results suggest a reduction of placental perfusion after 38 weeks of gestation in normal pregnancy, with redistribution of fetal circulation. Lung signal intensity increased abruptly at 32 weeks of gestation, which might reflect lung maturity. The new method showed signs of centralization of fetal circulation at the end of gestation. The results might suggest a possible clinical use for fetal surveillance in high-risk pregnancies.
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Automatic computer-assisted diagnosis reduces errors caused by subjective judgment and provides a standardization tool to improve diagnosis efficiency.
“Automatic computer-assisted diagnosis not only reduces errors caused by subjective judgment [8] but also provides an attractive and meaningful standardization tool [9 -11] to improve the ef fi ciency of diagnosis.”
From DilatedFormer: dilated granularity transformer network for placental maturity grading in ultrasound (2023) · cites this paper as [8]
Cites
Cardiovascular responses to hypoxemia and acidemia in fetal lambs
Cohn, H. E., Sacks, E. J., Heymann, M. A., & Rudolph, A. M. (1974) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(74)90587-0 · Cited by 800 · see citing works
Blood flow to fetal organs as a function of arterial oxygen content
Peeters, L. L. H., Sheldon, R. E., Jones, M., Makowski, E. L., & Meschia, G. (1979) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(16)32989-1 · Cited by 506 · see citing works
Gosling, R. G., Dunbar, G., King, D. H., Newman, D. L., SIDE, C. D., Woodcock, J. P., Fitzgerald, D. E., Keates, J. S., & Macmillan, D. (1971) · Angiology · doi:10.1177/000331977102200109 · Cited by 419 · see citing works
The ultrasonic changes in the maturing placenta and their relation to fetal pulmonic maturity
Grannum, P. A. T., Berkowitz, R. L., & Hobbins, J. C. (1979) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(79)90312-0 · Cited by 408 · see citing works
Middle cerebral artery flow velocity waveforms in normal and small-for-gestational-age fetuses
Mari, G., & Deter, R. L. (1992) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(11)90620-6 · Cited by 288 · see citing works
Trudinger, B., Stevens, D., Connelly, A., Hales, J. R. S., Alexander, G., Bradley, L., Fawcett, A., & Thompson, R. S. (1987) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(87)80241-7 · Cited by 245 · see citing works
Cerebral Doppler ultrasound of the human fetus
van den Wijngaard, J. A. G. W., Groenenberg, I. A. L., Wladimiroff, J. W., & Hop, W. C. J. (1989) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1989.tb03326.x · Cited by 122 · see citing works
Redistribution of cardiac output and oxygen delivery in the hypoxemic fetal lamb
Sheldon, R. E., Peeters, L. L. H., Jones, M., Makowski, E. L., & Meschia, G. (1979) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(79)90739-7 · Cited by 121 · see citing works
Gudmundsson, S., & Maršál, K. (1988) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/j.1600-0412.1988.tb07813.x · Cited by 119 · see citing works
Self-citationApplication of three‐dimensional power Doppler ultrasound in prenatal diagnosis
Chaoui, R., Kalache, K. D., & Hartung, J. C. (2001) · Ultrasound in Obstetrics and Gynecology · doi:10.1046/j.1469-0705.2001.00305.x · Cited by 104 · see citing works
Fetal branch pulmonary arterial vascular impedance during the second half of pregnancy
Rasanen, J. P., Huhta, J. C., Weiner, S., WOOD, D. C., & Ludomirski, A. (1996) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(96)70586-0 · Cited by 94 · see citing works
Sonographic, stereological and Doppler flow velocimetric assessments of placental maturity
Burton, G. J., & Jauniaux, E. R. M. (1995) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1995.tb10849.x · Cited by 91 · see citing works
Uterine artery color Doppler assisted veloeimetry and perinatal outcome
Hofstaetter, C., Dubiel, M., Gudmundsson, S., & Maršál, K. (1996) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.3109/00016349609054684 · Cited by 86 · see citing works
Self-citationLingman, G., & Maršál, K. (1986) · Early Human Development · doi:10.1016/0378-3782(86)90002-2 · Cited by 75 · see citing works
The assessment of ovarian tumor angiogenesis: what does three‐dimensional power Doppler add?
