Enterococcal infections: host response, therapeutic, and prophylactic possibilities

Koch, Stefanie; Hufnagel, Markus; Theilacker, Christian; Huebner, Johannes

doi:10.1016/j.vaccine.2003.11.027

Cited by 159Escherichia coli research studiesAntibiotic Resistance in BacteriaBacterial Genetics and Biotechnology

Enterococcal infections: host response, therapeutic, and prophylactic possibilities

Koch, Stefanie, Hufnagel, Markus, Theilacker, Christian, Huebner, Johannes·2004·Vaccine

DOI 10.1016/j.vaccine.2003.11.027

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Abstract

The emergence of resistance against multiple antibiotics and the increasing frequency with which Enterococcus faecalis and Enterococcus faecium are isolated from hospitalized patients underscore the necessity for a better understanding of the virulence mechanisms of this pathogen and the development of alternatives to current antibiotic treatments. The genetic plasticity of enterococci and their ability to rapidly acquire and/or develop resistance against many clinically important antibiotics and to transfer these resistance determinants to other more pathogenic microorganisms makes the search for alternative treatment and preventive options even more important. A capsular polysaccharide antigen has recently been characterized that is the target of opsonic antibodies. A limited number of clinically relevant serotypes exist, and the development of an enterococcal vaccine based on capsular polysaccharides may improve our ability to prevent and treat these infections. Additional enterococcal surface antigens, including ABC transporter proteins and other virulence factors, such as aggregation substance (AS), may also be useful targets for therapeutic antibodies.

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Surveillance of Enterococcus spp. reveals distinct species and antimicrobial resistance diversity across a One-Health continuum
Zaheer, R., Cook, S. R., Barbieri, R., Goji, N., Cameron, A., Petkau, A., Polo, R. O., Tymensen, L., Stamm, C., Song, J., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-61002-5 · Cited by 262 · see citing works
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“Several adhesion factors have been identified which facilitate binding to mucosal and epithelial surfaces and facilitate colonization or the formation of vegetation (Koch et al., 2004).”
Background
Identification of secreted and surface proteins from Enterococcus faecalis
Benachour, A., Morin, T., Hébert, L., Budin-Verneuil, A., Le Jeune, A., Auffray, Y., & Pichereau, V. (2009) · Canadian Journal of Microbiology · doi:10.1139/w09-052 · Cited by 28 · see citing works

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Authors: Koch, S., Hufnagel, M., Theilacker, C., & Huebner, J.
Affiliations: Brigham and Women's Hospital (US)
ORCID: Hufnagel, Markus
Theilacker, Christian
Venue: Vaccine
Publisher: Elsevier BV
Published: 2004-02
Volume: 22
Issue: 7
Pages: 822-830
ISSN: 0264-410X (ISSN-L)
DOI: 10.1016/j.vaccine.2003.11.027
OpenAlex: W2026693836
Cited by: 159
References: 132
Citations by year: 2025: 2 · 2024: 5 · 2023: 4 · 2022: 9 · 2021: 16 · 2020: 11 · 2019: 9 · 2018: 10 · 2017: 4 · 2016: 3 · 2015: 11 · 2014: 13 · 2013: 10 · 2012: 7
FWCI: 0.54
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Vaccine (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords: Enterococcus faecalis, Enterococcus faecium, enterococcal infections, antibiotic resistance, virulence factors, capsular polysaccharide antigen, capsular serotypes, therapeutic antibodies, aggregation substance, host immune response, genome plasticity, resistance gene transfer
MeSH terms: Animals, Antigens, Bacterial, Bacterial Vaccines, Humans, Lipopolysaccharides, Gram-Positive Bacterial Infections, Enterococcus, Bacterial Translocation, Virulence Factors

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Enterococcal infections: host response, therapeutic, and prophylactic possibilities

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