Single-transducer dual-frequency ultrasound generation to enhance acoustic cavitation
Abstract
Dual- or multiple-frequency ultrasound stimulation is capable of effectively enhancing the acoustic cavitation effect over single-frequency ultrasound. Potential application of this sonoreactor design has been widely proposed such as on sonoluminescence, sonochemistry enhancement, and transdermal drug release enhancement. All currently available sonoreactor designs employed multiple piezoelectric transducers for generating single-frequency ultrasonic waves separately and then these waves were mixed and interfered in solutions. The purpose of this research is to propose a novel design of generating dual-frequency ultrasonic waves with single piezoelectric elements, thereby enhancing acoustic cavitation. Macroscopic bubbles were detected optically, and they were quantified at either a single-frequency or for different frequency combinations for determining their efficiency for enhancing acoustic cavitation. Visible bubbles were optically detected and hydrogen peroxide was measured to quantify acoustic cavitation. Test water samples with different gas concentrations and different power levels were used to determine the efficacy of enhancing acoustic cavitation of this design. The spectrum obtained from the backscattered signals was also recorded and examined to confirm the occurrence of stable cavitation. The results confirmed that single-element dual-frequency ultrasound stimulation can enhance acoustic cavitation. Under certain testing conditions, the generation of bubbles can be enhanced up to a level of five times higher than the generation of bubbles in single-frequency stimulation, and can increase the hydrogen peroxide production up to an increase of one fold. This design may serve as a useful alternative for future sonoreactor design owing to its simplicity to produce dual- or multiple-frequency ultrasound.
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Double frequency ultrasonic significantly enhances the rate of cavitation compared to single frequency ultrasonic.
“Compared to single frequency ultrasonic, double frequency ultrasonic significantly enhance the rate of cavitation [101], [102], [103].”
From A comprehensive review of ultrasonic assisted extraction (UAE) for bioactive components: Principles, advantages, equipment, and combined technologies (2023) · cites this paper as [101]
Cites
Leighton, T. G. (2012) · Cited by 2,286 · see citing works
Effects of reaction conditions on the oxidation efficiency in the Fenton process
Kang, Y. W., & Hwang, K.-Y. (2000) · Water Research · doi:10.1016/s0043-1354(99)00388-7 · Cited by 647 · see citing works
O'Neil, H. T. (1949) · The Journal of the Acoustical Society of America · doi:10.1121/1.1906542 · Cited by 576 · see citing works
McDannold, N. J., Vykhodtseva, N. I., & Hynynen, K. (2006) · Physics in Medicine and Biology · doi:10.1088/0031-9155/51/4/003 · Cited by 449 · see citing works
The threshold for thermally significant cavitation in dog's thigh muscle in vivo
Hynynen, K. (1991) · Ultrasound in Medicine & Biology · doi:10.1016/0301-5629(91)90123-e · Cited by 432 · see citing works
Enhancement of ultrasonic cavitation yield by multi-frequency sonication
Feng, R., Zhao, Y., Zhu, C., & Mason, T. J. (2002) · Ultrasonics Sonochemistry · doi:10.1016/s1350-4177(02)00083-4 · Cited by 294 · see citing works
Ultrasound in materials chemistry
Peters, D. (1996) · Journal of Materials Chemistry · doi:10.1039/jm9960601605 · Cited by 207 · see citing works
Tang, H. L., Wang, C. C. J., Blankschtein, D., et al. (2002) · Pharmaceutical Research · doi:10.1023/a:1019898109793 · Cited by 170 · see citing works
Treatment of localised prostate cancer with transrectal high intensity focused ultrasound
Chapelon, J., Ribault, M., Birer, A., Vernier, F., Souchon, R., & Gelet, A. (1999) · European Journal of Ultrasound · doi:10.1016/s0929-8266(99)00005-1 · Cited by 166 · see citing works
Non-Invasive Assessment and Control of Ultrasound-Mediated Membrane Permeabilization
Jin, L., Lewis, T. N., & Prausnitz, M. R. (1998) · Pharmaceutical Research · doi:10.1023/a:1011984817567 · Cited by 155 · see citing works
Umemura, S.-I., Kawabata, K.-I., & Sasaki, K. (1997) · The Journal of the Acoustical Society of America · doi:10.1121/1.418120 · Cited by 107 · see citing works
Effect of exposure parameters on cavitation induced by low-level dual-frequency ultrasound
Barati, A. H., Mokhtari‐Dizaji, M., Mozdarani, H., Bathaie, S. Z., & Hassan, Z. M. (2007) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2006.12.016 · Cited by 105 · see citing works
Servant, G., Laborde, J.-L., Hita, A., et al. (2003) · Ultrasonics Sonochemistry · doi:10.1016/s1350-4177(03)00105-6 · Cited by 104 · see citing works
Dähnke, S., Swamy, Κ. Μ., & Keil, F. J. (1999) · Ultrasonics Sonochemistry · doi:10.1016/s1350-4177(98)00026-1 · Cited by 101 · see citing works
Ashokkumar, M., Hodnett, M., Zeqiri, B., et al. (2007) · Journal of the American Chemical Society · doi:10.1021/ja067960r · Cited by 101 · see citing works