Kurjak, A., Kupesic, S. P., Breyer, B., Šparac, V., & Jukic, S. (1998) · Ultrasound in Obstetrics and Gynecology · doi:10.1046/j.1469-0705.1998.12020136.x · Cited by 71 · see citing works
Suren, A., Osmers, R., & Kühn, W. M. (1998) · Ultrasound in Obstetrics and Gynecology · doi:10.1046/j.1469-0705.1998.11020133.x · Cited by 44 · see citing works
Factors affecting color Doppler energy ultrasound recordings in an in-vitro model
Gudmundsson, S., Valentin, L., PIRHONEN, J. P., Olofsson, P., Dubiel, M., & Maršál, K. (1998) · Ultrasound in Medicine & Biology · doi:10.1016/s0301-5629(98)00031-3 · Cited by 38 · see citing works
Self-citationFetal and newborn cerebral vascular responses and adaptations to hypoxia.
Longo, L. D., & Pearce, W. J. (1991) · PubMed · Cited by 27 · see citing works
Fetal and placental power Doppler imaging in normal and high-risk pregnancy
Dubiel, M., Kozber, H., Dębniak, B., Bręborowicz, G. H., Maršál, K., & Gudmundsson, S. (1999) · European Journal of Ultrasound · doi:10.1016/s0929-8266(99)00027-0 · Cited by 22 · see citing works
Self-citationDevelopment of three-dimensional power Doppler ultrasound imaging of fetoplacental vasculature
Welsh, A. W., Humphries, K. N., Cosgrove, D. O., Taylor, M. J. O., & Fisk, N. M. (2001) · Ultrasound in Medicine & Biology · doi:10.1016/s0301-5629(01)00409-4 · Cited by 22 · see citing works
Betamethasone treatment and fetal lung perfusion evaluated with color Doppler energy imaging
Dubiel, M., Gudmundsson, S., PIRHONEN, J. P., Breborowicz, G., & Maršál, K. (1997) · Ultrasound in Obstetrics and Gynecology · doi:10.1046/j.1469-0705.1997.10040272.x · Cited by 21 · see citing works
Self-citationComparison of power Doppler and velocimetry in predicting outcome of high-risk pregnancy
Dubiel, M., Dobek, A., Bręborowicz, G. H., Maršál, K., & Gudmundsson, S. (2001) · European Journal of Ultrasound · doi:10.1016/s0929-8266(00)00117-8 · Cited by 10 · see citing works
Self-citationVascular and Doppler ultrasound
Jaffe, C. C. (1984) · Churchill Livingstone eBooks · Cited by 8 · see citing works
Flagged first, then by citations
2 of the 25 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
IFPA Senior Award Lecture: Making sense of pre-eclampsia – Two placental causes of preeclampsia?
Redman, C. W. G., Sargent, I. L., & Staff, A. C. (2014) · Placenta · doi:10.1016/j.placenta.2013.12.008 · Cited by 437 · see citing works
Hernandez‐Andrade, E. A., Horacio Figueroa, D., Jansson, T. T., Rangel-Nava, H. A., & Gratacós, E. (2008) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.5377 · Cited by 129 · see citing works
Reproducibility of regional placental vascularity/perfusion measurement using 3D power Doppler
Lai, P., Wang, A. Y., & Welsh, A. W. (2010) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.7608 · Cited by 80 · see citing works
In Utero Imaging of the Placenta: Importance for Diseases of Pregnancy
Abramowicz, J. S., & Sheiner, E. (2007) · Placenta · doi:10.1016/j.placenta.2007.02.004 · Cited by 77 · see citing works
Placental vasculature as visualized by 3D power Doppler angiography and 3D color Doppler imaging
Campbell, S. C. (2007) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.5195 · Cited by 52 · see citing works
Three-dimensional ultrasound in prenatal diagnosis
Chaoui, R., & Heling, K. (2006) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/01.gco.0000192993.30342.6a · Cited by 34 · see citing works
Flow index evaluation of 3-d volume flow images: An in vivo and in vitro study
