Cited by 17Nanoplatforms for cancer theranosticsCancer, Hypoxia, and MetabolismPhotodynamic Therapy Research Studies

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Sonodynamic Therapy Combined to 2-Deoxyglucose Potentiate Cell Metastasis Inhibition of Breast Cancer

Xie, Lifen, Feng, Xiaolan, Huang, Minying, Zhang, Kun, Liu, Quanhong·2019·Ultrasound in Medicine & Biology

DOI 10.1016/j.ultrasmedbio.2019.07.008

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Abstract

Metastasis is a major dilemma of cancer therapy. It frequently occurs in breast cancer, which is the leading form of malignant tumor among females worldwide. Although there are therapies that provide a possible method for this challenge, such as chemotherapy, the tumoral metabolic pathway is unconventional and favors metastasis and proliferation. This magnifies the difficulty of treating breast cancer. In this study, we identified 2-deoxyglucose (2 DG) as an important glycolysis suppressor that can potentiate sonodynamic therapy (SDT) to inhibit migration and invasion. In addition, disruptions of the cell membrane microstructure were captured by a scanning electron microscope in cells treated with the co-therapy. Similarly, we detected blockages of the cell cycle process, using flow cytometry. Of note, we observed that hexokinase II (HK2), the rate-limiting enzyme of glycolysis, was notably uncoupled from the mitochondria in SDT + 2 DG co-therapy group. Furthermore, there was altered expression of HK2 and Glut1, which control glycolysis. Simultaneously, the in vivo results revealed that pulmonary metastasis was also seriously suppressed by SDT + 2 DG co-therapy. These results demonstrate this co-therapy is a promising strategy for breast cancer inhibition through metastasis and proliferation.

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Authors: Xie, L., Feng, X., Huang, M., Zhang, K., & Liu, Q.
Affiliations: Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Shaanxi Normal University (CN)
Corresponding author: Zhang, Kun
ORCID: Feng, Xiaolan
Zhang, Kun
Liu, Quanhong
Venue: Ultrasound in Medicine & Biology
Publisher: Elsevier BV
Published: 2019-11
Volume: 45
Issue: 11
Pages: 2984-2992
ISSN: 0301-5629 (ISSN-L)
DOI: 10.1016/j.ultrasmedbio.2019.07.008
OpenAlex: W2967770727
Cited by: 17
References: 48
Citations by year: 2026: 1 · 2025: 2 · 2024: 1 · 2023: 5 · 2022: 3 · 2021: 3 · 2020: 2
FWCI: 0.71
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Ultrasound in Medicine & Biology (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (81571834)
Fundamental Research Funds for the Central Universities (GK201803043)
Topics: Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
Keywords: sonodynamic therapy, 2-deoxyglucose, breast cancer, metastasis suppression, glycolysis inhibition, hexokinase 2, GLUT1, cell migration and invasion, cell cycle arrest, mitochondrial uncoupling, lung metastasis
MeSH terms: Animals, Cell Movement, Cell Survival, Deoxyglucose, Female, Flow Cytometry, Glycolysis, Mammary Neoplasms, Experimental, Mice, Inbred BALB C, Microscopy, Electron, Scanning, Neoplasm Metastasis, Ultrasonic Therapy, Cell Line, Tumor, Mice

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Sonodynamic Therapy Combined to 2-Deoxyglucose Potentiate Cell Metastasis Inhibition of Breast Cancer

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