Servant, G., Laborde, J.-L., Hita, A., et al. (2001) · Ultrasonics Sonochemistry · doi:10.1016/s1350-4177(01)00074-8 · Cited by 91 · see citing works
Experimental and theoretical investigations on sonoluminescence under dual frequency conditions
Kanthale, P. M., Brotchie, A., Ashokkumar, M., & Grieser, F. (2007) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2007.08.006 · Cited by 74 · see citing works
Enhancement of high-frequency acoustic cavitation effects by a low-frequency stimulation
Iernetti, G., Ciuti, P., Дежкунов, Н. В., et al. (1997) · Ultrasonics Sonochemistry · doi:10.1016/s1350-4177(97)00034-5 · Cited by 71 · see citing works
Cavitation activity stimulation by low frequency field pulses
Ciuti, P., Дежкунов, Н. В., Francescutto, A., et al. (2000) · Ultrasonics Sonochemistry · doi:10.1016/s1350-4177(99)00037-1 · Cited by 64 · see citing works
Focussed Extracorporeal Pyrotherapy: Experimental Results
Vallancien, G., Chartier-Kastler, E. J., Chopin, D. K., et al. (1991) · European Urology · doi:10.1159/000471702 · Cited by 61 · see citing works
Sokka, S., Gauthier, T. P., & Hynynen, K. (2005) · Physics in Medicine and Biology · doi:10.1088/0031-9155/50/9/017 · Cited by 60 · see citing works
Price, G. J., Ashokkumar, M., Hodnett, M., et al. (2005) · The Journal of Physical Chemistry B · doi:10.1021/jp0543227 · Cited by 56 · see citing works
Effect of Water-Soluble Solutes on Sonoluminescence under Dual-Frequency Sonication
Brotchie, A., Ashokkumar, M., & Grieser, F. (2007) · The Journal of Physical Chemistry C · doi:10.1021/jp067524r · Cited by 43 · see citing works
Comparison of enhancement of pentachlorophenol sonolysis at 20 kHz by dual-frequency sonication
Wang, S., Huang, B., Wang, Y., et al. (2005) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2005.10.004 · Cited by 43 · see citing works
Sonochemistry and Sonoluminescence under Simultaneous High- and Low-Frequency Irradiation
Brotchie, A., Ashokkumar, M., & Grieser, F. (2008) · The Journal of Physical Chemistry C · doi:10.1021/jp8006987 · Cited by 34 · see citing works
Carr, J. (1991) · Cited by 28 · see citing works
Fluorescence enhancement of the aqueous solution of terephthalate ion after bi-frequency sonication
Zhao, Y., Zhu, C., Feng, R., et al. (2002) · Ultrasonics Sonochemistry · doi:10.1016/s1350-4177(02)00077-9 · Cited by 23 · see citing works
Wu, S., Zhang, Z., & Zhao, J. (1998) · PubMed · Cited by 9 · see citing works
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Shen, L., Pang, S., Zhong, M., Sun, Y., Qayum, A., Liu, Y., Rashid, A., Xu, B., Liang, Q., Ma, H., et al. (2023) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2023.106646 · Cited by 892 · see citing works
Dzah, C. S., Duan, Y., Zhang, H., Wen, C., Zhang, J., Chen, G., & Ma, H. (2020) · Food Bioscience · doi:10.1016/j.fbio.2020.100547 · Cited by 544 · see citing works
Yang, X., Li, Y., Li, S., Oladejo, A. O., Ruan, S., Wang, Y., Huang, S., & Ma, H. (2017) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2017.02.026 · Cited by 212 · see citing works
Yang, X., Li, Y., Li, S., Oladejo, A. O., Wang, Y., Huang, S., Zhou, C., Wang, Y., Mao, L., Zhang, Y., et al. (2017) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2017.03.001 · Cited by 121 · see citing works
Yang, X., Li, Y., Li, S., Oladejo, A. O., Wang, Y., Huang, S., Zhou, C., Ye, X., Ma, H., & Duan, Y. (2018) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2017.08.028 · Cited by 100 · see citing works
Effect of dual-frequency pulsed ultrasonic excitation and catalyst size for biodiesel production
Wongwuttanasatian, T., & Jookjantra, K. (2020) · Renewable Energy · doi:10.1016/j.renene.2020.01.149 · Cited by 24 · see citing works
- Authors
- Liu, H.-L., & Hsieh, C.-M.
- Affiliations
- National Health Research Institutes (TW)
- Chang Gung University (TW)
- Corresponding author
- Liu, Hao-Li
- ORCID
- Liu, Hao-Li
- Venue
- Ultrasonics Sonochemistry
- Publisher
- Elsevier BV
- Published
- 2009-03
- Volume
- 16
- Issue
- 3
- Pages
- 431-438
- ISSN
- 1350-4177 (ISSN-L)
- OpenAlex
- W1987619742
- Cited by
- 125
- References
- 28
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 15 · 2023: 11 · 2022: 8 · 2021: 8 · 2020: 16 · 2019: 6 · 2018: 5 · 2017: 14 · 2016: 4 · 2015: 4 · 2014: 6 · 2013: 4 · 2012: 5
- FWCI
- 0.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Ultrasonics Sonochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Health Research Institutes
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Ultrasound and Cavitation Phenomena
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Physical Sciences › Engineering › Mechanics of Materials › Ultrasonics and Acoustic Wave Propagation
- Keywords
- dual-frequency ultrasound, acoustic cavitation, bubble formation, hydrogen peroxide production, stable cavitation, sonoluminescence
- MeSH terms
- Computer Simulation, Equipment Design, Hydrogen Peroxide, Oxygen, Ultrasonics, Equipment Failure Analysis, Microbubbles
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