Dubiel, M., Hamid, A., Bręborowicz, A., Pietryga, M., Sladkevicius, P., Olofsson, P., Bręborowicz, G. H., & Gudmundsson, S. (2006) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2006.01.016 · Cited by 32 · see citing works
Self-citationFetal brain sparing is strongly related to the degree of increased placental vascular impedance
Cheema, R., Dubiel, M., & Gudmundsson, S. (2006) · Journal of Perinatal Medicine · doi:10.1515/jpm.2006.061 · Cited by 30 · see citing works
Self-citationBartha, J. L., Moya, E., & Hervías‐Vivancos, B. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.70 · Cited by 30 · see citing works
State of the Art: Non-Invasive Ultrasound Assessment of the Uteroplacental Circulation
Urban, G., Vergani, P., Ghidini, A., Tortoli, P., Ricci, S., Patrizio, P., & Paidas, M. J. (2007) · Seminars in Perinatology · doi:10.1053/j.semperi.2007.06.002 · Cited by 27 · see citing works
Cruz-Martínez, R., Figueras, F., Hernandez‐Andrade, E. A., Benavides-Serralde, A., & Gratacós, E. (2010) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.7722 · Cited by 27 · see citing works
Sainz‐Bueno, J. A., Carrera, J., Borrero, C., García‐Mejido, J. A., Fernández-Palacín, A., Robles, A., Sosa‐Moreno, F., & Arroyo, E. (2020) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2020.08.017 · Cited by 26 · see citing works
Three-Dimensional Power Doppler in obstetrics and gynecology
Dubiel, M., Bręborowicz, G. H., Ludwikowski, G., Grabiec, M., & Gudmundsson, S. (2010) · Cited by 22 · see citing works
Self-citationIntrauterine programming of the cardiovascular system
Gardiner, H. M. (2008) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.6155 · Cited by 15 · see citing works
Multi-modal and multi-layout discriminative learning for placental maturity staging
Lei, B., Li, W., Yao, Y., Jiang, X., Tan, E.-L., Qin, J., Chen, S., Ni, D., & Wang, T. (2016) · Pattern Recognition · doi:10.1016/j.patcog.2016.09.037 · Cited by 12 · see citing works
López, F. S., Orozco‐Beltrán, D., Gil-Guillén, V. F., Lozano, J. M., Palacios, A., & Bernabéu, R. (2010) · Reproductive Sciences · doi:10.1177/1933719110371013 · Cited by 10 · see citing works
13-week Pulmonary Sonoangiogram by 3D HDlive Flow
Pooh, R. K. (2015) · Donald School Journal of Ultrasound in Obstetrics & Gynecology · doi:10.5005/jp-journals-10009-1421 · Cited by 9 · see citing works
El-Garhy, I. M. T., Sedek, A. E.-M. A. E.-H., & Ali, A.-R. A. A.-R. (2022) · International Journal of Health Sciences · doi:10.53730/ijhs.v6ns5.10281 · Cited by 8 · see citing works
Automatic placental maturity grading via hybrid learning
Lei, B., Tan, E.-L., Chen, S., Li, W., Ni, D., Yao, Y., & Wang, T. (2017) · Neurocomputing · doi:10.1016/j.neucom.2016.10.033 · Cited by 5 · see citing works
Andonotopo, W., Kristanto, H., Dewantiningrum, J., & Pramono, B. A. (2014) · Donald School Journal of Ultrasound in Obstetrics & Gynecology · doi:10.5005/jp-journals-10009-1372 · Cited by 4 · see citing works
Fetal pulmonary and cerebral artery Doppler velocimetry in normal and high risk pregnancy
Bręborowicz, A., Dubiel, M., Pietryga, M., Bręborowicz, G. H., & Gudmundsson, S. (2014) · Ginekologia Polska · doi:10.17772/gp/1686 · Cited by 4 · see citing works
Self-citationDilatedFormer: dilated granularity transformer network for placental maturity grading in ultrasound
Wu, Y., Yang, Y., Zhu, L., Han, Z., Luo, H., Xue, X., & Wang, W. (2023) · Frontiers in Physics · doi:10.3389/fphy.2023.1239400 · Cited by 2 · see citing works
Hybrid descriptor for placental maturity grading
Lei, B., Jiang, F., Zhou, F., Ni, D., Yao, Y., Chen, S., & Wang, T. (2020) · Multimedia Tools and Applications · doi:10.1007/s11042-019-08489-x · Cited by 3 · see citing works
3D POWER DOPPLER IN OBSTETRICS
Jones, N. W., Raine‐Fenning, N., & Bugg, G. J. (2011) · Fetal and Maternal Medicine Review · doi:10.1017/s0965539510000136 · Cited by 2 · see citing works
Placental Blood Flow by Three-dimensional Doppler Ultrasound
Žalud, I. (2016) · Donald School Journal of Ultrasound in Obstetrics & Gynecology · doi:10.5005/jp-journals-10009-1443 · Cited by 1 · see citing works
Physiology of the Developing Heart
Gardiner, H. M. (2009) · Elsevier eBooks · doi:10.1016/b978-0-443-11851-7.00008-2 · Cited by 1 · see citing works
3D Doppler ultrasound in the study of placental vascularization
Žalud, I. (2006) · The ultrasound review of obstetrics & gynecology/Ultrasound review of obstetrics and gynecology · doi:10.1080/14722240600645410 · Cited by 1 · see citing works
Ecografía tridimensional en ginecología y obstetricia
Zambrano, R., & Miguel, M. (2005) · Redalyc (Universidad Autónoma del Estado de México) · Cited by 1 · see citing works
Future Uses of Three/Four Dimensional Power Doppler Signal in Fetal Medicine
Bello‐Muñoz, J. C., Ayala, M., Carreras, E., Oliveros, P., Campo, N., Casasbuenas, A., Arvalo, S., & Cabero, L. (2012) · InTech eBooks · doi:10.5772/28494
Martínez, R. C. (2010) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
López, F. S., Gil-Guillén, V. F., Orozco‐Beltrán, D., & Alfredo Perales, M. (2009) · Progresos de Obstetricia y Ginecología · doi:10.1016/s0304-5013(09)71050-7
Intraplacental blood flow features inphysiological pregnancy
Zakurina, A. N., & Григорьевна, П. Н. (2013) · Journal of obstetrics and women s diseases · doi:10.17816/jowd62229-33
Muñoz, B., & Carlos, J. (2012) · TDX (Tesis Doctorals en Xarxa)
Sellers, F., Moliner, B., Palacios, A., Sellers, R., Llácer, J., & Bernabéu, R. (2017) · Medicina Reproductiva y Embriología Clínica · doi:10.1016/j.medre.2017.06.001
Placental maturity grading via hybrid descriptors based on fisher vector
Jiang, F., Ni, D., Chen, S., Yao, Y., Le, M. H., Wang, T., & Lei, B. (2018) · IEEE International Symposium on Biomedical Imaging (ISBI) · doi:10.1109/isbi.2018.8363861
Current awareness in prenatal diagnosis
(2005) · Prenatal Diagnosis · doi:10.1002/pd.1023
- Authors
- Dubiel, M., Breborowicz, G. H., Ropacka, M., Pietryga, M., Maulik, D., & Gudmundsson, S.
- Affiliations
- Poznan University of Medical Sciences (PL)
- Winthrop-University Hospital (US)
- Venue
- Ultrasound in Medicine & Biology
- Publisher
- Elsevier BV
- Published
- 2005-03
- Volume
- 31
- Issue
- 3
- Pages
- 321-327
- ISSN
- 0301-5629 (ISSN-L)
- OpenAlex
- W2118425210
- Cited by
- 36
- References
- 25
- Citations by year
- 2023: 1 · 2022: 1 · 2020: 2 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 3 · 2013: 1 · 2012: 2
- FWCI
- 4.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Ultrasound in Medicine & Biology (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Screening and Diagnostics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Keywords
- three-dimensional power Doppler ultrasound, fetal circulation, placental perfusion, fetal cerebral circulation, high-risk pregnancy, fetal lung maturity, fetal monitoring, gestational age
- MeSH terms
- Brain, Cerebrovascular Circulation, Cross-Sectional Studies, Echoencephalography, Female, Fetus, Gestational Age, Humans, Image Processing, Computer-Assisted, Infant, Newborn, Lung, Placenta, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Regional Blood Flow, Risk Factors, Ultrasonography, Prenatal, Ultrasonography, Doppler, Imaging, Three-Dimensional
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